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Altered Carbon Partitioning Enhances CO_(2)to Terpene Conversion in Cyanobacteria

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BioDesign Research 2022年第1期2022卷 369-380页

作者： Man Li Bin Long Susie y.dai James W.Golden Xin Wang Joshua S.yuan Synthetic and Systems Biology Innovation Hub Texas A&M UniversityCollege StationTexas 77843USA Department of Plant Pathology and Microbiology Texas A&M UniversityCollege StationTexas 77843USA Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application State Key Laboratory of Applied Microbiology Southern ChinaInstitute of MicrobiologyGuangdong Academy of ScienceChina Section of Molecular Biology University of California San DiegoLa JollaCA 92093USA Department of Microbiology Miami UniversityOxfordOhio 45056USA

Photosynthetic terpene production represents one of the most carbon and energy-efficient routes for converting CO_(2)into *** photosynthetic organisms,metabolic engineering has led to limited success in enhancing terpene productivity,partially due to the low carbon *** this study,we employed systems biology analysis to reveal the strong competition for carbon substrates between primary metabolism(e.g.,sucrose,glycogen,and protein synthesis)and terpene biosynthesis in Synechococcus elongatus PCC *** then engineered key“source”and“sink”***“source”limitation was overcome by knocking out either sucrose or glycogen biosynthesis to significantly enhance limonene production via altered carbon ***,a fusion enzyme complex with geranyl diphosphate synthase(GPPS)and limonene synthase(LS)was designed to further improve pathway kinetics and substrate *** synergy between“source”and“sink”achieved a limonene titer of 21.0 mg/***,the study demonstrates that balancing carbon flux between primary and secondary metabolism can be an effective approach to enhance terpene bioproduction in *** design of“source”and“sink”synergy has significant potential in improving natural product yield in photosynthetic species.

关键词： metabolism overcome kinetics

Enhanced ferroelectric polarization with less wake-up effect and improved endurance of Hf_(0.5)Zr_(0.5)O_(2)thin films by implementing W electrode

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Journal of Materials Science & Technology 2022年第9期104卷 1-7页

作者： Dao Wang yan Zhang Jiali Wang Chunlai Luo Ming Li Wentao Shuai Ruiqiang Tao Zhen Fan Deyang Chen Min Zeng Jiyan y.dai Xubing B.Lu J-M.Liu Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials and Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Laboratory of Solid State Microstructures and Innovation Centre of Advanced Microstructures Nanjing UniversityNanjing 210093China

This paper reports the improvement of electrical,ferroelectric and endurance of Hf_(0.5)Zr_(0.5)O_(2)(HZO)thinfilm capacitors by implementing W *** W/HZO/W capacitor shows excellent pristine 2 P_(r)values of 45.1 gC/cm^(2)at±6 V,which are much higher than those of TiN/HZO/W(34.4μC/cm^(2))and W/HZO/TiN(26.9μC/cm^(2))***,the maximum initial 2 P_(r)value of W/HZO/W capacitor can reach as high as 57.9μC/cm^(2)at±7.5 *** strong ferroelectric polarization effects are ascribed to the W electrode with a fairly low thermal expansion coefficient which provides a larger in-plane tensile strain compared with TiN electrode,allowing for enhancement of o-phase ***,the W/HZO/W capacitor also exhibits higher endurance,smaller wake-up effect(10.1%)and superior fatigue properties up to 1.5×10^(10)cycles compared to the TiN/HZO/W and W/HZO/TiN *** improvements of W/HZO/W capacitor are mainly due to the decreased leakage current by more than an order of magnitude compared to the W/HZO/TiN *** results demonstrate that capping electrode material plays an important role in the enhancement of o-phase formation,reduces oxygen vacancies,mitigates wake-up effect and improves reliability.

关键词： Hf_(0.5)Zr_(0.5)O_(2)films Ferroelectric polarization Endurance properties Thermal expansion coefficient W electrode

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A Superconducting Magnet with Center Field of 10 T and φ100 mm Warm Bore

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电工电能新技术 2006年第4期25卷 8-14,80页

作者： Q.Wang L.yan B.Zhao S.Song y.dai y.Lei H.Wang H.-C.Huang Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100080China Diamond Light Source Ltd.Diamond House Chilton Didcot OXONOX11 0DEUK

Aconduction-cooled superconducting magnet with central field of 10Tand warmbore of 100 mmwas designed based on a Nb3Sn and two NbTi superconducting *** the first stage,the NbTi coils havebeen fabricated ***-stage 4 KGifford-McMahon(GM) cryocooler withthe second-stage powerin1W,4.2Kis used to cool the magnet fromroomtemperature to 4 *** superconducting magnet with thesame power supply has the operating current of *** magnet can be rotated with a support frame to beoperated with either horizontal or vertical *** of Bi-2223 hightemperature superconductingcurrentleads was employedto reduce heat leakage into *** NbTi coils reachto the operating current of120Awithout training effect to be observed duringchargingof the magnet during40 minutes chargingtime andgenerate the center field of *** training effect inthe NbTi magnet directly cool-down by cryocooler andinter-winding support structure in magnet can be *** superconducting magnet has beenstably operatedfor more than 275 hours with *** this paper,the detailed design,fabrication,stressanalysis and quench protection characteristics are presented.

