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Indication of conservative treatment by antibiotics for uncomplicated and complicated acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2538-2545页

作者： yuichi hosokawa Masato Moritani yosuke Makuuchi yuichi Nagakawa Department of Surgery Nishitokyo Central General HospitalTokyo 188-0014Japan Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 166-0023Japan

BACKGROUND Acute appendicitis is one of the most common emergency abdominal disease,and recent studies have evaluated conservative treatment using antibiotics for uncomplicated *** the efficacy of conservative treatment for uncomplicated appendicitis is known,its efficacy for complicated appendicitis remains unknown,so are risk factors for the conservative treatment of *** our institution,conservative treatment has long been the first choice for most appendicitis cases,except for ***,this novel study inves-tigated the outcomes of conservative treatment for uncomplicated and compli-cated acute appendicitis and the risk factors associated with conservative *** significant and independent predictors of resistance to conservative treatment were body temperature≥37.3℃,appendicolith and Douglas sinus fluid visible on computed tomography(CT).The rate of resistance to conservative treatment was 66.7%(6/9)for patients with the above three factors,22.9%(8/35)for patients with two factors(appendicolith and body temperature≥37.3℃),16.7%(2/12)for patients with two factors(Douglas sinus fluid and appendicolith)and 11.1%(1/9)for patients with two factors(Douglas sinus fluid and body temperature≥37.3℃).CONCLUSION A temperature≥37.3℃,appendicolith and Douglas sinus fluid on CT might be clinical risk factors of resistance to conservative treatment for acute appendicitis.

关键词： Acute appendicitis Conservative treatment Antibiotics Appendicolith Uncomplicated appendicitis

Magnetic and magnetocaloric properties in GdZn_(2) synthesized by ball milling

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Journal of Rare Earths 2022年第3期40卷 462-466,I0004页

作者： Keisuke T.Matsumoto Akihiro hosokawa Koichi Hiraoka Graduate School of Science and Engineering Ehime University3Bunkyo-choMatsuyamaEhime790-8577Japan

In this study,we prepared GdZn_(2)by mechanical alloying method and measured its magnetization to reveal the magnetic and magnetocaloric *** a milling time(MT)≥10 and 20 h,the GdZn_(2)phase was confirmed by X-ray diffraction *** MT=40 and 60 h,amorphous like patterns are *** MT=10 and 20 h,magnetization(M)as a function of temperature below 80 K shows ferromagnetic-like *** observed values of M are 4.5μ_(B) at 5 K for MT=10 and 20 h,which is smaller than that of the theoretical expected value of 7μ_(B).For MT=40 and 60 h,the long-range ferromagnetic order collapses because there is no spontaneous *** value ofΔT,whereΔT is the full width at half maximum of the magnetic entropy change(ΔS_(m)(T)),increases significantly for MT≤20 h because of the gradual release of magnetic entropy by the milling *** M decreases with increasing MT,the maximum values of|ΔS_(m)|,the relative cooling power,and the refrigerant capacity also decreases.

关键词： Mechanical alloying Magnetocaloric effect GdZn_(2) Rare earths

Effective Palladium(Ⅱ)Catalyst for Oxypalladation of Alkene

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复旦学报(自然科学版) 2005年第5期44卷 711-712页

作者： T.hosokawa y.Kawamura K.Minami K.Koga Department of Environmental Systems Engineering Kochi University of Technology185 MiyanokuchiTosayamadaKochi782-8502Japan

1 Introduction A variety of Pd(Ⅱ)-catalyzed oxidative transformations ot allcenes with oxygen nucleophiles are catalyzed by PdX_(2)(X=OAc,Cl,etc)with CuX_(n)(n=1 or 2)under O_(2).In the so-called Wacker catalyst of such,Pd(OAc)_(2) is less reactive compared to PdCl_(2).In an attempt to increase the reactivity of Pd(OAc)_(2),we have now found that tuning of Cu site with catechol gives an intriguing reactivity to Pd(OAc)_(2),which is unprecedented in the chemistry of palladium.

