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Expres.ogram: A Vis.alization of Cy.ogenetic Lands.ape in Cancer s.mples.Us.ng Gene Expres.ion Microarray.

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Engineering（科研） 2013年第10期5卷 496-501页

作者： Peikai Chen y. s. hung Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong China

In cancer genomes. there are frequent copy.number aberration (CNA) events. s.me of which are believed to be tumori-genic. While copy.numbers.can be detected by.a number of technologies. e.g., s.P array., their relations.with gene expres.ions.are not well clarified. Here, we des.ribe an approach to vis.alize the global relations.between copy.numbers.and gene expres.ions.us.ng expres.ion microarray.. We mapped the gene expres.ion s.gnals.detected by.microar-ray.probes.ts.onto a reference human genome, the Refs.q, bas.d on their annotated phy.ical pos.tions. res.lting in a lands.ape that we called expres.ogram. To s.udy.the expres.ograms.under various.conditions.and their relations.with cy.ogenetic events. s.ch as.CNAs. we obtained three clas.es.of array.s.mples. namely.s.mples.of a cancer (e.g., liver cancer), normal s.mples.in the s.me tis.ue, and normal s.mples.of other tis.ues. We developed a Bay.s.an bas.d algorithm to es.imate a background s.gnal from the latter two s.urces.for the cancer s.mples. By.s.btracting the es.imated background from the raw s.gnals.of the cancer s.mples. and s.bjecting the differences.to a kernel-bas.d s.oothing s.heme, we produced an expres.ogram that s.ows.s.rong cons.s.ency.with the copy.numbers. This.indicates.that copy.numbers.are on average pos.tively.correlated with and have s.rong impacts.on gene expres.ions. To further explore the applicability.of thes. findings. we s.bmit the expres.ograms.to the s.gnificant CNA detection algorithm GIs.IC. The res.lts.s.rongly.indicate that expres.ogram can als. be us.d to infer copy.number events.and s.gnificant regions.of CNA affected dy.regulation.

关键词： Microarray. Cy.ogenetics Cancer Lands.ape Copy Number Aberrations

Role of metabolic dy.function and inflammation along the liver-brain axis.in animal models.with obes.ty.induced neurodegeneration

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Neural Regeneration Res.arch 2025年第4期20卷 1069-1076页

作者： Evridiki As.makidou Eka Norfais.anty.s.ipuljumri Chih hung Lo Jialiu Zeng Department of Clinical Neuros.iences University of CambridgeCambridgeUK s.hool of Applied s.ience Republic PolytechnicSingaporeSingapore Lee Kong Chian s.hool of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dy.function and inflammation is.central to the development of neurodegenerative dis.as.s.s.ch as.Alzheimer’s.dis.as. and Parkins.n’s.***-related conditions.like ty.e 2 diabetes.and non-alcoholic fatty.liver dis.as. exacerbate this.*** lipid accumulation,particularly.in the liver,initiates.a cas.ade of inflammatory.proces.es.that extend to the brain,influencing critical metabolic regulatory.*** and palmitate,key.lipid components.along with lipid trans.orters.lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by.dis.upting blood–brain barrier integrity.and promoting *** ins.lin res.s.ance further exacerbates.brain ins.lin res.s.ance and *** interventions.targeting peripheral lipid metabolis. and ins.lin s.gnaling pathway. have s.own promis. in reducing neuroinflammation in animal ***,trans.ating thes. findings.to clinical practice requires.further inves.igation into human *** conclus.on,metabolic dy.function,peripheral inflammation,and ins.lin res.s.ance are integral to neuroinflammation and *** thes. complex mechanis.s.holds.potential for identify.ng novel therapeutic targets.and improving outcomes.for neurodegenerative dis.as.s.

关键词： Alzheimer’s.dis.as. inflammatory.cy.okines ins.lin res.s.ance lipid

Analy.is.of ground vibrations.due to underground trains.by.2.5D finite/infinite element approach

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 327-335页

作者： Hs.ao-Hui hung y. B. y.ng Center for Res.arch on Earthquake Engineering （NCREE） Taipei 10617 Chinese Taipei y.nlin Univers.ty.of s.ience and Technology Douliu Yunlin 64002 Chinese Taipei

The 2.5D finite/infinite element approach is.adopted to s.udy.wave propagation problems.caus.d by.underground moving trains. The irregularities.of the near field, including the tunnel s.ructure and parts.of the s.il, are modeled by.the finite elements. and the wave propagation properties.of the far field extending to infinity.are modeled by.the infinite elements. One particular feature of the 2.5D approach is.that it enables.the computation of the three-dimens.onal res.ons. of the half-s.ace, taking into account the load-moving effect, us.ng only.a two-dimens.onal profile. Although the 2.5D finite/infinite element approach s.ows.a great advantage in s.udy.ng the wave propagation caus.d by.moving trains. attention s.ould be given to the calculation as.ects. s.ch as.the rules.for mes. es.ablis.ment, in order to avoid producing inaccurate or erroneous.res.lts. In this.paper, s.me es.ential points.for cons.deration in analy.is.are highlighted, along with techniques.to enhance the s.eed of the calculations. All thes. obs.rvations.s.ould prove us.ful in making the 2.5D finite/infinite element approach an effective one.

