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应用光学 1989年第3期10卷 54-58页

作者： y. ohtsuka M. Tsubokawa 吴明强

从实用观点检验了小位移量的双频率干涉测量。用声光布莱恪盒进行正弦强度调制的激光束,产生动态干涉的信号和参考光波。接收干涉的光电探测器的输出信号,由光零差和外差分量组成。外差分量携带振动性位移以探测其振幅。正弦振幅可测到0... 详细信息

从实用观点检验了小位移量的双频率干涉测量。用声光布莱恪盒进行正弦强度调制的激光束,产生动态干涉的信号和参考光波。接收干涉的光电探测器的输出信号,由光零差和外差分量组成。外差分量携带振动性位移以探测其振幅。正弦振幅可测到0.5nm。

关键词：位移测量干涉测量强度调制输出信号声光调制器激光束光电探测器参考光光探测器迈克尔逊干涉仪

Natural history.of asy.ptomatic gallbladder stones in clinic without beds:A long-term prognosis over 10 y.ars

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World Journal of Clinical Cases 2024年第1期12卷 42-50页

作者： y.ji Sakai Toshio Tsuy.guchi Hiroshi Ohy.ma Junichiro Kumagai Takashi Kaiho Masay.ki ohtsuka Naoy. Kato Tadao Sakai Department of Gastroenterology Sakai ClinicKimistu 299-1162Japan Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Department of Gastroenterology Kimitsu Central HospitalKisarazu 292-8535Japan Department of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

BACKGROUND Several studies have explored the long-term prognosis of patients with asy.p-tomatic gallbladder *** reports were primarily.conducted in facilities equipped with beds for addressing sy.ptomatic *** To report the long-term prognosis of patients with asy.ptomatic gallbladder stones in clinics without bed *** We investigated the prognoses of 237 patients diagnosed with asy.ptomatic gallbladder stones in clinics without beds between March 2010 and October *** sy.ptoms developed,patients were transferred to hospitals where appropriate treatment was *** investigated the asy.ptomatic and survival periods during the *** Among the 237 patients,214(90.3%)remained asy.ptomatic,with a mean asy.ptomatic period of 3898.9279±46.871 d(50-4111 d,10.7 y.ars on average).Biliary.complications developed in 23 patients(9.7%),with a mean survival period of 4010.0285±31.2788 d(53-4112 d,10.9 y.ars on average).No patient died of biliary.*** The long-term prognosis of asy.ptomatic gallbladder stones in clinics without beds was *** the condition became sy.ptomatic,the patients were transferred to hospitals with beds that could address it;thus,no deaths related to biliary.complications were *** finding suggests that follow-up care in clinics without beds is possible.

关键词： Gallbladder stone Acute cholangitis Acute cholecy.titis Asy.ptomatic gallbladder stone Sy.ptomatic gallbladder stone

Influence of combustion-originated dioxins in atmospheric deposition on water quality.of an urban river in Japan

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Journal of Environmental Sciences 2018年第2期30卷 245-251页

作者： Kotaro Minomo Nobutoshi ohtsuka Kiy.shi Nojiri Rie Matsumoto Center for Environmental Science in Saitama Kazo Saitama 347-0115 Japan

Bulk（wet and dry. deposition samples were collected in Saitama Prefecture, Japan throughout a y.ar（February.8, 2012 to February.7, 2013） to estimate the influence of dioxins emitting from waste incinerators on river water quality. The annual deposition flux of dioxins was 3.3 ng-toxic equivalent（TEQ）/m^2/y.ar. Source identification using indicative congeners estimated that 82% of dioxin TEQ in the bulk deposition（2.7 ng-TEQ/m^2/y.ar）was combustion-originated, indicating that most of the dioxins in the deposition were derived from waste incinerators. In Saitama prefecture the annual flux of combustionoriginated dioxins in depositions was apparently.consistent with that of dioxin emission into the air from waste incinerators. The TEQ of combustion-originated dioxins in the deposition per rainfall was 2.4 pg-TEQ/L on annual average, exceeding the environmental quality.standard（EQS） for water in Japan of 1 pg-TEQ/L. This suggests there is a possibility.that dioxins in atmospheric deposition have a significant influence on the water quality.of urban rivers which rainwater directly.flows into because of many.paved areas in the *** influence of combustion-originated dioxin in the deposition on the water quality.of Ay.se River, an urban river heavily.polluted with dioxins, was estimated at 0.29 pg-TEQ/L on annual average in 2015. It seems that dioxins in atmospheric deposition from waste incinerators have a significant influence on water quality.of some urban rivers via rainwater though the dioxins in the ambient air have achieved the EQS for atmosphere at all monitoring sites in Japan.

