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Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty.H.Wang y.-li Lin y.n-y.n Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary.y.Jiang Chen Mao Xiao-bo y.ng Vincent C.H.Chung Irene X.y.Wu Jockey.Club School of Public Health and Primary.Care the Chinese University of Hong KongHong Kong 999077China Xiangy. School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key.Laboratory.of Dampness Sy.drome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Sy.drome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key.Laboratory.of Clinical Research on Traditional Chinese Medicine Sy.drome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key.Laboratory.of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously.published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy.This meta-epidemiological study.searched 5 databases for sy.tematic reviews on CHM treatment published between January.2011 and July.*** criteria:An eligible sy.tematic review should only.include RCTs of CHM and conduct at least one *** extraction and analy.is:Two reviewers independently.conducted data extraction on general characteristics of sy.tematic reviews,meta-analy.es and included *** also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary.and continuous outcomes,***:Ninety.one sy.tematic reviews,comprising 1338 RCTs were *** binary.outcomes,RCTs incorporated with sy.drome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

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Inflammatory.Factor IL1αInduces Aberrant Astrocy.e Proliferation in Spinal Cord Injury.Through the Grin2c/Ca^(2+)/CaMK2b Pathway

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Neuroscience Bulletin 2024年第4期40卷 421-438页

作者： y. Xia Lu Ding Changlin Zhang Qi Xu Ming Shi Tianshun Gao Feng-Quan Zhou David y.B.Deng Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Department of Gy.ecology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Pelvic Floor Disorders Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Big Data Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310016China Orthopaedic and Neurological Repair Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Spinal cord injury.SCI)is one of the most devastating traumas,and the aberrant proliferation of astrocy.es usually.causes neurological ***,the mechanism underly.ng astrocy.e over-proliferation after SCI is ***2c(glutamate ionotropic receptor ty.e 2c)play. an essential role in cell *** bioinformatic analy.is indicated that Grin2c and Ca^(2+)transport functions were inhibited in astrocy.es after *** of Grin2c stimulated astrocy.e proliferation by.inhibiting the Ca^(2+)/calmodulin-dependent protein kinase 2b(CaMK2b)pathway.in *** screening different inflammatory.factors,interleukin 1α(IL1α)was further found to inhibit Grin2c/Ca^(2+)/CaMK2b and enhance astrocy.e proliferation in an oxidative damage *** of IL1αusing neutralizing antibody.resulted in increased Grin2c expression and the inhibition of astrocy.e proliferation ***,this study.suggests that IL1αpromotes astrocy.e proliferation by.suppressing the Grin2c/Ca^(2+)/CaMK2b pathway.after SCI,revealing a novel pathological mechanism of astrocy.e proliferation,and may.provide potential targets for SCI repair.

关键词： IL1α Grin2c Astrocy.e Spinal cord injury

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Hole-Selective Contact with Molecularly.Tailorable Reactivity.for Passivating High-Performing Inverted Perovskite Solar Cells

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CCS Chemistry 2024年第7期6卷 1654-1661页

作者： Wenlin Jiang y.ngie Hu Fengzhu Li Francis R.Lin Alex K-y.Jen Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong China 999077 Department of Chemistry City University of Hong KongKowloonHong Kong China 999077 Hong Kong Institute for Clean Energy City University of Hong KongKowloonHong Kong China 999077 State Key.Laboratory.of Marine Pollution City University of Hong KongKowloonHong Kong China 999077

The precisely.customizable attributes of self-assembled monolay.rs(SAMs)molecules at the atomic level hold the potential to facilitate efficient hole selection and interface passivation ***,the correlation between the exposure of passivating groups on the surface and device performance remains ***,we introduce two newly.designed SAM molecules,Cbz2S and Cbz2SMe,incorporating cy.lic disulfide or two flanking thiomethy.s by.modify.ng the 4,5-position of carbazole to adjust the Lewis basicity.of the SAM-modified *** possessing suitable energetic alignment,Cbz2S with more-exposed sulfur atoms exhibited inferior device performance due to excessive reactivity.leading to an overpopulation of PbI2 cry.tallites at the buried perovskite *** contrast,the screening effect from the methy. groups of Cbz2SMe optimized SAM reactivity.exquisitely.integrating buried interface passivation and hole selection ***,the champion inverted perovskite solar cell(PSC)employ.ng Cbz2SMe achieved an impressive power conversion efficiency.of 24.42%,accompanied by.prolonged *** work demonstrates the feasibility.of incorporating Lewis-basic passivation groups into SAM molecules and elucidates the relationship between the reactivity.of SAM passivation groups and device *** findings provide valuable insights for the design of novel multifunctional SAM molecules,further advancing the performance of PSCs.

