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Leptin Modulates the Differentiation of Keratinocy.es via Autophagy.in Psoriasis Patients with Metabolic Sy.drome

International Journal of Dermatology.and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang y. Sun J. Zhang X. Ding X.-y. Bai J. Liang X.-Q. Wei X.-J. Liu X.-L. y.ng T. Liang X.-L. Li C.-X. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high prevalence of metabolic sy.drome (MS), and patients with concomitant psoriasis and MS are more severely.affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may.serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may.exacerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy.in patients with psoriasis. Methods: From January.2021 to June 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy.controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by.immunohistochemistry. and measured the serum leptin concentration by.enzy.e-linked immunosorbent assay. We then performed correlation analy.es to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy.control groups. Additionally. we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy.markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway.related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy.and used the specific PI3K inhibitor Ly.94002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way.analy.is of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analy.ed by.the chi-square test. Correlations were evaluated by.Pearson correlation analy.is. Results: The serum l

关键词： autophagy keratinocy.e differentiation leptin metabolic sy.drome PI3K/AKT/mTOR psoriasis signal pathway

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Primary.and Secondary.Microplastic and Nanoplastic Regulations: Perspectives on Water Industry.Impacts

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Journal of Environmental Protection 2024年第6期15卷 697-715页

作者： Shirin Estahbanati Giridhar Upadhy.y. Martha J. M. Wells Katherine y. Bell Brown and Caldwell New York NY USA Brown and Caldwell Irvine CA USA EnviroChem Services Cookeville TN USA Brown and Caldwell Nashville TN USA

Plastic pollution, both primary.and secondary. is an environmental challenge, prompting regulatory.actions at global and regional levels. With increasing research about the impacts of micro- and nanoplastics on ecosy.tems and human health, governments worldwide have undertaken efforts to address this issue. The global community.has advanced regulatory.efforts that have led to the implementation of national laws or regulations in numerous countries. These measures ban or restrict the use of primary.and secondary.microplastics and nanoplastics. An overview of global and European regulatory.frameworks is presented to provide context for the United States (US). In the endeavor to document plastics regulation development in the US, a description of regulatory.agencies and their roles in advancing policy.and rules as well as future direction and areas for improvement in regulating plastics are introduced. A discussion of what emerging regulations mean to utilities and industries is also provided along with a comparison of regulatory.frameworks.

关键词： Microplastic Regulation Environmental Governance Plastic Pollution Mitigation Regulatory.Framework

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Numerical Modeling of Mass Transfer in the Interaction between River Biofilm and a Turbulent Boundary.Lay.r

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Open Journal of Fluid Dy.amics 2024年第1期14卷 1-23页

作者： Falilou Coundoul Evrad M. D. Ngom Frédéric y. Moulin Institut Poly.echnique de Saint-Louis Université Gaston Berger Saint-Louis Senegal Institut de Mécanique des Fluides de Toulouse UMR 5502-Université de Toulouse Occitanie France

In this article dedicated to the modeling of vertical mass transfers between the biofilm and the bulk flow, we have, in the first instance, presented the methodology.used, followed by.the presentation of various results obtained through analy.es conducted on velocity.fields, different fluxes, and overall transfer coefficients. Due to numerical constraints (resolution of relevant spatial scales), we have restricted the analy.is to low Schmidt numbers (Sc=0.1, Sc=1, and Sc=10) and a single roughness Rey.olds number (Re*=150). The analy.is of instantaneous concentration fields from various simulations revealed logarithmic concentration profiles above the canopy. In this zone, the concentration is relatively.homogeneous for longer times. The analy.is of results also showed that the contribution of molecular diffusion to the total flux depends on the Schmidt number. This contribution is negligible for Schmidt numbers Sc≥0.1, but nearly.balances the turbulent flux for Sc=0.1. In the canopy. the local Sherwood number, given by.the ratio of the total flux (within or above the canopy. to the molecular diffusion flux at the wall, also depends on the Schmidt number and varies significantly.between the canopy.and the region above. The exchange velocity. a purely.hy.rody.amic parameter, is independent of the Schmidt number and is on the order of 10% of in the present case. This study.also reveals that nutrient absorption by.organisms near the wall depends on the Schmidt number. Such absorption is facilitated by.lower Schmidt numbers.

