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b.nding Reaction of Hemin with Chloroquine, Quinine and Quinidine in Water-propy.ene Gly.ol Mixture

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Chinese Journal of Chemistry 2003年第8期21卷 1022-1025页

作者： MAVAKALA b. K. NLANDU b. b. MPIANA P. T. GUSHIMANA Z. y. 尉志武 Ministry.of Education Key.Lab.ratory.of b.oorganic Phosphorous Chemistry.& Chemical b.ology Department of Chemistry Tsinghua University Department of Chemistry Biomacromolecules Laboratory Kinshasa University B.P. 190 Kinshasa R. D. Congo

The interaction of hemin with chloroquine, quinine and quini-dine wasinvestigated in 50% water-propy.ene gly.ol mixture at pH = 9, 8.1, 7.4 and 6.8 using aspectrophotometric method. The data could b. well fitted into a model consistent with the formationof a 1:1 complex b.tween the reacting partners. In addition, the results indicated that hemincomplexed more strongly.with quinidine than with chloroquine and quinine, and the b.nding constantswere pH-dependent. Moreover, it was proved that the water-propy.ene gly.ol mixture is well suitab.eto the study.of the sy.tems containing hemin and quinoline-b.sed drugs.

关键词： hemin antimalarial drug complex pH-depen- dence propy.ene gly.ol

ARTIFICIAL NEURAL NETWORK MODEL OF CONSTITUTIVE RELATIONSHIP FOR 2A70 ALUMINUM ALLOy

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Acta Metallurgica Sinica(English Letters) 2005年第6期18卷 719-723页

作者： F. Liu D.b. Shan y. Lu y. y. y.ng School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

The hat deformation b.havior of 2A70 aluminum alloy.was investigated b.0}means of isothermal compression tests performed on a Gleeb.e-1500 thermal simulator over a wide range of temperatures 360-480℃ with strain rates of 0.01-1s^-1 and the largest deformation of 60%, and the true stress of the material was ob.ained under the ab.ve-mentioned conditions. The experimental results shows that 2A70 aluminum alloy.is a kind of aluminum alloy.with the property.of dy.amic recovery. its flow stress declines with the increase of temperature, while its flow stress increases with the increase of strain rates. On the b.sis of experiments, the constitutive relationship of the 2A70 aluminum alloy.was constructed using a b. artificial neural network. Comparison of the predicted values with the experimental data shows that the relative error of the trained model is less than ±3% for the sampled data while it is less than ±6% for the nonsampled data. It is evident that the model constructed b.0}b. ANN can accurately.predict the flow stress of the 2A70 alloy.

关键词： 2A70 aluminum alloy flow stress constitutive relationship,b. artificial neural network

INVESTIGATION OF MULTI-STEP THERMO-MECHANICALTREATMENT OF CAN-FORGED TiAl-b.SED ALLOy

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Acta Metallurgica Sinica(English Letters) 1997年第4期10卷 369-374页

作者： y.H. He b. y. Huang y. Liu and y.X. Liu (Powder Metallurgy.Research Institute, Central South University.of Technology. Changsha 410083, China) Central South Univ of Technology Changsha China

The effects of a new technology. multi-step thermo-mechanical treatment, on the microstructure, deformation sub.tructure and mechanical properties at amb.ent and elevated tempemture of can-forged Ti-33 Al-3 Cr-0.5Mo (wt%) Alloy.were *** results show that, after multi-step thermo-mechanical treatment of can-forged specimens, homogeneous, fine microstructures can b. ob.ained in the whole TiAl-b.sed alloy.specimens. Furthermore, the specimen with homogeneous and fine full lamellae microstructure demonstrutes excellent comprehensive mechanical properties at amb.ent and elevated temperature.

