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Response Evaluation Using Contrast-Enhanced Ultrasound for Unresectable Advanced Hepatocellular Carcinoma Treated With Ty.osine Kinase Inhibitors Plus Anti-PD-1 Antibody.Therapy

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COMPUTATIONAL SIMULATION OF RIVER SEDIMENTATION AND MORPHOLOGy.—A REVIEW OF THE STATE OF THE ART

Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zhao C.-K. Guan X. Pu y.-y. Zhou B.-y. wang L.-F. Sun y.-K. y.n H.-H. Xia H.-S. wang X. Han H. Xu H.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China Central Laboratory.and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work described here was to evaluate the role of contrast-enhanced ultrasound (CEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (HCC) treated with ty.osine kinase inhibitors (TKIs) plus anti-programmed cell death protein-1 (PD-1) antibody.therapy. Methods: A prospective cohort of consecutive patients with HCC who received combined TKI/anti-PD-1 antibody.treatment for unresectable HCC between January.2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and CEUS examinations before treatment and at follow-up. Changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography.(MRI/CT) and modified RECIST (mRECIST) with CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 HCC patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y. Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrahepatic target tumors) were studied. Calculations of degree of necrosis in the target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between RECIST version 1.1 of unenhanced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody.therapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody Contrast-enhanced ultrasound Hepatocellular carcinoma

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International Journal of Sediment Research 2005年第1期20卷 7-29页

作者： Sam S. y. wang F.A.P. Barnard Distinguished Prof. National Center for Computational Hy.roscience and Engineering MS 38677 The University.of Mississippi USA

In this paper, the state-of-the-art computational simulation technologies for river sedimentation and morphology.are comprehensively.reviewed. Emphasis is on computational modelling, which includes mathematical modelling equations and closures, numerical solution methods, verification and validation, model integration, and applications. Several important areas of future research are recommended.

关键词： River sedimentation Morphological processes Computational simulation

Nucleo-cy.oplasmic communication in apoptotic response to genotoxic and inflammatory.tress

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Cell Research 2005年第1期15卷 43-48页

作者： Jean y. J. wang La Jolla USA CA 92093-0322 San Diego Division of Biological Sciences and Moores Cancer Center University.of California

Genotoxic agents or inflammatory.cy.okines activate cellular stress responses and trigger programmed cell death. We have identified a signal transduction module, including three nuclear proteins that participate in the regulation of cell death induced by.chemotherapeutic agents and tumor necrosis factor (TNF). In this nuclear signaling module, retino- blastoma protein (Rb) functions as an inhibitor of apoptotic signal transduction. Inactivation of Rb by.phosphory.ation or caspase-dependent cleavage/degradation is required for cell death to occur. Rb inhibits the Abl ty.osine kinase. Thus, Rb inactivation is a pre-requisite for Abl activation by.DNA damage or TNF. Activation of nuclear Abl and its down- stream effector p73 induces mitochondriadependent cell death. The involvement of these nuclear signal transducers in TNF induced apoptosis, which does not require new gene expression, indicates that nuclear events other than transcrip- tion can contribute to extrinsic apoptotic signal transduction.

关键词： apoptosis DNA damage mitochondria TNF Rb Abl p73 p53.

DEPTH-AVERAGED 2-D CALCULATION OF FLOW AND SEDIMENT TRANSPORT IN CURVED CHANNELS

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International Journal of Sediment Research 2004年第4期19卷 241-257页

作者： Sam S. y. wang Director Distinguished Professor MS 38677 National Center for Computational Hy.roscience and Engineering The University.of Mississippi USA

The helical flow significantly.affects the flow, sediment transport and morphological evolution in curved channels. A semi-empirical formula is proposed to determine the cross-stream distribution of the helical flow intensity.in the developed regions of a channel bend. It is then used to evaluate the dispersion terms in the depth-averaged 2-D momentum equations and suspended-load transport equation as well as the bed-load transport angle, thus enhancing the depth-averaged 2-D model to account for the effect of helical flow. The tests in several experimental and field cases show that the enhanced depth-averaged 2-D model can much more reasonably.predict the shifting of main flow from inner bank to outer bank, the erosion along outer bank and deposition along inner bank than the depth-averaged 2-D model without considering this effect.

关键词： Secondary.flow Channel bends Dispersion Unsteady.flow Sediment transport Two- dimensional model Finite volume method

Fluctuating hy.rody.amic methods for fluid-structure interactions in confined channel geometries

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Applied Mathematics and Mechanics(English Edition) 2018年第1期39卷 125-152页

作者： y. wang H. LEI P.J. ATZBERGER Department of Mathematics University of California Santa Barbara Santa Barbara CA 93106 U. S. A. Pacific Northwestern National Laboratories Richland WA 99354 U. S. A.

We develop computational teractions subject to thermal fluctuations geometry. The methods take into account methods for the study.of fluid-structure in- when confined within channels with slit-like the hy.rody.amic coupling and diffusivity.of microstructures when influenced by.their proximity.to no-slip walls. We develop stochas- tic numerical methods subject to no-slip boundary.conditions using a staggered finite volume discretization. We introduce techniques for discretizing stochastic sy.tems in a manner that ensures results consistent with statistical mechanics. We show how an exact fluctuation-dissipation condition can be used for this purpose to discretize the stochastic driving fields and combined with an exact projection method to enforce incompressibil- ity. We demonstrate our computational methods by.investigating how the proximity.of ellipsoidal colloids to the channel wall affects their active hy.rody.amic responses and passive diffusivity. We also study.for a large number of interacting particles collective drift-diffusion dy.amics and associated correlation h/actions. We expect the introduced stochastic computational methods to be broadly.applicable to applications in which con- finement effects play.an important role in the dy.amics of microstructures subject to hy.rody.amic coupling and thermal fluctuations.

