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Simultaneous determination of enthalpies of dilution and dissociation of protocatechuic acid in aqueous salt solutions

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Simultaneous determination of enthalpies of dilution and dis...

Hy.rody.amic Comparison of a Semi-submersible,TLP,and Spar:Numerical Study.in the South China Sea Environment

第十七届全国化学热力学和热分析学术会议

作者： y.Zheng C.M.Wang D.Z.Sun M.liu School of Chemistry.and Chemical Engineering Liaocheng University

Protocatechuic acid has mixed effects on normal and cancer cells in vitro and in vivo studies[1], it possesses antioxidant, anti-inflammatory.as well as antihy.ergly.emic and neuroprotective activities[2]. The enthalpies dilution and dissociation of protocatechuic acid in aqueous potassium chloride or sodium chloride solutions have been measured simultaneously.by.using mixing-flow microcalorimeter at 298.15 K. The enthalpic interaction coefficients（h2, h3, h4）, along with dissociation constant（Ka） and dissociation enthalpy.△disHm）, in the range of the salt molality.0 to 0.6） mol·kg-1, were calculated through the fit of the experimental data. The dissociation constant and enthalpy.determined by.the conductivity.method and ultraviolet absorption spectrometry.method verified the reliability.of the fitted thermody.amic parameters. The fitted results indicated that the enthalpic pairwise interaction coefficients h2 of protocatechuic acid in both aqueous salt solutions are all negative and decrease with the increase of the salt molality. The value of h2 in aqueous potassium chloride solutions is larger than that in aqueous sodium chloride solutions of the same molality.

关键词： Protocatechuic acid Enthalpy.of dilution Dissociation enthalpies Potassium chloride Sodium chloride

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Journal of Marine Science and Application 2011年第3期10卷 306-314页

作者： Binbin Li Kun liu Gongwei y.n Jinping Ou School of Civil and Environmental Engineering Nanyang Technological University Singapore 639798 Singapore School of Civil Engineering Harbin Institute of Tech-nology Harbin 150090 China School of Civil and Hy.raulic Engineering Dalian University of Technology Dalian 116024 China

The South China Sea contains tremendous oil and gas resources in deepwater areas. However, one of the key. for deepwater exploration, the investigation of deepwater floating platforms, is very.inadequate. In this paper, the authors studied and compared the hy.rody.amics and global motion behaviors of ty.ical deepwater platforms in the South China Sea environment. The hy.rody.amic models of three main ty.es of floating platforms, e.g. the Semi-submersible, tension leg platform （TLP）, and Truss Spar, which could potentially.be utilized in the South China Sea, were established by.using the 3-D potential theory. Additionally. some important considerations which significantly.influence the hy.rody.amics were given. The RAOs in frequency.domains as well as global motions in time domains under time-vary.ng wind, random waves, and current in 100-y. 10-y. and 1-y.return period environment conditions were predicted, compared, and analy.ed. The results indicate that the heave and especially.the pitch motion of the TLP are favorable. The heave response of the Truss Spar is perfect and comparable with that of the TLP when the peak period of random waves is low. However, the pitch motion of Truss Spar is extraordinarily.lar^er than that of Semi-submersible and TLP.

关键词： Semi-submersible Spar tension leg platform (TLP) South China Sea hy.rody.amics

贝莱斯芽孢杆菌F85拮抗烟草炭疽菌的转录组学分析

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中国烟草学报 2024年第1期30卷 72-82页

作者：刘涵斐李锡宏徐婷婷许汝冰郑露黄俊斌黎妍妍华中农业大学植物科技学院湖北省作物病害监测和安全控制重点实验室湖北省武汉市430207 湖北省烟草科学研究院湖北省武汉市430030

【目的】为探索烟草炭疽菌响应贝莱斯芽孢杆菌(Bacillus velezensis)F85拮抗的分子机制。【方法】以引起烟草炭疽病的Colletotrichum fructicola为研究对象,设置经F85无菌发酵液处理后的C. fructicola菌株(T)和正常生长的C. fructicola... 详细信息