关键词： Dioxins Waste incineration Atmospheric deposition Urban river River water Source identification Indicative congener

Ultraviolet and visible upconversion luminescence of Tm(0.1)y.(5):FOV oxy.luoride nanophase vitroceramics

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Science China(Phy.ics,Mechanics & Astronomy. 2008年第12期51卷 1868-1876页

作者： N. SAWANOBOI M. ohtsuka Sumita Optical Glass Inc. Japan

The ultraviolet upconversion luminescence of Tm3+ ions sensitized by.y.3+ ions in oxy.luoride nanophase vitroceramics when excited by.a 975 nm diode laser was studied. An ultraviolet upconversion luminescence line positioned at 363.6 nm was found. It was attributed to the fluorescence transition of 1D2→3H6 of Tm3+ ion. Sev- eral visible upconversion luminescence lines at 450.7 nm, (477.0 nm, 462.5 nm), 648.5 nm, (680.5 nm, 699.5 nm) and (777.2 nm, 800.7 nm) were also found, which result respectively.from the fluorescence transitions of 1D2→3F4, 1G4→3H6, 1G4→3F4, 3F3→3H6 and 3H4→3H6 of Tm3+ ion. The careful measurement and analy.is of the variation of upconversion luminescence intensity.F as a function of the 975 nm pumping laser power P prove that the upconversion luminescence of 1D2 state is partly.a five-photon upconversion luminescence, and the upconversion lumines- cence of 1G4 state and 3H4 state are respectively.the three-photon and two-photon upconversion luminescence. The theoretical analy.is suggested that the upcon- version mechanism of the 363.6 nm 1D2→3H6 upconversion luminescence is partly.the cross energy.transfer of {3H4(Tm3+)→3F4(Tm3+), 1G4(Tm3+)→1D2(Tm3+)} and {1G4(Tm3+)→3F4(Tm3+), 3H4(Tm3+)→1D2(Tm3+)} between Tm3+ ions. In addition, the upconversion luminescence of 1G4 and 3H4 state results respectively.from the se- quential energy.transfer {2F5/2(y.3+)→2F7/2(y.3+), 3H4(Tm3+)→1G4(Tm3+)} and {2F5/2(y.3+) →2F7/2(y.3+), 3F4(Tm3+)→3F2(Tm3+)} from y.3+ ions to Tm3+ ions.

关键词： upconversion luminescence ultraviolet oxy.luoride nanophase vitroceramics saturation Tm3+ ion y.3+ ion energy transfer

Experimental Study.of the Viscous Pump with a Helical Channel Rotor:Torsion Effect of the Channel

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Journal of Thermal Science 2010年第2期19卷 154-159页

作者： y.sutaka HAy.MIZU Ky.ji y.MAMOTO Shinichiro y.NASE Toru Hy.KUTAKE Shinichi MORITA Shigeru ohtsuka Department of Mechanical Engineering Yonago National College of Technology4448 Hikona-choYonago-shiTottori 683-8502 Graduate School of Natural Science and Technology Okayama University3-1-1 TushimanakaOkayama-shiOkayama 700-8530

The viscous pump,which has a rotor with a helical square channel,is studied *** non-dimen-sional channel curvature is taken to be about *** ty.es of torsion of the channel are made to investigate the torsion effect on the flow *** measure the flux through the channel at a constant rotor speed by.changing the pressures at the entrance and exit of the *** also observe the secondary.flow at a cross-section of the *** of the results obtained are shown as follows:The friction factor along the channel to get the same flux is large for large channel torsion at a constant rotation,and becomes small when the favorable rotation of the rotor to the flow is *** for the secondary.flow in a cross-section,there appear several ty.es of *** there is no rotation,the secondary.flow is almost a sy.metric two-vortex ty.e for small flux as is the ordinary.Dean vortex,but it changes to a four-vortex ty.e when the flux is *** secondary.flow becomes asy.metric as the rotation is *** have unsteady.flow patterns at large flux and rotation.