关键词： fluctuating Eulerian-Lagrangian method hy.rody.amics immersed (SELM) ellipsoidal colloid boundary.method stochastic mobility nanochannel

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语义创新与方言的亲缘关系

方言 2005年第2期27卷 157-167页

作者：汪锋王士元北京大学北京100871 香港中文大学

本文提出语义创新可以作为衡量亲缘关系(genetic relationship)的特征。根据基本词的语义创新, 我们尝试以汉语方言为例探讨语言的亲缘关系,运用一个俭省(parsimonious)程序--PENNy.来进行汉语方言亲缘关系的量化分析。本文主要希望在... 详细信息

本文提出语义创新可以作为衡量亲缘关系(genetic relationship)的特征。根据基本词的语义创新, 我们尝试以汉语方言为例探讨语言的亲缘关系,运用一个俭省(parsimonious)程序--PENNy.来进行汉语方言亲缘关系的量化分析。本文主要希望在研究方法上作一个新的探索。

关键词：语义创新方言亲缘关系汉语俭省程序

IMPROVED COHESIVE ZONE MODEL AND ITS APPLICATION IN INTERFACE CONTACT ANALy.IS

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Acta Metallurgica Sinica(English Letters) 2008年第4期21卷 295-302页

作者： y. wang J. Chen H.B. Li National Die ＆ Mold CAD Engineering Research Center Shanghai Jiaotong University Shanghai 200030China

An improved interface cohesive zone model is developed for the simulation of interface contact, under mixed-mode loading. A new debonding initiation criterion and propagation of debonding law, taking into account the pressure stress influence on contact shear strength, is proposed. The model is implemented in a finite-element program using subroutine VUINTER of ABAQUS Explicit. An edge-notch four-point bending process and laminated vibration damping steel sheet punch forming test are simulated with the improved model in ABAQUS Explicit. The numerical predictions agree satisfactorily.with the corresponding experimental results.

关键词： Cohesive zone model Mixed mode Damage criterion Contact stress

Habitat relationships of reptiles in pine beetle disturbed forests of Alabama,*** guidelines for a modified drift-fence sampling method

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Current Zoology 2010年第4期56卷 411-420页

作者： W. B. SUTTON y. wang C. J. SCHWEITZER Department of Natural Resources and Environmental Sciences Alabama A＆M University Normal AL 35762 USA USDA Forest Service Southern Research Station PO Box 1568 Normal AL 35762 USA

Understanding vertebrate habitat relationships is important to promote management strategies for the longterm conservationof many.species. Using a modified drift fence method, we sampled reptiles and compared habitat variables within theWilliam B. Bankhead National Forest (BNF) in Alabama, U.S.A from April 2005 to June 2006. We captured 226 individual reptilesrepresenting 19 species during 564 total trap nights. We used canonical correspondence analy.is to examine habitat associationsfor the reptiles sampled and we detected a distinct habitat gradient ranging from sites with greater litter depth and percentcanopy.cover to more open sites with greater woody. herbaceous, and coarse woody.debris (CWD) coverage, and CWD *** brown skinks Scincella lateralis and eastern worm snakes Carphophis a. amoenus were associated with sites with greaterlitter depth and canopy.cover, whereas eastern fence lizards Sceloporus undulatus, copperheads Agkistrodon cnntortrix, and gray.atsnakes Pantherophis spiloides were associated with sites possessing greater CWD coverage and volume. We found that disturbancesdue to the southern pine beetle Dendroctonus frontalis were likely.important for influencing reptile distributions throughthe creation of canopy.gaps and fallen coarse woody.debris. Compared to other studies, our modified drift-fence trap techniquewas successful for sampling larger snake species (66 snakes in 564 trap nights). We have also provided detailed schematics forconstructing drift fence array.and box traps used in this study..

关键词：爬行动物阿拉巴马州围栏建设漂移抽样方法甲虫生境修改

Field Test of Optical and Electrical Fire Detectors in Simulated Fire Scenes in a Cable Tunnel

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Photonic Sensors 2014年第2期4卷 156-161页

作者： Dian FAN Hongjun DING Dorothy.y. wang Desheng JIANG National Engineering Laboratory.for Fiber Optic Sensing Technology Wuhan University of Technology Wuhan430070 China Sheny.ng Fire Research Institute Shenyang 110034 China Center for Photonics Technology Bradley Department of Electrical and Computer Engineering Virginia PolytechnicInstitute and State University Blacksburg VA 24061 USA

这份报纸论述火察觉者的三种类型的严峻的结果：电的热察觉到电报，光纤维拉曼温度察觉到察觉者，和光纤维布拉格栅栏(FBG ) 温度察觉到察觉者，在二模仿的火，在一个电报的场面掘。在有有限热放射和没有火焰的小规模的火，火警报仅仅... 详细信息

这份报纸论述火察觉者的三种类型的严峻的结果：电的热察觉到电报，光纤维拉曼温度察觉到察觉者，和光纤维布拉格栅栏(FBG ) 温度察觉到察觉者，在二模仿的火，在一个电报的场面掘。在有有限热放射和没有火焰的小规模的火，火警报仅仅来自直接与热来源一起联系的热传感器。在有大约 5

关键词：火灾探测器电缆隧道现场测试火灾场景模拟光纤布拉格光栅 FBG传感器电气