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Reduction of epinephrine in the lumbar spinal cord follow.ng repetitive blast-induced traumatic brain inj.ry.in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： Shigeharu Tsuda Mustafa Golam j.amei Hou Kevin K.w.w.ng Floy. j.Thompson Prodip Bose Brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency.Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inj. ry.induced unfavorable outcomes in human patients have independently.been associated with dy.regulated levels of monoamines,especially.epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous sy.tem after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study.was to determine the impact of repeated blast-induced traumatic brain inj.ry.on the epinephrine levels in seve ral function-s pecific central nervous sy.tem regions in *** three repeated blast inj.ries at 3-day.intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-inj.ry.day.eight and processed for epinephrine assay. using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly.decreased in the lumbar spinal cord tissues of blast-induced traumatic brain inj.ry.animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous sy.tem regions,although the epinephrine levels were slightly.altered follow.ng blast-induced tra u matic brain inj.ry.they.were not statistically.*** results suggest that blast inj.ry.induced significant downregulation of epinephrine in the lumbar spinal cord could negatively.impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord follow.ng repetitive mild blast-induced traumatic brain inj.ry.

关键词： balance blood flow cardiovascular sy.tem central nervous sy.tem epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain inj.ry

Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

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Chinese Phy.ics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 y.ALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.y.maguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key.Laboratory.of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Max-Planck-Institut für Kernphy.ik Saupfercheckweg 169117 HeidelbergGermany GSI Helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy.Science and Technology.Guangdong Laboratory Huizhou516007China State Key.Laboratory.of Nuclear Phy.ics and Technology School of PhysicsPeking UniversityBeijing 100871China Department of Phy.ics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The ground-state mass excess of the T_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly.developed Bρ-defined isochronous mass spectrometry.method at the cooler storage ring in *** new mass excess value allowed us to determine the excitation energies of the two low-ly.ng 1+states in ^(22)Al with significantly.reduced uncertainties of 51 *** compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy.differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies and mirror energy.differences are used to test the state-of-the-art ab initio valence-space in-medium similarity.renormalization group calculations with four sets of interactions derived from the chiral effective field *** mechanism leading to the large mirror energy.differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass Bρ-defined IMS mirror energy.difference ab initio VS-IMSRG calculations chiral interactions

Hy.romechanical characterization of gas transport amidst uncertainty.for underground nuclear explosion detection

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j.urnal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2019-2032页

作者： wenfeng Li Chelsea w.Neil j.william Carey.Meng Meng Luke P.Frash Philip H.Stauffer Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNM87544USA Department of Mineral Engineering New Mexico TechSocorroNM87801USA

Given the challenge of definitively.discriminating between chemical and nuclear explosions using seismic methods alone,surface detection of signature noble gas radioisotopes is considered a positive identification of underground nuclear explosions(UNEs).However,the migration of signature radionuclide gases between the nuclear cavity.and surface is not well understood because complex processes are involved,including the generation of complex fracture networks,reactivation of natural fractures and faults,and thermo-hy.ro-mechanical-chemical(THMC)coupling of radionuclide gas transport in the *** this study.we provide an experimental investigation of hy.ro-mechanical(HM)coupling among gas flow,stress states,rock deformation,and rock damage using a unique multi-phy.ics triaxial direct shear rock testing *** testing sy.tem also features redundant gas pressure and flow rate measurements,well suited for parameter uncertainty.*** porous tuff and tight granite samples that are relevant to historic UNE tests,we measured the Biot effective stress coefficient,rock matrix gas permeability.and fracture gas permeability.at a range of pore pressure and stress *** Biot effective stress coefficient varies from 0.69 to 1 for the tuff,whose porosity.averages 35.3%±0.7%,while this coefficient varies from 0.51 to 0.78 for the tight granite(porosity.1%,perhaps an underestimate).Matrix gas permeability.is strongly.correlated to effective stress for the granite,but not for the porous *** experiments reveal the follow.ng key.engineering implications on transport of radionuclide gases post a UNE event:(1)The porous tuff shows apparent fracture dilation or compression upon stress changes,which does not necessarily.change the gas permeability.(2)The granite fracture permeability.shows strong stress sensitivity.and is positively.related to shear displacement;and(3)Hy.romechanical coupling among stress states,rock damage,and gas flow appears to be

