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hIF-1αpromotes virus replication and cytokine storm in h1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

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Virologica Sinica 2024年第1期39卷 81-96页

作者： Xiaoxiao Meng yong Zhu Wenyu yang Jiaxiang Zhang Wei Jin Rui Tian Zhengfeng yang Ruilan Wang Department of Critical Care Medicine Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai201620China Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai201620China

The mortality of patients with severe pneumonia caused by.h.N1 infection is closely related to viral replication and cytokine ***,the specific mechanisms triggering virus replication and cytokine storm are still not fully ***,we identified hypoxia inducible factor-1α(hIF-1α)as one of the major host molecules that facilitates h1N1 virus replication followed by cytokine storm in alveolar epithelial ***,hIF-1αprotein expression is upregulated after h1N1 *** of hIF-1αattenuates pulmonary injury,viral replication and cytokine storm in *** addition,viral replication and cytokine storm were inhibited after hIF-1αknockdown in ***,the invasion of h1N1 virus into alveolar epithelial cells leads to a shift in glucose metabolism to glycolysis,with rapid production of ATP and *** of glycolysis significantly suppresses viral replication and inflammatory *** analysis revealed that h1N1-induced hIF-1αcan promote the expression of hexokinase 2(hK2),the key enzyme of glycolysis,and then not only provide energy for the rapid replication of h1N1 virus but also produce lactate,which reduces the accumulation of the MAVS/RIG-I complex and inhibits IFN-α/β*** conclusion,this study demonstrated that the upregulation of hIF-1αby.h.N1 infection augments viral replication and cytokine storm by cellular metabolic reprogramming toward glycolysis mainly through upregulation of hK2,providing a theoretical basis for finding potential targets for the treatment of severe pneumonia caused by.h.N1 infection.

关键词： h1N1 Severe pneumonia Virus replication hypoxia inducible factor-1α Glycolysis

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Spalling characteristics of high-temperature treated granitic rock at different strain rates

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1280-1288页

作者： L.F.Fan Q.h.yang X.L.Du The Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing100124China

The dynamic spalling characteristics of rock are important for stability analysis in rock *** paper presented an experimental investigation on the dynamic spalling characteristics of granite with different temperatures and strain rates.A series of dynamic spalling tests with different impact velocities were conducted on thermally treated granite at different *** dynamic spalling strengths of granite with different temperatures and strain rates were determined.A model was proposed to correlate the dynamic spalling strength of granite,high temperature and strain *** results show that the spalling strength of granite decreases with increasing ***,the spalling strength of granite with a higher strain rate is larger than that with a lower strain *** proposed model can describe the relationship among dynamic spalling strength of granite,high temperature and strain rate.

关键词： Dynamic spalling characteristics high temperature Strain rate Dynamic loading Granite

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Residue Based Open-Loop Modal Analysis Method for Detecting LFMR of PMSG-WFs Penetrated Power Systems

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1454-1465页

作者： Luonan Qiu Tianhao Wen yang Liu Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou510640China

This paper proposes a residue based open-loop modal analysis method to detect low frequency modal resonance(LFMR),including asymmetric low frequency modal attraction(ALFMA)and asymmetric low frequency modal repulsion(ALFMR),of permanent magnetic synchronous generator based wind farms(PMSG-WFs)penetrated power *** formation of ALFMA and ALFMR caused by two open-loop low frequency oscillation(LFO)modes moving close and apart is analyzed in *** predicting the trajectories of closed-loop LFO modes based on calculation of residue of open-loop LFO modes,both ALFMA and ALFMR can be *** proposed method can select LFO modes which move to the right half complex plane as control parameters *** studies are carried out on a three-machine power system and a four-machine 11-bus power system to verify the properties of the proposed method.

关键词： Asymmetric low frequency modal attraction asymmetric low frequency modal repulsion low frequency modal resonance residue based open-loop modal analysis method

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highly efficient electrosynthesis of h_(2)O_(2)in acidic electrolyte on metal-free heteroatoms co-doped carbon nanosheets and simultaneously promoting Fenton process

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Chinese Chemical Letters 2024年第7期35卷 514-518页

作者： Xiaodan Wang yingnan Liu Zhibin Liu Zhongjian Li Tao Zhang yi Cheng Lecheng Lei Bin yang yang hou Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Institute of Zhejiang University-Quzhou Quzhou 324000China Donghai Laboratory Zhoushan 316000China Ningbo Institute of Materials Technology&Engineering University of Chinese Academy of SciencesNingbo 315200China School of Biological and Chemical Engineering NingboTech UniversityNingbo 315100China Zhejiang hengyi Petrochemical Research Institute Co. Ltd.Hangzhou 310058China