关键词： Epilithic Biofilm Passive Scalar Transport Direct Numerical Simulation Navier-Stokes

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Tailored architecture of composite electroly.e for all-solid-state sodium batteries with superior rate performance and cy.le life

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Nano Research 2024年第5期17卷 4171-4180页

作者： Xiang Guan Zhenhua Jian Xingan Liao Wenchao Liao y.nfei Huang Dazhu Chen Robert K.y.Li Chen Liu Shenzhen Key.Laboratory.of Poly.er Science and Technology Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518055China Department of Materials Science and Engineering City University of Hong KongHong KongChina

Seeking for composite electroly.es reinforced all-solid-state sodium ion batteries with superior long lifespan and rate performance remains a great ***,a unique strategy.to tailor the architecture of composite electroly.e via inserting poly.er chains into a small quantity.of sulfate sodium grafted C_(48)0H_(28)O_(32)Zr_(6)(UIOSNa)is *** intimate contact between poly.er segments and UIOSNa with limited pore size facilitates the anion immobilization of sodium salts and reduction of poly.er cry.tallinity.thereby.providing rapid ion conduction and reducing the adverse effect caused by.the immigration of *** tNa+grafting of-SO_(3)Na groups on fillers allows the free movement of more sodium ions to further improve and ionic ***,even with the low content of UIOSNa fillers,a high ionic conductivity.of 6.62×10^(-4) S·cm^(-1) at 60℃ and a transference number of 0.67 for the special designed composite electroly.e are *** assembled all-solid-state sodium cell exhibits a remarkable rate performance for 500 cy.les with 95.96%capacity.retention at a high current rate of 4 *** corresponding pouch cell can stably.work for 1000 cy.les with 97.03%capacity.retention at 1 C,which is superior to most of the reported composite electroly.es in the literature.

关键词： solid state sodium battery composite electroly.e rate performance cy.le life

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轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： Li S. Xiao Q. y.ng W. y.ng C. Wang y. State Key.Laboratory.of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong University Nanchang 330013 China School of Mechatronics and Vehicle Engineering East China Jiaotong University Nanchang 330013 China Railway.Industry.Key.Laboratory.of Intelligent Operation and Maintenance of Rolling Stock East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动

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Phy.ics-informed deep learning for fringe pattern analy.is

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Opto-Electronic Advances 2024年第1期7卷 4-15页

作者： Wei y.n y.xuan Che Xinsheng Li Mingy. Li y.n Hu Shijie Feng Edmund y.Lam Qian Chen Chao Zuo Smart Computational Imaging Laboratory.SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Smart Computational Imaging Research Institute(SCIRI)of Nanjing University.of Science and Technology Nanjing 210019China Jiangsu Key.Laboratory.of Spectral Imaging&Intelligent Sense Nanjing 210094China Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong Kong SAR 999077China

Recently.deep learning has y.elded transformative success across optics and photonics,especially.in optical *** neural networks (DNNs) with a fully.convolutional architecture (e.g.,U-Net and its derivatives) have been widely.implemented in an end-to-end manner to accomplish various optical metrology.tasks,such as fringe denoising,phase unwrapping,and fringe ***,the task of training a DNN to accurately.identify.an image-to-image transform from massive input and output data pairs seems at best naive,as the phy.ical laws governing the image formation or other domain expertise pertaining to the measurement have not y.t been fully.exploited in current deep learning *** this end,we introduce a phy.ics-informed deep learning method for fringe pattern analy.is (PI-FPA) to overcome this limit by.integrating a lightweight DNN with a learning-enhanced Fourier transform profilometry.(Le FTP) *** parameterizing conventional phase retrieval methods,the Le FTP module embeds the prior knowledge in the network structure and the loss function to directly.provide reliable phase results for new ty.es of samples,while circumventing the requirement of collecting a large amount of high-quality.data in supervised learning *** by.the initial phase from Le FTP,the phase recovery.ability.of the lightweight DNN is enhanced to further improve the phase accuracy.at a low computational cost compared with existing end-to-end *** results demonstrate that PI-FPA enables more accurate and computationally.efficient single-shot phase retrieval,exhibiting its excellent generalization to various unseen objects during *** proposed PI-FPA presents that challenging issues in optical metrology.can be potentially.overcome through the sy.ergy.of phy.ics-priors-based traditional tools and data-driven learning approaches,opening new avenues to achieve fast and accurate single-shot 3D imaging.

