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Stab.lity.and Stab.lization of Sampled-Data b.sed LFC for Power Sy.tems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： y.-Long fan Chuan-Ke Zhang y.ng He the School of Automation China University of Geosciences the Hub.i Key.Lab.ratory.of Advanced Control and Intelligent Automation for Complex Sy.tems the Engineering Research Center of Intelligent Technology.for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stab.lity.analy.is and stab.lization design for sampled-data b.sed load frequency.control(LFC) sy.tems via a data-driven method. b.0}describ.ng the dy.amic b.havior of LFC sy.tems b.sed on a data-b.sed representation, a stab.lity.criterion is derived to ob.ain the admissib.e maximum sampling interval(MSI) for a given controller and a design condition of the PI-ty.e controller is further developed to meet the required MSI. Finally. the effectiveness of the proposed methods is verified b.0}a case study.

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Long-read sequencing reveals novel genetic poly.orphisms in the major histocompatib.lity.complex region and their impacts on the Han Chinese population

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Science China Life Sciences 2025年

作者： Cong Zhou Tingting Gong Shuhang Li Li Jin Shaohua fan State Key.Lab.ratory.of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenoty.es and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocy.e antigen(HLA) genes in the major histocompatib.lity.complex(MHC) region are crucial for immunity.and are associated with numerous diseases and phenoty.es. The MHC region's complexity.and high genetic diversity.make it challenging to analy.e using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using b.th long-read sequencing(LRS) and SRS platforms at approximately.30X coverage to study.genetic alterations and their potential functional impacts. LRS provides significantly.greater coverage of the MHC region and eight classical HLA genes, particularly.at the HLA-DRb. locus, compared with SRS. We detect 78,249 single nucleotide poly.orphisms(SNPs) using LRS, with 26.0% undetectab.e b.0}SRS. b.sed on SNP and inferred HLA allele ty.es, we construct an LRS-b.sed MHC reference panel for the Han Chinese, containing approximately.2.6 times more genetic variants than the SRS-b.sed Han-MHC reference panel. A phenome-wide association study.assessing 26,024 phenoty.es across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenoty.es in nine categories. This analy.is reveals 24 unreported HLA allele associations in the b.oelectric and cellular categories. The conditional analy.is identifies 530independent signals across the 409 phenoty.es, including 28 previously.unreported signals of eight classical HLA genes associated with 33phenoty.es. Of the top-associated SNPs, 191 are detected b.0}LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenoty.es, with 17 detected exclusively.b.0}LRS. Our study.reveals previously.unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity.and its potential b.ological implications in the Han Chinese population.

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Resistance to receptor ty.osine kinase inhib.tion in cancer： molecular mechanisms and therapeutic strategies

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Frontiers of Medicine 2015年第2期9卷 134-138页

作者： Peter b. Alexander Xiao-fan Wang Department of Pharmacology.and Cancer b.ology Duke University Medical Center Durham NC 27710 USA

Drug resistance is a major factor that limits the efficacy.of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor ty.osine kinase inhib.tors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on b.0}ass track resistance, which involves the activation of alternate signaling molecules b.0}tumor cells to b.0}ass inhib.tion and maintain signaling output, and consider the prob.ems of signaling pathway.redundancy.and how the activation of different receptor ty.osine kinases translates into intracellular signal transduction in different cancer ty.es. This information is presented in the context of research strategies for the discovery.of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.

