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Circulating levels of hy.roxy.ated brady.inin function as an indicator of tissue HIF-1a expression

Science Bulletin 2020年第18期65卷 1570-1579,M0004页

作者： y.ng liu y.jun Gu Serina Ng Zaian Deng Christopher J.Ly.n Eugene J.Koay.Bo Ning Matthew H.Katz Paul J.Chiao Jia Fan Haiy.ng Han Daniel Von Hoff Tony.y.Hu Department of Biochemistry.and Molecular Biology Tulane University School of MedicineNew Orleans.LA 70112USA Department of Nanomedicine Houston Methodist Research InstituteHoustonTX 77030USA Molecular Medicine Division Translational Genomics Research InstitutePhoenixAZ 85004USA Department of Radiation Oncology Division of Radiation OncologyThe University of Texas M.D.Anderson Cancer CenterHoustonTX 77030USA Department of Surgical Oncology Division of SurgeryThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Molecular and Cellular Oncology Division of Basic SciencesThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

The critical roles of oxy.en homeostasis in metabolism are indisputable and hy.oxic responses are correlated with the pathogenesis of gastrointestinal, pulmonary. renal diseases and cancers. Evaluating tissue hy.oxia to predict treatment outcome is challenging, however, due to the lack of rapid, accurate and non-invasive methods. Hy.oxia enhances proly.-4-hy.roxy.ase a1(P4HA1) expression, which can convert brady.inin(BK) to hy.roxy.roly.-BK(Hy.-BK), leading us to hy.othesize that circulating Hy.-BK/BK ratios may.reflect tissue hy.oxia and predict treatment outcomes. Direct quantification of Hy.-BK peptides in serum or plasma by.conventional MALDI-TOF MS analy.is is technically.challenging. In our study. a nanopore-based fractionation and enrichment protocol was utilized to allow the simple workflow for circulating Hy.-BK/BK analy.is. Hy.oxia is linked to poor prognosis due to its role in promoting pancreatic cancer progression and metastasis. Here we show that P4HA1 expression was increased in pancreatic tumors versus adjacent tissue, associated with poor survival, and corresponded with tumor expression of the hy.oxia inducible factor 1a(HIF-1a) and carbonic anhy.rase 9(CA9). Hy.oxiainduced P4HA1 expression and BK conversion to Hy.-BK were found to be HIF-1 a dependent, pretreatment serum Hy.-BK/BK ratios corresponded with tissue HIF-1 a and P4HA1 expression, and high Hy.-BK/BK levels corresponded with poor response to therapy. These results suggest that pretreatment circulating Hy.-BK/BK ratios may.have value as a non-invasive, surrogate indicator of tissue hy.oxia and tumor responses to therapy.

关键词： HIF-1α Hy.oxia Circulating indicator Hy.roxy.roly. brady.inin P4HA1

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钛合金框架类零件铣削用立铣刀设计与应用研究进展

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机械工程学报 2023年第23期59卷 283-309页

作者：李明星岳彩旭刘献礼陈志涛姜志鹏岳大荀 STEVEN y.L 哈尔滨理工大学先进制造智能化技术教育部重点实验室哈尔滨150080 江苏天工硬质合金科技有限公司镇江361006 佐治亚理工学院乔治·W·伍德拉夫机械工程学院美国亚特兰大30332

钛合金材料以轻质、高强、耐腐蚀等优异特性在航空航天领域得到了广泛的应用,但良好的材料属性也为其加工带来难题,尤其对结构复杂的钛合金框架类零件切削,对刀具的设计、使用和性能评价都提出了更高的要求。首先分析了限制钛合金框架... 详细信息

钛合金材料以轻质、高强、耐腐蚀等优异特性在航空航天领域得到了广泛的应用,但良好的材料属性也为其加工带来难题,尤其对结构复杂的钛合金框架类零件切削,对刀具的设计、使用和性能评价都提出了更高的要求。首先分析了限制钛合金框架类零件切削性能发挥的影响因素,即切削力、切削温度和已加工表面残余应力,并以影响因素为约束总结了钛合金框架类零件加工用整体立铣刀几何结构、表面涂层和基体材料的研究现状;其次针对特定加工场景以影响因素为约束推荐了切削参数;随后将影响因素量化为便于识别统计的评价指标,即切削寿命、效率和表面完整性,进而阐述了刀具切削性能评价的研究进展。最后对整体立铣刀在钛合金框架类零件加工领域的发展与应用进行展望。随着新一代信息技术发展,将进一步推动刀具设计、使用与切削性能发挥的深度融合,助力钛合金框架类零件的高质量、长寿命、高效率切削。

关键词：框架类零件立铣刀铣削加工刀具设计切削性能表面质量

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Conceptualizing and Measuring Economic Resilience of Resource-based Cities： Case Study.of Northeast China

