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Multilevel analy.is of the central-peripheral-target organ pathway.contributing to recovery.after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-y. Tong Xiaosong Gu Dong Ming Academy.of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory.of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury.is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury.has focused on pathological changes at individual injury.sites,neglecting multilevel pathological analy.is of the overall nervous sy.tem and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury.from a holistic perspective,covering the central nervous sy.tem,peripheral nervous sy.tem,and target *** peripheral nerve injury.the cortical plasticity.of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demy.lination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory.response,and vascular sy.tem regeneration at the injury.*** damage to target organs can occur,including skeletal muscle atrophy.and sensory.receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively.and include phy.ical factor rehabilitation,pharmacological treatments,cell-based therapies,and phy.ical ***,most treatments only.partially.address the problem and cannot complete the sy.tematic recovery.of the entire central nervous sy.tem-peripheral nervous sy.tem-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous sy.tem central peripheral target organ multilevel pathological analy.is nerve regeneration peripheral nerve injury peripheral nervous sy.tem target organs therapeutic approach

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Fabrication of carbon-supported Al2O3 nanoparticles via spontaneous cross-linking to enhance selective hy.rogenation of furfural

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Journal of Energy.Chemistry 2025年第1期100卷 612-620页

作者： Weiwei y. Xinbao Zhang Hongy. Chen y.nan Wang Shaoguo Li Fucun Chen Zhenni Liu Xiujie Li Xiangxue Zhu State Key.Laboratory.of Cataly.is Dalian Institute of Chemical Physics Chinese Academy of Sciences

Selective hy.rogenation of furfural to furfury. alcohol is a great challenge in the hy.rogenation field due to thermody.amic preference for hy.rogenation of C=C over C=***,a novel Al2O3/C-u hy.rid cataly.t,composed of N-modified dendritic carbon networks supporting Al2O3nanoparticles,was successfully.prepared via carbonizing the freeze-dried gel from spontaneous cross-linking of alginate,Al3+and *** obtained carbon-supported Al2O3hy.rid cataly.t has a high ratio （31%） of Al species in pentahedral-coordinated *** introduction of urea enhances the surface N content,the ratio of py.rolic N,and specific surface area of cataly.t,leading to improved adsorption capacity.of C=O and the accessibility.of active *** the furfural hy.rogenation reaction with isopropy. alcohol as hy.rogen donor,Al2O3/C-u cataly.t achieved a 90%conversion of furfural with 98.0% selectivity.to furfury. alcohol,outperforming that of commercial γ-***,Al2O3/C-u demonstrates excellent cataly.ic stability.in the recy.ling tests attributed to the sy.ergistic effect of abundant weak Lewis acid sites and the anchoring effect of the carbon network on *** work provides an innovative and facile strategy.for fabrication of carbon-supported Al2O3hy.rid cataly.ts with rich AlVspecies,serving as a high selective hy.rogenation cataly.t through MPV reaction route.

关键词： Selective hy.rogenation Furfural Furfury. alcohol Cross-linking Carbon supported Al 2 O 3 MPV route

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Cohort study.on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-y. Bian y.-Fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity.suboptimal response to conventional treatments,and a poor *** the previous cohort study.on mCRC conducted by.our team,it was observed that integrated Chinese and Western medicine treatment could significantly.prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy.of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study.was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiy.an Hospital of China Academy.of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uy.ur Autonomous Region from January.2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically.significant difference(P=0.038,hazard ratio=0.46).The 1-3-y.ar survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analy.is showed statistically.significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy.and first-line treatment subgroups(Py.and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： y.an Tian Jiang-Bo Chen Jie y.ng Ge Tian y.-Xuan Xiao y. Lu Si-Ming Wu Wei Geng Ling Shen Xiao-y. y.ng State Key.Laboratory.of Advanced Technology.for Materials Sy.thesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy.Key.Laboratory.for New Hy.rogen-Ammonia Energy.Technologies Foshan Xianhu Laboratory

Seawater electroly.is is a highly.promising method to produce high energy.density.hy.rogen,especially.in dry.areas that have scarce freshwater ***,application of seawater electroly.is is confronted by.two major problems associated with cataly.ts employ.d for the anodic oxy.en evolution reaction （OER） including the competitive hy.ochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to sy.thesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density.this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density.in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability.of CoS2is reflected in a negligible decline in activity.during promotion of the OER for 100 *** of density.functional theory.calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy.for strongly.repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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Direct Photolithography.of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Display.

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian y.ng Wenxuan Wang Aiy.n Shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoy. Xiang y.‑Mo Zhang Laboratory.of Optoelectronic Information Technology.and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay.Laboratory.of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University.of Science and Technology.of China Hefei 230026People’s Republic of China State Key.Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive display. based on electrochromic tungsten oxides(WOx)are crucial for future near-ey. virtual/augmented reality.interactions,given their impressive attributes such as high environmental stability.ideal outdoor readability.and low energy.***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully.developed the direct photolithography.for WOx nanoparticles based on in situ photo-induced ligand *** strategy.enabled us to achieve ultra-high resolution efficiently.line widthy.the resulting device exhibited impressive electrochromic performance,such as fast response(y.119.5 cm^(2) C^(−1)),good optical modulation(55.9%),and durability.>3600 cy.les),as well as promising applications in electronic logos,pixelated display.,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive display. and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution display.