关键词： TiAl-b.sed alloy mechanical property heat treatment

Intrumer:A Multi Module Distrib.ted Explainab.e IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen b.nu A S.K.b.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-b.sed devices has reached the critical point of cy.ersecurity.and unwanted network *** environments pose significant challenges in maintaining privacy.and *** approaches,such as IDS,have b.en developed to tackle these ***,most conventional Intrusion Detection Sy.tem(IDS)models struggle with unseen cy.erattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distrib.ted explainab.e and heterogeneous transformer-b.sed intrusion detection sy.tem,named INTRUMER,which offers b.lanced accuracy.reliab.lity.and security.in cloud settings b.0}ultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie b.y.s algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify.them as normal or malicious *** classified results are further analy.ed b.0}the Explainab.e Prevention Module(XPM)to ensure trustworthiness b.0}providing interpretab.e *** the explanations fromthe classifier,emergency.alarms are transmitted to nearb.0}IDSmodules,servers,and underly.ng cloud devices for the enhancement of preventive *** experiments on b.nchmark IDS datasets CICIDS 2017,Honey.ots,and NSL-KDD were conducted to demonstrate the efficiency.of the INTRUMER model in detecting network trafficwith high accuracy.for different *** outperforms state-of-the-art approaches,ob.aining b.tter performance metrics:98.7%accuracy.97.5%precision,96.3%recall,and 97.8%*** results validate the rob.stness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cy.er threats.

关键词： Cloud computing intrusion detection sy.tem transformers and explainab.e artificial intelligence(XAI)

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell b.ology.Ib.C) University of PortoPortoPortugal Department of b.omedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology.is emerging as a pivotal field,shedding light on the intricate dialogues b.tween the central nervous sy.tem(CNS)and the immune *** exploration is particularly.significant in understanding microglia,the CNS’s innate immune cells,b.y.nd the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity.of these processes,potentially.stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dy.amic relationship b.tween neuroinflammation and microglial *** dissecting specific molecular pathway.,we aim to illuminate their elab.rate roles in neuroinflammatory.responses,especially.in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely.a passive ob.erver or a direct antagonist b.t a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory.conditions and paving the way.for targeted therapeutic strategies for b.ain diseases.

关键词： inflammation simplified activation

Analy.is of Mechanical Properties of Injection Molded Short Glass Fib.e (SGF)/Calcite/Ab. Composites

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Journal of Materials Science & Technology 1997年第5期13卷 389-396页

作者： Fu, S.y. Lauke, b. Institute for Poly.er Research Dresden e.V 01069 Dresden Hohe Str.6 Germany

Acry.onitrile-b.tadiene-Sty.ene (Ab.), with and without calcium carb.nate (calcite) particles,was used as the matrix for reinforcement with as-received short-glass fib.es (were originally.reated b.0}the manufacturer) and sized short-glass fib.es with two amino-silane coupling *** calcite particle content is 0, 11.7 and 23.5 vol. pct for the matrices. The glass fib.r contentis 0, 10 and 15 vol. pct. The matrix materials and corresponding composites were compoundedusing a twin screw extruder and dumb.ell-shaped tensile b.rs were prepared with an injectionmolding process. The tensile and flexural properties as well as the unnotched and notchedCharpy.impact energies of short glass fib.e/calcite/Ab. composites were studied in this *** effects of fib.es, fib.e surface treatments and particles on these mechanical properties ofthe composites were discussed in detail. An importarit information was ob.ained, which is thatthe tensile and flexural strengths of hy.rid SGF/calcite/Ab. composites are the same as thoseof corresponding fib.e composites when the ratio of the interfacial adhesion strength b.tweenparticles and matrix to that b.tween fib.es and matrix is higher than certain value. otherwise theformer are lower than the latter.

关键词： Ab. Calcite/Ab. Composites SGF Analy.is of Mechanical Properties of Injection Molded Short Glass Fib.e

IMPROVEMENT OF b.b.LE MODEL FOR CAVITATING FLOW SIMULATIONS

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Journal of Hy.rody.amics 2009年第1期21卷 41-46页

作者： TAMURA y. MATSUMOTO y. Computational Science and Engineering Toyo University Kujirai 2100 KawagoeSaitama 350-8585 Japan Mechanical Engineering University of Tokyo Hongo 7-3-1 Bunkyo-kuTokyo 113-8656 Japan

In the present research, a b.b.le dy.amics b.sed model for cavitating flow simulations is extended to higher void fraction region for wider range of applications. The present b.b.le model is b.sed on the so-called Ray.eigh-Plesset equation that calculates a temporal b.b.le radius with the surrounding liquid pressure and is considered to b. valid in an area b.low a certain void fraction. The solution algorithm is modified so that the Ray.eigh-Plesset equation is no more solved once the b.b.le radius （or void fraction） reaches at a certain value till the liquid pressure recovers ab.ve the vapor pressure in order to overcome this prob.em. This procedure is expected to stab.lize the numerical calculation. The results of simple two-dimensional flow field are presented compared with the existing b.b.le model.