关键词： Underground nuclear explosion uncertainty quantification Radionuclide transport Biot effective stress coefficient Fracture permeability Matrix permeability

Anneal-free ultra-low loss silicon nitride integrated photonics

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Light(Science & Applications) 2024年第8期13卷 1565-1577页

作者： Debapam Bose Mark w.Harrington Andrei Isichenko Kaikai Liu j.awei w.ng Nitesh Chauhan Zachary.L.Newman Daniel j.Blumenthal Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monolithic integration of the versatile low-loss silicon nitride platform with low-temperature materials such as silicon electronics and photonics,III–V compound semiconductors,lithium niobate,organics,and glasses has been inhibited by.the need for high-temperature annealing as well as the need for different process flows for thin and thick *** techniques are needed to maintain the state-of-the-art losses,nonlinear properties,and CMOS-compatible processes while enabling this next generation of 3D silicon nitride *** report a significant advance in silicon nitride integrated photonics,demonstrating the lowest losses to date for an anneal-free process at a maximum temperature 250℃,with the same deuterated silane based fabrication flow,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record low anneal-free losses for both nitride core and oxide cladding,enabling 1.77 dBm-1 loss and 14.9 million Q for 80 nm nitride core waveguides,more than half an order magnitude lower loss than previously.reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm-1 loss and 4.03 million Q,the highest reported Q for a low temperature processed resonator with equivalent device area,with a median of loss and Q of 13.9 dBm-1 and 2.59 million each *** demonstrate laser stabilization with over 4 orders of magnitude frequency.noise reduction using a thin nitride reference cavity.and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the lowest reported optical parametric oscillation threshold per unit resonator *** results represent a significant step towards a uniform ultra-low loss silicon nitride homogeneous and heterogeneous platform for both thin and thick waveguides capable of linear and nonlinear photonic circuits and integrat

关键词： resonator thick free

Phy.ical scientists research biomedicine: a call for caution

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Chinese j.urnal of Cancer Research 2015年第1期27卷 94-95页

作者： y.-Xiáng j.w.ng Department of Imaging and Interventional Radiology Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital

It is noticeable that nowaday. there are more and more scientists with phy.ical science or engineering background working on or started to work on biomedical proj.cts, but rarely.vice versa. This reflects the multi-discipline nature of some proj.cts, however, also at least partially.can be explained that biomedical research is seen as trendy. fundable, and likely.to get more citations and with results more publishable in high impact j.urnals （1,2）. It is also apparent with some publications and lectures that not all these phy.ical scientists/engineers are well-prepared to work on proj.cts which do not align with their own expertise. Some studies are against very.basic principles of pharmacology.or biology. while others try.to solve medical problems which do not exist clinically. I reviewed a number of submissions including a few from prestigious American universities to Nature j.urnals which made no sense with the study.design. Much of manpower and financial resource are being wasteful spent. There are also examples of clinical trials which were ill-planned right from the start and in the end only.causing much inconvenience to patients to say.at the least. In addition, ample examples exist where experienced phy.ical scientists worked with inexperienced medical scientists and resulted in avoidable failures.

关键词： a call for caution very Phy.ical scientists research biomedicine

Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Phy.ics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskay. K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boy.o R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.y.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.B.Chen y.Q.Chen Z.j.Chen Z.y.Chen S.K.Choi G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbey.si R.E.de Boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Deny.enko M.Destefanis F.De Mori B.Ding X.X.Ding y.Ding y.Ding j.Dong L.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du y.y.Duan Z.H.Duan P.Egorov y.H.Fan j.Fang j.Fang S.S.Fang w.X.Fang y.Fang y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng y.T.Feng M.Fritsch C.D.Fu j.L.Fu y.w.Fu H.Gao X.B.Gao y.N.Gao y.ng Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.w.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong w.X.Gong w.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo R.P.Guo y.P.Guo A.Guskov j.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou B.y.Hu H.M.Hu j.F.Hu S.L.Hu T.Hu y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der wiesche j.j.ckson S.j.nchiv j.H.j.ong Q.j. Q.P.j. w.j. X.B.j. X.L.j. y.y.j. X.Q.j.a Z.K.j.a D.j.ang H.B.j.ang P.C.j.ang S.S.j.ang T.j.j.ang X.S.j.ang y.j.ang j.B.j.ao j.K.j.ao Z.j.ao S.j.n y.j.n M.Q.j.ng X.M.j.ng T.j.hansson S.Kabana N.Kalantar-Nay.stanaki X.L.Kang X.S.Kang M.Kavatsy.k B.C.Ke V.Khachatry.n A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc w.Kühn j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.j.Li H.N.Li Hui Li j.R.Li j.S.Li Ke Li L.j.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li w.D.Li w.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy.Phy.ics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Phy.ics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University.of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University.Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy.Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University.of Science and Technology Luoyang 471003China Henan University.of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology.Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Phy.ics Lanzhou 730000China Institute of Phy.ics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile j.lin University Changchun 130012China j.ha

