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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Structural and mass transport properties of liquid ytterbium in the temperature range 1123 K–1473 K

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Chinese Physics B 2023年第6期32卷 481-488页

作者： d d Satikunvar N K Bhatt B y Thakore department of Physics Sardar Patel UniversityVallabh VidyanagarGujarat 388120India department of Physics Maharaja Krishnakumarsinhji Bhavnagar UniversityBhavnagarGujarat 364001India

We have studied the structural and atomic transport properties of liquid f-shell yb in the temperature range 1123 K–1473 K. Pair interactions between atoms are derived using a local pseudopotential. The potential parameters are fitted to the phonon dispersion curve at room temperature. The local pseudopotential used in the present study is computationally more efficient with only three parameters, and it is found to be transferable to the liquid phase without changing the *** the various computed properties agree with reported theoretical and experimental findings, the adopted fitting scheme is justified. As a significant outcome of the study, we find that(i) the melting in yb is governed by the Lindemann's law,(ii)the mass transport mechanism obeys the Arrhenius law,(iii) the role of the three-particle correlation function in deriving the velocity autocorrelation function is small,(iv) the mean-square atomic displacement is more sensitive to the choice of interaction potential than the other bulk properties, and(v) liquid yb does not show liquid–liquid phase transition within the studied temperature range. Further, due to the good description of the structural and mass transport properties, we propose that yb remains divalent at reduced density.

关键词： transport properties pseudopotential single-particle dynamics ytterbium

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deposition of Nano-Scaled Coatings Using Inductively Coupled Plasma

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Journal of Rare Earths 2004年第z2期22卷 153-156页

作者： d H Jung B park J J Lee School of Materials Science and Engineering College of EngineeringSeoul National UniversitySeoul 151-744Korea School of Materials Science and EngineeringCollege of EngineeringSeoul National UniversitySeoul 151-744Korea School of Materials Science and EngineeringCollege of EngineeringSeoul National UniversitySeoul 151-744Korea

Nano-scaled Ti-B-N coatings could be produced by inductively coupled plasma (ICP) assisted magnetron spurtering. The properties and microstructure of the coating can be changed drastically by applying ICP to conventional magnetron sputtering. In this work, an internal type rf ICP process is used. The core of this technology is the efficient production and control of self-depositing ions and reactive gas ions by an induced electric field. Ti-B-N coatings were prepared by using a TiB2 target and a gas mixture of N2 and Ar at 200 ℃ and a pressure of 60 mTorr. In addition to ICP, the effect of the substrate bias voltage on the structure and properties of the coating was investigated. By applying ICP and a bias voltage to the substrate the hardness of the Ti-B-N coating is increased by more than 75 GPa, as a result of enhanced ionization in the plasma. The Ti-B-N coating, which has the highest hardness, shows the best surface uniformity and a very dense structure with a grain size of 3 nm. This sample also shows a high crystallinity compared to the coating prepared using other deposition parameters.

关键词： nano-scaled coatings industively conpled plasma

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AlTiN and AlTiON-coated hot work tool steels for tooling in steel thixoforming

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中国有色金属学会会刊：英文版 2010年第S3期20卷 1022-1028页

作者： y.BIROL d.ISLER Materials Institute Marmara Research CentreGebzeKocaeliTurkey department of Metallurgy and Materials Engineer ing Istanbul Technical UniversityIstanbulTurkey

X32CrMoV33 hot work tool steel samples coated with AlTiN and AlTiON were submitted to thermal cycling under conditions that approximate thixoforming of steels and to sliding wear tests at 750 ℃,measured to be the cavity surface temperature shortly after the steel slurry is forced into the thixoforming *** and AlTiON coatings provide adequate protection against oxidation of the tool steel substrate,but fail to avoid thermal fatigue *** is attributed to the extensive softening of the substrate,the thermal expansion mismatch between the hot work tool steel and the coatings and residual compressive stresses inherited from the deposition *** impact of AlTiN and AlTiON coatings on the high temperature wear resistance,on the other hand,is *** improved wear resistance is attributed to the stable,protective surface oxide films.

关键词： thixoforming physical vapor deposition coating tooling steels thermal fatigue wear

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<110> Fiber Texture Evolution of Ferrite Wires during drawn-torsion and drawn-annealing-torsion Process

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Journal of Materials Science & Technology 2012年第11期28卷 1010-1014页

作者： y.d. Liu y.d. Zhang A. Tidul L. Zuo Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education) Northeastern University Shenyang110004 China Letam/Isgmp CNRS Metz 57000 France

In this paper, the texture and microstructure evolution of drawn-torsion and drawn-annealing-torsion ferrite wires are studied by electron back scattering diffraction （EBSd） in order to investigate the special torsion texture evolution. Compared to the simulation results, the stable texture components {110}〈 110 〉 and {110}〈112〉 in both drawn-torsion and drawn-annealing-torsion wires display different evolution processes. The texture of the drawn-annealing-torsion wire fits to the Taylor model. A special texture evolution is found in drawn-torsion wires, related to the grain shape, and the heterogeneous deformation. A new plastic deformation viewpoint is suggested based on the special microstructure of drawn ferrite wire.

