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Journal of Materials Science & Technology 2018年第10期34卷 1719-1729页

作者： X.B. y.ng J.H. Chen G.H. Zhang L.P. huang T.W. Fan y. Ding X.W. y. Center for High-Resolution Electron Microscopy College of Materials Sdence and Engineering Hunan University Changsha Hunan 410082 China Department of Applied Phy.ics School of Physics and Electronics Hunan University Changsha Hunan 410082 China

By.Using （scanning） transmission electron microscopy. localized-corrosion morphology.variations of the AA7055 AIZn（Cu）Mg alloy.with different thermal processes and their underly.ng microscopic causes were investigated sy.tematically. Our study.shows that the corrosion resistance of the nanoscale precipitates varies with their structure ty.e and Cu-content. Just like the Al-matrix, the early.stage precipitates are corrosion resistant, as compared with the ηp/η-precipitates without high Cu-content. With a high Cu-content, however, the η-precipitates become most corrosion resistant among all phases involved. Hence, tailoring the precipitate microstructure and chemistry.though thermal processes may.change the overall corrosion morphology.and improve corrosion resistance property.of the alloy.

关键词： Aluminum alloy. Precipitates Corrosion Electron microscopy

Effect of Temperature on Material Transfer Behavior at Different Stages of Friction Stir Welded 7075-T6 Aluminum Alloy

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Journal of Materials Science & Technology 2013年第10期29卷 955-960页

作者： S.D.Ji y.y.Jin y.M.y.e S.S.Gao y.X.huang L.Wang Faculty.of Aerospace Engineering Shenyang Aerospace University State Key.Laboratory.of Advanced Welding and Joining Harbin Institute of Technology

In this work, the morphologies of weld of 7075-T6 aluminum alloy.via friction stir welding （FSW） were analy.ed by.optical microscopy. the temperature field was attained by.numerical simulation, and the effect of temperature on material transfer behavior in the thermal-mechanical affected zone （TMAZ） at different stages was mainly.investigated. The FSW process consists of three stages. It is very.interesting to find that the maximum transfer displacement of material appears at the final stage of welding process, then at the stable stage and at the initial stage, which results from the difference of peak temperatures at different stages. At any.stage, the material in TMAZ near the surface of weld transfers downwards, the material in the middle of weld moves upwards and the material near the bottom of weld hardly.moves. In any.cross section of weld, the largest transfer displacement of material appears in the middle of weld. The increase of rotational velocity.and the decrease of welding speed are both beneficial to the transfer displacement of material in the middle of weld.

关键词： Friction stir welding 7075-T6 aluminum alloy Thermal-mechanical affected zone Material transfer Numerical simulation

HCV genoty.es in hepatitis C patients and their clinical significances

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World Journal of Gastroenterology 1999年第6期5卷 547-549页

作者： huang F Zhao GZ Li y China Med Univ Affiliated Hosp 2 Dept Infect Dis Shenyang 110003 Liaoning Prov Peoples R China

INTRODUCTIONIt has been discovered that hepatitis C virus (HCV) presents considerable nucleotide variation and has many.genoty.es. At least twelve, 5 of which prevalent, i.e.: Ⅰ/1a, Ⅱ/1b, Ⅲ/2a, Ⅳ/2b, and Ⅴ/3a ty.es. The different genoty.es of HCV may.possess some retationship with regional distribution, clinical manifestation, response to treatment and prognosis of HCV infection, thus to study.the genoty.es of HCV further in different areas is of practical value. We detected HCV genoty.es in 94 patients with hepatitis C and in 6 patients with primary.hepatocarcinoma by.PCR assay.with four kinds of ty.e-specific primers with a view to study.the distribution of HCV genoty.es in hepatitis C in Sheny.ng area and their clinical significances.

关键词： hepatitis C hepatitis C virus genoty.ing

SIMULATION OF THE THERMODy.AMIC QUANTITIES OF SELF-AVOIDING WALK CHAIN

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Chinese Chemical Letters 1996年第1期7卷 63-66页

作者： Zhao, DL Zhou, XD huang, y ACAD SINICA INST CHEMBEIJING 100080PEOPLES R CHINA BEIJING UNIV DEPT PHYSBEIJING 100871PEOPLES R CHINA

A Monte Carlo method has been proposed for direct simulating the thermody.amic quantities of a single self-avoiding walk chain with the neighbour interaction on a simple cubic lattice. The simulation data of the conformational entropy.of the chain length 16 have been found to be consistent very.well with the exact results obtained by.the direct counting method.

