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Attention Eraser and Quantitative Measures for Automated Bone Age Assessment

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Computers, Materials & Continua 2025年第1期82卷 627-644页

作者： Liuqiang Shu Lei y. College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological *** predict bone age more accurately.based on radiographs,and for the left-hand X-ray.images of different races model can have better adaptability.we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for *** this study.a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained ***,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability.across images fromdifferent *** is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial *** model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE *** to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically.significant improvements(pth a reduction in MAE by.0.2±0.02 y.ars across different racial ***,t-tests on the features also confirm the statistical significance of our approach(p<0.05).

关键词： Bone age assessment attention eraser quantitative feature metacarpal bones

targeting trkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin y.ng y.-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

tropomy.sin receptor kinase B(trkB)signaling play. a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity.dependent release of brain-derived neurotrophic factor at sy.apses binds to pre-or postsy.aptic trkB resulting in the strengthening of sy.apses,reflected by.long-term ***,the association of postsy.aptic density.protein-95 with trkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidy.inositol 3-kinase-mechanistic target of rapamy.in signaling required for long-term *** this review,we discuss trkB-postsy.aptic density.protein-95 coupling as a promising strategy.to magnify.brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of trkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsy.aptic density.protein-95 association with trkB signaling could mitigate the observed deficiency.of neuronal connectivity.in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated trkB.t1 *** trkB agonists and antibodies that activate trkB are being intensively.investigated,they.cannot distinguish the multiple human trkB splicing isoforms or cell ty.e-specific *** trkB–postsy.aptic density.protein-95 coupling provides an alternative approach to specifically.boost trkB signaling at localized sy.aptic sites versus global stimulation that risks many.adverse side effects.

关键词： Angelman sy.drome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsy.aptic density.protein-95 sy.aptic plasticity trkB

Visible-light-responsive homologous heterostructure of oxy.itrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： Hai Zou y.nfeng Bao Xueshang Xin y. Qi tengfeng Xie Fuxiang Zhang State Key.Laboratory.of Cataly.is Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry.and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing ty.e II heterostructures represents a widely.recognized strategy.for enhancing charge separation and photocataly.ic efficiency.but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially.for popularly.investigated （oxy.nitrides with low thermal ***,we sy.thesized a homologous heterostructure （denoted as y.ON＿H） based on the oxy.itrides of y.aO4-xNy.nd y.a *** heterostructure exhibits ty.e II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely.reported heterologous heterostructures,the as-obtained y.ON＿H homologous heterostructure could similarly.exhibit enhanced charge separation as well as photocataly.ic water splitting performance with respect to its counterparts(y.aO4-xNy.nd y.aON2).Meanwhile,detailed structural characterizations and spectroscopy.analy.is have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxy.itride photocataly.is visible light

Finite element simulations on the mechanical properties of MHS materials

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Acta Mechanica Sinica 2007年第1期23卷 65-75页

作者： Z. y. Gao t. X. y. D. Karagiozova Department of Mechanical Engineering Hong Kong University of Science &Technology Clear Water Bay Kowloon Hong Kong China Institute of Mechanics Bulgarian Academy of Sciences Acad. G. Bonchev Street Block 4 Sofia 1113 Bulgaria

Finite element simulations are carried out to examine the mechanical behavior of the metallic hollow sphere （MHS） material during their large plastic deformation and to estimate the energy.absorbing capacity.of these materials under uniaxial compression. A simplified model is proposed from experimental observations to describe the connection between the neighboring spheres, which greatly.improves the computation efficiency. the effects of the governing phy.ical and geometrical parameters are evaluated; whilst a special attention is paid to the plateau stress, which is directly.related to the energy.absorbing capacity. Finally. the empirical functions of the relative material density.are proposed for the elastic modulus, y.eld strength and plateau stress for FCC packing arrangement of hollow spheres, showing a good agreement with the experimental results obtained in our previous study.