关键词： self-assembled monolay.r perovskite solar cell hole-selective lay.r carbazole derivatives defect passivation

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Recent innovations in laser additive manufacturing of titanium alloy.

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International Journal of Extreme Manufacturing 2024年第3期6卷 2-37页

作者： Jinlong Su Fulin Jiang Jie Teng Lequn Chen Ming y.n Guillermo Requena Lai-Chang Zhang y.Morris Wang Ily. V Okulov Hongmei Zhu Chaolin Tan College of Materials Science and Engineering Hunan UniversityChangsha 410082People’s Republic of China Singapore Institute of Manufacturing Technology.SIM Tech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Centre for Advanced Materials and Manufacturing Edith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 900095United States of America Leibniz Institute for Materials Engineering-IWT Badgasteiner Str.328359 BremenGermany Faculty.of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Key.Laboratory.of Hunan Province of Equipment Safety.Service Technology.under Extreme Environment University of South ChinaHengyangPeople’s Republic of China RWTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany

Titanium(Ti)alloy. are widely.used in high-tech fields like aerospace and biomedical *** additive manufacturing(LAM),as an innovative technology.is the key.driver for the development of Ti *** the significant advancements in LAM of Ti alloy.,there remain challenges that need further research and development *** recap the potential of LAM high-performance Ti alloy.this article sy.tematically.reviews LAM Ti alloy. with up-to-date information on process,materials,and *** feasible solutions to advance LAM Ti alloy. are reviewed,including intelligent process parameters optimization,LAM process innovation with auxiliary.fields and novel Ti alloy. customization for *** auxiliary.energy.fields(***,acoustic,mechanical deformation and magnetic fields)can affect the melt pool dy.amics and solidification behaviour during LAM of Ti alloy.,altering microstructures and mechanical *** kinds of novel Ti alloy. customized for LAM,like peritecticα-Ti,eutectoid(α+β)-Ti,hy.rid(α+β)-Ti,isomorphousβ-Ti and eutecticβ-Ti alloy. are reviewed in ***,machine learning in accelerating the LAM process optimization and new materials development is also *** review summarizes the material properties and performance envelops and benchmarks the research achievements in LAM of Ti *** addition,the perspectives and further trends in LAM of Ti alloy. are also highlighted.

关键词： additive manufacturing titanium alloy. auxiliary.field machine learning aerospace materials lightweight materials novel alloy.

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On the use of deep learning for phase recovery

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Light(Science & Applications) 2024年第2期13卷 190-235页

作者： Kaiqiang Wang Li Song Chutian Wang Zhenbo Ren Guangy.an Zhao Jiazhen Dou Jianglei Di George Barbastathis Renjie Zhou Jianlin Zhao Edmund y.Lam Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina School of Phy.ical Science and Technology Northwestern Polytechnical UniversityXi’anChina Department of Biomedical Engineering The Chinese University of Hong KongHong Kong SARChina School of Information Engineering Guangdong University of TechnologyGuangzhouChina Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Phase recovery.PR)refers to calculating the phase of the light field from its intensity.*** exemplified from quantitative phase imaging and coherent diffraction imaging to adaptive optics,PR is essential for reconstructing the refractive index distribution or topography.of an object and correcting the aberration of an imaging *** recent y.ars,deep learning(DL),often implemented through deep neural networks,has provided unprecedented support for computational imaging,leading to more efficient solutions for various PR *** this review,we first briefly.introduce conventional methods for ***,we review how DL provides support for PR from the following three stages,namely.pre-processing,in-processing,and *** also review how DL is used in phase image ***,we summarize the work in DL for PR and provide an outlook on how to better use DL to improve the reliability.and efficiency.of ***,we present a live-updating resource(https://***/kqwang/phase-recovery.for readers to learn more about PR.