关键词： conduction-cooled superconducting magnet FEAdetailed model training effect

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Systems Biology-based Exploration of Natural Biomass Utilization Systems for Reverse Design of Biorefinery

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Systems Biology-based Exploration of Natural Biomass Utiliza...

The Second International Symposium on Bioenergy and Biotechnology——in Conjunction with Miscanthus Workshop

作者： Ugur Uzunner Ryan Syrenne Nikos C.Kyrpides Eun-gyu No Susie y.dai Joshua S.yuan Department of Plant Pathology and Microbiology Texas A&M UniversityCollege StationTX77843 Institute for Plant Genomics and Biotechnology Texas A&M UniversityCollege StationTX77843 Genome Biology Group Joint Genome InstituteWalnut GreekCA94598 Department of Veterinary Pathobiology Texas A&M UniversityTX77843 Office of Texas State Chemist Texas A&M UniversityTX 77843 Advanced Research Institute for Sustainable Energy(ARISE) Texas A&M UniversityCollege StationTX 77845

One of the key issues for lignocellulosic ethanol to become a viable option for transportation fuel is the biomass conversion efficiency in biorefinery. Many natural

关键词： Systems Biology-based Exploration of Natural Biomass Utilization Systems for Reverse Design of Biorefinery

Regulation of protein signaling networks by the scaffold protein Shcl in time and space

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Regulation of protein signaling networks by the scaffold pro...

第七届全国医学生物化学与分子生物学和第四届全国临床应用生物化学与分子生物学联合学术研讨会暨医学生化分会会员代表大会

作者： yong Zheng Cunjie Zhang Mohamed A.Soliman Rick Bagshaw Adrian Pasculescu Lorne Taylor Anna y.dai Tony Pawson Samuel Lunenfeld Research Institute Mount Sinai HospitalToronto M5G 1X5Canada Department of Molecular Genetics University of TorontoToronto M5S 1A8Canada

Aim:Growth factors control cellular physiology by activating specific receptor tyrosine kinases(RTKs). Intracellular scaffold proteins,such as Shcl,in turn connect activated RTKs to their downstream targets, and thereby coordinate the selective activation of signaling pathways through the formation of multi-protein *** this study,we sought to investigate the kinetics with which Shc1 binds different signalling components,and the means by which its functional outputs may change in time and

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软组织肉瘤：基于MRI和组织病理切片的直接比较IVIM和DKI参数与Ki-67标记指数表达相关

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国际医学放射学杂志 2022年第5期45卷 619-620页

作者： K.Zhang y.dai y.J.Liu J.Tao Z.A.Pan L.Z.Xie 鹿娜

摘要目的探讨体素内不相干运动（IVIM）和扩散峰度成像（DKI）参数与Ki-67标记指数（LI）表达在软组织肉瘤（STS）中的相关性。方法共41例STS病人在3.0 T MR上接

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基于平扫和不同期相增强CT预测胃肠道间质瘤高Ki-67增殖指数

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国际医学放射学杂志 2024年第3期 376-377页

作者： Z.Xie S.Suo W.Zhang Q.Zhang y.dai y.Song 余翔玲

摘要目的评估和分析基于平扫和对比增强不同期相CT的影像组学模型，以预测经病理证实的胃肠道间质瘤（GIST）病人的Ki-67增殖指数（PI）。方法将383例经病理

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AN APPROACH TO OPTIMAL CONTROL OF PRESSURE IN LAPPING PROCESS

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AN APPROACH TO OPTIMAL CONTROL OF PRESSURE IN LAPPING PROCES...

第二届亚洲机械电子学学术会议

作者： y.dai~(1,2,a) J.J.Chen~(3,b) W.H.Zhao~(1,2,c) J.l.yuan~(1,2,d) 1 The MOE Key Laboratory of Mechanical Manufacture and Automation,Zhejiang University of Technology,Hangzhou,310032,China 2 Ultra-precision Machining Research Center,Zhejiang University of Technology,Hangzhou,310032,China 3 Junior College,Zhejiang Wanli University,Ningbo,315100,China

High efficiency is becoming to be more and more important in ultra-precision machining, when it is applied to the batch *** pressure is an important parameter which has great influence on efficiency in lapping process. High material removal rate may be obtained when high pressure is adopted,but the depth of cutting may still be *** is important to control the pressure properly.A grain contact model of lapping is established in this paper,and it is simplified by the grouping of abrasive grains,as make it possible to be used in the pressure control *** method of simulation by which the maximum depth of cutting is estimated and the strategy of the pressure control is *** super smooth surface may be formed more rapidly in this case.

关键词： optimal control pressure lapping simulation

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-yu Xu Zhong-Shang dai Guo-Zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(Py,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B