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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of n-acetyl-alpha-glucosaminidase to Parkinson’s disease

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neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao yidan Zhang Xin Liu jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng y.ng Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DnA,mRnA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified n-acetyl-alpha-glucosaminidase as a differentially expressed protein.n-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal n-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that n-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that n-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,n-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal n-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that n-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes n-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

REVIEW OF SOME RESEARCHES On nAnO-AnD SUBMICROn BROWnIAn PARTICLE-LADEn TURBULEnT FLOW

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Journal of Hydrodynamics 2012年第6期24卷 801-808页

作者： LIn jian-zhong HUAnG Li-zhong China Jiliang University Department of Mechanics Zhejiang University

The study of nano- and submicron Brownian particle-laden turbulent flow has wide industrial applicability and hence has received much attention. The purpose of the present paper is to provide and review some researches in this field. The topics are related to the universality, particularity, complexity and importance of nano- and submicron Brownian particle-laden turbulent flow, the models of particle general dynamical equation, the collision behavior of particles. Finally, several open research issues are identified.

关键词： particle-laden flow nano-particle submicron particle Brownian turbulence

Ultrasound-responsive Homopolymer nanoparticles

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Chinese Journal of Polymer Science 2020年第4期38卷 349-356,I0006页

作者： Bo y.ng jian-zhong Du Department of Orthopedics Shanghai Tenth People's HospitalTongji University School of MedicineShanghai 200072China Department of Polymeric Materials School of Materials Science and EngineeringKey Laboratory of Advanced Civil Engineering Materials of Ministry of EducationTongji UniversityShanghai201804China

nonin vasive ultraso und is a more effective strategy for on-demand drug delivery of polymeric nano particles than many other ***,the preparation of ultrasound-responsive homopolymer nanoparticles is still very *** this study,we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer nanoparticle *** nanoparticles such as vesicles and large compound micelles(LCMs)are self-assembled from poly(methoxyethyl methacrylate)(PMEMA)and poly(amic acid)(PAA),*** ultrasound responsiveness of PAA vesicles at metastable state could be regulated by tuning the self-assembly temperature(7^),and was optimized when Ts is around the glass transition temperature(7g)of ***,the PMEMA LCMs did not respond to ultrasound as they are at stable *** the other hand,poly(2-(2-ethoxyethoxy)ethyl acrylate)(PEEA)could self-assemble into vesicle aggregates or complex micelle aggregates,which were dissociated upon ***,the above findings provide us with a fresh in sight for designing ultrasound-responsive polymeric nanoparticles.

关键词： Ultrasound responsiveness Homopolymers Vesicles Micelles Self-assembly

On THE COnVERGEnCE OF WAVEFORM RELAXATIOn METHODS FOR LInEAR InITIAL VALUE PROBLEMS

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Journal of Computational Mathematics 2004年第5期22卷 681-698页

作者： jian-yuPan zhong-zhiBai LSEC ICMSECAcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing100080China

We study a class of blockwise waveform relaxation methods, and investigate its convergence properties in both asymptotic and monotone senses. In addition, the monotone convergence rates between different pointwise/blockwise waveform relaxation methods resulted from different matrix splittings, and those between the pointwise and blockwise waveform relaxation methods are discussed in depth.

关键词： Asymptotic and monotone convergence Blockwise waveform relaxation method Comparison results

HIGH-RESOLUTIOn SEMI-DISCRETE CEnTRAL SCHEME FOR DAM-BREAK PROBLEMS

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Journal of Hydrodynamics 2005年第5期17卷 585-589页

作者： CHEn jian-zhong SHI zhong-ke College of Automation Northwestern Polytechnical University Xi＇an 710072 China

A numerical model for simulating the dambreak problems was presented. The model was based on a high-resolution semi-discrete central-upwind difference scheme. In order to reduce spurious oscillation, the uniformly.non-oscillatory limiter was employed. A third-order total variation diminishing Runge-Kutta method is used for time integration. The main feature of the presented method is its simplicity. It requires no Riemann solvers, no flux splitting and no flux limiter. It is explicit and does not require dimensional splitting for two dimensions. The Simpson quadrature rule was employed to compute the source term. To verify the effectiveness and accuracy of the proposed method, the 1D dambreak, circular dam-break and partial dam-break problems were simulated. The results are shown to be in good agreement with analytical solution and numerical results obtained by other methods.