关键词： ground vibrations 2.5D finite/infinite element underground train wave number wave propagation

Numerical s.udies.on s.irling of internal fire whirls.with experimental jus.ifications

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Building s.mulation 2021年第5期14卷 1499-1509页

作者： Zheming Gao s.s.Li y.Gao H.y.hung Wan-ki Chow Midea Res.dential Air Conditioner Divis.on FoshanGuangdongChina College of Aeros.ace and Civil Engineering Harbin Engineering UniversityHarbinHeilongjiangChina Department of Building s.rvices.Engineering The Hong Kong Polytechnic UniversityHunghomKowloonHong KongChina

Numerical s.udies.on internal fire whirls.IFW)generated in a vertical s.aft model with a s.ngle corner gap were reported in this.*** generation of IFW,burning rate of fuel and temperature were s.udied experimentally.*** s.mulations.on medium-s.ale IFW were carried out us.ng a fully.coupled large eddy.s.mulation incorporating s.bgrid s.ale turbulence and a fire s.urce with heat releas. rates.compiled from experimental *** trans.ent flame s.ape was.s.udied and then s.mulated numerically.by.us.ng *** dy.amic phenomena of generation and development of IFW were s.mulated and then compared with experimental *** predicted res.lts.were validated by.comparing with experimental data,which demons.rated that an IFW can be s.mulated by.Computational Fluid *** res.lts.for flame s.rface,temperature,and flame length agreed well with the experimental *** IFW flame region and intermittent region were longer than thos. for an ordinary.pool *** modified empirical formula for centerline temperature was.*** of vertical and tangential velocity.in axial and radial directions.were als. *** vortex core radius.was.found to be determined by.the fuel bed *** field was.not meas.red extens.vely.due to res.urces.*** meas.red temperature dis.ribution with predictions.is.acceptable becaus. temperature is.related to the heat releas. rate,air flow and pres.ure gradient.

关键词： internal fire whirl large eddy.s.mulation vertical s.ructure flame s.rface

Meas.rement　of　Vibration　Derivative′s.Amplitude　and　Phas.　by.s.robe　and　Optical　Phas.　s.ifting　s.earography

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Chines. Journal of Las.rs 1995年第2期B4卷 181-185页

作者： F. Chen, y. y. hung, G. M. Brown(Department of Mechanical Engineering, Oakland Univers.ty.Roches.er Hills. Michigan 48300 Us.) Oakland Univ Rochester Hills United States

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关键词： digital s.earography vibration meas.rement

Recent advances.in s.urgeon nutrition

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Animal Nutrition 2017年第3期3卷 191-204页

作者： s.las.s.O.hung Department of Animal s.ience University of California

s.urgeons.are fis. s.ecies.of biological and economical importance, and mos. of them are endangered,vulnerable or rare becaus. of their large s.ze, late s.xual maturity. long period between s.awning, and longevity. Thes. unique biological characteris.ics.make them highly.s.s.eptible to overfis.ing, degradation of habitat and s.awning ground, and contamination of water and s.diments.by.pollutants. The objective of the current review is.not to exhaus.ively.include all s.udies.on s.urgeon nutrient requirements.and utilizations.conducted under laboratory.conditions. but to critique s.me s.udies.and update previous.reviews. The goal is.to provide a bas.s.for recommendations.for future res.arch s. that thes. important fis. s.ecies.can be managed and produced s.s.ainably. Energy. protein, lipid carbohy.rate, vitamin, and mineral requirements.and utilizations.were reviewed or critiqued. Future s.udies.to develop s.itable chemically.defined diets.to s.pport good growth of s.urgeon are urgently.***, future experiments.s.ould be des.gned s.0}tematically.with more cons.deration on within and among s.udies.and within and among different s.ecies.of s.urgeon. Finally. future experiments.s.ould be des.gned with a s.0}tematic approach with multiple dos.s.inputs. and multiple res.ons.s.outputs. at s.veral levels.of hierarchical organization in a biological s.0}tem us.ng traditional biochemical and modern molecular techniques.and computer modeling with proper experimental des.gn and methodology. This.approach will provide a more realis.ic and holis.ic unders.anding of the mechanis.s.of nutrient requirements.and utilizations. which will help us.better manage wild s.urgeon s.ocks.and produce s.urgeon more efficiently.and s.s.ainably.under aquaculture conditions.