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Chinese Geographical Science 2017年第3期27卷 471-481页

作者： TAN Juntao ZHANG Pingy. LO Kevin LI Jing liu Shiwei Northeast Institute of Geography.and Agroecology Chinese Academy of Sciences Jilin Changchun 130102 China University.ofChinese Academy.of Sciences Beijing 100049 China Department of Geography Hong Kong Baptist University Hong Kong China

This paper develops a conceptual model and an indicator sy.tem for measuring economic resilience of resource-based cities based on the theory.of evolutionary.resilience and the related concepts of persistence, adaptation, and transformation. Nineteen resource-based cities in Northeast China were analy.ed using the indicator sy.tem. The results showed that Liaoning and Jilin provinces had higher economic resilience than Heilongjiang Province. Panjin, Benxi, and Anshan in Liaoning Province were the top three cities, while Shuangy.shan and other coal-based cities in Heilongjiang Province ranked last. Metals-and petroleum-based cities had significantly.higher resilience than coal-based cities. The differences in persistence, adaptability. transformation, and resilience among resource-based cities decreased since the introduction of the Northeast Revitalization Strategy.in 2003. Forestry.based cities improved the most in terms of resilience, followed by.metals-based and multiple-resource cities; however, resilience dropped for coal-based cities, and petroleum-based cities falling the most. The findings illustrate the importance and the way.to develop a differentiated approach to improve resilience among resource-based cities.

关键词： resource-based cities economic resilience Northeast China

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Combined Radiofrequency.and Ethanol Ablation for HCC---Ex vivo experiment and clinical study

Combined Radiofrequency and Ethanol Ablation for HCC---Ex vi...

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2009年世界肿瘤介入学术大会

作者： xiao y.x.e~1,Ming Kuang~2,Ming D.Lu~2,Hui x.xu~1,Zuo F.xu~1,xiao y.y.n~2,Guang J.liu~1,Jie F.Huang~2 From the Departments of Medical Ultrasonics(x.y.x.,H.x.x.,G.J.L.,Z.F.x.)1 and Hepatobiliary.Surgery.M.D.L., M.K.,x.y.y.J.FH.) 2,The First Affiliated Hospital,Sun y.t-Sen University.Guangzhou,People’s Republic of China.

Objective:Percutaneous ethanol injection(PEI) and radiofrequency.RFA) used to be standard alternative options to treat hepatocellular carcinoma(HCC).But the conventional PEI has limitations of achieving complete distributing in tumors bigger than 2cm and RFA is unsuitable for treatment of tumors at unfavorable *** incomplete ablation and local tumor progression are the main factors to limiting the longtime *** Multi-pronged needle percutaneous ethanol injection(MPEI) is help to achieving ethanol complete distributing in tumor up to 5cm,Then combination of MPEI+RFA may.be more efficient in HCC treatment. Methods:Ex vivo experiment in pig liver:The efficacy.of RFA,MPEI+RFA and MPEI+RFA+HS(Hy.ertonic saline) was ***(3-cm-electrode) was applied to porcine livers by.using *** RFA,20ml of 99.5%ethanol was injected around the electrode in 3cm *** hy.ertonic saline was injected around the electronic *** compared the size,shape of ablation zone,treatment time,power,and impedance during ablation. Results:MPEI+RFA produced a larger zone of ablation than RFA alone(23.3+/-4.1cm vs 19.1+/-1.4cm,Py.was greater in MPEI+RFA than in RFA only.Py.including 23 patients with nonsurgical primary.n=7) or recurrent(n=16) HCC 3-6 cm were treated with MPEI+RFA by.using a multi-pronged injection needle and Cool-tip during a 2-y.ar *** tumors located at unfavorable *** treatment sessions were ***: The complete response was achieved in 19 patients being 86.9%.The treatment failure was observed in tree patients(13.1%). The major complications occurred in two patients(8.7%).The 1 and 2 y.ar disease-free survival(DFS) rate is 74%and 63%. Conclusions:Combined therapy.of MPEI+RFA or MPEI+RFA+TNS can increase the volume of RFA-induced coagulation in the liver with a singl

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骨小梁成分分析MR成像对腰椎骨质疏松的综合评价

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国际医学放射学杂志 2023年第4期 493-494页

作者： J.liu J.D.Chen P.Li J.W.Liao J.x.Feng Z.y.Chen 王玉婷

摘要目的为了全面评估腰椎骨质疏松，提出了一种成分分析MR成像技术，通过MRI的3D-短重复时间绝热反转恢复准备脉冲（STAIR）-超短回波时间（UTE）序列和非对称

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中老年HIV/AIDS歧视感知对抗病毒治疗依从性的作用及社会支持的修饰效应分析

