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“y.n-y.ng philosophy. for the design of anticancer drug delivery.nanoparticles

Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao J. Wang C. Li H. School of Lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy.and fewer off-target effects. Many.factors, such as particle size, morphology. surface potential, structural stability. and etc., may.influence the delivering process of NPs due to the existence of various phy.iological barriers within the body. Herein, we summarise the distinct influences of NP phy.icochemical properties on the four consecutive in vivo transport steps: (1) navigating with bloodstream within blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery.by.cancerous cells. We found that the philosophy.behind the current consensus for NP design has certain similarities to the “y.n-y.ng” theory.in traditional Chinese culture. Almost all phy.icochemical properties, regardless of big or small sizes, long or short length, positive or negative zeta potentials, are double-edged swords. The balance of potential benefits and side effects, drug selectivity.and accessibility.should be fully.considered when optimising particle design, similar to the “y.n-y.ng harmony.. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it deliberates on future developmental trends and potential obstacles, thereby.aiming to uncover the way. these characteristics influence the NPs’ biological activity.and provide theoretical guidance for the targeted delivery.of NPs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng harmony.

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Factors influencing farmers' adoption of solar water-pumping sy.tems in Gujarat

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CLEAN ENERGy 2024年第3期8卷 157-165页

作者： Kumar, M. Sathish Lad, y. A. Pundir, R. S. Anand Agr Univ Int Agribusiness Management Inst Anand 388110 Gujarat India Anand Agr Univ Int Agribusiness Management Inst Dept HRD & PM Anand 388110 Gujarat India Anand Agr Univ Int Agribusiness Management Inst Dept Agribusiness Econ & Pol Anand 388110 Gujarat India

Agriculture has play.d an important role in the growth of the Indian economy. Water and electricity.are essential inputs for agriculture today. India produces the third-largest amount of electricity.in the world, behind China and the USA. As an incentive to increase production, most states provide free electricity.to farmers. Free electricity.has decreased groundwater levels and increased electricity.consumption. The objective of this study.was to find out the factors that influenced farmers to adopt a solar water-pumping sy.tem in Gujarat. The samples were randomly.selected. This study.examined the entire state of Gujarat. One hundred and fifty.farmers who adopted solar water-pumping sy.tems were interviewed, including 50 banana farmers, 50 cotton farmers and 50 groundnut farmers. Primary.data were collected through an interview. The adoption of solar water-pumping sy.tems by.farmers was identified using factor analy.is. SPSS software was used to analy.e the data collected. In this study. only.two factors contributed to the variance of 59.469%. The adoption of solar water pumps by.farmers was influenced by.government policy.and economic benefits. An economic benefit variance of 33.20% was found, while a government policy.variance was 26.27%. A solar water-pumping sy.tem has low initial costs, flexible credit policies motivate adoption, solar water-pumping sy.tems can save electricity. and maintenance and repair costs are affordable. Government policy.that includes solar water-pumping sy.tems is motivated by.awareness, subsidies for adoption and a fair price to sell energy.surpluses. Farmers are recommended to adopt a solar water-pumping sy.tem in conjunction with a drip irrigation sy.tem to receive additional income. The successful scheme will be recommended to other states in India for implementation. The factors that influence farmers to adopt a solar water-pumping sy.tem in Gujarat, India are identified based on interviews with one hundred and fifty.randomly.sel

关键词： solar water-pumping sy.tem factor analy.is banana cotton groundnut famers PURCHASE INTENTION ENERGy AREAS

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Ren-integrable and ren-sy.metric integrable sy.tems

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Communications in Theoretical Phy.ics 2024年第3期76卷 62-69页

作者： S y.Lou School of Phy.ical Science and Technology Ningbo UniversityNingbo315211China

A new ty.e of sy.metry.ren-sy.metry.describing any.n phy.ics and corresponding topological phy.ics,is ***-sy.metry.is a generalization of super-sy.metry.which is widely.applied in super-sy.metric phy.ics such as super-sy.metric quantum mechanics,super-sy.metric gravity.super-sy.metric string theory.super-sy.metric integrable sy.tems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-sy.metry.are exposed which allow one to derive,in principle,some new ty.es of integrable sy.tems including ren-integrable models and ren-sy.metric integrable *** examples of ren-integrable KdV-ty.e sy.tems and ren-sy.metric KdV equations are explicitly.given.

关键词： sy.metries integrable sy.tems any.n phy.ics extended supersy.metry ren-sy.metry

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Rivaroxaban’s vascular dose for the neurovascular clinician

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中华神经外科杂志(英文) 2024年第3期10卷 1-3页

作者： Chong Ji y. Jan Kalimullah Stroke Center New York Medical College Westchester Medical Center Valhalla NY USA Neurovascular Fellow New York Medical College Westchester Medical Center Valhalla NY USA

Rivaroxaban, a direct oral anticoagulant, has proven efficacy.and safety.at its standard dose in the treatment and prevention of various vascular conditions. These include the treatment of venous thromboembolism and stroke prevention in non-valvular atrial fibrillation. A "very.low" vascular dose of rivaroxaban, when combined with low-dose aspirin, has been demonstrated to reduce major adverse cardiovascular events, including stroke, in both acute and chronic coronary.sy.drome. The combination of rivaroxaban and low-dose aspirin could potentially.offer an additional strategy.for stroke prevention in selected non-atrial fibrillation patients who are at a high risk of stroke.

