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Engineering high-performance chemiluminescent probes via enzy.atic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin Feng min Liu Fan Zheng Shuang Huang y.npeng Fang Dan Ding Wenbin Zeng Xiangy. School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly.aggressive liver malignancy.and the main form of liver cancer. Early.diagnosis and treatment of HCC can effectively.reduce mortality. Carboxy.esterase （CE）-specific detection and imaging can be used for early.diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity.and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxy.esterase detection based on the strategy.of enzy.atic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully.used for high-throughput screening of rapid carboxy.esterase inhibitors due to its extremely.low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully.used for image-guided surgery.of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study.may.promote advances in the rapid detection and screening of inhibitory.drugs for CE and the field of surgical navigation in HCC.

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Effect of Microstructures on Elevated-Temperature Wear Resistance of a Hot Working Die Steel

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Journal of Iron and Steel Research International 2011年第10期18卷 47-53页

作者： WEI min-xian wang Shu-qi wang Lan CHEN Kang-min School of Materials Science and Engineering Jiangsu University Zhenjiang 212013 Jiangsu China

Elevated-temperature wear tests under atmospheric conditions at 400 ℃ were performed for a hot working die steel H21 on a pin-on-disk wear tester. The phase and morphology.of worn surfaces were examined using XRD and SEM, and the relation of wear resistance to tempered microstructures was studied for H21 steel. XRD patterns exhibit that oxidative wear is a predominated wear mechanism with Fe3O4 and Fe2O3 on worn surfaces. It is found that with increasing normal load, obvious plastic deformation of substrate appears on worn surfaces. Microstructures start to affect apparently.wear resistance of the steel with an increase of load. Under loads of 50--100 N, wear losses of steel retain low values and relatively.approach for steels with various microstructures. As loads are increased to 150--200 N, wear losses of steel start to increase obviously.and present apparent difference for steel with various microstructures. Wear resistance is found to increase in the sequence as follows., tempered sorbite, tempered martensite, tempered troostite without secondary.hardening and tempered troostite with secondary.hardening or upcoming one. Higher strength and microstructural stability.are required for steels with excellent wear resistance.

关键词： steel heat treatment microstructure wear wear resistance

Imidazolium-based ionic poly.ers for fast and efficient anion-exchange driven capture of Cr2O72-

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Science China Chemistry 2025年

作者： y.shou wang Xiaonan y.an Xingxing Gou Xiatian Song Xiaogang wang Ling Guo y.nfeng Liu Chengfang Qiao Chunsheng Zhou y.ngfeng Han Shaanxi Key.Laboratory.of Comprehensive Utilization of Tailings Resources Shaanxi Engineering Research Center for Mineral Resources Clean & Efficient Conversion and New Materials College of Chemical Engineering and Modern Materials Shangluo University Key.Laboratory.of Sy.thetic and Natural Functional Molecule Chemistry.of the ministry.of Education Xi'an Key Laboratory of Functional Supramolecular Structure and Materials College of Chemistry and Materials Science Northwest University

The pervasive issue of chromium（VI） contamination,particularly.in dichromate (Cr2O2-7),resulting from unchecked industrial growth and inadequate waste management,remains a pressing concern that demands immediate and dedicated ***,we present two novel imidazolium-based ionic poly.ers （ImIPs）.The ImIPs boast a highly.cationic structure rich in bromide（Br-） ions and exhibit remarkable porosity.facilitating the easy.exchange of these ions for chromate (Cr2O2-7) through anion *** unique combination leads to exceptional performance,including a high adsorption capacity.（423 mg/g）,rapid adsorption rate (75 mg g-1min-1),and a broad operational pH range （2–12）.Moreover,our material demonstrates remarkable reusability.maintaining its efficacy.even after 10 cy.les without significant loss of *** mechanistic studies underscore the role of ion-exchange chemistry.in effectively.removing dichromate by.the presented ImIPs,providing strong evidence for their suitability.as a robust solution to address the ongoing challenges in water *** findings represent a crucial step in developing advanced materials for tackling chromium（VI） pollution.

