检索结果-南通市图书馆

Single-cell and spatial omics:exploring hypothalamic heterogeneity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

continuous edge chromatic numbers of abelian group actions

在线全文

学校读者我要写书评

暂无评论

Science china Mathematics 2025年

作者： su Gao Ruijun Wang Tianhao Wang School of Mathematical Sciences and Laboratory of Pure Mathematics and combinatorics Nankai University

We prove that for any generating set S of Z~n, the continuous edge chromatic number χ′c（G） of the Schreier graph of the Bernoulli shift action G = F(S, 2Z~n) is χ′（G） + 1 = |S| + 1. In particular, for the stan...

关键词：

A new design of dual-constituent triangular lattice metamaterial with unbounded thermal expansion

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2019年第3期35卷 507-517页

作者： y.c.Zhang y.J.Liang S.T.Liu y.D.su State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China New Functional Structural Design and Verification Key Laboratory of Aeronautical Technology Shenyang 110035China

Triangular lattice metamaterials composed of bi-layer curved rib elements (called the Lehman-Lakes lattice) possess unbounded thermal expansion, high stiffness and impossibility of thermal buckling, which are highly desirable in many engineering structural applications subjected to large fluctuations in temperature. However, the requirement of such lattice metamaterial is that it must be a hinged joint in order to achieve the bending deformation upon heating freely, which directly leads to poor manufacturability, especially in small dimensions. In this study, a new design of dual-constituent triangular lattice metamaterial (DTLM) with good manufacturability is proposed to achieve the identical unbounded thermal expansion. In this lattice, a special bi-layer curved rib element where layer one is partially covered by layer two is presented, where the hinge joints are not necessary because the flexural rigidity in the single-layer part is much smaller than that in the bi-layer part, and the desirable thermal bending deformation can be achieved. A sample fabricated by additive manufacturing is given in order to show the good manufacturability;simultaneously, the multifunctional performance of the tailored DTLM with zero, large positive or negative coefficient of thermal expansion (cTE) can remain excellent, as well as the Lehman-Lakes lattice. Examples illustrate that the DTLM with zero cTE has about 34.2% improvement in stiffness and meanwhile has 17% reduction in weight compared with the Lehman-Lakes lattice. The stiffness of the DTLM has a moderate reduction when achieving the same large positive or negative cTE. In addition, the thermomechanical properties of the DTLM are given by the closed-form analytical solution and their effectiveness is verified by the detailed numerical simulation.

关键词： Metamaterial Zero thermal expansion Lattice material Multifunctional design Additive manufacturing

Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

china Foundry 2025年

作者： Gang Huang Qian Dang cong-cong su Jing Zhao chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern University School of Materials Science and Engineering Shenyang University of Technology

The grain size of TiAl alloy castings prepared by traditional casting process is coarse, thus showing poor mechanical properties. In this study, a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was introduced. This research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings, employing both experimental approaches and Procast simulation methodologies. The findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed grains. Under the condition of pouring temperature of 1,600 °c, rotation speed of 800 r·min-1and pouring time of 6 s, the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa, and the tensile strength at 800 °c reaches 705 MPa, which is significantly higher than that of traditional as-cast Ti-Al alloy.

关键词：

ORTHOGONAL POLyNOMIAL EXPANSIONS OF THERMODyNAMIcPROPERTIES OF BINARy AND TERNARy SySTEMS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1998年第5期11卷 329-334页

作者： y.su L.Liu Z.c.Wang central Iron & Steel Research Inst Beijing China

Orthogonal polynomial expansions are ased to present integral properties of binary and ternary sgstems. The partial property of each component can be expressed with the same set of coeffcients. It was shown that the coefficients are completely independent. Ternary system of Pb-Sb-Sn and its three binary sub-systems are calculated as example.

关键词： orthogonal polynomial thermodynamic property binary andternary systems

Expression of IGF-Ⅱ,p53,p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFBI and/or HBV in tree shrews

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第1期6卷 138-139页

作者： Qin LL su JJ Li y yang c Ban Kc yian RQ Department of Pathology Guangxi Cancer InstituteNanning 530021China Department of Pathology Cancer InstituteSun Yat-Sen University of Medical SciencesGuangzhou510060China

INTRODUcTIONIn order to study the relationship between oncogeneexpression and Hcc generation,we observed theprecancerous hepatic GGT loci,IGF-Ⅱ,p53 andp21 expression during hepatocarcinogenesis of treeshrew induced b... 详细信息

关键词： subject heading liver neoplasms carcinoma hepatocellular hepatitis B virus IGF-Ⅱ p53 gene p21 gene HBxAg aflatoxin B1

Simultaneous enhancement of mechanical and shape memory properties by heat-treatment homogenization of Ti_(2)Ni precipitates in TiNi shape memory alloy fabricated by selective laser melting

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第6期101卷 205-216页

作者： H.Z.Lu L.H.Liu c.yang X.Luo c.H.Song Z.Wang J.Wang y.D.su y.F.Ding L.c.Zhang y.y.Li National Engineering Research center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Musculoskeletal Oncology Department Sun Yat-Sen University Cancer CenterGuangzhouGuangdong ProvinceChina Shenyang Aircraft Design and Research Institute Shenyang 110035China Guangdong Huayi Plumbing Fittings Industry co. Ltd.Kaiping 529321China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA 6027Australia

