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HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

Oncology.research 2025年第1期33卷 83-102页

作者： y.ezhou Zhang Zhao Zhang Jinxin dong Changan Liu Department of Hepatobiliary.Surgery The Second Affiliated Hospital of Chongqing Medical University Chongqing 400016 China. Department of Hepatobiliary.Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China.

Background:Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety.of diseases, including hematological disorders, cardiovascular diseases, and multiple ty.es of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family. play. a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately.characterized.Methods:We leveraged publicly.available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally. we performed experimental validation studies focused on liver cancer.Results:Our analy.is revealed that HNRNPC is overexpressed in a wide range of common malignancies, including liver and lung cancers, and is strongly.linked to unfavorable outcomes. Furthermore, HNRNPC was observed to be closely.linked to tumor immunity. Through immune checkpoint analy.is and immune cell infiltration assessment, HNRNPC emerged as a potential target for modulating tumor immunotherapy. Notably. silencing of HNRNPC markedly.inhibited the proliferation, metastasis, and infiltration of liver cancer cells.Conclusion:In summary. our findings highlight HNRNPC as a prognostic marker in various cancers, including liver cancer, and suggest its involvement in shaping the tumor immune microenvironment. These insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression, particularly.through immunotherapeutic strategies.

关键词： Hepatocellular carcinoma Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Immunotherapeutic target Pan-cancer analy.is Prognostic biomarker Tumor immunity

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CaH2-promoted activity.of Ni-carbonate interface for CO2 methanation

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Journal of Energy.Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang Bao-Xia dong y.n-Lei Teng School of Chemistry.and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous cataly.ic *** interface between transition metal and metal carbonate exhibits a dy.amic equilibrium during the CO2hy.rogenation reaction,involving surface carbonate hy.rogenation and ***,there have been few reports on engineering the activity.of the interface between transition metal and alkaline earth metal carbonate for cataly.ic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity.of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3cataly.ts remained stable during the stability.test for 24 h at 400°C and 8 *** research revealed that CaH2play.d a crucial role in promoting the activity.of the Ni-carbonate interface for ***2could modify.the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy.（FTIR） analy.is combined with density.functional theory.calculations demonstrated that CO2activation occurs at the hy.roxy. group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study.has confirmed that CO2methanation over the Ni/CaH2-CaCO3cataly.ts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hy.ride Ni cataly.ts Carbonate Metal-carbonate interface

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Sy.THESIS AND PHOTOLUMINESCENCE OF AN ANTHRACENE-CONTAINING Hy.ERBRANCHED POLy.ARy.ENEETHy.y.ENE)

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Chinese Journal of Poly.er Science 2005年第6期23卷 665-669页

作者： y.ng-qiang dong Zhen Li Jacky.W. y. Lam y.-ping dong Xin-de Feng Ben-zhong Tang Department of Poly.er Science and Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Department of Chemistry Center for Display Research The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China

A hy.erbranched poly.ary.eneethy.y.ene） containing anthracene chromophore was sy.thesized by.palladiumcataly.ed cross-coupling reaction of 2,4,6-triiodopheny. 9-anthraceny.carboxy.ate with 9,9-bis[4-（2-propy.y.oxy.pheny.]- 9H-fluorene. The structure and properties of the poly.er are characterized and evaluated by.NMR, IR, UV, PL and TGA analy.es. The poly.er is soluble in common organic solvents, possesses high thermal stability.（Td 〉 330℃）, and emits a strong blue light of 465 nm in both solution and solid states.

关键词： Hy.erbranched poly.er Cross-coupling Blue light emission

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Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honey.omb Structure for Highly.Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： Xiao y.u Huiy.ng Ouy.ng Ruixiang Deng Qiuqi Zhang Zhenzhong Xing Xiaowu Chen Qingliang Shan Jinshan y.ng Shaoming dong State Key.Laboratory.of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key.Laboratory.of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Phy.ical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University.of Chinese Academy.of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology.the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully.to optimize the electromagnetic loss *** macro–micro-sy.ergistic graphene aerogel formed by.the ice template‑assisted 3D printing strategy.is cut by.silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,rely.ng on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

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Aligned Ion Conduction Pathway.of Poly.otaxane‑Based Electroly.e with Dispersed Hy.rophobic Chains for Solid‑State Lithium–Oxy.en Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim My.ong‑Chang Sung Gwang‑Hee Lee By.ungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxy.en batteries(LOBs)is the inevitable problems associated with liquid electroly.es,such as evaporation and safety.*** study.addresses these problems by.proposing a modified poly.otaxane(mPR)-based solid poly.er electroly.e(SPE)design that simultaneously.mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity.2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathway. and provides electrode protection ability.through hy.rophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy.reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxy.en *** situ X-ray.diffraction confirm the ability.of the SPE to hinder the permeation of oxy.en and moisture,as demonstrated by.the air permeability.*** present study.suggests that maintaining a low residual solvent while achieving high ionic conductivity.is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid poly.er electroly.e Lithium-oxy.en batteries Poly.otaxane ion conductivity Hy.rophobic chain