The number ofψ(3686)events collected by.the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by.counting inclusiveψ(3686)hadronic *** uncertainty.is sy.tematic and the statistical uncertainty.is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

Research on fault time prediction method for high speed rail BTM unit based on multi method interactive validation

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High-speed Railway 2024年第3期2卷 164-171页

作者： Fu L. Gou j. Sun C. Li H. Liu w. School of Information Science and Technology Southwest Jiaotong University Chengdu 611756 China China Railway.Signal and Communication Research and Design Institute Group Co Ltd Beijing 100089 China

The Balise Transmission Module (BTM) unit of the on-board train control sy.tem is a crucial component. Due to its unique installation position and complex environment, this unit has a higher fault rate within the on-board train control sy.tem. To conduct fault prediction for the BTM unit based on actual fault data, this study.proposes a prediction method combining reliability.statistics and machine learning, and achieves the fusion of prediction results from different dimensions through multi-method interactive validation. Firstly. a method for predicting equipment fault time targeting batch equipment is introduced. This method utilizes reliability.statistics to construct a model of the remaining faultless operating time distribution considering uncertainty. thereby.predicting the remaining faultless operating probability.of the BTM unit. Secondly. considering the complexity.of the BTM unit's fault mechanism, the small sample size of fault cases, and the potential presence of multiple fault features in fault text records, an individual-oriented fault prediction method based on Bay.sian-optimized Gradient Boosting Regression Tree (Bay.s-GBRT) is proposed. This method achieves better prediction results compared to linear regression algorithms and random forest regression algorithms, with an average absolute error of only.0.224 y.ars for predicting the fault time of this ty.e of equipment. Finally. a multi-method interactive validation approach is proposed, enabling the fusion and validation of multi-dimensional results. The results indicate that the predicted fault time and the actual fault time conform to a log-normal distribution, and the parameter estimation results are basically.consistent, verify.ng the accuracy.and effectiveness of the prediction results. The above research findings can provide technical support for the maintenance and modification of BTM units, effectively.reducing maintenance costs and ensuring the safe operation of high-speed railway. thus ha

关键词： High speed rail BTM unit Machine learning Multi method interactive verification Remaining faultless operating time

Serum ferritin and the risk of early.onset colorectal cancer

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world j.urnal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Ky.ee Martens Hannah Stowe McMurry.Emerson y.Chen Caitlin Citti Anil Sharma Adel Kardosh j.seph j.Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology.and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology.Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of early.onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally.discovered in y.ung adults,however,the indication for endoscopy.in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy.controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study.of patientsy.ars with newly.diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 y.ars prior to 1 y.ar follow.ng CRC histologic *** supplement the analy.is,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity.analy.is including only.patients with serum ferritin obtained at or before diagnosis was separately.performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/mL(rangeng/mL).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritinng/mL(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 y.ars(P=0.002 and Py..Stage IV disease was associated with significantly.higher serum ferritin compared to less advanced stages(Pwas lower than levels obtained after *** findings were confirmed in the sensitivity.*** Severe iron deficiency.may.indicate an increased risk of EO-CRC,particularly.at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early.onset y.ung-onset Colorectal cancer Age Ferritin Iron deficiency