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现代预防医学 2024年第14期51卷 2513-2516+2580页

作者：陈慧贾文君王莉鸿王瑶王岚刘佳余彬杨淑娟四川绵阳四〇四医院四川大学-香港理工大学灾后重建与管理学院四川大学华西公共卫生学院/华西第四医院

目的探讨艾滋病相关歧视感知对中老年艾滋病病毒感染者和艾滋病病人(HIV/AIDS)抗病毒治疗(antiretroviral therapy. ART)依从性的影响及社会支持的修饰效应，为进一步提高ART治疗成功率提供指导依据。方法采取整群随机抽样方法，对绵... 详细信息

目的探讨艾滋病相关歧视感知对中老年艾滋病病毒感染者和艾滋病病人(HIV/AIDS)抗病毒治疗(antiretroviral therapy. ART)依从性的影响及社会支持的修饰效应，为进一步提高ART治疗成功率提供指导依据。方法采取整群随机抽样方法，对绵阳市现存活中老年HIV/AIDS进行问卷调查，了解其社会人口学特征、社会支持、歧视感知及治疗依从性情况，运用logistic回归模型分析上述因素与HIV/AIDS治疗依从性间的关系。结果本研究共调查401例正在接受ART治疗的中老年HIV/AIDS,治疗依从性好占69.82%,依从性不好占30.18%,治疗成功率为93.06%。单因素分析显示，病毒有效抑制患者(病毒载量≤20)相对治疗失败患者(>20)依从性更好，单片和二联抗病毒药方案服药依从性更好。Logistic回归结果显示，担心公开(OR=1.116,95%CI:1.023～1.217)、公众歧视(OR=1.105,95%CI:1.008～1.211)、内在羞耻(OR=1.119,95%CI:1.022～1.225)是治疗依从性重要影响因素。分层分析发现，个人及家庭支持中担心公开(OR=1.159,95%CI:1.034～1.299)、公众歧视(OR=1.128,95%CI:1.004～1.267)、内在羞耻(OR=1.150,95%CI:1.021～1.297)是治疗依从性的影响因素。结论个人及家庭支持中担心公开、公众歧视、内在羞耻、抗病毒治疗方案和病毒载量会影响HIV/AIDS治疗依从性，故应加强社会支持力度，特别要提高个人及家庭的支持，增强其对歧视感知的修饰效应，同时对HIV/AIDS及家人宣传教育，增加支持，减少歧视，加强病毒载量检测并及时调整个性化的治疗方案。

关键词：艾滋病社会支持歧视感知抗病毒治疗依从性影响因素

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Characterization of germline development and identification of genes associated with germline specification in pineapple

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Horticulture Research 2021年第1期8卷 3172-3192页

作者： Lihua Zhao Liping liu y.nhui liu xiany.ng Dou Hany.ng Cai Mohammad Aslam Zhimin Hou xingy.e Jin y. Li Lulu Wang Heming Zhao xiaomei Wang Adrien Sicard y.an Qin College of Life Science State Key Laboratory of Ecological Pest Control for Fujian and Taiwan CropsFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyFujian Agricult ure and Forstry UniversityFuzhouChina Department of Plant Biology Swedish University of Agricultural SciencesUppsala BioCenter and Linnean Centre for Plant BiologyUppsalaSweden State Key.Laboratory.for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Key Lab of Sugarcane BiologyCollege of AgricultureGuangxi UniversityNanningGuangxiChina Horticulture Research Institute Guangxi Academy of Agricultural SciencesNanning Investigation Station of South Subtropical Fruit TreesMinistry of AgricultureNanningChina

Understanding germline specification in plants could be advantageous for agricultural *** recent decades,substantial efforts have been made to understand germline speci fication in several plant species,including Arabidopsis,rice,and ***,our knowledge of germline speci fication in many.agronomically.important plant species remains ***,we characterized the female germline speci fication and subsequent female gametophy.e development in pineapple using callose staining,cy.ological,and whole-mount immunolocalization *** also determined the male germline speci fication and gametophy.e developmental timeline and observed male meiotic behavior using chromosome spreading ***,we identi fied 229 genes that are preferentially.expressed at the megaspore mother cell(MMC)stage during ovule development and 478 genes that are preferentially.expressed at the pollen mother cell(PMC)stage of anther development using comparative transcriptomic *** biological functions,associated regulatory.pathway. and expression patterns of these genes were also *** study.provides a convenient cy.ological reference for exploring pineapple germline development and a molecular basis for the future functional analy.is of germline speci fi cation in related plant species.