Recently electrochemical synthesis of h_(2)O_(2)through oxygen reduction reaction(ORR)via 2e^(-)pathway is considered as a green and on-site ***,it still remains a big challenge for fabricating novel metal-free catalysts under acidic solutions,since it suffers from high overpotential due to the intrinsically week*OOh ***,a co-doped carbon nanosheet(O/N–C)catalyst toward regulating O and N content was synthesized for improving the selectivity and activity of h_(2)O_(2)electrosynthesis *** O/N–C exhibits outstanding 2e-ORR performance with low onset potential of 0.4 V(***)and a selectivity of 92.4%in 0.1 mol/L hClO_(4)*** in situ electrochemical impedance spectroscopy(EIS)tests reveals that the N incorporation contributes to the fast ORR *** density functional theory(DFT)calculations demonstrate that the binding strength of*OOh was optimized by the co-doping of oxygen and nitrogen at certain content,and the O/N–C–COOh site exhibits a lower theoretical overpotential for h_(2)O_(2)formation than O–C–COOh ***,the promoted kinetics for typical organic dye degradation in simultaneous electron-Fenton process on O/N–C catalyst was demonstrated particularly for broadening its environmental application.

关键词： Oxygen reduction Metal-free catalyst h_(2)O_(2)electrosynthesis N doping Carbon materials

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Facile semisynthesis of histone h3 enables nucleosome probes for investigation of histone h3K79 modifications

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Chinese Chemical Letters 2024年第10期35卷 347-350页

作者： Kun Zou y.h.ng Xiao Jinyu yang Mingxuan Wu Department of Chemistry Zhejiang University Department of Chemistry School of Science Westlake University Institute of Natural Sciences Westlake Institute for Advanced Study

histone h3K79 modifications are essential to regulate chromatin structure and gene transcription, but understanding of the molecular mechanisms is limited. Because h3K79 is at globular domain, short histone peptide cannot mimic h3K79 in chromatin. Instead, reconstituted nucleosome-based chemical tools are ideally used to investigate h3K79 modifications. In consequence, h3K79-modified histone h3 with additional chemical handles are required, but such synthesis is challenging and laborious. here we report a facile semisynthesis method that enables multifunctional histone h3 readily available. h3K79-containing fragment is short for straight peptide synthesis that was later ligated to recombinant expressed h3 fragments for full-length product in large scale. As a result, nucleosomes with h3K79 modifications as well as photo-reactive group and affinity tag were obtained to investigate potential binding proteins. We believe this method that enhances synthetic accessibility of nucleosome probes will accelerate understanding of the underexplored h3K79 modifications.

关键词： h3K79 modifications histone Methylation Nucleosome probes Semisynthesis Succinylation

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Search for production of dark fermion candidates in association with heavy neutral gauge boson decaying to dimuon in proton-proton collisions at√s=8 TeV using CMS open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： y.Mahmoud h.Abdallah M.T.hussein S.Elgammal Centre for theoretical physics The British University in EgyptEgypt Physics Department Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark matter using a part of the data recorded by the CMS experiment during run-I of the LhC in 2012 with a center of mass energy of 8 TeV and an integrated luminosity of 11.6 fb−*** data were gathered from the CMS open *** matter,in the framework of the simplified model(mono-Z′),can be produced from proton-proton collisions in association with a new hypothetical gauge boson,Z′.Thus,the search was conducted in the dimuon plus large missing transverse momentum *** benchmark scenario of mono-Z′,which is known as light vector,was used for interpreting the CMS open *** evidence of dark matter was observed,and exclusion limits were set on the masses of dark matter and Z′at 95%confidence level.

关键词： dark matter large hadron collider CMS open data search for new physics dark fermion

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Synthesizing active and durable cubic ceria catalysts(<6 nm)for fast dehydrogenation of bio-polyols to carboxylic acids coproducing green h_(2)

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Green Energy & Environment 2024年第3期9卷 529-543页

作者： Mengyuan Liu Puhua Sun Guangyu Zhang Xin Jin Chaohe yang honghong Shan State Key Laboratory of heavy Oil Processing College of Chemical EngineeringChina University of PetroleumNo.66 Changjiang West RoadQingdaoShandong266580China SINOPEC Research Institute of Safety Engineering Co. Ltd.No.339 Songling RoadQingdaoShandong266000China