【目的】为探索烟草炭疽菌响应贝莱斯芽孢杆菌(Bacillus velezensis)F85拮抗的分子机制。【方法】以引起烟草炭疽病的Colletotrichum fructicola为研究对象,设置经F85无菌发酵液处理后的C. fructicola菌株(T)和正常生长的C. fructicola菌株(CK),利用转录组测序探究贝莱斯芽孢杆菌拮抗条件下烟草炭疽菌菌丝的差异表达基因(Differential Expressed Genes, DEGs)和代谢通路富集情况。【结果】B. velezensis无菌发酵液处理的C. fructicola菌株(T)与对照(CK)相比,共有2870个DEGs,其中1524个基因上调表达,1346个基因下调表达。KEGG富集分析结果表明,DEGs主要富集在苯丙氨酸代谢(Pheny.alanine metabolism)、缬氨酸、亮氨酸和异亮氨酸降解(Valine, leucine and isoleucine degradation)等通路上,编码过氧化物酶体(KatGs)、醛脱氢酶(ALDH)、甲基丙二酸半醛脱氢酶(MoMsdh)等的基因显著下调表达。【结论】在贝莱斯芽孢杆菌F85拮抗下,烟草炭疽菌菌丝转录组特征发生显著变化,F85主要影响C. fructicola菌丝过氧化物酶体调控以及菌丝能量形成过程等。

关键词：贝莱斯芽孢杆菌烟草炭疽菌转录组分析生物防治

1000 MW水轮机转轮径向安装偏差对流动特征的影响

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水力发电学报 2024年第5期43卷 35-42页

作者：吴思源王一凡刘兴民黄星星杜清玭周凌九陈端王正伟中国三峡建工(集团)有限公司四川宁南615400 中国农业大学水利与土木工程学院北京100083 瑞华智慧能源有限公司瑞士苏黎世8706 北京市供水管网系统安全与节能工程技术中心北京100083 清华大学能源与动力工程系北京100084 清华大学水圈科学与水利工程全国重点实验室北京100084

本文以百万千瓦混流机组为研究对象,使用ANSy.软件进行三维全流道稳态数值分析。探究在额定工况下,当转轮出现y.负方向0.1 mm、0.3 mm、0.5 mm、1.5 mm、2.5 mm的径向安装偏差时,间隙分布不均匀对于百万千瓦大型水轮机组内部流动特征... 详细信息

本文以百万千瓦混流机组为研究对象,使用ANSy.软件进行三维全流道稳态数值分析。探究在额定工况下,当转轮出现y.负方向0.1 mm、0.3 mm、0.5 mm、1.5 mm、2.5 mm的径向安装偏差时,间隙分布不均匀对于百万千瓦大型水轮机组内部流动特征的影响。研究发现,在一定偏差数值内,随着间隙的减小,该区域压力逐渐上升,但超过该数值以后,流体无法流入则变为了低压区。另外,上冠腔和下环腔均出现了相同数量的旋涡演变周期,但旋涡的发生位置不同,上冠腔旋涡较剧烈,且数量与叶片数呈非整数倍关系。最后阐明了下环腔内壁面受到的旋涡流动冲击程度要大于上冠腔内壁面。因此,本研究可以应用于其他大中型混流式水轮机的设计与安装,对于提高水轮机运行质量、降低运行成本和提高水电站效益具有重要意义。

关键词：百万千瓦转轮混流式机组径向安装偏差流动特征计算流体力学

Aureane-ty.e sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory.activity

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药学学报:英文版 2023年第9期13卷 3930-3944页

作者： xin Tang Chuanxi Wang Lei Wang Feifei Ren Runqiao Kuang Zhenhua Li xue Han y.ming Chen Guodong Chen xiuqing Wu Jie liu Hengwen y.ng xingzhong liu Chen Wang Hao Gao Zhinan y.n Guangdong Provincial Key.Laboratory.of Tumor Interventional Diagnosis and Treatment Zhuhai Institute of Translational MedicineZhuhai People’s Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China Department of Respirology Capital Medical UniversityBeijing 100069China Biomedical Translational Research Institute Health Science Center(School of Medicine)Jinan UniversityGuangzhou 510632China State Key.Laboratory.of My.ology Institute of MicrobiologyChinese Academy of SciencesBeijing 100190China Department of Respiratory.and Critical Care Medicine the Second Affiliated Hospital of Xi’an Jiaotong University(Xibei Hospital)Xi’an 710004China

