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Deciphering the molecular mechanisms of Simiaowan in the treatment of hy.eruricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： y.ng-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-y. Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology.Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employ.d to treat hy.eruricemia(HUA)and gout for ***,the bioactive components and underly.ng mechanisms have not been *** objective of this study.was to identify.the active components and potential mechanisms of SMW by.integrating pharmacological experimentation,serum pharmacochemistry.network pharmacology.and molecular ***:HUA rats modelling by.high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacody.amic effects of ***-Q-Exactive-MS/MS was employ.d to detect the bioactive components present in SMW-containing *** pharmacology.and molecular docking were utilized to elucidate the potential targets and underly.ng ***:SMW effectively.ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory.and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary.active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly.participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key.targets(*** carrier family.22 member 12(URAT1),solute carrier family.22 member 6(OAT1),ATP-binding cassette sub-family.G member 2(ABCG2),solute carrier family.2,facilitated glucose transporter member 9(GLUT9),xanthine dehy.rogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H sy.thase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hy.eruricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Strain-Rate-Dependent In-Plane Compressive Properties of 3D Fine Weave Pierced C/C Composite:Failure Mechanism and Constitutive Model

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Acta Mechanica Solida Sinica 2022年第1期35卷 63-78页

作者： fei Guo Qingguo fei y.nbin LiL Nikhil Gupta Jiangsu Engineering Research Center of Aerospace Machinery Southeast UniversityNanjing 211189China Department of Engineering Mechanics Southeast UniversityNanjing 211189China School of Mechanical Engineering Southeast UniversityNanjing 211189China Composite Materials and Mechanics Laboratory Department of Mechanical and Aerospace EngineeringTandon School of EngineeringNew York UniversityBrooklynNY 11201USA

In-plane compression experiments are performed on 3D fine weave pierced C/C composite at a wide strain rate range of 0.0001/s-1000/*** in-plane compressive failure mechanism of the composite at quasi-static and high strain rates is analy.ed by.a scanning electron *** results show that the in-plane compressive modulus,maximum stress and the corresponding strain increase with increasing strain *** quasi-static in-plane compressive failure mode of the 3D fine weave pierced C/C composite is characterized by.the shear failure at the angle of 45°and the local buckling of the^direction fiber *** comparison,the high strain rate in-plane compression failure mode of the composite is characterized by.the compressive fracture of the interlaminar matrix and the progressive compression failure of the a>direction fiber bundles.A strain-rate-dependent in-plane compressive constitutive model is proposed to predict the dy.amic in-plane compressive response of the *** proposed constitutive model is verified by.experimental data.

关键词： C/C composite Compression Failure mechanism Constitutive model

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Deriving a kinetic uncertainty.relation for piecewise deterministic processes:from classical to quantum

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Communications in Theoretical Phy.ics 2021年第12期73卷 149-158页

作者： fei Liu School of Phy.ics Beihang UniversityBeijing 100191China

From the perspective of Markovian piecewise deterministic processes(PDPs),we investigate the derivation of a kinetic uncertainty.relation(KUR),which was originally.proposed in Markovian open quantum ***,stationary.distributions of classical PDPs are explicitly.***,a tilting method is used to derive a rate functional of large ***,based on an improved approximation scheme,we recover the *** classical results are directly.extended to the open quantum *** use a driven two-level quantum sy.tem to exemplify.the quantum results.

关键词： Nonequilibrium fluctuations kinetic uncertainty.relations large deviation principle open quantum sy.tems piecewise deterministic processes trajectory

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Constraints on the primordial curvature power spectrum by.pulsar timing array.data:a poly.omial parameterization approach

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Communications in Theoretical Phy.ics 2024年第1期76卷 96-104页

作者： Qin fei School of Mathematics and Phy.ics Hubei Polytechnic UniversityHuangshi 435003China

The recent stochastic signal observed jointly.by.NANOGrav,parkes pulsar timing array.European pulsar timing array.and Chinese pulsar timing array.can be accounted for by.scalarinduced gravitational waves(SIGWs).The source of the SIGWs is from the primordial curvature perturbations,and the main contribution to the SIGWs is from the peak of the primordial curvature power *** effectively.model this peak,we apply.the Tay.or expansion to parameterize *** the Tay.or expansion parameterization,we apply.Bay.sian methods to constrain the primordial curvature power spectrum based on the NANOGrav 15 y.ar data *** constraint on the primordial curvature power spectrum possesses a degree of generality.as the Tay.or expansion can effectively.approximate a wide range of function profiles.