关键词： dam-break shallow water equations central-upwind difference scheme

SOLUTIOn OF 2D SHALLOW WATER EQUATIOnS By GEnUInELy MULTIDIMEnSIOnAL SEMI-DISCRETE CEnTRAL SCHEME

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Journal of Hydrodynamics 2006年第4期18卷 436-442页

作者： CHEn jian-zhong, SHI zhong-ke College of Automation Northwestern Polytechnical University Xi＇an 710072 China

A numerical two-dimensional shallow water method was based on method for solving the equations was presented. This the third-order genuinely multidimensional semi-discrete central scheme for spatial discretization and the optimal third-order Strong Stability Preserving （SSP） Runge-Kutta method for time integration. The third-order compact Central Weighted Essentially.non-Oscillatory （CWEnO） reconstruction was adopted to guarantee the non-oscillatory behavior of the presented scheme and improve the resolution. Two kinds of source terms were considered in this work. They were evaluated using different approaches. The resulting scheme does not require Riemann solvers or characteristic decomposition, hence it retains all the attractive features of central schemes such as simplicity and high resolution. To evaluate the performance of the presented scheme, several numerical examples were tested. The results demonstrate that our method is efficient, stable and robust.

关键词： 2D shallow water equations semi-discrete central scheme Central Weighted Essentially.non-Oscil]atory (CWEnO) reconstruction

Recent progress in self-propelled particles

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Journal of Hydrodynamics 2024年第1期36卷 61-77页

作者： Zhen-yu Ouy.ng jian-zhong Lin Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo315201China Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou310027China

Self-propelled particles are commonly found in a large number of planktonic organisms such as bacteria,fungi,and algae in nature,and researchers have taken a long interest in exploring their swimming mechanisms for more than a *** in the past 20 years,with the development of computational fluid dynamics and flow display technology,as well as the need for the design of synthetic self-propelled particles and micro-swimming devices,self-propelled particles have become the forefront and hotspot of current research in the field of fluid *** paper first introduces the swimming characteristics of common self-propelled particles,leading to a classic“squirmer”type self-propelled particle *** this basis,a systematic introduction and summary of the theoretical and numerical simulation research of“squirmer”will be ***,the main challenges and opportunities faced by the current research will be summarized.

关键词： Self-propelled particles multiphase flow hydrodynamic interaction

openGauss:An Open-Source Database for the Era of Artificial Intelligence

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Journal of Computer Science & Technology 2024年第5期39卷 1005-1006页

作者： jian-zhong Li Shenzhen Institute of Advanced Technology Shenzhen 518055China School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150001China

Databases play a vital role in data management in many fields,such as finance,government,telecommunications,energy,electricity,transportation,*** the database management system has become a core foundational *** is an enterprise-grade open-source database,a product of deep integration of research and development from Huawei,Tsinghua University,and China Mobile in the past decade.

关键词： database Open finance

Optimal Grading Policies in the Online Acquisition of Used Products

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Journal of Systems Science and Systems Engineering 2021年第1期30卷 29-43页

作者： Xiang Chu zhong Wen jian Chen School of Maritime Economics and Management Dalian Maritime UniversityDalian116026China International Business School Beijing Foreign Studies UniversityBeijing100089China School of Economics and Management Tsinghua UniversityBeijing100084China

Although online reverse commerce(recommerce)is convenient and efficient,it is not without *** limits recommerce firms’flexibility to offer personalized prices and may cause mismatched grading between the firms and sellers of used *** study examines a recommerce firm’s decision on grading criteria and *** find that the firm’s optimal policy exhibits two distinctly different patterns depending on the trade value of the *** demonstrate that sellers’overestimate and underestimate errors have qualitatively different effects on firm profitability,and the effects crucially rely on the type of optimal *** findings can apprise firms on how to preset sorting criteria and prices as well as reduce grading errors.

关键词： Closed-loop supply chains used-product acquisition management recommerce grading error grading policy