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On the mechanism of Si-promoted destabilization of Tic_(x)particles in Al alloys

Journal of Materials Science & Technology 2023年第34期165卷 17-26页

作者： H.Dong y.c.guo y.Z.chen F.Xia Q.Q.guo Q.chen G.L.Li J.y.Zhao y.Zhong J.P.Li School of Materials and chemical Engineering Xi’an Technological UniversityXi’an 710021China State Key Lab.of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China School of Science Xi’an University of Science and TechnologyXi’an 710054China

Tic_(x)is an excellent composite strengthening particle and grain refiner for Al ***,the stability of Tic_(x)is poor when solute Si exists in Al alloy melts,which significantly depresses its strengthening and grain refining *** this work,the destabilization mechanisms of the Tic_(x)particles in Al-Si alloy melt with a composition of Al-7Si-7.5Tic were explored via experiments,first-principles calculations and thermodynamic *** experimental results show that Si atoms diffuse into Tic_(x)and Ti atoms are released into the Al melt to form a Ti-rich transition zone during the insulation of Tic_(x)in Al-Si melt,and the TiAlySiz and Al_(4)c_(3)phases are solidified in the Ti-rich zone and at Ti-rich zone/Tic_(x)interface,*** first principles calculations show that the low formation energy of c vacancies facilitates the rapid diffusion of Si atoms in Tic_(x),while the doping of Si atoms reduces the energy barrier of diffusion of Ti atoms in Tic_(x)and promotes the formation of Ti-rich *** thermodynamic calculations show that the wide crystallization temperature range of the destabilized product TiAlySiz phase is the key to continuous decomposition of Tic_(x)*** addition,the driving force of the main destabilization reaction of Tic_(x)in the Al-Si alloys is about 44 times higher than that in the Al alloys without Si *** indicates that the presence of solute Si remarkably promotes the subsequent decomposition process of Tic_(x)in the Al-Si alloy melts.

关键词： Al-Si alloy Tic_(x)particles Destabilization First principles calculations Thermodynamics

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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c-X-c chemokine receptor type 5+cD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-yu Xu Zhong-Shang Dai guo-Zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BAcKGROUND c-X-c chemokine receptor type 5(cXcR5)+cD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of cXcR5+cD8+T cells in chronic hepatitis B(cHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between cXcR5+cD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between cXcR5+cD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive cHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze cXcR5 and programmed death-ligand 1(PD-L1)expression on cD8+T cells by flow cytometry,cXcR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with cHB exhibited significantly lower levels of circulating cXcR5+cD8+T cells compared to healthy controls(Py,cXcR5+cD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between cXcR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and cXcR5+cD8+lymphocytes(r=-0.03,P=0.62

关键词： c-X-c chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha chronic hepatitis B

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clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu guo-chao Zhang Wu Ning Hai-Bin Liu Hua yang chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BAcKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(Py of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of c-X-c chemokine receptor type 1,c-X-c chemokine receptor type 2,c-c chemokine receptor type 2,and c-c chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(Pc-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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ＳＴＡＢＬＥＡＮＤＵＮＳＴＡＢＬＥＩＤＥＡＬＰＬＡＮＥＦＬＯＷＳ

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chinese Annals of Mathematics,Series B 2002年第2期23卷 149-164页

作者： c.BARDOS y.guo W.STRAUSS Universite DivisionDepartment Denis Diderot and LAN Universite Pierre et Marie CurieParisFrance.of Applied MathematicsBrown UniversityProvidenceRhode Island 02912U?

The authors investigate the stability of a steady ideal plane flow in an arbitrary domain in terms of the L^2 norm of the vorticity. Linear stability implies nonlinear instability provided the growth rate of the linearized system exceeds the Liapunov exponent of the flow. In contrast,a maximizer of the entropy subject to constant energy and mass is stable. This implies the stability of certain solutions of the mean field equation.

关键词： Stable ideal plane flows Unstable ideal plane flows Liapunov exponent

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constructing Donor–Acceptor‑Linked cOFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma conghui Zhang yongxin yang Shuyuan yu Haiye Zhu yongjiang Sun Hong guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China yunnan yuntianhua co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(cOFs)based on intramolecular charge transfer *** other reported cOFbased solid-state electrolyte,the developed concept with D–A-linked cOFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in cOF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5c)than substituted c-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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Experimental methods for determination of mechanical behaviors of materials at high temperatures via the split Hopkinson bars

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Acta Mechanica Sinica 2020年第6期36卷 1275-1293,I0003页

作者： Q.B.Dou K.R.Wu T.Suo c.Zhang X.guo y.Z.guo W.G.guo y.L.Li School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Joint International Research Laboratory of Impact Dynamics and its Engineering Application Xi’an710072China Shaanxi Key Laboratory of Impact Dynamics and its Engineering Application Xi’an710072China State Key Laboratory for Strength and Vibration of Mechanical Structures School of AerospaceXi’an Jiaotong UniversityXi’an710049China

Full understanding of the thermomechanical behaviors of materials at high strain rates and high temperatures are of great importance from not only scientific meaning but also practical value in engineering structure design and safety *** efforts have been made for abilities of operation the split Hopkinson bars,the most popular technique for experimental determination of mechanical behaviors of materials over the strain rates from 10^2 to 10^4 s^−1 over the past 70 years,at high temperatures since 1960s.A review of experiment work is presented in this paper to give an overview of the development of experimental techniques at high temperatures based on Hopkinson bar *** principles of the split Hopkinson bar requires the loading bars avoiding temperature gradient or keeping relatively low temperature when performing high temperature *** such as performing temperature gradient corrections,rapid heating or using special designed automatically assembled systems were proposed by researchers to enable the operation of the split Hopkinson bars at temperature as high as ***,to the application of high speed photographic technique for capturing the dynamic deformation process of the specimen in high temperature Hopkinson bar testing,some key issues of eliminating the strong thermal radiation induced lights oversaturation and de-blurring of images due to insufficient exposure at high temperature and high strain rate condition,as well as fabrication of high contrast speckle pattern for high temperature digital image correlation measurement were also *** technique can now enable the split Hopkinson bar testing to be performed at high temperature up to 1873 K under the loading conditions of compression or tension with the in situ observation and full field measurement of deformation as *** paper concludes with summaries of the most important achievements and highlighting of the prospects,trends and remaining challenge

