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Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： yuncong Shi Zhengzhipeng Zhang Binyan Wang yu Wang Xiangyi Kong yong Sun Aimin Li yimin Cui yan Zhang Jianping Li yong Huo Hui huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

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Enhanced identification and localization of metabolites in Scutellariae Radix using ion mobility enabled MALDI-q-TOF/MS imaging

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Journal of Pharmaceutical Analysis 2024年第2期14卷 284-286页

作者： Lixing Nie Lieyan huang Xiaofei Jia Shuai Kang Lingwen yao yanpei Wu Hao yuan yongli Liu Feng Wei Hongyu Jin Xiang Li Shuangcheng Ma National Institutes for Food and Drug Control Beijing102629China Chinese Academy of Medical Science and Peking Union Medical College Beijing100006China Waters Corporation Beijing102600China Hebei Institute for Drug and Medical Device Control Shijiazhuang050227China Department of Pharmacy Medical Supplies Center of the PLA General HospitalBeijing100853China

Unraveling the distribution of metabolites in traditional Chinese medicine(TCM)provides direct indications for understanding their regulatory and functional basis,which is of paramount significance for better utilization and quality control of medicinal plants[1].Recently,imaging techniques such as near-infrared spectroscopy,Raman spectroscopy,and mass spectrometry(MS)were explored to reveal the spatial context of component accumulation and localization[2,3].

关键词： medicine(TCM) Radix Scutellaria

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Terpyridine-based metallo-cuboctahedron nanomaterials for efficient photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： qixia Bai yan huang Zhihong Chen yilin Pan Xiaohan Zhang qingwu Long qiaoan yang Tun Wu Ting-Zheng Xie Mingjian Wang Hongguang Luo Chun Hu Pingshan Wang Zhe Zhang Key Laboratory for Water quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China College of Light Chemical Industry and Materials Engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye Inspection&Testing Group Co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-Zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95% ***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/L hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H_(2)O_(2) *** work not only proposes a simple and efficient synthesis method for supramolecular photocatalysts but also opens up opportunities for efficient,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production

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青藏高原及其周边志留纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 1026-1057页

作者：陈中阳陈清王光旭方翔唐鹏闫冠州袁文伟黄冰张小乐燕夔张元动王怿中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学北京100049

青藏高原志留纪的古生物学与地层学研究已有百余年的历史,随着第二次青藏高原综合科学考察研究项目的启动,对于青藏高原志留纪的地层系统和化石群的总结,及其与周边地区的对比亟待更新.本文在青藏高原及其周边选择了33条代表剖面,从地... 详细信息

青藏高原志留纪的古生物学与地层学研究已有百余年的历史,随着第二次青藏高原综合科学考察研究项目的启动,对于青藏高原志留纪的地层系统和化石群的总结,及其与周边地区的对比亟待更新.本文在青藏高原及其周边选择了33条代表剖面,从地层区划、岩石地层、年代地层和生物地层等方面,对已有的资料进行了总结,将青藏高原及其周边划为了4个地层区:西藏-滇西-川西地层区、昆仑-祁连地层区、华南地层区和塔里木地层区.其中青藏高原主体部分被划入了西藏-滇西-川西地层区,该地层区地层和生物组合发育基本完整,一定程度上弥补了我国其他地区志留系研究的不足.通过对志留纪青藏高原及其周边古生物地理研究的总结,尤其是对鱼类动物群、孢型植物组合和腕足动物群分布特征的梳理,指出华南、塔里木和印支等三大板块之间的关系应该比此前认为的更为密切.与研究程度较高的周边地区相比,青藏高原主体部分的志留系尚处于初步研究阶段,诸多问题和领域有待开展和深入研究.未来需要对志留系底部黑色岩系的时限、分布和资源量进行研究,为我国未来页岩气勘探开发提供新的方向.志留系中-上部浅海地层需要进行进一步的划分.由于青藏高原地区的志留系发育较完整,在生物地层学工作基础上,更有潜力补充和完善我国志留纪的碳同位素地层学研究.

关键词：青藏高原志留纪地层区划岩石地层生物地层古地理演化

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A Review of Botulism in China

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Biomedical and Environmental Sciences 1990年第3期3卷 326-336页

作者： GAO q.y. huang y.F. WU J.G. LIU H.D. XIA H.q Institute of Food Safety Control and Inspection Ministry of Public Health 29 Nan Wei Road Beijing 100050 Sanitary and Antiepidemic Station of Urumqi City Urumqi Xinjiang Autonomous Region Sanitary and Antiepidemic Station of Tachen District Tachen Xinjiang Autonomous Region Pipeline Bureau Hospital Ministry of Petroleum Langfang HebeiPeople's Republic of China

The epidemiological characteristics and etiology of botulisin in China, as well as the distribution of different types of Clustridium bolulinum in China; are *** 1989, 15 provinces and autonomous regions reported the occurrence of *** were 2861 cases involved in 745 *** the cases 421 died, with a case fatality of 14.7%.The main epidemiological characteristics of botulism in China are: (i) the major foods causing botulism are homemade fermented bean products which accounted for 62.6% of the cases; (ii) the incubation period is longer (3 h-54 days) than that described in the western literature (mostly 2-7 days); (iii) the peak occurrence is from February to May; (iv) the progression of symptoms and signs is slower than that of western *** types of *** the exception of type G, have been found in *** distribution of various types of *** is significantly different between southern and northern China; this is related to the latitude and is correlated with the prevalence of this *** of the botulism outbreaks occurred above 30° north latitude in northern China and outbreaks rarely occurred below 30° north *** surveys showed that the average detection rate of C bolulinum spores in soil and foods in the northern parts of China was 14.8%.while it was only 2.5% in the *** types A, B, *** F, which are involved in human botulism, were frequently found in the North, while types C and D, which are involved only in animal intoxication, were found more frequently in the south. 1990 Academic ***.