关键词： Palladium(Ⅱ)acetate copper(Ⅱ)acetate catechol wacker oxidation allylic alcohols vinyl ethers 2-alkoxy-4-benzylidenetetrahydrofurans

Effective Palladium(Ⅱ) Catalyst for Oxypalladation of Alkene

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复旦学报(自然科学版) 2005年第5期 101-102页

作者： T. hosokawa,y. Kawamura,K. Minami,K. Koga Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan

Role of ultrasound in the treatment of pediatric infectious diseases:case series and narrative review

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World Journal of Pediatrics 2023年第1期19卷 20-34页

作者： Takahiro hosokawa yutaka Tanami yumiko Sato Kuntaro Deguchi Haruka Takei Eiji Oguma Department of Radiology Saitama Children's Medical Center1-2 Shintoshin Chuo-kuSaitama 330-8777Japan Department of Infectious Diseases and Immunology Saitama Children's Medical CenterSaitamaJapan

Background Infectious diseases are common in pediatric *** these patients,ultrasound is a useful imaging modality that involves no irradiation or sedation and can be performed repeatedly at the patient's *** purpose of this review was to show pediatric cases with infectious disease that used ultrasound to decide the methods of *** sources Literature review was performed using Pubmed as the medical database *** year-of-publication restric-tion was *** mesh terms used were:"ultrasound","sonography","infectious disease","treatment","antibiotics","surgical intervention","pediatric","children","deep neck abscess","pyothorax","empyema","pneumonia","urinary tract infection","intra-abdominal abscess","soft tissue infection","septic arthritis","osteomyelitis",and"surgical site infection".Results We presented pediatric case series with infectious diseases,including deep neck abscess,pyothorax and empyema,pneumonia,urinary tract infection,intra-abdominal abscess,soft tissue infection,septic arthritis and osteomyelitis,and surgical-site *** was useful for evaluating the extent and location of inflammation and abscess and for decision-making concerning surgical *** Knowledge of these sonographic findings is important for sonographers during examinations and for physicians when determining the treatment plan and period of antibiotic therapy for infected lesions.

关键词： Infectious diseases Intra-abdominal abscess Osteomyelitis Pyothorax Ultrasound

Rotation of Biological Cells:Fundamentals and Applications

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Engineering 2022年第3期8卷 110-126页

作者： Tao Tang yoichiroh hosokawa Takeshi Hayakawa yo Tanaka Weihua Li Ming Li yaxiaer yalikun Division of Materials Science Nara Institute of Science and TechnologyNara 630-0192Japan Institute of Innovation for Future Society Nagoya UniversityAichi 464-8603Japan Department of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Graduate School of Frontier Biosciences Osaka UniversityOsaka 565-0871Japan RIKEN Center for Biosystems Dynamics Research Osaka 565-0871Japan School of Mechanical MaterialsMechatronicand Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia School of Engineering Macquarie UniversitySydneyNSW 2109Australia

Cell rotation is one of the most important techniques for cell manipulation in modern bioscience,as it not only permits cell observation from any arbitrary angle,but also simplifies the procedures for analyzing the mechanical properties of cells,characterizing cell physiology,and performing *** approaches have been reported for rotating cells in a wide range of academic and industrial *** them,the most popular are micro-robot-based direct contact manipulation and field-based non-contact methods(e.g.,optical,magnetic,electric,acoustic,and hydrodynamic methods).This review first summarizes the fundamental mechanisms,merits,and demerits of these six main groups of approaches,and then discusses their differences and limitations in *** aim to bridge the gap between each method and illustrate the development progress,current advances,and prospects in the field of cell rotation.

关键词： Cell rotation Cell reorientation Micromanipulation Microfluidics

Single-incision laparoscopic cholecystectomy:Single institution experience and literature review

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World Journal of Gastroenterology 2010年第2期16卷 270-274页

作者： yasumitsu Hirano Toru Watanabe Tsuneyuki Uchida Shuhei yoshida Kanae Tawaraya Hideaki Kato Osamu hosokawa Department of Surgery Yokohama Sakae Kyousai Hospital132 Katsura-choSakae-kuYokohamaKanagawa 247-8581Japan