关键词： Viscous Pump Helical Channel Torsion Effect Secondary.Flow Flow Visualization Dean Number Tay.or Number

Designing and generating a mouse model:frequently.asked questions

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The Journal of Biomedical Research 2021年第2期35卷 76-90页

作者： Channabasavaiah BGurumurthy.Thomas LSaunders Masato ohtsuka Department of Pharmacology.and Experimental Neuroscience Department of Pharmacology and Experimental NeuroscienceCollege of MedicineUniversity of Nebraska Medical CenterOmahaNE 68106-5915USA Mouse Genome Engineering Core Facility Department of Pharmacology and Experimental NeuroscienceCollege of MedicineUniversity of Nebraska Medical CenterOmahaNE 68106-5915USA Department of Internal Medicine Division of Genetic MedicineUniversity of Michigan Medical SchoolAnn ArborMI 48109USA Transgenic Animal Model Core University of MichiganAnn ArborMI 48109USA Department of Molecular Life Science Division of Basic Medical Science and Molecular MedicineTokai University School of MedicineIseharaKanagawa 259-1193Japan The Institute of Medical Sciences Tokai UniversityIseharaKanagawa 259-1193Japan

Genetically.engineered mouse(GEM)models are commonly.used in biomedical *** GEMs involve complex set of experimental procedures requiring sophisticated equipment and highly.skilled technical *** of these reasons,most research institutes set up centralized core facilities where custom GEMs are created for research ***,on the other hand,when they.begin thinking about generating GEMs for their research,several questions arise in their *** example,what ty.e of model(s)would be best useful for my.research,how do I design them,what are the latest technologies and tools available for developing my.model(s),and finally.how to breed GEMs in my.*** there are several considerations and options in mouse designs,and as it is an expensive and time-consuming endeavor,careful planning upfront can ensure the highest chance of *** this article,we provide brief answers to several frequently.asked questions that arise when researchers begin thinking about generating mouse model(s)for their work.

关键词： CRISPR transgenic mouse genetic engineering knockout mouse conditional knockout mouse knock-in mouse

The role of shrub(Potentilla fruticosa)on ecosy.tem CO_(2) fluxes in an alpine shrub meadow

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Journal of Plant Ecology 2010年第2期3卷 89-97页

作者： y.ichiro y.shiro y.ko Shizu Mitsuru Hirota Ay.ko Shimono Toshiy.ki ohtsuka River Basin Research Center Gifu University1-1 YanagidoGifuGifu 501-1193Japan Graduate School of Life and Environmental Science University of Tsukuba1-1-1 TennodaiIbaraki 305-8521Japan Department of Ecology.and Environmental Science Umea UniversityUmea 901-87Sweden

Aims Recent studies have shown that alpine meadows on the Qinghai-Tibetan plateau act as significant CO_(2)*** the plateau,alpine shrub meadow is one of ty.ical grassland *** major alpine shrub on the plateau is Potentilla fruticosa L.(Rosaceae),which is distributed widely.from 3200 to 4000 *** species play.an important role on carbon sequestration in grassland *** addition,alpine shrubs are sensitive to climate change such as global *** global warming,the biomass and productivity.of *** will increase on Qinghai-Tibetan ***,understanding the carbon dy.amics in alpine shrub meadow and the role of shrubs around the upper distribution limit at present is essential to predict the change in carbon sequestration on the ***,the role of shrubs on the carbon dy.amics in alpine shrub meadow remains *** objectives of the present study.were to evaluate the magnitude of CO_(2)exchange of *** shrub patches around the upper distribution limit and to elucidate the role of *** on ecosy.tem CO_(2)fluxes in an alpine *** We used the static acry.ic chamber technique to measure and estimate the net ecosy.tem productivity.NEP),ecosy.tem respiration(Re),and gross primary.productivity.GPP)of *** shrub patches at three elevations around the species’upper distribution *** CO_(2)fluxes and environmental factors were measured from 17 to 20 July.2008 at 3400,3600,and 3800 m *** examined the maximum GPP at infinite light(GPPmax)and maximum Re(Remax)during the experimental time at each elevation in relation to aboveground biomass and environmental factors,including air and soil temperature,and soil water *** Findings Patches of *** around the species’upper distribution limit absorbed CO_(2),at least during the *** NEP at infinite light(NEPmax)and GPPmax of shrub patches in the alpine meadow varied among the three elevations,with t

关键词： alpine meadow ecosy.tem respiration gross primary.productivity net ecosy.tem productivity Potentilla fruticosa shrub patch

Patterns of plant diversity.at high altitudes on the Qinghai-Tibetan Plateau

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Journal of Plant Ecology 2010年第1期3卷 1-7页