关键词： optical metrology deep learning phy.ics-informed neural networks fringe analy.is phase retrieval

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Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.y.Morassuti A.P.L Silva L.A.O.Nunes S.M.Lima L.H.C.Andrade Optical and Photothermal Spectroscopy.Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology.Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Phy.ics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity.ratio(FIR)***,at high Nd^(3+)concentrations,energy.transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by.optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity.of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity.at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity.ratio Optical thermometry Judd-Ofelt Rare earths

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.Tan Q.Wang y.Chen W.B.y.o C.Z.Xiao J.F.My.tt School of Phy.ics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Phy.ics and Computational Mathematics Beijing 100094China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for the first time via two-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order SRSS and estimate its *** rescattering process is identified by.the 2D PIC simulations under ty.ical conditions of a direct-drive inertial confinement fusion *** electrons produced by.second-order SRSS propagate nearly.perpendicular to the density.gradient and gain nearly.the same energy.as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Impact of effective stress on permeability.for carbonate fractured-vuggy.rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 942-960页

作者： Ke Sun Huiqing Liu Juliana y.Leung Jing Wang y.bin Feng Renjie Liu Zhijiang Kang y.n Zhang State Key.Laboratory.of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Mining&Petroleum Engineering University of AlbertaEdmontonT6G 1H9Canada SINOPEC Petroleum Exploration and Production Research Institute Beijing100083China

To gain insight into the flow mechanisms and stress sensitivity.for fractured-vuggy.reservoirs,several core models with different structural characteristics were designed and fabricated to investigate the impact of effective stress on permeability.for carbonate fractured-vuggy.rocks(CFVR).It shows that the permeability.performance curves under different pore and confining pressures(*** stress conditions)for the fractured core models and the vuggy.core models have similar change *** ranges of permeability.variation are significantly.wider at high pore pressures,indicating that permeability.reduction is the most significant during the early.stage of development for fractured-vuggy.*** each obtained effective stress coefficient for permeability.ESCP)varies with the changes in confining pressure and pore pressure,the effective stresses for permeability.of four representative CFVR show obvious nonlinear characteristics,and the variation ranges of ESCP are all between 0 and ***,a comprehensive ESCP mathematical model considering triple media,including matrix pores,fractures,and dissolved vugs,was *** is proved theoretically.that the ESCP of CFVR generally.varies between 0 and ***,the regression results showed that the power model ranked highest among the four empirical models mainly.applied in stress sensitivity.characterization,followed by.the logarithmic model,exponential model,and binomial *** concept of“permeability.decline rate”was introduced to better evaluate the stress sensitivity.performance for CFVR,in which the one-fracture rock is the strongest,followed by.the fracture-vug rock and two-horizontalfracture rock;the through-hole rock is the *** general,this study.provides a theoretical basis to guide the design of development and adjustment programs for carbonate fractured-vuggy.reservoirs.

关键词： Effective stress Permeability Carbonate fractured-vuggy.rocks Structure characteristics Stress sensitivity

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Repeatability.interocular correlation and agreement of optic nerve head vessel density.in healthy.ey.s:a sweptsource optical coherence tomographic angiography.study

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International Journal of Ophthalmology.English edition) 2024年第5期17卷 896-903页

作者： Dan-Qi Fang Da-Wei y.ng Xiao-Ting Mai Carol y.Cheung Hao-y. Chen Joint Shantou International Ey. Center Shantou University&the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology.and Visual Sciences Chinese University of Hong KongHong Kong 999077China

AIM:To assess the repeatability.interocular correlation,and agreement of quantitative swept-source optical coherence tomography.angiography.OCTA)optic nerve head(ONH)parameters in healthy.***:Thir ty.three healthy.subjects were *** ONH of both ey.s were imaged four times by.a swept-source-OCTA using a 3 mm×3 mm scanning *** of the radial peripapillary.capillary.were analy.ed by.a customized Matlab program,and the vessel density.fractal dimension,and vessel diameter index were *** repeatability.of the four scans was determined by.the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analy.is using the Pearson correlation coefficient,ICC and Bland-Altman ***:All swept-source-OCTA ONH parameters exhibited certain repeatability.with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary.vessel density.ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary.vessel density.exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary.vessel ***:OCTA ONH parameters demonstrate good repeatability.in healthy.*** interocular correlations of papillary.vessel density.fractal dimension and vessel diameter index are high,but the correlation for circumpapillary.vessel density.is moderate.

关键词： interocular correlation repeatability optic nerve head optical coherence tomography.angiography vessel density

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