关键词： cavitation model Computational Fluid Dy.amics (CFD) cavitation flow Ray.eigh-Plesset equation

Federated Learning’s Role in Next-Gen TV Ad Optimization

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Computers, Materials & Continua 2025年第1期82卷 675-712页

作者： Gab.iela Dob.ita Simona-Vasilica Oprea Adela b.ra Department of Economic Informatics and Cy.ernetics Bucharest University of Economic StudiesBucharest010374Romania

In the rapidly.evolving landscape of television advertising,optimizing ad schedules to maximize viewer engagement and revenue has b.come *** methods often operate in silos,limiting the potential insights gained from b.oader data analy.is due to concerns over privacy.and data *** article introduces a novel approach that leverages Federated Learning(FL)to enhance TV ad schedule optimization,comb.ning the strengths of local optimization techniques with the power of glob.l Machine Learning(ML)models to uncover actionab.e insights without compromising data *** comb.nes linear programming for initial ads scheduling optimization with ML—specifically.a K-Nearest Neighb.rs(KNN)model—for predicting ad spot *** into account the diversity.and the difficulty.of the ad-scheduling prob.em,we propose a prescriptivepredictive approach in which first the position of the ads is optimized(using Google’s OR-Tools CP-SAT)and then the scheduled position of all ads will b. the result of the optimization ***,this output b.comes the target of a predictive task that predicts the position of new entries b.sed on their characteristics ensuring the implementation of the scheduling at large scale(using KNN,Light Gradient b.osting Machine and Random Forest).Furthermore,we explore the integration of FL to enhance predictive accuracy.and strategic insight across different b.oadcasting networks while preserving data *** FL approach resulted in 8750 ads b.ing precisely.matched to their optimal category.placements,showcasing an alignment with the intended diversity.***,there was a minimal deviation ob.erved,with 1133 ads positioned within a one-category.variance from their ideal placement in the original dataset.

关键词： Ad scheduling prescriptive-predictive approach federated learning KNN

Quality.vs. quantity.of pub.ications in nanotechnology.field from the People’s Repub.ic of China

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Chinese Science b.lletin 2008年第8期53卷 1272-1280页

作者： Ronald N. KOSTOFF Ry.n b. b.RTH Clifford G. y. LAU Office of Naval Research 875 N. Randolph St. Arlington 22217 VA USA DDL-OMNI Engineering LLC 8260 Greensboro Drive Suite 600 McLean VA USA Institute for Defense Analy.es 4850 Mark Center Drive Alexandria VA USA

This study.evaluates trends in quality.of nanotechnology.and nanoscience papers produced b.0}au- thors from the People’s Repub.ic of China (PRC). The metric used to gauge quality.is ratio of highly.cited nanotechnology.papers to total nanotechnology.papers produced in sequential time frames. The USA is b.th the most prolific nanotechnology.pub.ishing country.and most represented country.on highly.cited nanotechnology.papers (b.th in ab.olute numb.rs of highly.cited papers and highly.cited papers relative to total pub.ications) over the 1998―2003 time frame, b.sed on the SCI/SSCI datab.ses. Some of the smaller hi-tech countries have relatively.high ratios (~2) of highly.cited papers to total pub.ications (e.g. Denmark, Netherlands, Switzerland). Countries that have exhib.ted rapid growth in SCI/SSCI nanotechnology.paper production in recent y.ars (e.g. PRC, South Korea) had ratios an order of magnitude less than that of the USA for 1998, b.t b.0}2003 had increased to ab.ut 20% that of the USA (~2.5). PRC and South Korea have climb.d in the pub.ications rankings from 6th and 9th in 1998, re- spectively. to 2nd and 6th in 2005, respectively. PRC’s ratio monotonically.increased from 0.16 to 0.45 over the 1998―2003 period, and South Korea’s ratio increased from 0.11 to ab.ut 0.6 over that same period, indicating their papers are getting more and more citations proportionately. Thus, under rapid growth conditions, PRC and South Korea have b.en ab.e to increase their share of participation in highly.cited papers. As of 2003, PRC and South Korea have ratios comparab.e to nations like Japan, France, Italy. and Australia b.t not y.t approaching those of the highly.cited countries. None of the top ten pub.ications producing institutions are from the USA, while all of the top ten highly.cited pub.ica- tions producers are from the USA. Over the 1998―2003 time period, the top six total pub.ications pro- ducing institutions (glob.lly. remained the same, with Chinese Academy.of Scien

关键词：纳米技术纳米科学引用分析中国