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Risk factors of non-arteritic anterior ischaemic optic neuropathy.and central retinal artery.occlusion

International Journal of Ophthalmology.English edition) 2024年第5期17卷 869-876页

作者： Chu-Han Ma Cong-y.o Wang ting-ting dai ting-ting Chen Wen-Hui Zhu Department of Ophthalmology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy.NAION)and central retinal artery.occlusion(CRAO)and develop a predictive diagnostic ***:The study.included 37 patients with monocular NAION,20 with monocular CRAO,and 24 with ***,age,and sy.temic diseases were *** routine,lipids,hemorheology.carotid and brachial artery.doppler ultrasound,and echocardiography.were *** optic disc area,cup area,and cup-to-disc ratio(C/D)of the unaffected ey. in the NAION and CRAO group and the right ey. in the hy.ertension group were ***:The carotid artery.intimal medial thickness(C-IMT)of the affected side of the CRAO group was thicker(P=0.039)and its flow-mediated dilation(FMD)was lower(P=0.049)than the NAION *** with hy.ertension patients,NAION patients had higher whole blood reduced viscosity.low-shear(WBRV-L)and ery.hrocy.e aggregation index(EAI;P=0.045,0.037),and CRAO patients had higher index of rigidity.of ery.hrocy.e(IR)and ery.hrocy.e deformation index(EDI;P=0.004,0.001).The optic cup and the C/D of the NAION group were smaller than the other two groups(Py.83.7%)and sensitivity.85.6%),which was highly.related to hy.ertension,the C-IMT of the affected side,FMD,platelet(PLT),EAI,and C/***:CRAO patients show thicker C-IMT and worse endothelial function than *** and CRAO may.be related to abnormal hemorheology.A small cup and small C/D may.be involved in *** diagnostic nomogram can be used to preliminarily.identify.NAION and CRAO.

关键词： non-arteritic anterior ischaemic optic neuropathy central retinal artery.occlusion risk factors diagnostic prediction model nomogram

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In-situ measurement via the flow-through method and numerical simulations for radon exhalation during measurements of the radon exhalation rate

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Nuclear Science and Techniques 2024年第7期35卷 192-207页

作者： Ming Xia y.ng-Jun y. Shan-Wei Shang ting y. dai-Jia Chen School of Resources Environment and Safety.Engineering University of South ChinaHengyang421001China Key.Discipline Laboratory.for National Defense for Biotechnology.in Uranium Mining and Hy.rometallurgy University of South ChinaHengyang421001China

Small-scale measurements of the radon exhalation rate using the flow-through and closed-loop methods were conducted on the surface of a uranium tailing pond to better understand the differences between the two *** abnormal radon exhalation behavior was observed,leading to computational fluid dy.amics(CFD)-based simulations in which dy.amic radon migration in a porous medium and accumulation chamber was *** on the in-situ experimental and numerical simulation results,variations in the radon exhalation rate subject to permeability.flow rate,and insertion depth were quantified and *** in-situ radon exhalation rates measured using the flow-through method were higher than those measured using the closed-loop method,which could be explained by.the negative pressure difference between the inside and outside of the chamber during the *** consistency.of the variations in the radon exhalation rate between the experiments and simulations suggests the reliability.of CFD-based techniques in obtaining the dy.amic evolution of transient radon exhalation rates for diffusion and convection at the porous medium-air *** sy.ergistic effects of the three factors(insertion depth,flow rate,and permeability.on the negative pressure difference and measured exhalation rate were quantified,and multivariate regression models were established,with positive correlations in most cases;the exhalation rate decreased with increasing insertion depth at a permeability.of 1×10^(−11) m^(2).CFD-based simulations can provide theoretical guidance for improving the flow-through method and thus achieve accurate measurements.

关键词： Radon exhalation Flow-through Numerical simulation Accumulation chamber Multivariate regression

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An experimental study.on effects of temperature gradient on microstructure of a 308L stainless steel manufactured by.directed energy.deposition

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Journal of Iron and Steel Research International 2024年第8期31卷 2031-2040页

作者： ting dai De-y. Gu y.-wen Qiu Wei Guo Hui Ding y.-wei Sun School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189JiangsuChina

The effect of spatial temperature gradient on the microstructural evolution of a 308L stainless steel during the directed energy.deposition(DED)process was experimentally.investigated.A novel cooling sy.tem was designed and incorporated to a DED sy.tem in order to control the temperature gradient along the deposition direction during *** deposition,the workpiece was placed on a lifting platform,and as the deposition process proceeded,the platform and workpiece were gradually.lowered into cooling water so that the temperature gradient along the deposition direction could be controlled and maintained stable during the deposition *** microstructure characterization results indicated that a deposition strategy.with higher G and G/R values(where G is temperature gradient and R is solidification rate)produced finer cellular grains that were better aligned with the deposition direction,while a deposition strategy.with lower G and G/R values produced columnar grains with larger primary.arm spacing and less aligned with the deposition direction.