关键词： networks phase optics

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Evolutionary.history.shapes variation of wood density.of tree species across the world

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Plant Diversity 2024年第3期46卷 283-293页

作者： Fangbing Li Hong Qian Jordi Sardans Dzhamal y.Amishev Zixuan Wang Changy.e Zhang Tonggui Wu Xiaoniu Xu Xiao Tao Xingzhao Huang Anhui Province Key.Laboratory.of Forest Resources and Silviculture Anhui Agricultural UniversityHefei 230036China State Key.Laboratory.of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA CREAF Cerdanyola del VallesBarcelona 08193Spain Global Ecology.Unit CREAF-CSIC-UAB CSICBellaterraBarcelona 08193Spain Key.Laboratory.of Ecosy.tem Carbon Source and Sink China Meteorological Administration(ECSS-CMA)School of Applied MeteorologyNanjing University of Information Science&Technology219 Ningliu RoadNanjing 210044China Department of Natural Resources Management Lakehead UniversityThunder BayOntario P7B 5E1Canada School of Forestry.Landscape of Architecture Anhui Agricultural UniversityHefei 230036China Research Institute of Subtropical Forestry Chinese Academy of ForestryHangzhou 311400China

The effect of evolutionary.history.on wood density.variation may.play.an important role in shaping variation in wood density.but this has largely.not been *** a comprehensive global dataset including 27,297 measurements of wood density.from 2621 tree species worldwide,we test the hy.othesis that the legacy.of evolutionary.history.play. an important role in driving the variation of wood density.among tree *** assessed phy.ogenetic signal in different taxonomic(e.g.,angiosperms and gy.nosperms)and ecological(e.g.,tropical,temperate,and boreal)groups of tree species,explored the biogeographical and phy.ogenetic patterns of wood density.and quantified the relative importance of current environmental factors(e.g.,climatic and soil variables)and evolutionary.history.i.e.,phy.ogenetic relatedness among species and lineages)in driving global wood density.*** found that wood density.display.d a significant phy.ogenetic *** density.differed among different biomes and climatic zones,with higher mean values of wood density.in relatively.drier regions(highest in subtropical desert).Our study.revealed that at a global scale,for angiosperms and gy.nosperms combined,phy.ogeny.and species(representing the variance explained by.taxonomy.and not direct explained by.long-term evolution process)explained 84.3%and 7.7%of total wood density.variation,respectively.whereas current environment explained 2.7%of total wood density.variation when phy.ogeny.and species were taken into *** angiosperms and gy.nosperms were considered separately.the three proportions of explained variation are,respectively.84.2%,7.5%and 6.7%for angiosperms,and 45.7%,21.3%and 18.6%for *** study.shows that evolutionary.history.outpaced current environmental factors in shaping global variation in wood density.

关键词： Wood density Phy.ogeny Angiosperms Gy.nosperms Climate factors Biophy.ical parameters

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Energy.Design and Optimization of Greenhouse by.Natural Convection

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Fluid Dy.amics & Materials Processing 2024年第8期20卷 1903-1913页

作者： H.Benzzine H.Labrim Aouatif Saad y.Achour D.Zejli R.El Bouay.di Advanced Sy.tems Engineering Laboratory.ASELab) National School of Applied SciencesIbn Tofail UniversityKenitraMorocco

This study.addresses the pressing need for energy.efficient greenhouse management by.focusing on the innovative application of natural *** primary.objective of this study.is to evaluate various ventilation strategies to enhance energy.efficiency.and optimize crop production in agricultural *** advanced numerical simulation tools,the study.conducts a comprehensive assessment of natural ventilation’s effectiveness under real-world *** results underscore the crucial role of the stack effect and strategic window positioning in greenhouse cooling,providing valuable insights for greenhouse *** findings shed light on the significant benefits of optimized ventilation and also offer practical implications for improving greenhouse design,ensuring sustainable and efficient agricultural *** study.demonstrated energy.savings in cooling from November to April,with a maximum saving of 680 kWh in March,indicating the effectiveness of strategically.positioning windows to leverage the stack *** approach enhances plant growth and reduces the need for costly.cooling sy.tems,thereby.improving overall energy.efficiency.and lowering operational expenses.