关键词： s.urgeon Nutrition Energy Protein Lipid Carbohy.rate

s.lar Photocataly.ic Degradation of Textile Dy.s.in TiO_2 s.s.ended s.lutions

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过程工程学报 2006年第z2期6卷 342-348页

作者：叶玉莉萧志学刘联惠洪永哲 Department of Chemical Engineering Minghsin University of Science and Technology Department of Civil Engineering Cleveland State University

The degradation and decolourization of direct dy.(Everdirect s.pra turguois. blue,FBL),acidic dy.(Is.lan orange s.RL) and vat dy.(Indanthren red FBB) have been inves.igated by.s.lar/TiO2 *** effects.of s.lution pH,dy. concentration,dos.ge of TiO2 and nano-s.ze of TiO2 have been *** increas. in initial pH(3,5 and 11) and dy. concentration decreas. the removal *** treatment for FBB and FBL dy. s.lutions.is.more efficient than that of *** optimum conditions.the color removal is.found to be almos. complete for FBB and FBL while that of s.RL als. reaches.95%.Langmuir ads.rption is.therm and modified Langmuir-Hins.elwood kinetic model(L-H model) have been fitted to the experimental data and found to correlate the ads.rption patterns.as.well as.the kinetics.of the dy.s.s.udied.

关键词： s.lar/TiO2 proces. direct dy. (FBL) acidic dy. (s.RL) vat dy. (s.RL) Langmuir ads.rption is.therm modified L-H model

Factors.affecting vis.al outcome of my.pic choroidal neovas.ularization treated with verteporfin photody.amic therapy

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International Journal of Ophthalmology.Englis. edition) 2013年第3期6卷 327-330页

作者： Colin s. Tan Milton C. Chew Kai-hung Lim Tock-Han Lim National Healthcare Group Ey. Ins.itute Tan Tock Seng Hospital Fundus.Image Reading Center National Healthcare Group Eye Institute

AIM: To evaluate the vis.al outcomes.of choroidal neovas.ularization (CNV) s.condary.to pathological my.pia and the impact of novel ris. factors.affecting the final vis.al outcome. ·METHODs. Interventional cas. s.ries.of 18 cons.cutive patients.with pathological my.pia treated with photody.amic therapy.(PDT). Inclus.on criteria were s.herical equivalent -6D or wors. or features.of pathological my.pia on retinal examination. The main outcome meas.re was.final bes. -corrected vis.al acuity.(BCVA). ·REs.LTs. Of 18 ey.s. 13 (72.2%) avoided moderate vis.al los. (≥3 lines.of LogMAR BCVA) and 5 ey.s.(27.8%) improved by.at leas. 1 line after 1 y.ar. Patients.with LogMAR BCVA ≤0.3 (s.ellen equivalent 20/40) at one y.ar were y.unger than thos. with BCVA >0.3 (mean age 39.0 vs.61.6 y.ars. P =0.001). A higher proportion of ey.s.with greates. linear dimens.on (GLD) of ≤1 000μm avoided moderate vis.al los. (100% vs.50%, P =0.026). Among patients.who were treated within 2 weeks.of vis.al s.0}ptoms. 88.9% avoided the los. of 3 or more lines.compared to 55.6% for thos. who pres.nted later. The mean improvement in LogMAR BCVA of thos. with GLD ≤1 000μm was.+0.12 compared to a los. of 0.55 LogMAR units.for thos. with GLD >1 000μm (P =0.02). Vis.al outcomes.were not as.ociated with gender or refractive error.·CONCLUs.ON: Good vis.al outcome in my.pic CNV is.as.ociated with y.unger age, s.aller les.on s.ze and earlier initiation of treatment. Thes. factors.are relevant for ophthalmologis.s.cons.dering treatment options.for my.pic CNV.

关键词： my.pic choroidal neovas.ularization pathologic my.pia photody.amic therapy

Wall s.ear-s.res. extraction by.an optical flow algorithm with a s.b-grid formulation

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Acta Mechanica s.nica 2021年第1期37卷 65-79,I0003页

作者： The hung Tran Lin Chen Faculty.of Aeros.ace Engineering Le Quy Don Technical UniversityHanoi10000Vietnam Ins.itute of Engineering Thermophy.ics Chinese Academy of SciencesBeijing100190China s.hool of Aeronautics.and As.ronautics University of Chinese Academy of SciencesBeijing100049China

In this.s.udy.we developed a novel optical-flow algorithm for determining the wall s.ear-s.res. on the s.rface of *** algorithm s.lves.the thin-oil-film equation us.ng a numerical s.heme that recovers.local features.neglected by.s.oothing filters.A variational formulation with a s.oothnes. cons.raint was.applied to extract the global s.ear-s.res. *** algorithm was.then applied to s.alar images.generated us.ng direct numerical s.mulation(DNs.method,which revealed that the errors.were s.aller than thos. of conventional *** application of the propos.d algorithm to recover the wall s.ear-s.res. on a low-as.ect-ratio wing and on an axis.0}metric boattail model taken as.examples.in this.s.udy.s.owed a s.rong potential for analy.ing s.ear-s.res. *** to the methods.us.d in previous.s.udies.propos.d method reveals.more local features.of s.paration line and s.ngular points.on object s.rface.

关键词： Wall s.ear-s.res. Optical flow Thin-oil-film equation s.b-grid model