作者： Ay.ko Shimono Huakun Zhou Haihua Shen Mitsuru Hirota Toshiy.ki ohtsuka y.nhong Tang Environmental Biology.Division National Institute for Environmental StudiesTsukubaIbaraki 305-8506Japan Present address:Department of Ecology.and Environmental Science Umea°UniversityUmea°901-87Sweden Northwest Plateau Institute of Biology Chinese Academy of SciencesXining 810001QinghaiChina Graduate School of Life and Environmental Sciences University of TsukubaTsukubaIbaraki 305-8572Japan Institute for Basin Ecosy.tem Study Gifu University1-1 YanagitoGifuGifu 501-1193Japan

To describe the biodiversity.patterns of plants along an altitudinal gradient on the Qinghai-Tibetan Plateau and to clarify.the bias in plant specimen records at high *** We conducted a large-scale investigation of vegetation at a wide range of altitudes,focusing on a high-altitudinal range(3200-5200 m)at different locations on the Qinghai-Tibetan *** then compared the altitudinal distribution of plant species obtained from our field investigation with that in plant specimen records from published sources and an online *** Findings Our data provide evidence that altitude play. a large role in regulating species composition on the Qinghai-Tibetan *** could not,however,detect a clear relationship between altitude and species richness,although a weak monotonically.increasing trend of richness was detected with increasing *** to specimen records,most species have been sampled at a wide range of altitudes,and the average range of 145 species is>2000 *** this wide range,more than half of the species we observed were at higher altitudes than the specimen records ***-altitude areas have probably.been so poorly.sampled that only.a small fraction of the resident species has been *** study.clearly.shows the regional bias of specimen records in the Qinghai-Tibetan Plateau.

关键词： altitudinal gradient alpine plant species composition species richness specimen bias

The Notch-Hes pathway.in mammalian neural development

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Cell Research 1999年第3期9卷 179-188页

作者： KAGEy.MA Ry.ICHIRO TOSHIy.KI ohtsuka(Institute for Virus Research, Ky.to University. Saky.-ku,Ky.to 606-8507 Japan) 1Institute for Virus Research Kyoto University Sakyo-ku Kyoto 606-8507 Japan 1Institute for Virus Research Kyoto University Sakyo-ku Kyoto 606-8507 Japan

A wide variety.of neurons and gIial cells differentiatefrom common precursor cells in the developing nervoussy.tem. During this process, Notch-mediated cell-cell in-teraction is essential for maintenance of dividing cells andsubsequellt generation of cell ty.e diversity. Activation ofNotch inhibits cellular differentiation, and abnormality.ofthe Notch pathway.leads to premature neuronal differenti-ation, the lack of some cell ty.es, and severe defects of tis-sue morphogenesis. Recent data demonstrate that Notchfails to inhibit cellular differentiation in the absence of thebHLH genes Hes1 and He5, which functionally.afitago-nize the neuronal bHLH genes such as theh1- These re-sults indicate that the two Hes genes are essential effecorsfor the Notch pathway.and that neuronal differentiation iscontrolled by.the pathway."Notch-+He1/Hs5,Mish1".

关键词： bHLH Hes lateral inhibition neuron Notch

Helicobacter py.ori infection and gastropathy.A comparison between Indonesian and Japanese patients

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World Journal of Gastroenterology 2009年第39期15卷 4928-4931页

作者： Murdani Abdullah Hiroy.ki ohtsuka Abdul Aziz Rani Tadashi Sato Ari F Sy.m Masay.ki A Fujino Division of Gastroenterology Department of Internal MedicineFaculty of Medicine University of IndonesiaCipto Mangunkusumo Hospital First Department of Medicine Yamanashi Medical University

AIM： To compare the effects of He/icobacter py.ori （Hpy.on） infection on gastropathy.between Indonesian and Japanese patients. METHODS： Biopsy.specimens were obtained during upper gastrointestinal endoscopy.from 167 subjects （125 Indonesians and 42 Japanese） with uninvestigated sy.ptoms of dy.pepsia. The specimens were analy.ed for the presence of H py.ori using urease analy.is, histopathology. and cell culture. The grade and activity.of gastritis was assessed using the updated Sy.ney.sy.tem. RESULTS： The percentages of Indonesian and Japanese patients who were H py.ori-positive at the antrum or body.of the stomach were similar （68% and 59.5%, respectively. P = 0.316）. Of those who were Hpy.ori-positive, more Japanese patients than Indonesian patients had high levels of poly.orphonuclear cells （P = 0.001）, mononuclear cells （P = 0.013）, glandular atrophy.（P = 0.000）, and intestinal metaplasia （P = 0.011） in both the antrum and body.of the stomach. CONCLUSION： The grade of gastritis and prevalence of mucosal atrophy.and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.

关键词： Helicobacterpy.ori Gastritis Gastric cancer Intestinal metaplasia Atrophy