关键词： Texture Electron back scattering diffraction (EBSd) Torsion Plastic deformation

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Characteristics of urban ozone level in Hong kong

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Journal of Environmental Sciences 2001年第1期13卷 1-7页

作者： d.y.C.LEUNG d.N.ZHANG department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongChina Research Institute of Environmental Engineering East China University of Science and TechnologyShanghai 200237China

The long term trend of ozone level in Hong Kong has been investigated. One of the characteristics of ozone level in Hong Kong is the existence of autumn maximum and summer minimum. Observations of the diurnal variation of ozone level have been made in different area categories. There are early morning peak and afternoon peak occurred in the diurnal variation, which are different from some metropolitans where only an afternoon peak is observed. A negative correlation coefficient was found between monthly ozone level with nitric oxide level. On the contrary, there is a positive correlation between ozone and nitrogen dioxide. The positive correlation coefficient between nitric oxide and nitrogen dioxide shows that the total amount of nitric oxide emitted from a series of moving and fixed sources greatly exceeded the stoichiometric amount of ozone formed from chemical reactions of precursors and long distance transportation.

关键词： ozone urban air pollution Hong kong China

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Photoluminescence enhancement of red-emitting GdVO_4:Eu and yVO_4:Eu phosphors by adding zinc

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Journal of Rare Earths 2013年第1期31卷 13-17页

作者： K.park J.Kim K.y.Kim J.y.Kim y.Kim S.J.dhoble Faculty of Nanotechnology and Advanced Materials Engineering Sejong University department of Advanced Materials Engineering Hoseo University department of Chemistry and Institute of Basic Sciences Dankook University department of Physics R.T.M. Nagpur University

We synthesized the rare-earth activated Ro.94_xEuo.06ZnxVO4 （R： Gd and y; 0〈_x〈_0.08） phosphors with a spherical mor- phology and a smooth surface by the ultrasonic spray pyrolysis. The annealed Ro.94_xEuo.06ZnxVO4 crystallized in the tetragonal zircon type structure, belonging to the space group of I41/amd. The incorporation of a small amount of Zn to Ro.94Euo.06VO4 improved the emission characteristics. The emission intensities of the Gdo.88EUo.06Zno.06VO4 and yo.9Euo.06Zno.04VO4 phosphors at 619 nm were 72% and 2 1% stronger than those of the Gdo,94Euo.06VO4 and yo.94Euo.06VO4 phosphors, respectively. We demonstrated that the addi- tion of Zn to Ro.94Euo.06VO4 was quite effective for improving the photoluminescent properties.

关键词： rare earths photolurninescence vanadate ultrasonic spray pyrolysis

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Heavy Metals in Brown Rice(Oryza sativa L.) and Soil After Long-Term Irrigation of Wastewater discharged from domestic Sewage Treatment Plants

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Pedosphere 2011年第5期21卷 621-627页

作者： B.y.CHUNG C.H.SONG B.J.park J.y.CHO Advanced Radiation Technology Institute Korea Atomic Energy Research Institute(KAERI) Korea Testing & Research Institute(KTR) department of Horticultural Science Chungbuk National University department of Bio-environmental Chemistry Chonbuk National University

A pot experiment was conducted in a plastic film house to evaluate the translocation and uptake of heavy metals(Pb,Cd,Cu,and Zn) into brown rice(Oryza sativa L.) and the heavy metals residues in soils which had previously been irrigated with domestic wastewater for a long time(3 years).The range of Pb,Cd,Cu,and Zn was 5.10 ± 0.01,0.105 ± 0.017,5.76 ± 0.42,and 23.56 ± 1.40 mg kg-1,respectively in the domestic wastewater-irrigated soil,and 0.370 ± 0.006,0.011 ± 0.001,0.340 ± 0.04,and 2.05 ± 0.18 mg kg-1,respectively,in the domestic wastewater-irrigated brown *** results indicated that application of domestic wastewater to arable land slightly increased the levels of Pb,Cd,Cu,and Zn in soil and brown rice(P y metals in brown rice were lower than the recommended tolerable levels proposed by the Joint FAO/WHO Expert Committee on Food ***,the continuous monitoring and pollution control of hazardous materials from domestic wastewater are needed in order to prevent excessive build-up of heavy metals in the food chain.

关键词： accumulation domestic wastewater ground water irrigation P2O5 total N

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Measurement of L X-Ray Intensity Ratios for^92U and ^90Th Elements Using Photoionization in an External Magnetic Field

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Chinese Physics Letters 2007年第3期24卷 668-671页

作者： d.demir y. Sahin department of Physics Faculty of Arts and Science Ataturk University 25240 Erzurum Turkey

L x-ray intensity ratios Le/Lγ, Lα/L7 and Lβ/Lγ for ^92U and ^90Th are measured by using 59.5keV incident photon energy at 110° and 125° scattering angles. The samples are located in the external magnetic field of intensities ±0.15T, ±0.30T, ±0.45T, ±0.60T and ±0.75T. The experimental results obtained for B = 0 are compared with the theoretical values calculated using Scofield＇s tables based on the Hartree Slater theory. The contribution to the alignment of the external magnetic field is discussed. It is observed that the L x-ray intensity ratios decrease with the increasing magnetic field intensity.

关键词： PHOTOIONIZATION MAGNETIC fields PHOTONS SCATTERING (Physics) NUMERICAL calculations HARTREE-Fock approximation

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KELVIN-HELMHOLTZ STABILITy ANd TWO-PHASE FLOW

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Acta Mathematica Scientia 1989年第2期9卷 189-197页

作者： d.y.Hsieh division of Appl.Math. Brown Univ.Providence RI 02912 USA

The ill-posedness of the two-phase flow problems is explicitly related to the Kelvin-Helmholtz instability of two compressible fluid Layers. A long wavelength formulation of the Kelvin-Helmholtz problem is derived. Va... 详细信息

关键词： Helmholtz formulation Kelvin explicitly briefly compressible instability Landau argue subjee

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