关键词： In A Review of Botulism in China

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WIDE-BAND LASER CLADDING: WEAR AND CORROSION RESISTANCE OF A Ni-BASED ALLOy

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Acta Metallurgica Sinica(English Letters) 1997年第5期10卷 445-452页

作者： Pan, q.y. huang, W.D. Li, y.M. Lin, X. Zhou, y.H. yang, X.C. Northwestern Polytechnical Univ Xi'an China

A novel wide-band laser cladding system, with high rate of cladding, has been developed in the present work. The system mainly consisted of a 5kW CO2 laser, an automatic powder feeder and a wide-band scanning rotative polygon mirror which can produce a linear or rectangular focused laser beam. Using this system, a Ni-Cr-Si-B alloy powder was cladded on the surface of type 321 austenitic stainless steel in order to improve its wear and corrosion resistance. The pitting corrosion, high temperature oxidation and wear tests were conducted in order to evaluate the properties of the laser cladded layer. The results demonstrated that the cladded layer can significantly improve the adhesive wear and pitting corrosion resistance of the substrate. Moreover, the cladded layer exhibited good oxidation resistance, which is almost the same as that of GMR-235D Ni-based superalloy.

关键词： Boron Chromium alloys Cladding (coating) Laser applications Nickel alloys Silicon alloys Wear resistance

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Plastic Strain Energy Model for Rock Salt Under Fatigue Loading

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Acta Mechanica Solida Sinica 2018年第3期31卷 322-331页

作者： M.M.He N.Li B.q.huang C.H.Zhu y.S.Chen Institute of Geotechnieal Engineering Xi'an University of TechnologyXi'an 710048China State Key Laboratory of Eco-hydraulics in Northwest Arid Region Xi'an University of TechnologyXi'an 710048China College of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China Shaanxi Key Laboratory of Loess Mechanics and Engineering Xi'an University of TechnologyXi'an 710048China

The fatigue test for rock salt is conducted to investigate the effects of stress ampli- tude, loading frequency and loading rate on the plastic strain energy, from which the evaluation rule of the plastic strain energy is analyzed, which is divided into three stages： cyclic hardening, saturation and cyclic softening. The total accumulated plastic strain energy only depends on the mechanical behavior of rock salt, but is immune to the loading conditions. A novel model for fatigue life prediction is proposed based on the invariance of the total plastic dissipation energy and the stability of the plastic energy per cycle.

关键词： Rock salt Fatigue life Plastic energy

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Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： ye-qiang Han yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang Ben Zhong Tang Jonathan L.Sessler Feihe huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

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Phase separation and domain crystallinity control enable open-air-printable highly efficient and sustainable organic photovoltaics

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InfoMat 2024年第3期6卷 131-143页

作者： Jie Lv Xiaokang Sun Hua Tang Fei Wang Guangye Zhang Liangxiang Zhu Jiaming huang qianguang yang Shirong Lu Gang Li Frédéric Laquai Hanlin Hu Hoffmann Institute of Advanced Materials Shenzhen Polytechnic UniversityShenzhenthe People's Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhenthe People's Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtanthe People's Republic of China KAUST Solar Center Physical Sciences and Engineering Division(PSE)Materials Science and Engineering Program(MSE)King Abdullah University of Science and Technology(KAUST)ThuwalKingdom of Saudi Arabia College of New Materials and New Energies Shenzhen Technology UniversityShenzhenthe People's Republic of China Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong SARthe People's Republic of China Department of Material Science and Technology Taizhou UniversityTaizhouthe People's Republic of China

Organic solar cells(OSCs)have emerged as a promising solution for sustainable energy production,offering advantages such as a low carbon footprint,short energy payback period,and compatibility with ***,the use of hazardous solvents continues to dominate the best-performing OSCs,mainly because of the challenges of controlling phase separation and domain crystallinity in *** this study,we combined the solvent vapor treatment of CS2 and thermal annealing to precisely control the phase separation and domain crystallinity in PM6:M-Cl and PM6:O-Cl systems processed with the eco-solvent *** method resulted in a maximum power conversion efficiency(PCE)of 18.4%,which is among the highest values reported for sustainable binary ***,the fabrication techniques were transferred from spin coating in a nitrogen environment to blade printing in ambient air,retaining a PCE of 16.0%,showing its potential for high-throughput and scalable *** addition,a comparative analysis of OSCs processed with hazardous and green solvents was conducted to reveal the differences in phase *** work not only underscores the significance of sustainability in OSCs but also lays the groundwork for unlocking the full potential of open-air-printable sustainable OSCs for commercialization.

关键词： open-air printable organic solar cells sustainability

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Automation 5.0: The Key to Systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong huang Mariagrazia Dotoli yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na qing-Long Han Fei-yue Wang Institute of Intelligent and Integrated Systems and the School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-Systems University of Southern CaliforniaLos AngelesCA 90007 USA School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel Sensing Beijing 101499China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence

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