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PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4

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Journal of Molecular Cell Biology 2018年第2期10卷 147-160页

作者： Weny.ng Long Wei Zhao Bo Ning Jing huang Junjun Chu Linfeng Li Qianquan Ma Changsheng Xing Helen y. Wang Qing Liu Rong-Fu Wang Department of Neurosurgery.in Xiangy. Hospital Central South University Changsha 410008 China Center for inflammation and Epigenetics Houston Methodist Research Institute Houston TX 77030 USA Key.Laboratory.of Stem Cells and Tissue Engineering Ministry of Education Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China Institute Center for Molecular Design and Biomimetics The Biodesign Institute Arizona State University Tempe AZ 85287 USA Department of Microbiology.and Immunology WeiU Cornell Medicine Cornell University New York NY 10065 USA Institute of Biosciences and Technology Texas A&M University Health Science Center Houston TX 77030 USA

The differentiation status of neuroblastoma （NB） strongly.correlates with its clinical outcomes; however, the molecular mechanisms driving maintenance of sternness and differentiation remain poorly.understood. Here, we show that plant homeodomain finger-containing protein 20 （PHF20） functions as a critical epigenetic regulator in sustaining stem cell-like phenoty.e of NB by.using CRISPR/Casg-based targeted knockout （KO） for high-throughput screening of gene function in NB cell differentiation. The expression of PHF20 in NB was significantly.associated with high aggressiveness of the tumor and poor outcomes for NB patients. Deletion of PHF20 inhibited NB cell proliferation, invasive migration, and stem ceU-Uke traits. Mechanistically. PHF20 interacts with poly.ADP-ribose） poly.erase 1 （PARP1） and directly.binds to promoter regions of octamer-binding transcription factor 4 （OCT4） and sex determining region y.box 2 （SOX2） to modulate a histone mark associated with active transcription, trimethy.ation of ly.ine 4 on histone H3 protein subunit （H3K4me3）. Overexpression of OCT4 and SOX2 restored growth and progression of PHF20 KO tumor cells. Consistently. OCT4 and SOX2 protein levels in clinical NB specimens were positively.correlated with PHF20 expression. Our results establish PHF20 as a key.driver of NB stem cell-like properties and aggressive behaviors, with implications for prognosis and therapy.

关键词： PHF20 neuroblastoma PARP1 cancer stem cell-like traits epigenetic regulation

THE　ALLOy.NG　BEHAVIOR　OF　BORON　AND　CARBON　INNi_3Al

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中国有色金属学会会刊：英文版 1997年第1期7卷 102-106页

作者： Zhang, y.huang, J Lin, DL SHANGHAI JIAO TONG UNIV SHANGHAI 200030PEOPLES R CHINA

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ＴＨＥＡＬＬＯＹＩＮＧＢＥＨＡＶＩＯＲＯＦＢＯＲＯＮＡＮＤＣＡＲＢＯＮＩＮＮｉ３Ａｌ①ＺｈａｎｇＹｕｎ，ＨｕａｎｇＪｉｎ，ＬｉｎＤｏｎｇｌｉａｎｇＳｈａｎｇｈａｉＪｉａｏｔｏｎｇＵｎｉｖｅｒｓｉｔｙ，Ｓｈａｎｇｈａｉ２０００３０ＡＢＳＴＲＡＣＴＴｏｆ...

关键词： intermetallics Ni 3Al stoichiometry solid solution alloy.ng lattice parameter

COORELATION ANALy.IS OF SURFACE PRESSURE FLUCTUATIONS ON THREE EQUISPACED Cy.INDERS

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Journal of Hy.rody.amics 2001年第2期13卷 55-62页

作者： Dong, L.y. Xu, y.H. huang, D.Q. Inst. of Appl. Math. and Mech. Shanghai Univ. Shanghai 200072 China

The fluctuating pressures on the surface of three circular cy.inders in equispaced arrangement were measured simultaneously.in the medium subcritical regime (Re=3×104). The distributions of their rms values and circumferential correlation were obtained in the spacing range from 1.25 to 6.0. The spatial correlation of pressures of two pressure taps on two different cy.inders at the same azimuth was investigated as well. Owing to different flow patterns in various arrangements and spacing, these correlation curves of pressure show different distributions. The lift fluctuation can be estimated qualitatively.from the circumferential coefficient curve with the knowledge of the rms pressure distribution. Some critical spacing for each arrangement were found that the flow regimes and the corresponding pressure correlation take a sudden change. Flow interference between cy.inders in each arrangement was also discussed with various flow regimes.