Single-incision laparoscopic surgery is a rapidly evolving field as a bridge between traditional laparoscopic surgery and natural orifice transluminal endoscopic *** report one of the initial clinical experiences in Japan with this new *** cases of gallbladder diseases were selected for this new technique.A single curved intra-umbilical 25-mm incision was made by pulling out the umbilicus.A 12-mm trocar was placed through an open approach,and the abdominal cavity was explored with a 10-mm semiflexible *** 5-mm ports were inserted laterally from the laparoscope port.A 2-mm mini-loop retractor was inserted to retract the fundus of the *** was performed using an electric cautery hook and an Endograsper *** were two women and two men with a mean age of 50.5 years(range:40-61 years).All procedures were completed successfully without any perioperative *** all cases,there was no need to extend the skin *** operative time was 88.8 *** follow-up didnot reveal any umbili-cal wound ***-incision laparoscopic cholecystectomy is feasible and a promising alternative method as scarless abdominal surgery for the treatment of some patients with gallbladder disease.

关键词： Laparoscopic Cholecystectomy Incision Single-incision laparoscopic cholecystectomy Singleincision laparoscopic surgery Single-incision endoscopic surgery Minimally invasive surgery

A STUDy OF THE Fe-Ni ALLOy ELECTROPLATING

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材料保护 1992年第3期 4-9页

作者： University of Science and Technology Beijing Wu Jixun Kyushu University of Technology M Matsunaga K hosokawa

In this work, the Fe-Ni alloy electroplating were studied by selecting the sulphate system with a small amount of buffer additive, using the direct current (DC) method, the galvanostatic pulse (PC) method and the asymmetric alternating current (AAC) method. The influences of the three kinds of current wave types on the plating quality have been investigated. It is shown that the asymmetric alternating current (AAC) electroplating is preferred for the Permalloy (i. e. the Fe-Ni alloy containing 20% Fe) electroplating. The influence of the current wave type on the deposition process has also been studied.

关键词： Fe A STUDy OF THE Fe-Ni ALLOy ELECTROPLATING Ni

Integration of Droplet Microfluidic Tools for Single-cell Functional Metagenomics:An Engineering Head Start

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 504-518页

作者： David Conchouso Amani Al-Ma’abadi Hayedeh Behzad Mohammed Alarawi Masahito hosokawa yohei Nishikawa Haruko Takeyama Katsuhiko Mineta Takashi Gojobori Department of Industrial and Mechanical Engineering Universidad de las Américas PueblaPuebla 72810Mexico Computational Bioscience Research Center King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia Biological and Environmental Sciences and Engineering Division King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia Research Organization for Nano&Life Innovation Waseda UniversityTokyo 162-0041Japan Department of Life Science and Medical Bioscience Waseda UniversityTokyo 162-8480Japan Institute for Advanced Research of Biosystem Dynamics Waseda Research Institute for Science and EngineeringWaseda UniversityTokyo 169-8555Japan Computational Bio Big-Data Open Innovation Laboratory AIST-Waseda UniversityTokyo 169–0072Japan Computer Electricaland Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

Droplet microfluidic techniques have shown promising outcome to study single cells at high ***,their adoption in laboratories studying“-omics”sciences is still irrelevant due to the complex and multidisciplinary nature of the *** facilitate their use,here we provide engineering details and organized protocols for integrating three droplet-based microfluidic technologies into the metagenomic pipeline to enable functional screening of bioproducts at high ***,a device encapsulating single cells in droplets at a rate of~250 Hz is described considering droplet size and cell ***,we expand on previously reported fluorescence-activated droplet sorting systems to integrate the use of 4 independent fluorescence-exciting lasers(i.e.,405,488,561,and 637 nm)in a single platform to make it compatible with different fluorescence-emitting *** this sorter,both hardware and software are provided and optimized for effortlessly sorting droplets at 60 ***,a passive droplet merger is also integrated into our pipeline to enable adding new reagents to already-made droplets at a rate of 200 ***,we provide an optimized recipe for manufacturing these chips using silicon dry-etching *** of the overall integration and the technical details presented here,our approach allows biologists to quickly use microfluidic technologies and achieve both single-cell resolution and high-throughput capability(>50,000 cells/day)for mining and bioprospecting metagenomic data.

关键词： Droplet microfluidics Single cell Metagenomics Droplet sorter Biotechnology