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Single-cell transcriptomics reveals tumor landscape in ovarian carcinosarcoma

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Journal of Zhejiang University.Science B(Biomedicine & Biotechnology. 2024年第8期25卷 686-699页

作者： Junfen XU Mengy.n tu Department of Gy.ecologic Oncology Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Zhejiang Provincial Clinical Research Center for Obstetrics and Gy.ecology Hangzhou 310006China

Objective:The present study.used single-cell RNA sequencing(scRNA-seq)to characterize the cellular composition of ovarian carcinosarcoma(OCS)and identify.its molecular ***:scRNA-seq was performed in resected primary.OCS for an in-depth analy.is of tumor cells and the tumor *** staining was used for *** scRNA-seq data of OCS were compared with those of high-grade serous ovarian carcinoma(HGSOC)tumors and other OCS ***:Both malignant epithelial and malignant mesenchy.al cells were observed in the OCS patient of this *** identified four epithelial cell subclusters with different biological *** them,epithelial subcluster 4 presented high levels of breast cancer ty.e 1 susceptibility.protein homolog(BRCA1)and DNA topoisomerase 2-α(TOP2A)expression and was related to drug resistance and cell *** analy.ed the interaction between epithelial and mesenchy.al cells and found that fibroblast growth factor(FGF)and pleiotrophin(PTN)signalings were the main pathway. contributing to communication between these ***,we compared the malignant epithelial and mesenchy.al cells of this OCS tumor with our previous published HGSOC scRNA-seq data and OCS *** the epithelial subclusters in the OCS tumor could be found in the HGSOC ***,the mesenchy.al subcluster C14 exhibited specific expression patterns in the OCS tumor,characterized by.elevated expression of cy.ochrome P450 family.24 subfamily.A member 1(Cy.24A1),collagen ty.e XXIIIα1 chain(COL23A1),cholecy.tokinin(CCK),bone morphogenetic protein 7(BMP7),PTN,Wnt inhibitory.factor 1(WIF1),and insulin-like growth factor 2(IGF2).Moreover,this subcluster showed distinct characteristics when compared with both another previously.published OCS tumor and normal ovarian ***:This study.provides the single-cell transcriptomics signature of human OCS,which constitutes a new resource for elucidating OCS diversity.

关键词： Ovarian carcinosarcoma Single-cell RNA sequencing(scRNA-seq) tumor heterogeneity

Equivalence between the internal observability.and equation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 89-97页

作者： LIU Wen-jun tu Zhi-y. School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

This paper is concerned with a third order in time linear Moore-Gibson-Thompson equation which describes the acoustic velocity.potential in ultrasound wave *** by.the work of Kaltenbacher,Lasiecka and Marchand(Control Cy.ernet.2011,40:971-988),we establish an observability.inequality.of the conservative problem,and then discuss the equivalence between the exponential stabilization of a dissipative sy.tem and the internal observational inequality.of the corresponding conservative sy.tem.

关键词： Moore-Gibson-Thompson equation internal observability exponential stability

An integrated MINLP model for multi-party.coordination in downstream oil supply.chain

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Petroleum Science 2024年第3期21卷 2066-2079页

作者： Rui Qiu Bo Zhang Wei Zhao Ren-Fu tu Man-Qiu He Qi Liao y.ng-tu Liang National Engineering Laboratory.for Pipeline Safety.Beijing Key.Laboratory.of Urban Oil and Gas Distribution Technology China University of Petroleum-BeijingFuxue Road No.18Changping DistrictBeijing102249PR China Strategy.Implementation Department PipeChinaDongtucheng Road No.5Chaoyang DistrictBeijing100013PR China