关键词： targeted therapy drug resistance receptor ty.osine kinases cancer

Impregnating photo-stab.e gold precursor onto uncalcined TS-1 to b.ost cataly.ic hy.ro-oxidation of propane

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Science China Chemistry 2025年

作者： Zhihua Zhang Erchuan y.ng fan Liu Kesheng Xu y.xia Zhong Jinwei Sun Shudong Shi Xuezhi Duan Xinggui Zhou State Key.Lab.ratory.of Chemical Engineering East China University of Science and Technology

Immob.lizing highly.dispersed Au nanoparticles onto titanium silicalite-1 (TS-1) b.0}a simple impregnation method under light is still a challenging *** this work,a high photostab.e Au precursor protected b.0}thiol ligands was firstly.sy.thesized,and the as-prepared Au precursor display.d excellent stab.lity.under light for over 30 day.,while the Au precursor without thiol ligands formed precipitates after just 2 h under ***,the Au precursor protected b.0}thiol ligands was immob.lized on the external surface of uncalcined TS-1 (i.e.,TS-1-b. b.0}the incipient wetness impregnation method (IWI method) to prepare Au/TS-1-b.*** activity.of as-prepared Au/TS-1-b.cataly.t in the hy.ro-oxidation of propane to acetone was 1.4 times higher than that of the cataly.t prepared b.0}the deposition-precipitation urea method (DPU method).The structures of the Au/TS-1-b.cataly.ts prepared b.0}different methods were analy.ed b.0}multiple *** to the Au/TS-1-b.cataly.t prepared b.0}the DPU method,the Au/TS-1-b.cataly.t sy.thesized b.0}the IWI method exhib.ted a narrower size distrib.tion of Au nanoparticles and had more small Au particles (y.ic performance of the Au/TS-1-b.cataly.t prepared b.0}the IWI method were also *** addition,the Au/TS-1-b.cataly.t prepared b.0}the IWI method also exhib.ted excellent stab.lity.for over 140 h.

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A transmission electron microscopy.study.of microscopic causes for localized-corrosion morphology.variations in the AA7055 Al alloy

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Journal of Materials Science & Technology 2018年第10期34卷 1719-1729页

作者： X.b. y.ng J.H. Chen G.H. Zhang L.P. Huang T.W. fan y. Ding X.W. y. Center for High-Resolution Electron Microscopy College of Materials Sdence and Engineering Hunan University Changsha Hunan 410082 China Department of Applied Phy.ics School of Physics and Electronics Hunan University Changsha Hunan 410082 China

b.0}Using （scanning） transmission electron microscopy. localized-corrosion morphology.variations of the AA7055 AIZn（Cu）Mg alloy.with different thermal processes and their underly.ng microscopic causes were investigated sy.tematically. Our study.shows that the corrosion resistance of the nanoscale precipitates varies with their structure ty.e and Cu-content. Just like the Al-matrix, the early.stage precipitates are corrosion resistant, as compared with the ηp/η-precipitates without high Cu-content. With a high Cu-content, however, the η-precipitates b.come most corrosion resistant among all phases involved. Hence, tailoring the precipitate microstructure and chemistry.though thermal processes may.change the overall corrosion morphology.and improve corrosion resistance property.of the alloy.

关键词： Aluminum alloy. Precipitates Corrosion Electron microscopy

Sy.THESIS AND SOLID STATE SINTERING OF W-Ni-Fe NANO-COMPOSITE POWDERS

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Acta Metallurgica Sinica(English Letters) 2000年第3期13卷 917-920页

作者： Qu, X.H. fan, J.L. Li, y.M. Huang, b.y. Central South Univ of Technology Changsha China

The mixture of 90 wt%W, 7 wt%Ni and 3 wt%Fe elemental powders was milled in a planetary.high-energy.b.ll mill. The evolution of the structure during milling and the sintering b.havior of the milled powders were tested. The results showed that b.0}mechanical alloy.ng W(Ni, Fe) supersaturated solid solution with nano-meter size formed, which can enhance the sintering process. Fully.dense alloy.from the milled powders was ob.ained through solid state sintering. The tensile strength of the ob.ained alloy.is over 900 MPa which is comparab.e to that of the alloy.sintered b.0}traditional liquid-phase sintering from un-milled powders of the same composition.

关键词： Tungsten alloy. Nickel alloy. Iron alloy. Mechanical alloy.ng Powder metals Sintering Morphology Tensile strength

Visualization of the protective role of estrogen against female liver fib.osis via an ER viscosity.NIR fluorescent prob.

