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ARTIf.CIAL NEURAL NETWORK MODEL Of.CONSTITUTIVE RELATIONSHIP f.R 2A70 AluMINUM ALLOy

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Acta Metallurgica Sinica(English Letters) 2005年第6期18卷 719-723页

作者： f. Liu D.B. Shan y. lu y. y. y.ng School of.Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

The hat def.rmation behavior of.2A70 aluminum alloy.was investigated by.means of.isothermal compression tests perf.rmed on a Gleeble-1500 thermal simulator over a wide range of.temperatures 360-480℃ with strain rates of.0.01-1s^-1 and the largest def.rmation of.60%, and the true stress of.the material was obtained under the above-mentioned conditions. The experimental results shows that 2A70 aluminum alloy.is a kind of.aluminum alloy.with the property.of.dy.amic recovery. its f.ow stress declines with the increase of.temperature, while its f.ow stress increases with the increase of.strain rates. On the basis of.experiments, the constitutive relationship of.the 2A70 aluminum alloy.was constructed using a BP artif.cial neural network. Comparison of.the predicted values with the experimental data shows that the relative error of.the trained model is less than ±3% f.r the sampled data while it is less than ±6% f.r the nonsampled data. It is evident that the model constructed by.BP ANN can accurately.predict the f.ow stress of.the 2A70 alloy.

关键词： 2A70 aluminum alloy f.ow stress constitutive relationship,BP artif.cial neural network

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by.downregulating B7H3

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Oncology.research 2025年第1期33卷 103-121页

作者： y.n lu Kang Wang y.anhong Peng Meng Chen Lin Zhong luji Huang f.U Cheng Xindan Sheng Xin y.ng Manzhao Ouy.ng George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of.Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of.Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of.Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of.Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play.an important role in the treatment of.solid tumors, but the currently.used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cy.otoxic T-ly.phocy.e antigen-4 (CTLA-4) show limited clinical ef.icacy.in many.breast cancers. B7H3 has been widely.reported as an immunosuppressive molecule, but its immunological f.nction in breast cancer patients remains unclear.Methods:We analy.ed the expression of.B7H3 in breast cancer samples using data f.om the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory.role of.the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-lucif.rase reporter assay., which identif.ed the specif.c action sites of.interaction. The expression levels of.B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantif.ed using Western blotting and quantitative PCR (qPCR). experiments were perf.rmed to observe the ef.ects of.modulating the expression of.B7H3 or hsa-miR-214-3p on breast cancer cell prolif.ration and apoptosis. Additionally. the regulatory.impact of.hsa-miR-214-3p on B7H3 was examined. Enzy.e-linked immunosorbent assay. (ELISA) and f.ow cy.ometry.were employ.d to assess the ef.ects of.co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cy.okines.Results:In breast cancer tissues, the expression level of.B7H3 is inversely.correlated with that of.hsa-miR-214-3p, as well as with the regulatory.ef.ects on breast cancercell behavior. Hsa-miR-214-3p was f.und to inhibit breast cancer cell growth by.downregulating B7H3. Importantly. our research identif.ed, f.r the f.rst time, two binding sites f.r hsa-miR-214-3p on the 3' UTR of.B7H3, both of.which exert similar ef.ects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Protein arginine methy.transf.rase-6 regulates heterogeneous nuclear ribonucleoprotein-f.expression and is a potential target f.r the treatment of.neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoy. Zhang y.qi Liu f.ngxia Xu Chengcheng Zhou Kaimei lu Bin f.ng Lijuan Wang Lina Huang Zif.ng Xu Department of.Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of.Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key.Laboratory.of.Embry. Original Diseases ShanghaiChina

Protein arginine methy.transf.rase-6 participates in a range of.biological f.nctions,particularly.RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methy. transf.rase-6 modif.es neuropathic pain and,if.so,what the mechanisms of.this *** this study.protein arginine methy.transf.rase-6 expression levels and its ef.ect on neuropathic pain were investigated in the spared nerve injury.model,chronic constriction injury.model and bone cancer pain model,using immunohistochemistry.western blotting,immunoprecipitation,and label-f.ee proteomic *** results showed that protein arginine methy.transf.rase-6 mostly.co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased f.llowing spared nerve injury.chronic constriction injury.and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of.spared nerve injury.induced hy.ersensitivity.to mechanical pain was attenuated by.blocking the decrease in protein arginine methy.transf.rase-6 ***,when protein arginine methy.transf.rase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury.increased levels of.phosphory.ated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methy.transf.rase-6 appeared to contribute to spared nerve injury.induced neuropathic pain by.regulating the expression of.heterogeneous nuclear ***,protein arginine methy.transf. rase-6-mediated modulation of.hete rogeneous nuclear ribonucleoprotein-f.expression required amino atids 319 to 388,but not classical H3R2 *** f.ndings indicated that protein arginine methy.transf.rase-6 is a potential therapeutic target f. r the treatment of.peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein f neuropathic pain protein arginine methy.transf.rase-6 sensory.neurons