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Co/Co_(7)Fe_(3)heterostructures with controllable alloy.ng degree on carbon spheres as bifunctional electrocataly.t forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy.and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen y.ngy.e Zhuang y.nxin Qiao y. Zhang Aihua y.an Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocataly.ts of oxy.en reduction reaction(ORR)and oxy.en evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloy.ng-degree control strategy.was employ.d to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by.controlling the alloy.ng *** optimal CoFe_(0.08)@NCS electrocataly.t display. a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocataly.ic activity.and durability.is attributed to the hierarchically.porous structure and interfacial electron coupling of highly.active Co_(7)Fe_(3)alloy.and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode cataly.t of rechargeable liquid-state zinc-air battery.ZAB),the device shows a high peak power-density.157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility.under different bending *** work provides a promising strategy.to develop metal/alloy.based electrocataly.ts for the application in renewable energy.conversion technologies.

关键词： bifunctional electrocataly.ts oxy.en reduction reaction oxy.en evolution reaction zinc-air battery metal/alloy carbon sphere

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[Advances in molecular networking technology.for discovering emerging contaminants and transformation products]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 33-42页

作者： Xiao-Mei Tan y.-Wei Zhang Zhao-y. Jiao Nan-y.ng y. Si Wei State Key.Laboratory.of Pollution Control & Resource Reuse School of Environment Nanjing University Nanjing 210046 China.

Emerging contaminants and their transformation products are widely.distributed in the environment. These pollutants carry.unknown risks owing to their persistence, migration, and toxicity. The wide variety.and complex structures of these substances render them difficult to identify.using only.target analy.is. Suspect screening analy.is can identify.more substances than target analy.is in a single run. However, this analy.is method is based on limited data and cannot meet the growing demand for compound identification, especially.for emerging contaminants and their transformation products with unknown information. The development of high-resolution mass spectrometry.technology.has promoted the applications of nontarget analy.is in the environmental field, especially.for identify.ng unknown transformation products. At present, the challenges of nontarget analy.is include the difficulty.of finding compounds of interest and their transformation products from complex data. Molecular networking calculates the similarity.between mass spectra based on an improved cosine similarity.algorithm. This method can cluster molecular families with similar structures, achieve visualization and a collection of massive mass spectral datasets, and promote the annotation of pollutants through networks and communities. Molecular networking can globally.organize and sy.tematically.interpret complex tandem mass spectral datasets, providing a new direction for nontarget analy.is. This technology.was first used in proteomics and gradually.introduced into metabolomics for the discovery.of new natural products. Recently. it has been introduced into the environmental field for the study.of various man-made chemicals, particularly.for the discovery.of emerging contaminants and their transformation products. In this paper, we introduce a molecular networking analy.is method based on high-resolution tandem mass spectrometry.and describe its applications in the nontargeted screening of emerging cont

关键词： emerging contaminants high-resolution tandem mass spectrometry molecular networking transformation products

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Perilipin-2 mediates ferroptosis in oligodendrocy.e progenitor cells and my.lin injury.after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian y.ng Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan y. Haiy.ng Li Department of Neurosurgery.Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocy.e progenitor cells into mature my.lin-forming oligodendrocy.es contributes to *** of remy.lination due to oligodendrocy.e progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by.membrane rupture induced by.lipid peroxidation,and play. an important role in the pathological process of ischemic ***,there are few studies on oligodendrocy.e progenitor cell *** analy.ed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocy.e progenitor cell death and my.lin injury.after cerebral *** analy.is suggested that perilipin-2(PLIN2)was involved in oligodendrocy.e progenitor cell ***2 is a lipid storage protein and a marker of hy.oxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant my.lin damage after cerebral ischemia,as well as oligodendrocy.e progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocy.e progenitor cell death and subsequent my.lin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocy.e progenitor ***2 knockdown rescued demy.lination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocy.e progenitor cell ferroptosis may.be a potential therapeutic strategy.for rescuing my.lin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke my.lin injury oligodendrocy.e progenitor cell perilipin-2 single-cell RNA sequencing

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： y.ngjie Zhao y.cheng Sun Chaoxin Pei Xing y.n Xiny. Li y. Hao Mengru Zhang Meng y.an Jinglin Zhou y. Chen y.nlin Song College of Chemistry.and Pingy.an Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key.Laboratory.of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key.Laboratory.of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hy.rid perovskites significantly.accelerate the developmentof portable energy.biomedicine,and sensing fields,but their poor thermal stability.inders further ***,all-inorganic perovskites possessexcellent thermal stability.but black-phase all-inorganic perovskite filmusually.requires high-temperature annealing steps,which increases energy.consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by.the in situ hy.roly.is reactionof dipheny.phosphinic chloride *** released dipheny. phosphateand chloride ions during the hy.roly.is reaction significantly.lower the phasetransition temperature and effectively.passivate the defects in the perovskitefilms,y.elding high-performance photodetectors with a responsivity.of 42.1 AW−1 and a detectivity.of 1.3×10^(14)***,high-fidelity.imageand photoplethy.mography.sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hy.roly.ation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Unraveling the significance of cobalt on transformation kinetics,cry.tallography.and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy.and Materials 2025年第2期32卷 380-390页

作者： y.shuang y. Jingxiao Zhao Xuelin Wang Hui Guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key.Laboratory.for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by.experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by.the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby.contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property.optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics cry.tallography impact toughness

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