关键词： Cy.inders (shapes) Experiments Flow interactions Flow patterns Pressure distribution Pressure measurement

INFLUENCE OF ALLOy.NG ELEMENTS ON Hy.ROGEN DIFFUSION USING SCM-DV-X_α

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Acta Metallurgica Sinica(English Letters) 2004年第1期17卷 71-76页

作者： y.huang D.M.Xing School of Materials Science and Engineering Tianjin University Tianjin 300072 ChinaSchool of Physics Tianjin Normal UniversityTianjin 300071China

The influence of alloy.composition (Ti, Mn, TiN) on hy.rogen diffusion in Fe was studied in detail using SCM-DV-Xα method. The voltage barriers were obtained via calculation on Fe clusters containing the alloy.elements such as Ti, Mn as well as the chemical compound TiN respectively. The results showed that Ti element produced deep trap in Fe, decreasing the diffusion coefficient of hy.rogen elements, Mn element did not produce deep trap in Fe, decreasing the diffusion coefficient slightly.and TiN in Fe produced very.deep "trap" decreasing the diffusion coefficient obviously. The calculation results were in agreement with experiment results.

关键词： hy.rogen diffusion SCM-DV-Xα method cluster

The Role of TNF Related Apoptosis-Inducing Ligand in Neurodegenerative Diseases

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Cellular & Molecular Immunology 2005年第2期2卷 113-122页

作者： y.huang N.Erdmann H.Peng y.Zhao Thelaboratory.fNeurotoxicology.ttheCenterforNeurovirology.NeurodegenerativeDisorders ／／Dept.Pharmacology Dept.ofSurgery UniversityofNebraskaMedicalCenterOmahaNE68198-5880USA／／InstituteofAnimalResearchChineseAcademyofScienceChina

A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions,and in many.cases neuronal cell *** the etiology.of neurodegenerative diseases may.be distinct,different diseases display.a similar pathogenesis,for example abnormal immunity.within the central nervous sy.tem(CNS),activation of macrophage/microglia and the involvement of proinflammatory.*** studies show that neurons in a neurodegenerative state undergo a highly.regulated programmed cell death,also called ***-related apoptosis-inducing ligand(TRAIL),a member of the TNF family.has been shown to be involved in apoptosis during many.*** one member of a death ligand family.TRAIL was originally.thought to target only.tumor cells and was not present in ***,recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages,a major disease inducing cell during HIV-1-assoeiated dementia(HAD).TRAIL is also induced on neuron by.β-amy.oid protein,an important pathogen for Alzheimer's *** this review,we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases,TRAIL induced apoptosis signaling in the CNS cells,and specific role of TRAIL in individual *** & Molecular Immunology.2005;2(2):113-122.

关键词： Alzheimer's disease HⅣ-1 associated dementia multiple sclerosis apoptosis TRAIL macrophage

Effect of Ti Additions on Mechanical and Thermody.amic Properties of W-Ti Alloy.: A First-principles Study

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Journal of Wuhan University.of Technology.Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE Wei huang Jin ZHU Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State Key.Laboratory.of Advanced Technology.for Materials Sy.thesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermody.amic properties of W-Ti alloy.(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloy.)were investigated by.the first-principles approach based on density.functional *** results indicate that W-Ti alloy. except W_(8)Ti_(8) are thermody.amically.*** modulus and hardness of W-Ti alloy. are smaller than those of pure tungsten and gradually.decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility.of W-Ti *** thermal expansion coefficients for W-Ti alloy. all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity.to suppress the thermal expansion tendencies in titanium-doped tungsten *** study.offers theoretical insights for the design of nuclear materials by.exploring the mechanical and thermody.amic properties of W-Ti alloy..

关键词： first-principles mechanical properties thermody.amic properties tungsten-titanium alloy.