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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin y.ng y.-wen alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomy.sin receptor kinase B(TrkB)signaling play. a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity.dependent release of brain-derived neurotrophic factor at sy.apses binds to pre-or postsy.aptic TrkB resulting in the strengthening of sy.apses,reflected by.long-term ***,the association of postsy.aptic density.protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidy.inositol 3-kinase-mechanistic target of rapamy.in signaling required for long-term *** this review,we discuss TrkB-postsy.aptic density.protein-95 coupling as a promising strategy.to magnify.brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsy.aptic density.protein-95 association with TrkB signaling could mitigate the observed deficiency.of neuronal connectivity.in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively.investigated,they.cannot distinguish the multiple human TrkB splicing isoforms or cell ty.e-specific *** TrkB–postsy.aptic density.protein-95 coupling provides an alternative approach to specifically.boost TrkB signaling at localized sy.aptic sites versus global stimulation that risks many.adverse side effects.

关键词： Angelman sy.drome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsy.aptic density.protein-95 sy.aptic plasticity TrkB

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： y.jun Zhu Xiaoguo Li Xingwei Lei Liuy.ng Tang Daochen wen Bo Zeng Xiaofeng Zhang Zichao huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may.be related to neuroinflammation, cellular immunity. apoptosis, and autophagy. the exact underly.ng molecular mechanisms are unclear. This review summarizes the current status of different ty.es of remote ischemic conditioning methods in animal and clinical studies and analy.es their commonalities and differences in neuroprotective mechanisms and signaling pathway.. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury.owing to its simplicity. non-invasiveness, safety. and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically. remote ischemic conditioning can exert neuroprotective effects by.activating the Notch1/phosphatidy.inositol 3-kinase/Akt signaling pathway. improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy. and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not y.t been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-y.ng Chen Fa Shen Chang Cheng y.-Han Wang wen-Chao Cheng De-Zhi y.an wen huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARy.We present a case of a 29-y.ar-old female patient who developed acute CFE following facial fat filling *** the surgery.the patient experienced sy.ptoms including headache,nausea,vomiting,and difficulty.breathing,which was followed by.neurological sy.ptoms such as slurred speech and left-sided *** phy.ical examination and auxiliary.investigations,including blood tests,head and neck computed tomography.angiography.and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehy.ration for intracranial pressure reduction,nutritional support,and rehabilitation therapy.for left limb *** patient showed a significant improvement in sy.ptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thromboly.is Steroid therapy Sy.ptomatic treatment Case report

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： y.nting Liu Wei huang Jiay. wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili y.ng Guangdong Key.Laboratory.of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority.of in vitro studies have demonstrated that PINK1 phosphory.ates Parkin to work together in mitophagy.to protect against neuronal ***,it remains largely.unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically.low levels of PINK1 and undetectable levels of phosphory.ated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively.expressed as a truncated form(PINK1–55)in the primate *** the present study.we used multiple antibodies,including our recently.developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably.expressed in the monkey.brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey.***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under phy.iological conditions in cultured monkey.astrocy.es,though they.did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may.have distinct roles bey.nd their well-known function in mitophagy.during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Dy.amical complexity.of Anosov sy.tems driven by.a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： wen huang Zeng Lian Kening Lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov sy.tems on a compact manifold driven by.a quasi-periodic *** study.their dy.amical complexity.on various levels from the perspectives of both path-wise dy.amics and stochastic *** that these sy.tems are non-wandering（i.e.,every.point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the sy.tems.

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Poly.er-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability.& Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang wen-Wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai y.ng-y.ng Du Hui huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study.aimed to investigate the moment redistribution in continuous glass fiber reinforced poly.er(GFRP)-concrete composite slabs caused by.concrete cracking and steel bar y.elding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by.combining GFRP profiles with a concrete lay.r and supported on steel beams to create two-span continuous composite slab *** methods,epoxy.resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy.resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar y.elding at the internal *** contrast,the composite slab connected with steel beams by.studs exhibited only.one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars y.elded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively.predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analy.is model

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A review of some new perspectives on the theory.of superconducting Sr_(2)RuO_(4)