关键词： pulsar timing array scalar-induced gravitational waves inflation

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Agent's Optimal Compensation Under Inflation Risk by.Using Dy.amic Contract Model

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Journal of Sy.tems Science & Complexity 2021年第6期34卷 2291-2309页

作者： fei Chen fei Weiy.n ZHANG Fanhong y.NG Xiaoguang School of Business University of Shanghai for Science and TechnologyShanghai 200093China School of Mathematics-Phy.ics and Finance Anhui Polytechnic UniversityWuhu 241000China School of Mathematics Shanghai University of Finance and EconomicsShanghai 200433China Academy.of Mathematics and Sy.tems Science Chinese Academy of SciencesBeijing 100190China

This paper studies the problem of principal-agent with moral hazard in continuous *** firm’s cash flow is described by.geometric Brownian motion(hereafter GBM).The agent affects the drift of the firm’s cash flow by.her hidden ***,the firm rewards the agent with corresponding compensation and equity.which depend on the *** model extends dy.amic optimal contract theory.to an inflation ***,the authors obtain the dy.amic equation of the firm’s real cash flow under inflation by.using the It?***,the authors use the martingale representation theorem to obtain agent’s continuation value ***,the authors derive the Hamilton-Jacobi-Bellman(HJB)equation of investor’s value process,from which the authors derive the investors’scaled value function by.solving the second-order ordinary.differential *** with He;,the authors find that inflation risk affects the agent’s optimal compensation depending on the firm’s position in the market.

关键词： Equity.incentive inflation risk It?formula principal-agent problem the martingale representation theorem

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Processing and analy.is of transient pressure measurements from permanent down-hole gauges

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Petroleum Science 2012年第3期9卷 330-335页

作者： Wang fei School of Petrolcum Engineering China University of PetroleumBeijing 102249China

With permanent down-hole gauges （PDGs） widely.installed in oilfields around the world in recent y.ars, a continuous stream of transient pressure data in real time is now available, which motivates a new round of research interests in further developing pressure transient processing and analy.is techniques. Transient pressure measurements from PDG are characterized by.long term and high volume data. These data are recorded under unconstrained circumstances, so effects due to noise, rate fluctuation and interference from other wells cannot be avoided. These effects make the measured pressure trends decline or rise and then obscure or distort the actual flow behavior, which makes subsequent analy.is difficult. In this paper, the problems encountered in analy.is of PDG transient pressure are investigated. A newly.developed workflow for processing and analy.ing PDG transient pressure data is proposed. Numerical well testing sy.thetic studies are performed to demonstrate these procedures. The results prove that this new technique works well and the potential for practical application looks very.promising.

关键词： Permanent down-hole gauge transient pressure data processing deconvolution technique numerical well testing

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A route to truly.realize the chirality.specific growth of aligned carbon nanotubes

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Science China Chemistry 2017年第6期60卷 681-682页

作者： fei Wei Beijing Key.Laboratory.of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Single-walled carbon nanotubes（SWNTs）are regarded as one of the most promising candidates as building blocks in the next generation *** most advanced opportunities demand the ability.to form perfectly.aligned,horizontal array. of SWNTs with a uniform ***,sy.thesizing them by.conventional chemical vapor deposition（CVD）methods would result in poorly.aligned nanotubes with a variety.of chiral species,

关键词： nanotubes aligned SWNTs truly.walled sy.thesizing electronics blocks perfectly.poorly

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Cohomology.of Moduli Space of Cubic Fourfolds Ⅰ

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Acta Mathematica Sinica,English Series 2023年第5期39卷 773-798页

作者： fei SI Shanghai Research Center For Mathematical Science Shanghai 200433P.R.China

In this paper we compute the cohomology.of moduli space of cubic fourfolds with ADE ty.e singularities rely.ng on Kirwan’s blowup and Laza’s GIT construction. More precisely. we obtain the Betti numbers of Kirwan’s resolution of the moduli space. Furthermore, by.apply.ng decomposition theorem we obtain the Betti numbers of the intersection cohomology.of Baily.Borel compactification of the moduli space.

关键词： Cubic fourfold Moduli space Cohomology

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Organic tandem solar cells with PCE over 12%

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Science China Chemistry 2017年第4期60卷 433-434页

作者： fei Huang Institute of Poly.er Optoelectronic Materials and Devices South China University of Technology Guangzhou 510641 China

In contrast to inorganic solar cells, organic solar cells （OSCs） show advantages such as low cost, light weight, and flexi- bility. In fact, the most attractive feature of OSCs is that they.could be produced in large scale and at low cost by.roll-to-roll printing, just like printing newspapers, which does not in- volve complicated and high-cost procedures that are required in the production of inorganic solar cells. It is this fascinat- ing feature that has drawn great attention on the OSC study.during the past two decades.

关键词： Solar cells

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Efects of Rare Earth on Austenite–Ferrite Phase Transformation in a Low‑Carbon Fe–C Alloy

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Acta Metallurgica Sinica(English Letters) 2023年第1期36卷 141-146页

作者： fei Guo Cheng‑Wu Zheng Pei Wang Dian‑Zhong Li y.‑y Sheny.ng National Laboratory.for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

The infuence of rare earth(RE)elements on austenite–ferrite phase transformation in Fe–0.14%C alloy.has been investigated by.in situ observing the nucleation,growth and morphology.of ferrite using high temperature laser scanning confocal microscopy.and controlled atmosphere decarburization *** is found that under the low-oxy.en condition in steel,trace RE addition can signifcantly.infuence the nucleation,morphology.and growth of ferrite in Fe–0.14%C alloy.by.the combined efects of RE slowing down the carbon difusion and decreasing grain boundary.energy.by.segregating at grain *** research provides evidences of adjusting the phase transformation and improving the mechanical properties of steels by.RE addition.

关键词： Steels Difusion Austenite-ferrite transformation Kinetics Rare earth

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