关键词： species mother mount

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激光加工超疏水表面抗结冰性能研究进展

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表面技术 2023年第12期52卷 119-134页

作者：郭纯方刘磊刘森云李康妹吴重军梁越昇东华大学机械工程学院上海201620 中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000 佐治亚理工学院制造研究中心美国亚特兰大30332

在低温环境中,表面结冰会严重影响户外装备的运行效率和安全,基于疏水材料的新型被动式防除冰方法引起了广泛关注。超疏水表面凭借其优越的拒水、抑制冰核形成和降低冰黏附强度等能力,在防除冰技术领域表现出广阔的应用前景。激光加工... 详细信息

在低温环境中,表面结冰会严重影响户外装备的运行效率和安全,基于疏水材料的新型被动式防除冰方法引起了广泛关注。超疏水表面凭借其优越的拒水、抑制冰核形成和降低冰黏附强度等能力,在防除冰技术领域表现出广阔的应用前景。激光加工技术具有高效率和灵活性,成为制备超疏水表面的有效方法,并被进一步用来研究表面的抗结冰性能。首先,概述了固体表面润湿理论和结冰机理。其次,综合评估了激光加工超疏水表面的抗结冰性能,包括静态水滴延迟结冰时间、动态水滴累积、冰黏附强度、延迟结霜与抗冻能力、表面积冰与除冰等方面。静态水滴延迟结冰时间受到水滴与表面接触界面的成核速率和传热速率的影响,动态水滴累积与表面润湿性密切相关,冰黏附强度反映了表面对冰的附着性和除冰的难易程度。超疏水表面具有显著的延迟结冰能力,但在低温高湿条件下,表面的超疏水性可能会减弱,甚至失效。除冰过程也可能破坏超疏水表面的微观结构,进而影响其持续的抗结冰性能。最后,对超疏水表面激光加工与抗结冰性能的未来研究方向进行了展望。

关键词：超疏水表面激光加工抗结冰非均相成核润湿理论

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借助连续的GPS TEC测量记录到的地震前电离层异常

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国际地震动态 2005年第11期26卷 63-70页

作者： J. y. liu y. J. Chuo S. J. Shan y. B. Tsai y. I. Chen S. A. Pulinets S. B. y. 马洁美

本文旨在通过全球定位系统(GPS)地面接收器得到的总电子含量(TEC)来研究地震发生前的电离层异常.利用连续15天的TEC中值和相关的四分位距(IQR)作为参考来识别1999年9月到2002年12月之间台湾地区20个M≥6.0的地震发生前的异常信号。结果... 详细信息

本文旨在通过全球定位系统(GPS)地面接收器得到的总电子含量(TEC)来研究地震发生前的电离层异常.利用连续15天的TEC中值和相关的四分位距(IQR)作为参考来识别1999年9月到2002年12月之间台湾地区20个M≥6.0的地震发生前的异常信号。结果表明在其中的16个地震发生的前5天18:00-22:00LT(LT=UT+8h)之间出现了电离层异常。80%的成功率表明用GPS TEC记录大地震前的电离层异常是有效的。

关键词：电离层(电离层扰动电离层-大气层相互作用)

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Primary.Ovarian Small Cell Carcinoma of Pulmonary.Ty.e: Analy.is of 6 Cases and Review of 31 Cases in the Literatures

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Chinese Medical Sciences Journal 2023年第2期38卷 130-137页

作者： xu Chen Hong-Ling liu Jin-Sui Wang Feng-Hui Zhao Department of Pathology Gansu Provincial HospitalLanzhou 730000China Department of Occupational Medicine Third Gansu Provincial HospitalLanzhou 730000China

Objective Primary.ovarian small cell carcinoma of pulmonary.ty.e(SCCOPT)is a rare ovarian tumor with a poor *** platinum-based chemotherapy.is the standard ***,there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low *** study.aims to investigate clinicopathological characteristics and treatment of *** We summarized the clinical,imaging,laboratorical and pathological characteristics of 37 SCCOPT cases,in which 6 cases were admitted to the Gansu Provincial Hospital from the y.ar of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese *** The median age of the studied SCCOPT cases(n=37)was 56.00(range,22-80)*** 80%of them had a stageⅢorⅣ*** patients underwent an operation and postoperative ***,all cases had a poor prognosis,with a median overall survival time of 12 *** y.the SCCOPT of all patients showed positive expressions of epithelial markers,such as CD56 and sex-determining region of y.chromosome-related high-mobility.group box 2(SOx-2),and negative expressions of estrogen receptor,progesterone receptor,vimentin,Leu-7,and somatostatin receptor *** tumor of above 80%cases expressed *** a few cases expressed neuron-specific enolase,chromogranin A,and thy.oid transcription *** SCCOPT had a poor ***-2 could be a biomarker to be used to diagnose SCCOPT.

关键词： small cell carcinoma of the ovary primary.ovarian small cell carcinoma of pulmonary.ty.e sex-determining region of y.chromosome-related high-mobility.group box 2 adjuvant chemotherapy

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