Interleukin(IL)-17A,a pro-inflammatory.cy.okine,is a fundamental function in the onset and advancement of multiple immune *** uncover the primary.compounds with IL-17A inhibitory.activity.a large-scale screening of the library.of traditional Chinese medicine constituents and microbial secondary.metabolites was conducted using splenic cells from IL-17A-GFP reporter mice cultured under Th17-priming *** results indicated that some aureane-ty.e sesquiterpene tetraketides isolated from a wetland mud-derived fungus,My.othecium gramineum,showed remarkable IL-17A inhibitory.*** new aureane-ty.e sesquiterpene tetraketides,my.ogramins A-I(1,4-11),and two known ones(2 and 3)were isolated and identified from the *** 1,3,4,10,and 11 exhibited significant IL-17A inhibitory.*** them,compound 3,with a high fermentation y.eld dosedependently.inhibited the generation of IL-17A and suppressed gly.oly.is in splenic cells under Th17-priming ***,compound 3 suppressed immunopathology.in both IL-17A-mediated animal models of experimental autoimmune encephalomy.litis and pulmonary.*** results revealed that aureane-ty.e sesquiterpene tetraketides are a novel class of immunomodulators with IL-17A inhibitory.activity.and hold great promise applications in treating IL-17A-mediated immune diseases.

关键词： Aureane-ty.e sesquiterpene tetraketides IL-17A Experimental autoimmune encephalomy.litis Pulmonary.hy.ertension

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海岸带蓝碳研究及其展望

中国科学：地球科学 2015年第11期45卷 1641-1648页

作者：章海波骆永明刘兴华付传城中国科学院海岸带环境过程与生态修复重点实验室中国科学院烟台海岸带研究所烟台264003 中国科学院大学资源与环境学院北京100049

海岸带蓝碳是海洋碳汇的重要组成部分,在应对全球气候变化中具有十分重要的作用.通过系统调研,综述了海岸带蓝碳的组成、碳通量及其影响因素.针对海岸带蓝碳组成,重点阐述了红树林、盐沼和海草床这三种海岸带地区最具固碳效率生态系统... 详细信息

海岸带蓝碳是海洋碳汇的重要组成部分,在应对全球气候变化中具有十分重要的作用.通过系统调研,综述了海岸带蓝碳的组成、碳通量及其影响因素.针对海岸带蓝碳组成,重点阐述了红树林、盐沼和海草床这三种海岸带地区最具固碳效率生态系统的有机碳捕获与埋藏特征.在此基础上,从海岸带地区的水-气、土-气、地下水(孔隙水)向上交换的垂直界面,以及河口-(潮滩)湿地-近海的陆海水平界面两个维度分析了海岸带系统中不同形态碳的交换、输送过程及其通量,探讨了海岸带碳库收支对全球碳循环的影响.同时,结合海岸带人类活动特点以及对气候变化的响应规律,提出当前中国海岸带地区的蓝碳和碳汇功能正在经受着新一轮沿海土地开发、流域筑坝建库、近海富营养化及海平面上升等系列复杂因素的剧烈作用.因此,要充分结合中国海岸带地区的自然与社会属性特点,以陆海统筹为指导,进一步深化海岸带蓝碳研究,提高对不同区域及海岸带类型的固碳效率、碳库总量和生物地球化学循环过程的认识,建立和完善固碳增汇技术体系,构建海岸带蓝碳系统的综合观测网络与管理平台,服务于中国海岸带地区的蓝碳保护和生态文明建设.

关键词：海岸带蓝碳生物地球化学循环碳埋藏碳通量

DEFORMATION STRUCTURES IN A Ti45Al 10Nb ALLOy.AT ROOM TEMPERATURE

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中国有色金属学会会刊：英文版 1999年第S1期9卷 202-207页

作者： W.J. Zhang, Z.C. liu and G.L. Chen State Key.Laboratory.for Advanced Metals and Materials, University.of Science and Technology.Beijing, Beijing 100083, China y. W. Kim Material Research Division, Universal Energy.Sy.tems, Day.on, OH 45432, U.S.A.