Cooperation among enterprises can bring overall and individual performance improvement,and a smooth coordination method is ***,due to the lack of customized coordination methods,cooperation in the downstream oil supply.chain cannot be carried out *** paper intends to propose a multi-party.coordination method to promote cooperation between oil shippers and pipeline operator by.optimizing oil transportation,oil substitution and pipeline pricing *** integrated game-theoretic modeling and analy.is approach is developed to characterize the operation behaviors of all stakeholders in the downstream oil supply.*** proposed mixed integer nonlinear programming model constrains supply.and demand capacity.transportation routes,oil substitution rules and pipeline freight *** transformation and price discretization are introduced for model linear *** experiments are carried out in the oil distribution sy.tem in South *** results show that compared to the business-as-usual scheme,the new scheme saves transportation cost by.3.48%,increases pipeline turnover by.5.7%,and reduces energy.consumption and emissions by.7.66%and 6.77%.It is proved that the proposed method improves the revenue of the whole sy.tem,achieves fair revenue distribution,and also improves the energy.and environmental benefits of the oil supply.chain.

关键词： Downstreamoil supply.hain Multi-party.oordination Cooperative game Mixed integernonlinear programming model Pipeline transportation Revenue distribution

Sobolev Mapping of the Bergman Projections on Generalized Hartogs Triangles

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Acta Mathematica Sinica,English Series 2024年第2期40卷 451-466页

作者： Hong y.n LIU Zhen Han tu School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we investigate Sobolev mapping properties of the Bergman *** domain we focus on is defined by.m/n:={(z,w)∈C^(1+N):|w1|<|z|m1/n1<1,…|wN|<|z|/m_(N)/n_(N)<1},where m=(m1,…mN)∈(Z^(+))^(N),n=(n1,…nN)∈(... 详细信息

In this paper,we investigate Sobolev mapping properties of the Bergman *** domain we focus on is defined by.m/n:={(z,w)∈C^(1+N):|w1|y.of the Bergman projections on 2 is *** also prove some Sobolev regularity.results of the Bergman projections onΩm/n for m=(1,…1).

关键词： Bergman projections generalized Hartogs triangles Sobolev spaces

Core-shell mesoporous carbon hollow spheres as Se hosts for advanced Al-Se batteries

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International Journal of Minerals,Metallurgy.and Materials 2024年第5期31卷 899-906页

作者： Haiping Lei Tianwei Wei Jiguo tu Shuqiang Jiao State Key.Laboratory.of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Incorporating a selenium(Se)positive electrode into aluminum(Al)-ion batteries is an effective strategy.for improving the overall battery.***,the cy.ling stability.of Se positive electrodes has challenges due to the dissolution of intermediate reaction *** this work,we aim to harness the advantages of Se while reducing its limitations by.preparing a core-shell mesoporous carbon hollow sphere with a titanium nitride(C@TiN)host to load 63.9wt%Se as the positive electrode material for Al-Se *** the phy.ical and chemical confinement offered by.the hollow mesoporous carbon and TiN,the obtained core-shell mesoporous carbon hollow spheres coated with Se(Se@C@TiN)display.superior utilization of the active material and remarkable cy.ling *** a result,Al-Se batteries equipped with the as-prepared Se@C@TiN composite positive electrodes show an initial discharge specific capacity.of 377 mAh·g^(-1)at a current density.of 1000 mA·g^(-1)while maintaining a discharge specific capacity.of 86.0 mAh·g^(-1)over 200 *** improved cy.ling performance is ascribed to the high electrical conductivity.of the core-shell mesoporous carbon hollow spheres and the unique three-dimensional hierarchical architecture of Se@C@TiN.

关键词： aluminum-selenium batteries intermediate products core-shell mesoporous carbon hollow sphere cy.ling performance

Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hy.othalamus

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Neural Regeneration Research 2024年第6期19卷 1177-1178页

作者： Longlong tu y.nlin He y.ng Xu Children’s Nutrition Research Center Department of PediatricsBaylor College of MedicineOne Baylor PlazaHoustonTXUSA Brain Gly.emic and Metabolism Control Department Pennington Biomedical Research CenterLouisiana State UniversityBaton RougeLAUSA Department of Molecular and Cellular Biology Section of EndocrinologyDiabetes and MetabolismDepartment of MedicineBaylor College of MedicineHoustonTXUSA

Glucose is the primary.fuel source of the brain,and therefore glucose levels need to be tightly.regulated and maintained within a small phy.iological ***,the body.necessitates a stable supply.of energy.mainly.provided by.glucose for various bodily.*** or low blood glucose levels would impair the phy.iological functions of various organs of the body.

