检索结果-南通市图书馆

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 57-65页

作者： RyUL kim JOO kyUNG PARk MINSUk kWON MINAE AN JUNG yONG HONG JOON OH PARk SUNG HEE LIM SEUNG TAE kim Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(Nk)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for Nk cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

胰腺小腺癌的术前检测:常规MR成像加扩散加权成像在提高检测可信度上的价值

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第1期 65-65页

作者： M.J.Park y.k.kim S.Choi H.Rhim W.J.Lee D.Choi Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine

目的评价在常规MR成像加入扩散加权成像(DWI)对胰腺小腺癌(≤3.0 cm)术前检测的效能。材料与方法机构伦理委员会批准了本回顾性研究,并且免除知情同

关键词：加权成像 MR 胰腺术前腺癌腺瘤常规

A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong Cho Byeori kim Haehyun Cho Taek-young youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

钆塞酸二钠增强MRI对壶腹周围癌病人肝微脓肿和转移瘤鉴别诊断的价值

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2017年第6期 746-746页

作者： S.y.Choi y.k.kim J.H.Min D.I.Cha W.k.Jeong W.J.Lee 李欣然 Department of Radiology Soonchunhyang University College of Medicine Bucheon Hospital

摘要目的采用钆塞酸二钠增强MRI对壶腹周围癌病人检查,旨在识别能够鉴别的肝微脓肿和转移瘤的影像特征。方法共纳入72例病人(31例病人有83处肝微脓肿灶,

关键词：壶腹周围癌钆塞酸二钠 MRI 转移瘤

用扩散加权成像定性慢性肝病中钆塞酸增强MRI乏血供低信号结节

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第5期 471-471页

作者： J.Hwang y.k.kim W.k.Jeong D.Choi H.Rhim W.J.Lee 李燕菊 Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine

摘要目的比较MR成像中DWI及T2WI特征表现,对于鉴别钆塞酸增强MR成像肝胆期检出的低信号结节中乏血供肝细胞肝癌(HCC)与发育不良结节的能力。材料与方法本回顾性研究经本单位伦理委员会批准并免除病人知情同意。研究对象为2011年3月—201... 详细信息

摘要目的比较MR成像中DWI及T2WI特征表现,对于鉴别钆塞酸增强MR成像肝胆期检出的低信号结节中乏血供肝细胞肝癌(HCC)与发育不良结节的能力。材料与方法本回顾性研究经本单位伦理委员会批准并免除病人知情同意。研究对象为2011年3月—2014年1月期间做过钆塞酸增强MRI检查并经病理确诊乏血供HCC(n=25)和(或)发育

关键词：结节发育不良 HCC 血供 MRI

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2)Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2)Production

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon kim Jaebeom Park Sunmi Im Michael R.Hoffmann kangwoo Cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence Research and Education in Advanced Technology(I‑CREATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2)production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2)overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2)marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).Robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) Reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

维普期刊数据库

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 417-431页

作者： yunjian Guo kunpeng Li Wei yue Nam‑young kim yang Li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

维普期刊数据库

Photoluminescence enhancement of red-emitting GdVO_4:Eu and yVO_4:Eu phosphors by adding zinc

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2013年第1期31卷 13-17页

作者： k.Park J.kim k.y.kim J.y.kim y.kim S.J.Dhoble Faculty of Nanotechnology and Advanced Materials Engineering Sejong University Department of Advanced Materials Engineering Hoseo University Department of Chemistry and Institute of Basic Sciences Dankook University Department of Physics R.T.M. Nagpur University

We synthesized the rare-earth activated Ro.94_xEuo.06ZnxVO4 （R： Gd and y; 0〈_x〈_0.08） phosphors with a spherical mor- phology and a smooth surface by the ultrasonic spray pyrolysis. The annealed Ro.94_xEuo.06ZnxVO4 crystallized in the tetragonal zircon type structure, belonging to the space group of I41/amd. The incorporation of a small amount of Zn to Ro.94Euo.06VO4 improved the emission characteristics. The emission intensities of the Gdo.88EUo.06Zno.06VO4 and yo.9Euo.06Zno.04VO4 phosphors at 619 nm were 72% and 2 1% stronger than those of the Gdo,94Euo.06VO4 and yo.94Euo.06VO4 phosphors, respectively. We demonstrated that the addi- tion of Zn to Ro.94Euo.06VO4 was quite effective for improving the photoluminescent properties.

关键词： rare earths photolurninescence vanadate ultrasonic spray pyrolysis

维普期刊数据库