关键词： Mechanical behaviors Split Hopkinson bar High strain rate High temperature

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HI in High Gas-phase Metallicity Dwarf Galaxy WISEA J230615.06+143927.9

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Research in Astronomy and Astrophysics 2024年第1期24卷 292-299页

作者： yan guo c.Sengupta T.c.Scott P.Lagos y.Luo Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of Astrophysics and Space Sciences(IA Porto) Rua das Estrelas4150-762PortoPortugal

We present resolved Giant Metrewave Radio Telescope H I observations of the high gas-phase metallicity dwarf galaxy WISEA J230615.06+143927.9(z = 0.005)(hereafter J2306) and investigate whether it could be a Tidal Dwarf Galaxy(TDG) candidate. TDGs are observed to have higher metallicities than normal dwarfs. J2306 has an unusual combination of a blue g-r color of 0.23 mag, irregular optical morphology and high-metallicity(12 +log(O/H) = 8.68 ± 0.14), making it an interesting galaxy to study in more detail. We find J2306 to be an H I rich galaxy with a large extended, unperturbed rotating H I disk. Using our H I data we estimated its dynamical mass and found the galaxy to be dark matter(DM) dominated within its H I radius. The quantity of DM, inferred from its dynamical mass, appears to rule out J2306 as an evolved TDG. A wide area environment search reveals J2306 to be isolated from any larger galaxies which could have been the source of its high gas metallicity. Additionally, the H I morphology and kinematics of the galaxy show no indication of a recent merger to explain the *** detailed optical spectroscopic observations of J2306 might provide an answer to how a seemingly ordinary irregular dwarf galaxy achieved such a high level of metal enrichment.

关键词： galaxies:abundances galaxies:dwarf galaxies:irregular radio lines:galaxies radio lines:ISM

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Numerical Modeling and Analysis of Grooved Surface Applied to Film cooling

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Journal of Bionic Engineering 2011年第4期8卷 464-473页

作者： L. guo Z. c. Liu y. y. yan Z. W. Han Faculty of Engineering University of Nottingham Nottingham NG7 2RD UK Department of Internal combustion Engine Jilin University Changchun 130022 P. R. China Key Laboratory of Bionic Engineering （Ministry of Education China） Jilin University Changchun 130022 P. R. China

In order to improve the efficiency of film cooling, numerical investigation was carried out to study the effects of different film-cooled plates on surface heat transfer. Both grooved and non-grooved surfaces were concerned. The modeling was per- formed using Fluent software with the adoption of Shear-Stress Transport （SST） k-ωmodel as the turbulence closure. The coolant was supplied by a single film cooling hole with an inclination angle of 30°. The Mach numbers for the coolant flow and the mainstream flow were fixed at 0 and 0.6, respectively. At three blowing ratios of 0.5, 1.0 and 1.5, the aerodynamic behaviour of the mixing process as well as the heat transfer performance of the film cooling were presented. The numerical results were validated using experimental data extracted from a benchmark test. Good agreements between numerical results and the ex- perimental data were observed. For the film cooling efficiency, it shows that both local and laterally averaged cooling effectiveness can be improved by the non-smooth surface at different blowing ratios. Using the grooved surface, the turbulence intensity upon the plate can be reduced notably, and the mixing between the two flows is weakened due to the reduced turbu lence level. The results indicate that the cooling effectiveness of film cooling can be enhanced by applying the grooved surface.

关键词： film cooling non-smooth surface cooling effectiveness grooved structure blowing ratio

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STUDy ON PROPERTIES OF PULSE ELEcTRODEPOSITED RE-Ni-W-P-Sic cOMPOSITE cOATINGS

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Acta Metallurgica Sinica(English Letters) 2007年第2期20卷 111-116页

作者： Z.c. guo X.y. Zhu R.D. Xu Faculty of Materials and Metallurgical Engineering Kunming University of Science and Technology Kunming 650093 China

The effects of pulse frequency f and duty cycle r on the deposition rate, composition, morphology, and hardness of pulse electrodeposited RE （rare earth）-Ni-W-P-Sic composite coatings have been studied. The results indicate that pulse current can improve the deposition rate of RE-Ni-W-P-Sic composite coatings; W, P, and Sic contents in the coating decrease with the increase of pulse frequency and reach the lowest value at f = 33Hz, whereas the RE content in the composite coatings increases with the increase of pulse frequency. Sic content decreases with the increase of duty cycle, W content reaches the lowest value, and P content reaches the highest value at r = 0.4; pulse current and RE can lead to smaller size of the crystalline grains; however, the effects of different pulse frequency and duty cycle on the morphologies of RE-Ni-W-P-Sic composite coatings are not obvious. The hardness of RE-Ni-W-P-Sic composite coatings is the highest when the duty cycle is at 0.6 and 0.8 and pulse frequency is at 50Hz. At the same pulse frequency, the hardness of RE-Ni-W-P-Sic composite coatings at r= 0.8 is higher than that at r= 0.6.

关键词： frequency duty cycle electrodeposition RE-Ni-W-P-Sic composite coating

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