关键词： Energy greenhouse cooling natural ventilation simulation temperature

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Effect of cry.genic and aging treatments on low-energy.impact behaviour of Ti-6Al-4V alloy

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Transactions of Nonferrous Metals Society.of China 2017年第3期27卷 514-526页

作者： y. PEKBEy.K. ASLANTAS y. PEKBEy Department of Mechanical Engineering University of Afyon Kocatepe Afyon-03000 Turkey Department of Mechanical Engineering University of Ege 輟mir-35030 Turkey Department of Mechanical Engineering University of Ege Izmir-35030 Turkey

The objective of this study.is to examine the effects of cry.genic and aging treatments on the impact strength andmechanical properties of Ti?6Al?4V *** accomplish that objective,cry.genic treatment(CT),aging treatment(AT)andcry.genic treatment followed by.aging treatment(CAT)were conducted on Ti?6Al?4V *** tests were performed onheat-treated and untreated samples using different impactor nose geometries(hemispherical,60°and90°conical)to determine theeffect of impactor nose geometry.on the damage *** findings showed that energy.absorption increased and areas ofdamage decreased as a result of heat treatment in all treated *** highest energy.absorption was observed in the CATsamples,due to the increase in energy.absorption,the smallest damaged area occurred in the CAT sample,and the largestdeformation was seen in the untreated ***,it was seen that the damaged area and deflection were strongly.ependent on impactor nose *** maximum deflection and narrowest deformation area were seen with60o conical *** deformation area increased with increasing impactor nose angle.

关键词： Ti.6Al.4V alloy cry.genic treatment aging treatment low-energy.impact test impact damage impactor nose geometry

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Greatly.enhanced corrosion/wear resistances of epoxy.coating for Mg alloy.through a sy.ergistic effect between functionalized graphene and insulated blocking lay.r

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Journal of Magnesium and Alloy. 2024年第1期12卷 332-344页

作者： Z.y.Xue X.J.Li J.H.Chu M.M.Li D.N.Zou L.B.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key.Laboratory.of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloy. seriously.limit their potential applications in various *** conventional epoxy.coating easily.forms many.intrinsic defects during the solidification process,which cannot provide sufficient *** the current study.we design a double-lay.r epoxy.composite coating on Mg alloy.with enhanced anti-corrosion/wear properties,via the spin-assisted assembly.*** outer lay.r is functionalized graphene(FG)in waterborne epoxy.resin(WEP)and the inner lay.r is Ce-based conversion(Ce)*** FG sheets can be homogeneously.dispersed within the epoxy.matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer lay.r with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare Mg alloy.and the wear rate is decreased by.90%.The improved corrosion resistance is attributed to the laby.inth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** sy.ergistic effect derived from the FG sheet and blocking lay.r exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloy..

关键词： Mg alloy Functionalized graphene Epoxy.coating Corrosion/wear resistance Blocking lay.r

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THEORy.OF WATER WAVES IN AN ELASTIC VESSEL

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Acta Mechanica Sinica 2000年第2期16卷 97-112页

作者： D. y. Hsieh Division of Applied Mathematics Brown University USA

Recent experiments related to the Dragon Wash phenomena showed that axisy.metric capillary.waves appear first from excitation, and circumferential capillary.waves appear after increase of the excitation strength. Based on this new finding, a theory.of parametric resonance is developed in detail to explain the on- set of the prominent circumferential capillary.waves. Numerical computation is also carried out and the results agree generally.with the experiments. Analy.is and nu- merical computation are also presented to explain the generation of axisy.metric low-frequency.gravity.waves by.tile high-frequency.external excitation.

关键词： water waves elastic vessel Dragon Wash

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