Dehydrogenation is considered as one of the most important industrial applications for renewable *** ceria-based catalysts are known to display promising dehydrogenation performances in this *** particle size(>20 nm)and less surface defects,however,hinder further application of ceria ***,an alternative strategy involving lactic acid(LA)assisted hydrothermal method was developed to synthesize active,selective and durable cubic ceria ofhydrogenation *** studies of growth mechanism revealed that,the carboxyl and hydroxyl groups in LA molecule synergistically manipulate the morphological evolution of ceria *** groups determine the cubic shape and particle size,while hydroxyl groups promote compositional transformation of ceria precursors into CeO_(2) ***,enhanced oxygen vacancies(Vo)on the surface of CeO_(2) were obtained owing to continuous removal of O species under reductive *** CeO_(2) catalysts synthesized by the LA-assisted method,immobilized with bimetallic PtCo clusters,exhibit a record high activity(TOF:29,241 h^(-1))and Vo-dependent synergism for dehydrogenation of bio-derived polyols at 200℃.We also found that quenching Vo defects at air atmosphere causes activity loss of PtCo/CeO_(2) *** regenerate Vo defects,a simple strategy was developed by irradiating deactivated catalysts using hernia *** outcome of this work will provide new insights into manufacturing durable catalyst materials for aqueous phase dehydrogenation applications.

关键词： Cubic ceria Oxygen vacancy Dehydrogenation C-h bond activation

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Optimization of chemistry and process parameters for control of intermetallic formation in Mg sludges

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Journal of Magnesium and Alloys 2024年第4期12卷 1431-1448页

作者： y.Fu G.G.Wang A.hu y.Li K.B.Thacker J.P.Weiler h.hu Department of Mechanical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Global Technology Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,holding and high pressure die casting practices is a very important ***,very often it is overlooked by academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of this study was to minimize the intermetallic formation in Mg sludge via the optimization of the chemistry and process *** Al8Mn5 intermetallic particles were identified by the microstructure analysis based on the Al and Mn *** design of experiment(DOE)technique,Taguchi method,was employed to minimize the intermetallic formation in the sludge of Mg alloys with various chemical compositions of Al,Mn,Fe,and different process parameters,holding temperature and holding *** sludge yield(Sy)and intermetallic size(IS)was selected as two *** optimum combination of the levels in terms of minimizing the intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,690℃ for the holding temperature and holding at 30 mins for the holding time,*** best combination for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,630℃ for the holding temperature and holding at 60 mins for the holding time,*** groups of sludge factors,Chemical Sludge(CSF),Physical Sludge(PSF)and Comprehensive Sludge Factors(and CPSF)were established for prediction of sludge yields and intermetallic sizes in Al-containing Mg *** CPSF with five independent variables including both chemical elements and process parameters gave high accuracy in prediction,as the prediction of the PSF with only the two processing parameters of the melt holding temperature and time showed a relatively large deviation from the experimental *** Chemical Sludge Factor was primarily designed for small ingot producers and die casters with a limited melting and holding capacity,of which process parameters could be fixed *** Physical Sludge Factor could be used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguchi method Sludge factor Chemical composition Process parameter

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Dealuminated hβ zeolite for selective conversion of fructose to furfural and formic acid

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Green Energy & Environment 2024年第2期9卷 311-320页

作者： Rui Li Qixuan Lin Junli Ren Xiaobao yang yingxiong Wang Lingzhao Kong State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510640China Institute of Coal Chemistry Chinese Academy of Sciences27 South Taoyuan RoadTaiyuan030001China CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai201210China School of Environmental Science and Technology Suzhou University of Science and Technology Suzhou Jiangsu215009China

The fructose-to-furfural transformation is facing major challenges in the selectivity and high efficiency. herein, we have developed a simple and effective approach for the selective conversion of fructose to furfural using hβ zeolite modified by organic acids for dealuminization to regulate its textural and acidic properties. It was found that citric acid-dealuminized hβ zeolite possessed high specific surface areas, wide channels and high Brønsted acid amount, which facilitated the selective conversion of fructose to furfural with a maximum yield of 76.2% at433 K for 1 h in the γ-butyrolactone(GBL)-h_(2)O system, as well as the concomitant formation of 83.0% formic acid. The^(13)C-isotope labelling experiments and the mechanism revealed that the selective cleavage of C1–C2 or C5–C6 bond on fructose was firstly occurred to form pentose or C5 intermediate by weak Brønsted acid, which was then dehydrated to furfural by strong Brønsted acid. Also this dealuminized hβ catalyst showed the great recycling performance and was active for the conversion of glucose and mannose.

关键词： Fructose Dealuminated-hb zeolite Selective conversion Furfural

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen h.Chen h.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen h.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.h.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.h.Guo A.Guskov K.L.han L.han M.han X.Q.hao J.B.he S.Q.he X.G.he y.L.he Z.B.he Z.X.heng B.L.hou T.J.hou y.R.hou C.y.h. h.M.hu K.hu R.J.hu W.h.hu X.h.hu y.C.hu J.hua G.S.huang J.S.huang M.huang Q.y.h.ang W.Q.huang X.T.huang X.J.huang y.B.huang y.S.huang N.hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.h.Li C.Li D.y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li y.Li y.y.Li Z.J.Li h.Liang J.h.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei h.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer h.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of Science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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