关键词： Cellular material Hollow sphere Large plastic deformation Numerical simulation FEM

Morphology.structure and magnetic behavior of orthorhombic and hexagonal HoFeO_(3)sy.thesized via solution combustion approach

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Journal of Rare Earths 2022年第2期40卷 296-301,I0004页

作者： K.D.Martinson I.S.Kondrashkova M.I.Chebanenko A.S.Kiselev t.yu Kiseleva V.I.Popkov Ioffe Institute 26 PoliteknicheskayaSL Petersburg194021Russia Saint Petersburg State Institute of technology 26 MoskovskySt.Petersburg190013Russia Faculty.of Phy.ics M.V.Lomonosov State UniversityLeninskie CoryMoscow119991Russia

Nanostructured HoFeO_(3)powders were obtained by.solution combustion method at various gly.inenitrate ratios(G/N=0.2,0.4,...,1.4).According to X-ray.powder diffractometry.data,the presence of two modifications of HoFeO_(3)in the sy.thesized samples was established:orthorhombic(Pbnm)and hexagonal(P63/mmc).the cry.tallite size of the obtained compositions varies from 62±6 to 29±3 nm,depending on the G/N *** magnetic structure studies,it is found that HoFeO_(3)obtained with a stoichiometric amount of gly.ine in the reaction solution is in the magnetically.ordered state and is represented by.a sextet with quadrupole splitting(QS)=0 mm/s,isomeric shift(IS)=0.36 mm/s and effective field strength(Heff)=497 *** to the results of vibrational magnetometry.it is found that the orthoferrites obtained have a ferromagnetic structure,the main parameters of which(Ms,Mr and Hc)sy.tematically.change with a change in the redox ratio of the reaction mixture and,as a consequence,their phase composition,and reach maximum values at a G/N ratio=*** the samples obtained with a significant excess and lack of gly.ine(G/N=0.2 and 1.4),despite their amorphous nature,hy.teresis loops characteristic of the ferromagnetic state of the substance is *** is hopeful to obtain a pure hexagonal modification of HoFeO_(3)via heat treatment on amorphous products of gly.ine-nitrate combustion.

关键词： Cry.tal structure Rare earth compounds Perovskites Nanomaterials Magnetic materials

Engine Misfire Fault Detection Based on the Channel Attention Convolutional Model

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Computers, Materials & Continua 2025年第1期82卷 843-862页

作者： Feifei y. y.ngxian Huang Guoy.n Chen Xiaoqing y.ng Cany. Du y.ngkang Gong School of Mechatronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou510665China School of Automotive and transportation Engineering Guangdong Polytechnic Normal UniversityGuangzhou510665China

to accurately.diagnosemisfire faults in automotive engines,we propose a Channel Attention Convolutional Model,specifically.the Squeeze-and-Excitation Networks(SENEt),for classify.ng engine vibration signals and precisely.pinpointing misfire *** the experiment,we established a total of 11 distinct states,encompassing the engine’s normal state,single-cy.inder misfire faults,and dual-cy.inder misfire faults for different *** collection was facilitated by.a highly.sensitive acceleration signal collector with a high sampling rate of 20,*** collected data were methodically.divided into training and testing sets based on different experimental groups to ensure generalization and prevent overlap between the two *** results revealed that,with a vibration acceleration sequence of 1000 time steps(approximately.50 ms)as input,the SENEt model achieved a misfire fault detection accuracy.of 99.8%.For comparison,we also trained and tested several commonly.used models,including Long Short-term Memory.LStM),transformer,and Multi-Scale Residual Networks(MSRESNEt),y.elding accuracy.rates of 84%,79%,and 95%,*** underscores the superior accuracy.of the SENEt model in detecting engine misfire faults compared to other ***,the F1 scores for each ty.e of recognition in the SENEt model surpassed 0.98,outperforming the baseline *** analy.is indicated that the misclassified samples in the LStM and transformer models’predictions were primarily.due to intra-class misidentifications between single-cy.inder and dual-cy.inder misfire *** delve deeper,we conducted a visual analy.is of the features extracted by.the LStM and SENEt models using t-distributed Stochastic Neighbor Embedding(t-SNE)*** findings revealed that,in the LStMmodel,data points of the same ty.e tended to cluster together with significant ***,in the SENEt model,data points of various ty.es were more widely.and evenly.dispersed,demonstra