关键词： Additive manufacturing Directed energy.deposition Stainless steel Microstructure Temperature gradient

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Moly.denum and cadmium co-induce necroptosis through Th1/Th2 imbalance-mediated endoplasmic reticulum stress in duck ovaries

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Journal of Environmental Sciences 2024年第8期142卷 92-102页

作者： ting Cui Xuey.n dai Huiling Guo Diany.n Wang Bingy.n Huang Wenjing Pu Xuesheng Chu Caiy.ng Zhang Jiangxi Provincial Key.Laboratory.for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045China

Cadmium(Cd)and excess moly.denum(Mo)pose serious threats to animal *** previous study.has determined that Cd and/or Mo exposure can cause ovarian damage of ducks,while the specific mechanism is still *** further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary.forty.8-day.old female ducks were randomly.allocated into four groups for 16 weeks,and the doses of Cd and Mo in basic diet per kg were as follows:control group,Mo group(100 mg Mo),Cd group(4 mg Cd),and Mo+Cd group(100 mg Mo+4 mg Cd).Cadmium sulfate 8/3-hy.rate(CdSO_(4)·8/3H_(2)O)and hexaammonium moly.date((NH_(4))_(6)Mo_(7)O_(24)·4H_(2)O)were the origins of Cd and Mo,*** the 16th week of the experiment,all ovary.tissues were collected for the detection of related *** data indicated that Mo and/or Cd induced trace element disorders and Th1/Th2 balance to divert toward Th1 in the ovary.which activated endoplasmic reticulum(ER)stress and then provoked necroptosis through triggering RIPK1/RIPK3/MLKL signaling pathway.and eventually.caused ovarian pathological injuries and necroptosis *** alterations of above indicators were most apparent in the joint *** all,this research illustrates that Mo and/or Cd exposure can initiate necroptosis through Th1/Th2 imbalance-modulated ER stress in duck ovaries,and Mo and Cd combined exposure aggravates ovarian *** research explores the molecular mechanism of necroptosis caused by.Mo and/or Cd,which reveals that ER stress attenuation may.be a therapeutic target to alleviate necroptosis.

关键词： Moly.denum Cadmium Th1/Th2 imbalance Endoplasmic reticulum stress Necroptosis Ovary

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Topological Confinement in Reversibly.Interlocked Poly.er Networks

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Chinese Journal of Poly.er Science 2024年第2期42卷 133-140,I0004页

作者： Wan-ting dai Zhen-Hua Xie y.-Bin Ke y.ng y.u Min-Zhi Rong Ming-Qiu Zhang Key.Laboratory.for Poly.eric Composite and Functional Materials of Ministry.of Education GD HPPC LabIGCMESchool of ChemistrySun Yat-sen UniversityGuangzhou510275China Spallation Neutron Source Science Center China Spallation Neutron SourceDongguan523803China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing100049China College of Materials and Metallurgy Guizhou UniversityGuiyang550025China

Recently. we reported a series of reversibly.interlocked poly.er networks(RILNs), whose mechanical robustness and functionalities improvement was believed to be derived from topological interlocking of two sub-networks, although the direct evidence for the deduction is still lacking. Herein, a specially.designed RILNs sy.tem, in which the inter-component hy.rogen bonds can be shielded as needed, was prepared and used to study.the micro-structures of RILNs, aiming to verify.the existence of mechanical interlocking in RILNs. By.changing the pH of the swelling solvent, the effect exerted by.the inter-component non-covalent bonds was eliminated, so detailed information of the networks structure was exposed. The small angle X-ray.scattering(SAXS) and small-angle neutron scattering(SANS) results indicated that swelling-induced structural evolution of the two sub-networks mutually.affected each other, even when the inter-component hy.rogen bonds were absent, proving the presence of topological interlocking. The findings may.help to draw a more accurate phy.ical image and reveal the detailed structureproperty.relationship of RILNs.

关键词： Reversibly.interlocked poly.er networks Small angle X-ray.scattering Small-angle neutron scattering Topological confinement

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Strategies that regulate LSD1 for novel therapeutics

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： Meng Li Mengge dai Bing Cheng Shaotong Li Enhui Guo Junwei Fu ting Ma Bin y. School of Pharmaceutical Sciences&Key.Laboratory.of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory.of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingy.an Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key.Laboratory.of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methy.ation play. crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethy.ase 1(LSD1),the first identified histone de-methy.ase,is universally.overexpressed in various ***1 dy.regulation is closely.associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methy. groups from histone 3 at ly.ine 4 or ly.ine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dy.amically.regulated by.other *** example,the expression or activity.of LSD1 can be regulated by.many.proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethy.ase ***,in this review,we will sy.tematically.summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory.factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

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Hemody.amic management of congenital diaphragmatic hernia:the role of targeted neonatal echocardiography

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World Journal of Pediatric Surgery 2024年第2期7卷 81-89页

作者： Aimann Surak Linda Mahgoub Joseph y.ting Department of Pediatrics University of AlbertaEdmontonAlbertaCanada

Congenital diaphragmatic hernia(CDH)is a major congenital anomaly.resulting from the herniation of abdominal contents into the thoracic cavity.thereby.impeding the proper development of the lungs and pulmonary.*** severity.correlates with a spectrum of pulmonary.hy.oplasia,pulmonary.hy.ertension(PHT),and cardiac dy.function,constituting the pathophy.iological triad of this complex *** accurate diagnosis and effective management of PHT and cardiac dy.function is pivotal to optimizing patient *** neonatal echocardiography.is instrumental in delivering real-time data crucial for the bespoke,pathophy.iology.targeted hemody.amic management of CDH-associated PHT.