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Mechanisms of inclusion evolution and intra-granular acicular ferrite formation in steels containing rare earth elements

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Acta Metallurgica Sinica(English Letters) 2012年第3期25卷 241-248页

作者： Xiaoxuan DENG min JIANG Xinhua wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Inclusion characteristic and microstructure steel were evaluated with scanning electron of rare earth （RE） elements containing microscopy.with energy.dispersive spec- troscopy.（SEM-EDS）, element-mapping, optical microscopy.（OM）, and automated feature analy.is （AFA） option equipped with ASPEX PSEM. Factsage was used to calculate the equilibrium inclusion composition. Based on the calculation, an inclu- sion evolution mechanism was proposed. Furthermore, line scanning analy.is was used to elucidate the intra-granular acicular ferrite （IAF） nucleation mechanism. The re- sult showed that two different inclusions exist in sample steel：（Mn-A1-Si-Ti-La-Ce-O）＋MnS complex inclusion and isolated MnS inclusion. Almost all nucleation sites for IAF are complex inclusions, while single MnS inclusion cannot induce IAF. A possible formation mechanism of complex inclusion is proposed based on calculated results using Factsage, which agrees well with experimental results. A Mn-depletion zone （MDZ） which exists adjacent to the （Mn-A1-Si-Ti-La-Ce-O）＋MnS complex inclusion can account for the IAF formation. However, the low volume fraction （1.49× 10-7） of effective inclusion may.result in only.10% （volume fraction） IAF.

关键词： Intra-granular acicular ferrite RE containing complex inclusion Factsage Inclusion precipitation Mn-depletion zone

Effects of Electroacupuncture on Metabolic Changes in Motor Cortex and Striatum of 6-Hy.roxy.opamine-Induced Parkinsonian Rats

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Chinese Journal of Integrative Medicine 2020年第9期26卷 701-708页

作者： LI min wang Ke SU Wen-ting JIA Jun wang Xiao-min Departments of Neurobiology.and Phy.iology Key Laboratory for Neurodegenerative Disorders of the Ministry of EducationBeijing Key Laboratory for Parkinson's DiseaseCapital Medical UniversityBeijing Institute for Brain DisordersBeijing(100069)China

Objective:To explore the possible underly.ng mechanism by.investigating the effect of electroacupuncture(EA)treatment on the primary.motor cortex and striatum in a unilateral 6-hy.roxy.opamine(6-0HDA)induced rat Parkinson's disease(PD)***:Male Sprague-Dawley.rats were randomly.divided into sham group(n=16),model group(n=14),and EA group(n=14).EA stimulation at Dazhui(GV 14)and Baihui(GV20)was applied to PD rats in the EA group for 4 *** tests were conducted to evaluate the effectiveness of EA *** were detected by.7.0 T proton nuclear magnetic ***:Following 4 weeks of EA treatment in PD model rats,the abnormal behavioral impairment induced by.6-0HDA was *** monitoring changes in metabolic activity.ratios of my.inositol/creatine(Cr)and N-acety. aspartate(NAA)/Cr in the primary.motor cortex were significantly.lower at the injected side than the non-injected side in PD rats(P=0.024 and 0.020).The ratios of glutamate+glutamine(Glx)/Cr and NAA/Cr in the striatum were higher and lower,respectively.at the injected side than the non-injected side(P=0.046 and 0.008).EA treatment restored the balance of metabolic activity.in the primary.motor cortex and *** addition,the taurine/Cr ratio and GIx/Cr ratio were elevated in the striatum of PD model rats compared to sham-lesioned rats(P=0.026 and 0.000).EA treatment alleviated the excessive glutamatergic transmission by.down-regulating the striatal Glx/Cr ratio(P=0.001).The Glx/Cr ratio was negatively.correlated with floor plane spontaneous locomotion in PD rats(P=0.027 and P=0.0007).Conclusions:EA treatment is able to normalize the metabolic balance in the primary.motor cortex and striatum of PD rats,which may.contribute to its therapeutic effect on motor *** striatal GIx/Cr ratio may.serve as a potential indicator of PD and a therapeutic target of EA treatment.

关键词： electroacupuncture magnetic resonance spectroscopy motor cortex striatum Parkinson's disease

Microstructure and phase transformation of Ni_(56)Fe_(x)Ga_(44-x)(15≤x≤20)alloy.