CORROSION PROTECTION Of.Al CATHODES IN ZINC ELECTROLy.IS

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Acta Metallurgica Sinica(English Letters) 1999年第3期12卷 221-228页

作者： lu, f. Van Ooij, W.J. Beijing Inst of.Aeronautical Materials Beijing China

A new pretreatment or a coating f.r Al was developed and tested to protect the Al ef.ectively.f.om corrosion when it was connected to pure zinc at electroplating potential and exposed to an acidic sulf.te solution. It was f.und out that (1) Al alloy.purity.and electroplating potential have a large ef.ect on galvanic corrosion between Zn-Al couples; (2) BTSE silane pretreatment and poly.rethane coating have better perf.rmance in corrosion protection, which are evaluated by.EIS, salt spray.test and immersion test f.r Al cathodes in Zinc electroly.e; (3) BTSE treatment or BTSE plus poly.rethane coating has the best anti-corrosion perf.rmance and can protect the Al cathode ef.ectively.in zinc electroly.is.

关键词： Aluminum Electroly.is

Ef.ects of.Strain Rate and Def.rmation Temperature on Microstructures and Hardness in Plastically.Def.rmed Pure Aluminum

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Journal of.Materials Science & Technology 2011年第1期27卷 1-7页

作者： f. Huang N.R. Taot K. lu Sheny.ng National Laboratory.f.r Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang110016 China

The microstructures and hardness of.pure Al samples subjected to plastic def.rmation with dif.erent tem- peratures and strain rates were investigated. The results showed that the strain-induced grain ref.nement is signif.cantly.benef.ted by.increasing strain rate and reducing def.rmation temperature. The saturated size of.ref.ned subgrains in Al can be as small as about 240 nm in cry.genic dy.amic plastic def.rmation （DPD）. Grain boundaries of.the DPD Al samples are low-angle boundaries due to suppression of.dy.amic recovery.during def.rmation. Agreement of.the measured hardness with the empirical Hall-Petch relation extrapolated f.om the coarse-grained Al implies that the low-angle boundaries can contribute to strengthening as ef.ective as the conventional grain boundaries.

关键词： Dy.amic plastic def.rmation Microstructure Hardness Strain rate Temperature

A Statistical Analy.is of.Point-like Sources in the Chandra Galactic Center Survey

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Chinese Journal of.Astronomy.and Astrophy.ics 2007年第1期7卷 81-90页

作者： J. E Wu S. N. Zhang f.J. lu y. K. Jin Department of.Phy.ics and Center f.r Astrophy.ics Tsinghua University Beijing 100084 Key.Laboratory.of.Particle Astrophy.ics Institute of High Energy Physics Chinese Academy ofSciences Beijing 100049 Department of.Engineering Phy.ics and Center f.r Astrophy.ics Tsinghua University Beijing 100084

The Chandra Galactic Center Survey.detected -800 X-ray.point-like sources in the 2°× 0.8° sky.region around the Galactic Center. We study.the spatial and luminosity.distributions of.these sources according to their spectral properties. f.urteen bright sources detected are used to f.t jointly.an absorbed power-law model, f.om which the power-law photon index is determined to be -2.5. Assuming that all other sources have the same power-law f.rm, the relation between hardness ratio and HI column density.NH is used to estimate the NH values f.r all sources. Monte Carlo simulations show that these sources are more likely.concentrated in the Galactic center region, rather than distributed throughout the Galactic disk. We also f.nd that the luminosities of.the sources are positively.correlated with their HI column densities, i.e., a more luminous source has a higher HI column density. f.om this relation, we suggest that the X-ray.luminosity.comes f.om the interaction between an isolated old neutron star and interstellar medium （mainly.dense molecular clouds）. Using the standard Bondi accretion theory.and the statistical inf.rmation of.molecular clouds in the Galactic center, we conf.rm this positive correlation and calculate the luminosity.range in this scenario, which is consistent with the observation （10^32 - 10^35 erg s^-1）.