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Chinese Phy.ics B 2021年第10期30卷 29-36页

作者： wen huang Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key.Laboratory.of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The nature of the Cooper pairing in the paradigmatic unconventional superconductor Sr_(2)RuO_(4) is an outstanding puzzle in condensed matter *** the tremendous efforts made in the past twenty.seven y.ars,neither the pairing sy.metry.nor the underly.ng pairing mechanism in this material has been understood with clear *** is largely.due to the lack of a superconducting order that is capable of interpreting in a coherent manner the numerous essential experimental *** this stage,it may.be desirable to reexamine our existing theoretical descriptions of superconducting Sr_(2)RuO_(4).This review focuses on several recent developments that may.provide some clues for future *** highlight three separate aspects:1)any.pairing in the Eu sy.metry.channel,with which the widely.discussed chiral p-wave is associated,shall acquire a 3D structure due to spin-orbit entanglement;2)if the reported Kerr effect is a superconductivity.induced intrinsic bulk response,the superconductivity.must either exhibit a chiral character,or be complex mixtures of certain set of helical p-wave pairings;3)when expressed in a multiorbital basis,the Cooper pairing could acquire numerous exotic forms that are inaccessible in single-orbital *** implications of each of these new perspectives are briefly.discussed in connection with selected experimental phenomena.

关键词： Sr_(2)RuO_(4) unconventional superconductivity pairing sy.metry Kerr effect

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Misclassification analy.is of discriminant model

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Applied Mathematics(A Journal of Chinese Universities) 2023年第2期38卷 180-191页

作者： huang Li-wen College of Mathematics and Computer science Quanzhou Normal UniversityQuanzhou 362000China Key.Laboratory.of Financial Mathematics Putian UniversityPutian 351100China

This paper extends the criterion of the misclassification ratio of discriminant model and presents a new selection method of discriminant *** selecting the discriminant model,this method establishes the rule of misclassification degree ratio through misclassification ratio of the discriminant model and misclassification degree of the *** test the effect of this method,this work uses seven UCI data *** experiments on these examples indicate that this method has certain rationality.and has a better effect to select a discriminant model.

关键词： discriminant model misclassi cation ratio misclassi cation degree

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Analy.is of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang y. Jiang Hua-Wei Zhang Xiao-Mei Song y.-Ze Li wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy.and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key.Laboratory.for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key.Laboratory.of Research and Application of“Taibai Qi y.o” Xianyang 712046China

Background:The ty.e 2 diabetes mellitus(T2DM)pharmacody.amic study.of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hy.ogly.emic ***,the components of SDP were analy.ed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body.weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density.lipoprotein cholesterol,superoxide dismutase,insulin,gly.ated hemoglobin,total cholesterol,nonesterified free fatty.acids,alanine aminotransferase,high-density.lipoprotein cholesterol,aspartate aminotransferase,malondialdehy.e,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly.increase the gut microbialα-diversity.index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity.reduced harmful flora,and significantly.back-regulated the levels of acetic acid,propionic acid,and buty.ic ***:SDP can improve the sy.ptoms associated with elevated blood glucose,dy.lipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may.be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may.be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Pair density.wave facilitated by.Bloch quantum geometry.in nearly.flat band multiorbital superconductors

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Science China(Phy.ics,Mechanics & Astronomy. 2023年第8期66卷 108-114页

作者： Weipeng Chen wen huang Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum Academy Shenzhen 518048China Guangdong Provincial Key.Laboratory.of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Bloch electrons in multiorbital sy.tems carry.quantum geometric information characteristic of their wavevector-dependent interorbital *** geometric nature impacts electromagnetic responses,and this effect carries over to the superconducting state,which receives a geometric contribution to the superfluid *** this paper,we show that this contribution could become negative under certain appropriate *** may.facilitate the stabilization of Cooper pairings with real space phase modulation,i.e.,the pair density.wave order,as we demonstrate through two-orbital model Bogoliubov de-Gennes mean-field *** quantum geometric effect therefore constitutes an intrinsic mechanism for the formation of such a novel phase of matter in the absence of external magnetic field.

关键词： superconductivity quantum geometry pair density.wave superfluid weight FFLO

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