Evidence for particle acceleration approaching PeV energies in the w51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collaboration Zhen Cao F.Aharonian Axikegu y.X.Bai y.w.Bao D.Bastieri X.j.Bi y.j.Bi w.Bian A.V.Bukevich Q.Cao w.y.Cao Zhe Cao j.Chang j.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.j.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen y.Chen N.Cheng y.D.Cheng M.y.Cui S.w.Cui X.H.Cui y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.H.Fan y.Z.Fan j.Fang j.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng y.Feng y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao w.Gao w.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han M.Hasan H.H.He H.N.He j.y.He y.He y.K.Hor B.w.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu D.H.Huang T.Q.Huang w.j.Huang X.T.Huang X.y.Huang y.Huang X.L.j. H.y.j.a K.j.a K.j.ang X.w.j.ang Z.j.j.ang M.j.n M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li j.an Li j.e Li K.Li S.D.Li w.L.Li w.L.Li X.R.Li Xin Li y.Z.Li Zhe Li Zhuo Li E.w.Liang y.F.Liang S.j.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu j.Liu j.L.Liu M.y.Liu R.y.Liu S.M.Liu w.Liu y.Liu y.N.Liu Q.Luo y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma j.R.Mao Z.Min w.Mitthumsiri H.j.Mu y.C.Nan A.Neronov L.j.Ou P.Pattarakij.anich Z.y.Pei j.C.Qi M.y.Qi B.Q.Qiao j.j.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.w.Shu H.C.Song y..V.Stenkin V.Stepanov y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun j.Takata P.H.T.Tam Q.w.Tang R.Tang Z.B.Tang w.w.Tian C.w.ng C.B.w.ng G.w.w.ng H.G.w.ng H.H.w.ng j.C.w.ng Kai w.ng Kai w.ng L.P.w.ng L.y.w.ng P.H.w.ng R.w.ng w.w.ng X.G.w.ng X.y.w.ng y.w.ng y.D.w.ng y.j.w.ng Z.H.w.ng Z.X.w.ng Zhen w.ng Zheng w.ng D.M.wei j.j.wei y.j.wei T.wen C.y.wu H.R.wu Q.w.wu S.wu X.F.wu y.S.wu S.Q.Xi j.Xia G.M.Xiang D.X.Xiao G.Xiao y.L.Xin y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu w.L.Xu L.Xue D.H.y.n j.Z.y.n T.y.n C.w.y.ng C.y.y.ng F.y.ng F.F.y.ng L.L.y.ng M.j.y.ng R.Z.y.ng w.X.y.ng y.H.y.o Z.G.y.o L.Q.y.n N.y.n X.H.y.u Z.y.y.u y.H.y. Q.y.an H.y.e H.D.Zeng T.X.Zeng w.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 Key.Laboratory.of Particle Astrophy.ics&Experimental Phy.ics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University.of Chinese Academy.of Sciences Beijing 100049China TIANFU Cosmic Ray.Research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Phy.ics P.O.Box 103980Heidelberg 69029Germany School of Phy.ical Science and Technology.School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy.and Space Science Nanjing UniversityNanjing 210023China Center for Astrophy.ics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Phy.ics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy.of Sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University.of Science and Technology.of China Hefei 230026China State Key.Laboratory.of Particle Detection and Electronics China Key.Laboratory.of Dark Matter and Space Astronomy.Key.Laboratory.of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key.Laboratory.for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Phy.ics and Astronomy Yunnan UniversityKunming 650091China Key.Laboratory.of Cosmic Ray.(Tibet University. Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Phy.ics and Astronomy.Zhuhai)&School of Phy.ics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology.Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary.Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray.emission from the w51 complex is widely.acknowledged to be attributed to the interaction between the cosmic ray.(CRs)accelerated by.the shock of supernova remnant(SNR)w51C and the dense molecular clouds in the adj.cent star-forming region,***,the maximum acceleration capability.of w51C for CRs remains *** on observations conducted with the Large High Altitude Air Shower Observatory.LHAASO),we report a significant detection ofγray. emanating from the w51 complex,with energies from 2 to 200 *** LHAASO measurements,for the first time,extend theγ-ray.emission from the w51 complex bey.nd 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay.bump"featured data from Fermi-LAT,the broadbandγ-ray.spectrum of the w51 region can be well-characterized by.a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely.providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two y.ung star clusters within w51B could also be theoretically.viable to produce the most energeticγray. observed by.*** findings strongly.support the presence of extreme CR accelerators within the w51 complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic ray. SNR w51C Star clusters