关键词： methods data analy.is-Galaxy center-X-ray stars

Ef.ects of.Impurity.on Microstructure and Hardness in Pure Al Subjected to Dy.amic Plastic Def.rmation at Cry.genic Temperature

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Journal of.Materials Science & Technology 2011年第7期27卷 628-632页

作者： f. Huang N.R. Tao K. lu Sheny.ng National Laboratory.f.r Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Microstructure and hardness were investigated in pure Al samples with dif.erent purities （5N： 99.999%, 4N： 99.993%, and 2N： 99.7% in weight） subjected to dy.amic plastic def.rmation at cry.genic temperatures. The saturated sizes of.ref.ned grains/subgrains in these samples induced by.plastic def.rmation are about 240 nm without an obvious impurity.ef.ect, but the dislocation density.in 2N Al is evidently.higher than that in other samples. Boundary.misorientations f.r 5N and 4N Al are below 10° with average values of.2–3°, while the average misorientation f.r 2N Al is obviously.larger, being about 14°. Microhardness of.LNT-DPD 2N Al is higher than that of.5N and 4N Al, owing to the enhanced dislocation density.as their grain/subgrain sizes are almost identical.

关键词： Aluminum Impurity Nanostructure Grain ref.nement

A new design of.3D-printed orthopedic bone plates with auxeticstructures to mitigate stress shielding and improve intra-operative bending

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Bio-Design and Manuf.cturing 2020年第2期3卷 98-108页

作者： Sanjairaj Vijay.venkataraman Akhil Gopinath Wen f.lu Division of.Engineering New York University Abu DhabiAbu DhabiUAE Department of.Mechanical and Aerospace Engineering Tandon School of EngineeringNew York UniversityBrooklynNYUSA Department of.Mechanical Engineering National University of Singapore(NUS)SingaporeSingapore

Orthopedic bone plates are most commonly.used f.r bone f.acture f.xation f.r more than 100 *** bone plate design had evolved over time overcoming many.challenges such as insuf.icient strength and excessive plate–bone contact af.ecting the blood ***,it is only.made of.two materials,either stainless steel(AISI 316L)or titanium(Ti–6Al–4V).There are two main limitations of.metallic bone implants,namely.stress shielding and the problem of.malocclusion caused by.the displacement of.the f.acture site during *** overcome the two problems,a new bone plate design with the incorporation of.auxetic structures is proposed in this *** study.aims to use auxetic structure section in the bone plate that would decrease the stif.ness of.the region,thereby.mitigating the stress-shielding ef.ect and at the same time act as a def.rmable section to enable intra-operative bending f.r ef.ective alignment while having enough bending strength and *** dif.erent auxetic structures namely.re-entrant honey.omb and missing rib structures were *** auxetic structure incorporated bone plates were designed,f.nite element analy.is was done,f.bricated using direct metal laser sintering technique,and *** results indicate that the re-entrant honey.omb structure incorporated bone plates serve as an ef.ective bone design compared to the conventional bone plate design,in terms of.stress shielding and intra-operative bending while of.ering similar mechanical and bending strength.

关键词： Bone plates Negative Poisson's ratio structures 3D printing Additive manuf.cturing Stress shielding

BRIGHT LONG Af.ERGLOW PHOSPHORESCENCE GLASS MADE Of.SrAl_(2)O_(4): Eu^(2+), Dy.(3+) AND GLASS f.ITS

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Acta Metallurgica Sinica(English Letters) 2005年第6期18卷 736-740页

作者： X. y. Zhang Z. f. Cao L.P. lu Z.H. Bai W.Z. Wang X. C. Wang Department of.Materials Science and Engineering Changchun University of Science and Technology Changchun 130022 China

Bright long af.erglow phosphorescence glasses were prepared by.using SrAl2O4： Eu^2＋, Dy.3＋ phosphors and suitable glass f.its together. The SrAl2O4： Eu^2＋, Dy.3＋ phosphors were initially.prepared by.the solid reaction method. Three kinds of.glass f.its were prepared to match the SrAl2O4： Eu^2＋, Dy.3＋ phosphors. Ef.ects of.the compositions of.the glass f.its, the ratios of.the phosphors to the f.its us well us the f.ring temperature and f.ring times on the properties of.the samples were discussed. XRD analy.is indicated the samples exhibited the ty.ical dif.raction peaks of.SrAlwO4： Eu^2＋, Dy.3＋. The emission spectra of.the samples showed broad bands peaking at *** excitation spectra of.the samples showed broad bands ranging f.om 300 to 480hm. These are believed due to the 5d4f.4f.transitions of.Eu^2＋ in the SrAl2O4： Eu^2＋, Dy.3＋ phosphors. The af.erglow luminescence of.the samples excited by.a 40W f.uorescence lamp f.r 30min can be observed in the dark f.r more lOh with the naked ey.s. It can f.nd wide applications in many.f.elds.

关键词： long af.erglow phosphorescence glass StAl2O4 :Eu^2+ Dy.3+,glass f.it