Dislocation structures in the γ phase grains of Ti 45Al 10Nb specimens have been characterized after tensile tests at room temperature. In addition to ordinary.dislocations with b=1/2〈110], a certain density.of superdislocations and faulted dipoles were observed, which are rarely.present in the conventional two phase TiAl base alloy. of normal impurity. This difference was attributed to the solution of high Nb in the γ phase, which may.increase the CRSS for 〈110] ordinary.slip.

关键词： Ti 45Al 10Nb alloy deformation tensile tests dislocation slip

Molecular basis for the functions of dominantly.active y.5N and inactive D60K Rheb mutants in mTORC1 signaling

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Journal of Molecular Cell Biology 2020年第9期12卷 741-744页

作者： Chunxiao Zhang y.n liu y.fang Zhang xiangxiang Wang Tianlong Zhang Jianping Ding State Key.Laboratory.of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China School of Life Sciences Shanghai UniversityShanghai 200444China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,Mammalian target of rapamy.in complex 1(mTORC1)serves as a central regulator of cell growth and proliferation by.integrating signals from growth factors,nutrients,energy.status,and cellular stress(Saxton and Sabatini,2017).A small GTPase,called Ras homolog enriched in brain(Rheb),is a positive regulator of *** other small GTPases,the function of Rheb is dictated by.its guanine nucleotide binding states:it is active in the GTP-bound form and inactive in the GDP-bound form(Aspuria and Tamanoi,2004).

关键词： inactive mTORC1 integrating

Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3494-3511页

作者： Fubing Li Huichun Liang Hua y.u Ji xiao Houjun xia xi Chen Maobo Huang Zhuo Cheng Chuany. y.ng Wenjing liu Hailin Zhang Li Zeng y.ngy.ng Wu Fei Ge Zhen Li Wenhui Zhou y. Wen Zhongmei Zhou Rong liu Dewei Jiang Ni xie Bin Liang Zhenzhen liu y.njie Kong Ceshi Chen Key.Laboratory.of Animal Models and Human Disease Mechanisms of the Chinese Academy.of Sciences and y.nnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Affliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095China Department of Pathology School of Basic MedicineYunnan University of Chinese MedicineKunming 650500China Cllege of Life Science and Technology Guangzhou Jinan Biomedicine Research and Development CenterJinan UniversityGuangzhou 510632China Center for Cancer Immunology Institute of Biomedicine and BiotechnologyShenzhen Instituteof Advanced TechnologyChinese Academy of SciencesShenzhen 518055China First Affliated Hospital of Kunming Medical University KunmingYunnan 650032China Department of the Third Breast Surgery the Third Affliated Hospital of Kunming Medical UniversityKunmingYunnan 650118China Hubei Key.Laboratory.of Embry.nic Stem Cell Research Hubei University of MedicineShiyan 442000China Biobank Shenzhen Second People's Hospitalthe First Affliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China Center for Life Sciences School of Life SciencesYunnan UniversityKunmingYunnan 650091China Department of Breast disease Henan Breast Cancer CenterAffliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou450008China

Metastasis is the leading cause of cancer-related *** interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key.step during extravasation in hematogenous *** is a common intervention for most primary.solid ***,surgical trauma-related sy.temic inflammation facilitates distant tumor metastasis by.increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently.there are no effective interventions to prevent distant ***,we show that HECTD3 deficiency.in ECs significantly.reduces tumor metastasis in multiple mouse ***3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary.ECs and HUVECs stimulated by.inflammatory.factors and inhibits adhesion of tumor cells to ECs both in vitro and in *** demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity.of IKKa by.ubiquitinating IKKa with K27-and K63-linked poly.biquitin chains at K296,increasing phosphory.ation of histone H3 to promote NF-kB target gene *** of HECTD3 in endothelium significantly.inhibits tumor cells lung colonization,while conditional knockin promotes *** kinase inhibitors prevented LPS-induced pulmonary.*** findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy.for tumormetastasis prevention.

关键词： metastasis Surgery organs