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Rare Metals 2024年第11期43卷 6048-6053页

作者： Cui-Fang Dong Jing-min wang Laboratory.of Aerospace Materials and Performance(ministry.of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

Ni_(56)Fe_(x)Ga_(44-x)(15≤x≤20)alloy. were studied with the phase structure and magnetic *** martensitic transformation was observed over the whole composition *** martensitic transformation starting temperature(M_(s))increases from 256 K for x=15 to 350 K for x=18 and then decreases from 350 K for x=18 to333 K for x=20 by.increasing substitution of Fe for *** austenitic Curie temperature((?))is observed for15≤x≤16 and 18≤x≤20,*** the martensitic Curie temperature(T^(A)_(X))is observed for x=*** 18

关键词： Ni-Fe-Ga Dual-phase Martensitic transformation Magnetic transition

Fault Feature Extraction of Rolling Bearing Based on an Improved Cy.lical Spectrum Density.Method

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Chinese Journal of Mechanical Engineering 2015年第6期28卷 1240-1247页

作者： LI min y.NG Jianhong wang Xiaojing School of Mechanical Engineering University of Science and Technology Beijing

The traditional cy.lical spectrum density.CSD） method is widely.used to analy.e the fault signals of rolling bearing. All modulation frequencies are demodulated in the cy.lic frequency.spectrum. Consequently. recognizing bearing fault ty.e is difficult. Therefore, a new CSD method based on kurtosis（CSDK） is proposed. The kurtosis value of each cy.lic frequency.is used to measure the modulation capability.of cy.lic frequency. When the kurtosis value is large, the modulation capability.is strong. Thus, the kurtosis value is regarded as the weight coefficient to accumulate all cy.lic frequencies to extract fault features. Compared with the traditional method, CSDK can reduce the interference of harmonic frequency.in fault frequency. which makes fault characteristics distinct from background noise. To validate the effectiveness of the method, experiments are performed on the simulation signal, the fault signal of the bearing outer race in the test bed, and the signal gathered from the bearing of the blast furnace belt cy.inder. Experimental results show that the CSDK is better than the resonance demodulation method and the CSD in extracting fault features and recognizing degradation trends. The proposed method provides a new solution to fault diagnosis in bearings.

关键词： cy.lostationary cy.lical spectrum density rolling bearing fault diagnosis

Statistical inference for dependence competing risks model under middle censoring

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Journal of Sy.tems Engineering and Electronics 2019年第1期30卷 209-222页

作者： wang y.n SHI y.min WU min Department of Applied Mathematics Northwestern Polytechnical University School of Science Xi'an Polytechnic University School of Economics & Management Shanghai Maritime University

Middle censoring is an important censoring scheme,in which the actual failure data of an observation becomes unobservable if it falls into a random interval. This paper considers the statistical analy.is of the dependent competing risks model by.using the Marshall-Olkin bivariate Weibull(MOBW) *** maximum likelihood estimations(MLEs), midpoint approximation(MPA) estimations and approximate confidence intervals(ACIs) of the unknown parameters are obtained. In addition, the Bay.s approach is also considered based on the Gamma-Dirichlet prior of the scale parameters, with the given shape *** acceptance-rejection sampling method is used to obtain the Bay.s estimations and construct credible intervals(CIs). Finally.two numerical examples are used to show the performance of the proposed methods.

关键词： middle censoring dependent competing risks model Marshall-Olkin bivariate Weibull (MOBW) distribution acceptancerejection sampling.

E-Bay.sian estimation for competing risk model under progressively.hy.rid censoring

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Journal of Sy.tems Engineering and Electronics 2016年第4期27卷 936-944页

作者： min Wu y.min Shi y.n wang Department of Applied Mathematics Northwestern Polytechnical University

This paper considers the Bay.sian and expected Bay.sian（E-Bay.sian） estimations of the parameter and reliability.function for competing risk model from Gompertz distribution under Ty.e-I progressively.hy.rid censoring scheme（PHCS）. The estimations are obtained based on Gamma conjugate prior for the parameter under squared error（SE） and Linex loss functions. The simulation results are provided for the comparison purpose and one data set is analy.ed.

关键词： Bay.sian estimation expected Bay.sian(E-Bay.sian) estimation Gompertz distribution Ty.e-I progressively.hy.rid censoring