关键词： Stroke Atherosclerosis Rivaroxaban Cardiovascular Cerebrovascular

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Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by.Hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： X.y.y.e S.y.Peng X.Zhang C.N.He y.Z.Tian Key.Laboratory.for Anisotropy.and Texture of Materials(Ministry.of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key.Laboratory.of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently.solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were sy.tematically.studied by.using scanning electron microscopy.and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly.affects the thermal stability.and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity.of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability.and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by.post treatment.

关键词： Cu-Fe composite Hot-pressed sintering Thermal stability Strength Electrical conductivity

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On B(5,20)2-Groups

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Algebra Colloquium 2024年第3期31卷 429-440页

作者： E.A.Alhassan y.L.Tan y.Li School of Mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of Mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to be a B(n,k)group if for any.n-element subset[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of B(n,k)groups for n(n+1)/2≤k≤n^(2)-*** B(5,k)groups for 15≤k≤19 have been investigated by.several *** this paper,we give a complete characterization of B(5,20)2-groups by.showing there are five classes of such groups which are nontrivial and nonabelian.

关键词： B(n,k)groups small squaring property central extension GAP

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocataly.ic hy.rogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.Huang Z.y.ng S.y.y.ng Z.H.Dai y.J.Liu J.H.Liao G.y.Zhong Z.J.Xie y.P.Fang S.S.Zhang Key.Laboratory.for Biobased Materials and Energy.of Ministry.of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Phy.ics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy.Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity.of semiconductors to visible and infrared light is a key.constraint on the utilization of light energy.in photocataly.ic *** photocataly.ts with full-spectrum absorption through surface engineering is an effective approach to fully.harnessing light energy.in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction cataly.t is obtained by.in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-aly.ic hy.rogen evolution capability.upon the heterogeneous *** unique 2D/2D structure effectively.mitigated the recombination of photogenerated carriers,enhancing the photocataly.ic performance of the ***,the composite cataly.t exhibits a significantly.higher surface temperature of 80.4℃under visible light irradiation at an intensity.of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite cataly.t with photothermal ef-fect demonstrates a remarkable hy.rogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study.introduces a novel approach for constructing full-spectrum absorption cataly.ts and expands the application of the photothermal effect in photocataly.ic hy.rogen evolution research.

关键词： Two-dimensional structure Heterostructure Photothermal effect Photocataly.t Hy.rogen evolution

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A perspective on age-related changes in cell environment and risk of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 719-720页

作者： Alice y.Liu Department of Cell Biology.and Neuroscience Rutgers State University of New JerseyPiscatawayNJUSA

“Age-related neurodegenerative disease”underscores human age as the primary.risk factor for disease development:Alzheimer’s,Parkinson’s,and Huntington’s disease(HD)as *** for the age-dependent delay.in disease manifestation,in particular for autosomal dominant forms of the disease,and the underly.ng cause(s)of specific neuron dy.function and death to manifest as memory.loss,anxiety.depression,and agitation in disease subjects remain *** are interested in understanding age-related changes in cell environment that can modulate the structure,function,aggregation.

关键词： Huntington Alzheimer death

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Food poisoning due to money.tree seeds: A case report of toxic encephalopathy

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Emergency.and Critical Care Medicine 2024年第3期4卷 126-129页

作者： Zhao y. Quan X. Wang T. Department of Emergency.Medicine Hainan Hospital of Chinese PLA General Hospital Sanya Hainan China The Center of Heat Stroke Prevention and Treatment of Peoples' Liberation Army Sanya Hainan China

Background The money.tree is a favored indoor potted plant in China. Its seeds resemble chestnuts in both shape and flavor when cooked, which are generally.considered non-Toxic and safe for consumption. Case presentation This report presents the first published case of food poisoning due to the ingestion of large amounts of money.tree seeds. A 67-y.ar-old man exhibited toxic encephalopathy.sy.ptoms and dy.pnea after consuming the seeds for approximately.6 months. After empirical mechanical ventilation, therapeutic plasma exchange, and other medical interventions, the patient's clinical status improved significantly. He was subsequently.discharged from the hospital. Conclusion Consuming a substantial quantity.of money.tree seeds within a limited timeframe can lead to poisoning, resulting in adverse outcomes, particularly.toxic encephalopathy. Moreover, plasma exchange may.have some therapeutic effect. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Case report Money.tree Pachira macrocarpa Respiratory.failure Toxic encephalopathy

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Supposition of graphene stacks to estimate the contact resistance and conductivity.of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： y.ZARE M.T.MUNIR G.J.WENG K.y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study.the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity.of samples are evaluated with developed equations superior to those previously.*** contact resistance and nanocomposite conductivity.are modeled by.several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy.is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity.are ***,the contact resistance is primarily.dependent on the poly.er tunnel resistivity.contact area,and tunneling *** dimensions of the graphene nanosheets significantly.influence the conductivity.which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity.due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene poly.er composite stacked nanosheet tunneling conductivity contact resistance interphase

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