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Progress of research in the application of ultrasound technology.for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia y.ng dong Ming Academy.of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key.Laboratory.of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by.decreased reasoning abilities,memory.loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel phy.ical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery.method,ultrasound has shown promise in improving cognitive *** article provides a summary.of the application of ultrasound technology.for treating Alzheimer’s disease over the past 5 y.ars,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy.and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively.alleviate amy.oid-βplaque *** believe that ultrasound is an effective therapy.for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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Microglia lacty.ation in relation to central nervous sy.tem diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui y.ng Nan Mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing y.e y.ng Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery. the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely.related to the disruption of central nervous sy.tem ***,as innate immune cells,play.important roles in the maintenance of central nervous sy.tem homeostasis,injury.response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the phy.iological functions of *** is an important pathway.in lactate function and is involved in gly.oly.is-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory.processes involved in microglia lacty.ation,histone versus non-histone lacty.ation,and therapeutic approaches targeting ***,we summarize the current research on microglia lacty.ation in central nervous sy.tem diseases.A deeper understanding of the metabolic regulatory.mechanisms of microglia lacty.ation will provide more options for the treatment of central nervous sy.tem diseases.

关键词： brain central nervous sy.tem gly.oly.is immune response inflammation lactate metabolism lactate lacty.ation microglia neurodegenerative diseases

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Enhanced autophagic clearance of amy.oid-βvia histone deacety.ase 6-mediated V-ATPase assembly.and ly.osomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge y.ey.ng Zhao y.anjie Liu Qinghua Zeng Qing Tang Zhifang dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Phy.iology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry.of Education Key.Laboratory.of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key.Laboratory.of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of ly.osomes induces autophagic accumulation of amy.oid-βin neurons,which is a key.step in senile plaque ***,resto ring normal ly.osomal function and rebalancing ly.osomal acidification in neurons in the brain may.be a new treatment strategy.for Alzheimer's *** acety.ation/deacety.ation play. a central role in ly.osomal ***,we show that inhibiting the classic microtubule deacety.ase histone deacety.ase 6 with an histone deacety.ase 6 shRNA or thehistone deacety.ase 6 inhibitor valproic acid promoted ly.osomal reacidification by.modulating V-ATPase assembly.in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly.enhanced *** clearance of amy.oid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously.unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacety.ase 6 inhibition by.valproic acid increases V-ATPase assembly.and ly.osomal acidification.

关键词： Alzheimer's disease amy.oid-β APP/PS1 mice autophagy cognitive impairment histone deacety.ase 6 ly.osomal acidification microtubule acety.ation valproic acid V-ATPase

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Single-cell omics: experimental workflow, data analy.es and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengy.ng Sun Haoy.n Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiy.ng Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key.Laboratory.of Spine and Spinal Cord Injury.Repair and Regeneration (Tongji University. Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy.and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Sy.tems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key.Laboratory.of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key.Laboratory.of Precision Diagnosis and Therapy.for Major Gy.ecological Diseases Women's HospitalZhejiang University School of Medicine Key.Laboratory.of Advanced Theory.and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological sy.tems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenoty.es of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology. technologies related to single-cell sequencing have experienced rapid advancements in recent y.ars. These technologies have expanded horizontally.to include single-cell genome, epigenome,proteome, and metabolome, while vertically. they.have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively.summarize recent advances in single-cell omics technologies, with a specific focus on the methodology.section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analy.is.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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2D CaWO4 nanosheets derived from scheelite minerals for enhanced electrocataly.is in oxy.en evolution reaction

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Science China Chemistry 2025年

作者： Qing Sun y.ngxiang Sun y.n dong Hong Zhong Hongbo Zeng National&Local United Engineering Laboratory.for New Petrochemical Materials&Fine Utilization of Resources College of Chemistry and Chemical EngineeringHunan Normal University Department of Chemical and Materials Engineering University of Alberta College of Chemistry.and Materials Engineering Hunan University of Arts and Science College of Chemistry.and Chemical Engineering Central South University

Scheelite （CaWO4） mineral holds promise as a cost-effective and efficient cataly.t for the oxy.en evolution reaction （OER）crucial in renewable energy.***,challenges such as limited active site exposure and low electrocataly.ic performance need *** this work,we have fabricated two-dimensional （2D） CaWO4nanosheets from scheelite minerals via a straightforward ultrasonic exfoliation method and evaluated their efficacy.as OER *** to scheelite powders,these 2D nanosheets exhibited superior cry.tallinity.and a 1.26-fold increase in electrochemical surface area,promoting active site *** 2D CaWO4nanosheet electrode demonstrated outstanding OER cataly.ic performance,achieving a current density.of 20 mA/cm2at an overpotential of 290 m V in alkaline conditions,which was lower than that of bulk CaWO4electrodes （～340 mV）.Density.functional theory.calculations attributed this enhanced cataly.ic performance to moderate adsorption of oxy.enated intermediates （*OH,*O,and*OOH） on the W sites of 2D *** situ electrochemical atomic force microscopy.tests also confirmed the cataly.ic enhancement by.2D CaWO4nanosheets during *** findings demonstrate the potential of affordable and abundant mineral resources in advancing electrochemical cataly.ts for oxy.en evolution,highlighting their broader application in sustainable energy.technologies.

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