The excellent shape memory and mechanical properties of Ti Ni shape memory alloys(SMAs) fabricated using selective laser melting(SLM) are highly desirable for a wide range of critical applications. In this study, we examined the simultaneous enhancement of mechanical and shape memory properties using heat-treatment homogenization of Ti_(2)Ni precipitates in a Ti_(50.6)Ni_(49.4)SMA fabricated using SLM. Specifically, because of the complete solution treatment, nanoscale spherical Ti_(2)Ni precipitates were homogeneously dispersed throughout the grain interior. Interestingly, the resultant SMA exhibited an ultrahigh tensile strength of 880 ± 13 MPa, a large elongation of 22.4 ± 0.4%, and an excellent shape memory effect, with a recovery rate of > 98% and ultrahigh recoverable strain of 5.32% after ten loading–unloading cycles. These simultaneously enhanced properties are considerably superior than those of most previously reported Ti Ni SMAs fabricated using additive manufacturing. Fundamentally, the enhancement in tensile strength is ascribed to precipitation strengthening and work hardening, and the large plasticity is mainly attributed to the homogeneous nanoscale globular Ti_(2)Ni precipitates, which effectively impeded the rapid propagation of microcracks. Furthermore, the enhanced shape memory properties are derived from the suppression of dislocation movement and formation of retained stabilized martensite by the presence of high-density dislocations, nanoscale Ti_(2)Ni precipitates, and abundant interfaces. The obtained results provide insight into the enhancement of the two types of properties in Ti Ni SMAs and will accelerate the wider application of SMAs.

关键词： Shape memory alloy Selective laser melting Heat treatment Mechanical properties Shape memory properties

EFFEcT OF Zr ADDITION TO Ti-KILLED STEEL ON INcLUSION FORMATION AND MIcROSTRUcTURAL EVOLUTION IN WELDING INDUcED cOARSE-GRAINED HEAT AFFEcTED ZONE

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2008年第3期21卷 220-226页

作者： F. chai c.F. yang H. su y.Q. Zhang Z. Xu y.H. yang Institute for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China School of Materials Science and Engineering Shanghai Jiaotong University Shanghai 200030 China School of Materials Science and Engineering Kunming University of Science and Technology Kunming650093 China

Effects of Zirconium on the chemical component and size distribution of Ti-bearing inclusions, favored the grain refinement of the welding reduced, coarse-grained heat affected zone （cGHAZ） with enhanced impact toughness in Ti-killed steels, which were examined based on experimental observations and thermodynamic calculations. It indicated that the chemical constituents of inclusions gradually varied from the TiO oxide to the Ti-O＋Zr-O compound oxide and a single phase of the ZrO2 oxide, as the Zr content increased from zero to 0.0100%. A trace of Zr （0.0030%-0.0080%, depending on the oxygen content in liquid steel） provided a large amount of nucleating core for Ti oxide because of the larger specific density of ZrO2 oxide, and produced a small size distribution of the inclusions favorable for acicular ferrite transformation with a high nucleation rate in the cGHAZ, and a high volume fraction of acicular ferrite was obtained in the cGHAZ, with enhanced impact toughness. Otherwise, a high content of Zr （-0.0100%） produced a single phase Zr02, which was impotent to nucleate acicular ferrite, and a microstructure composed of ferrite side plate and grain boundary ferrite developed in the cGHAZ. The experimental results were confirmed by thermodynamic calculations.

关键词： Nonmetallic inclusions Zirconium Acicular ferrite coarse-grain heat affected zone (cGHAZ)

Equivalent series system to model a multiple friction pendulum system with numerous sliding interfaces for seismic analyses

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2014年第1期13卷 85-99页

作者： c.S.Tsai H.c.su T.c.chiang Department of civil Engineering Feng Chia University Department of Water Resources Engineering and conservation Feng Chia University Earthquake Proof Systems Inc.

current structural analysis software programs offer few if any applicable device-specifi c hysteresis rules or nonlinear elements to simulate the precise mechanical behavior of a multiple friction pendulum system(MFPS) with numerous sliding *** on the concept of subsystems,an equivalent series system that adopts existing nonlinear elements with parameters systematically calculated and mathematically proven through rigorous derivations is *** aim is to simulate the characteristics of sliding motions for an MFPS isolation system with numerous concave sliding interfaces without prior knowledge of detailed information on the mobilized forces at various sliding *** MFPS with numerous concave sliding interfaces and one articulated or rigid slider located between these interfaces is divided into two subsystems: the fi rst represents the concave sliding interfaces above the slider,and the second represents those below the *** equivalent series system for the entire system is then obtained by connecting those for each subsystem in *** equivalent series system is validated by comparing numerical results for an MFPS with four sliding interfaces obtained from the proposed method with those from a previous study by Fenz and ***,these numerical results demonstrate that an MFPS isolator with numerous concave sliding interfaces,which may have any number of sliding interfaces,is a good isolation device to protect structures from earthquake damage through appropriate designs with controllable mechanisms.

关键词： seismic isolation base isolation earthquake engineering multiple friction pendulum system structural control mathematical modeling equivalent series system