关键词： Channel attention SENEt model engine misfire fault fault detection

Gradient‑Lay.red MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao tongtong Fu Dian y. Jane Howe Kaiwen Chen Ning y.n Hao Ren Huamin Zhai Jiangsu Provincial Key.Lab of Sustainable Pulp and Paper technology.and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy.storage devices has *** this work,a novel gradient-lay.red architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(ti_(3)C_(2)t_(x) MXene)for fabricating highly.stretchable and durable *** depositing and inserting HLNPs in the MXene lay.rs with a bottom-up decreasing gradient,a multilay.red porous MXene structure with smooth ion channels was constructed by.reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively.extended the contact area between lignin and MXene to improve ion and electron accessibility.thus better utilizing the pseudocapacitive property.of *** these strategies effectively.enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene lay.r,enhanced mechanical properties of the wrinkled stretchable electrodes by.releasing stress through slip and deformation during the stretch-release cy.ling and greatly.improved the structural integrity.and capacitive stability.of the *** electrodes and sy.metric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study.showcased new possibilities of incorporating biobased lignin nanospheres in energy.storage devices to fabricate stretchable devices leveraging sy.ergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-lay.red architecture Wrinkled electrodes Stretchable supercapacitors

Low‑temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： y.ngjie Zhao y.cheng Sun Chaoxin Pei Xing y.n Xiny. Li y. Hao Mengru Zhang Meng y.an Jinglin Zhou y. Chen y.nlin Song College of Chemistry.and Pingy.an Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key.Laboratory.of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key.Laboratory.of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hy.rid perovskites significantly.accelerate the developmentof portable energy.biomedicine,and sensing fields,but their poor thermal stability.inders further ***,all-inorganic perovskites possessexcellent thermal stability.but black-phase all-inorganic perovskite filmusually.requires high-temperature annealing steps,which increases energy.consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by.the in situ hy.roly.is reactionof dipheny.phosphinic chloride *** released dipheny. phosphateand chloride ions during the hy.roly.is reaction significantly.lower the phasetransition temperature and effectively.passivate the defects in the perovskitefilms,y.elding high-performance photodetectors with a responsivity.of 42.1 AW−1 and a detectivity.of 1.3×10^(14)***,high-fidelity.imageand photoplethy.mography.sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hy.roly.ation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

Drosophila models used to simulate human AtP1A1 gene mutations that cause Charcot-Marie-tooth ty.e 2 disease and refractory.seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： y.o y.an Lingqi y. Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiay. Xie Shengan Ling Xiaoy.e Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key.Laboratory.of technical Evaluation of Fertility.Regulation for Non-human Primate(Fujian Maternity.and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology.and Institute of Neurology.of the First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-AtPase pump,AtPase Na^(+)/K^(+)transporting subunit alpha 1(AtP1A1),cause Charcot-Marie-tooth disease ty.e 2(CMt2)disease and refractory.*** develop in vivo models to study.the role of Na^(+)/K^(+)-AtPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human AtP1A1 gene mutations that cause *** located within the helical linker region of human AtP1A1(I592t,A597t,P600t,and D601F)were simultaneously.introduced into endogenous Drosophila Atpαby.CRISPR/Cas9-mediated genome editing,generating the Atpα^(tttF)*** addition,the same strategy.was used to generate the corresponding single point mutations in flies(Atpα^(I571t),Atpα^(A576t),Atpα^(P579t),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozy.otes(Atpα^(I571t)and Atpα^(P579t)).three alleles(Atpα^(A576t),Atpα^(P579)and Atpα^(D580F))can form heterozy.otes with the Atpαmut *** found that the Atpαallele carry.ng these CMt2-associated mutations showed differential phenoty.es in *** heterozy.ous for Atpα^(tttF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for study.ng the function and regulation of the sodium-potassium pump.

关键词： AtP1A1 Atpα bang-sensitive paraly.is Charcot-Marie-tooth disease ty.e 2 CRISPR/Cas9 homology.directed repair Na^(+)/K^(+)-AtPase point mutation seizures sodium pump