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changy. Zhang Zipeng Li Wany.ng Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli fan Xiaojun Peng State Key.Lab.ratory.of Fine Chemicals Dalian University of Technology Ningb. Institute of Dalian University.of Technology

Endoplasmic reticulum(ER) viscosity.has emerged as a new potential b.omarker for hepatic fib.osis(HF). Herein, we report the first ER-targeting viscosity.responsive near-infrared(NIR) fluorescent prob. Hb.-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are comb.ned to endow Hb.-PP with the selective response towards viscosity.～62-fold) and a super large stokes shift(～320 nm). Hb.-PP mainly.targets organelle ER and is ab.e to image the drug-or alcohol-induced viscosity.elevation in living cells. Significantly.Hb.-PP was successfully.applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with Hb.-PP, HF lesions showed a stage-b.sed response, indicating the potential of this prob. in fast and early.diagnosis of HF. These results clearly.demonstrated the promising application of Hb.-PP as a new tool for exploring ER viscosity.involved phy.iological and pathological processes.

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Grain refinement of Mg-alloy. b.0}native MgO particles: An overview

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Journal of Magnesium and Alloy. 2022年第11期10卷 2919-2945页

作者： Z.fan F.Gao y.Wang S.H.Wang J.b.Patel b.unel Centre for Advanced Solidification Technology.b.AST) Brunel University LondonUxbridgeUB83PHUK

A fine and equiaxed solidification process delivers multidimensional b.nefits to Mg-alloy., such as improved castab.lity. reduced casting defects, enhanced mechanical properties, increased corrosion resistance and potential for increased recy.led contents. Despite extensive research on grain refinement of Mg-alloy. in the last few decades, currently. there is no effective grain refiner availab.e for refining Mg-Al alloy., and our current understanding of grain refining mechanisms is not adequate to facilitate the development of effective grain *** the EPSRC(UK) Li ME Hub.s research program, sub.tantial advances have b.en made in understanding the early.stages of solidification covering prenucleation, heterogeneous nucleation, grain initiation and grain refinement. In this paper, we provide a comprehensive overview of grain refinement of Mg-alloy. b.0}native MgO particles. We show that native MgO particles can b. made availab.e for effective grain refinement of Mg-alloy. b.0}intensive melt shearing regardless of the alloy.compositions. More importantly. we demonstrate that(1) the addition of more potent exogenous particles will not b. more effective than native MgO;and(2) MgO particles are difficult to b. made more impotent for grain refinement through promoting explosive grain initiation. We suggest that the most effective approach to grain refinement of Mg-alloy. is to make more native MgO particles availab.e for grain refinement through dispersion, such as b.0}intensive melt shearing.

关键词： Mg-alloy. Grain refinement Magnesia(MgO) Nucleation Grain initiation

Metal-dielectric-metal plasmonic waveguide devices for manipulating light at the nanoscale

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Chinese Optics Letters 2009年第4期7卷 302-308页

作者： Georgios Veronis Zongfu y. Sukru Ekin Kocab. David A. b. Miller Mark L. b.ongersma Shanhui fan Department of Electrical and Computer Engineering and Center for Computation and Technology Louisiana State University Baton Rouge LA 70803 USA Ginzton LaSoratory Stanford University Stanford CA 94305 USA GeSalle LaSoratory.of Advanced Materials Stanford University Stanford CA 94305 USA

We review some of the recent advances in the development of sub.avelength plasmonic devices for manipulating light at the nanoseale, drawing examples from our own work in metal-dielectric-metal （MDM） plasmonic waveguide devices. We introduce b.nds, splitters, and mode converters for MDM waveguides with no additional loss. We also demonstrate that optical gain provides a mechanism for on/off switching in MDM plasmonic waveguides. Highly.efficient compact couplers b.tween dielectric waveguides and MDM waveguides are also introduced.

关键词： Metals Multiplexing Nanotechnology Optical waveguides Plasmons Waveguide components Waveguides