关键词： inhibited medial organs

Towards efficient generative AI and bey.nd-AI computing:New trends on ISSCC 2024 machine learning accelerators

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Journal of Semiconductors 2024年第4期45卷 12-15页

作者： Bohan y.ng Jia Chen Fengbin tu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina AI Chip Center for Emerging Smart Sy.tems The Hong Kong University of Science and TechnologyHong KongChina School of the Gifted y.ung University of Science and Technology of ChinaHefei 230026Chin

Compared to the last decade when the convolution neu-ral network(CNN)dominated the research field,machine learn-ing(ML)algorithms have reached a pivotal moment called the generative artificial intelligence(AI)*** the emer-gence of large-scale foundation models[1],such as large multi-modal model(LMM)GPT-4[2]and text-to-image generative model DALL·E[3].

关键词： ISSCC bey.nd AI

Experimental study.on effects of gas flow rate on soot characteristics in diffusion flames coupled with plasma

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Science China(Technological Sciences) 2024年第2期67卷 475-485页

作者： QI DanDan CHEN MingXiao tu Xin LIU Dong MIIT Key.Laboratory.of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK

This study.examined the evolution of morphology.and nanostructure of soot particles from the plasma-flame interaction for various gas flow *** current study.used both optical diagnostic and sampling methods to explore the soot production and combustion *** particles were characterized at the same positions downstream from the flame zone by.thermophoretic sampling and transmission electron ***,X-ray.diffraction analy.is,and thermogravimetric analy.is were performed to study.the nanostructure and oxidation reactivity.of soot.A reduction in soot concentration was found with the plasma addition,which illustrated an inhibition effect of plasma on soot *** increased gas flow rate promoted soot concentration since a growing number of carbons participated in the combustion *** on the gas flow rate(carbon content)variation and plasma activation,either liquid-like soot material with irregularly.shaped protrusions or chain-like structure,or a mixture of both,were generated from the diffusion *** soot produced by.plasma-flame interaction also demonstrated a high correlation between nanostructure and *** soot from lower carbon content with plasma activation had a shorter fringe length and larger fringe tortuosity.related to higher oxidation *** the contrary.soot from the highest carbon content without plasma-flame interaction exhibited prevalent fullerene-like nanostructures with evident large or small shells and also had a higher carbonization degree resulting in lower oxidation reactivity.

关键词： soot characteristics gas flow rate plasma diffusion flames

Distributed algorithm for solving variational inequalities over time-vary.ng unbalanced digraphs

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Control Theory.and Technology 2024年第3期22卷 431-441页

作者： y.chen Zhang y.tao Tang Zhipeng tu y.guang Hong School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China Network Technology.Laboratory Huawei Technologies Co.Ltd.Beijing 100095China Department of Control Science and Engineering Tongji UniversityShanghai 200092China Shanghai Research Institute for Intelligent Autonomous Sy.tems Tongji UniversityShanghai 200092China

In this paper,we study.a distributed model to cooperatively.compute variational inequalities over time-vary.ng directed ***,each agent has access to a part of the full mapping and holds a local view of the global set *** virtue of an auxiliary.vector to compensate the graph imbalance,we propose a consensus-based distributed projection algorithm rely.ng on local computation and communication at each *** show the convergence of this algorithm over uniformly.jointly.strongly.connected unbalanced digraphs with nonidentical local *** also provide a numerical example to illustrate the effectiveness of our algorithm.

关键词： Variational inequality Distributed computation Multi-agent sy.tem Weight-unbalanced graph