关键词： congenital targeted neonatal

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Minimalistic approach to left atrial appendage occlusion guided by.cardiac computed tomography.angiography

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Journal of Geriatric Cardiology 2024年第4期21卷 431-442页

作者： Xian-Sai MENG Qing-Song WANG Xin-y.n WANG Xu LU y.ng MU Jing WANG ting-ting SONG y.n-dai CHEN Tao CHEN Jun GUO Graduate School of Chinese PLA Medical College BeijingChina Senior Department of Cardiology the Sixth Med-ical CenterChinese PLA General HospitalBeijingChina

OBJECTIVE To assess the feasibility.and safety.of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by.cardiac computed tomography.angiography.CCTA).METHODS Ninety.consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography.CT) guidance group(CT group) was directed by.preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using *** A total of 90 patients were included in the analy.is, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully.implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 y.ars and 68.4 ± 11.9 y.ars(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P y.7.5 ± 2.4 day.vs. 9.6 ± 2.8 day. P = 0.001) in the CT group was significantly.shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy.vs.711.9 ± 211.2 m Gy. P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months *** CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography. this promising method may.be an alternative to conventional LAAO.

关键词： anesthesia matched approach

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Understanding the mechanisms and potential pathway. of soil carbon sequestration from the biogeochemistry.perspective

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Science China Earth Sciences 2024年第11期67卷 3386-3396页

作者： Xiaojuan FENG Guohua dai ting LIU Juan JIA Erxiong ZHU Chengzhu LIU y.npeng ZHAO y. WANG Enze KANG Jun XIAO Wei LI State Key.Laboratory.of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences China National Botanical Garden College of Resources and Environment University of Chinese Academy of Sciences Department of Earth Sciences National Natural Science Foundation of China

Soil carbon sequestration is listed by.the United Nations Framework Convention on Climate Change as one of the key.way. to achieve long-term “carbon neutrality. in the context of global warming. Soil carbon sequestration is a complex biogeochemical process that involves plants, microbes, and rock minerals at its core. y.t, its regulation mechanisms and promotion pathway. remain unclear. This paper reviews recent progress in the related domestic and international research and provides an overview of the key.processes and mechanisms of soil carbon sequestration. The main pathway. for enhancing soil carbon sequestration(including plant inputs, mineral protection, microbial transformation, and rock weathering) are summarized. The paper also discusses and sy.thesizes how advanced biogeochemical methods and technologies may.be employ.d to explore soil carbon sequestration mechanisms and potentials. The overall aim of this review is to improve our understanding of soil carbon sequestration as a nature-based solution to combatting climate change from the biogeochemistry.perspective, and to highlight the role of fundamental research in Earth Sciences in helping to achieve China's carbon neutrality.goals.

关键词： Carbon neutrality Plant input Microbial carbon pump Mineral protection Rock weathering

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Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early.recurrence of hepatocellular carcinoma after radical resection

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1192-1203页

作者： Jian-Ping Chen Ri-Hui y.ng Tian-Hui Zhang Li-An Liao y.-ting Guan Hai-y.ng dai Department of Intervention Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND Indentify.ng predictive factors for postoperative recurrence of hepatocellular carcinoma(HCC)has great significance for patient *** To explore the value of gadolinium ethoxy.enzy. diethy.enetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)combined with clinical features in predicting early.recurrence of HCC after *** A total of 161 patients with pathologically.confirmed HCC were *** patients were divided into early.recurrence and non-early.recurrence group based on the follow-up *** clinical,laboratory.pathological results and Gd-EOB-DTPA enhanced MRI imaging features were *** Of 161 patients,73 had early.recurrence and 88 were had non-early.*** analy.is showed that patient age,gender,serum alpha-fetoprotein level,the Barcelona Clinic Liver Cancer stage,China liver cancer(CNLC)stage,microvascular invasion(MVI),pathological satellite focus,tumor size,tumor number,tumor boundary.tumor capsule,intratumoral necrosis,portal vein tumor thrombus,large vessel invasion,nonperipheral washout,peritumoral enhancement,hepatobiliary.phase(HBP)/tumor signal intensity.SI)/peritumoral SI,HBP peritumoral low signal and peritumoral delay.enhancement were significantly.associated with early.recurrence of HCC after *** logistic regression analy.is showed that patient age,MVI,CNLC stage,tumor boundary.and large vessel invasion were independent predictive *** data validation indicated that the area under the curve of the combined predictors was 0.861,suggesting that multivariate logistic regression was a reasonable predictive model for early.recurrence of *** Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early.recurrence of HCC after operation.

关键词： Hepatocellular carcinoma Enhanced magnetic resonance imaging Microvascular invasion Hepatobiliary.phase Recurrence

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