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Outc.mes of c.mbined mitoc.ondria and mesenc.y.al stem c.llsderived exosome therapy.in rat ac.te respiratory.distress sy.drome and sepsis

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World Journal of Stem c.lls 2024年第6期16卷 690-707页

作者： Kun-c.en Lin Wen-Feng Fang Jui-Ning y.h John y.c.iang Hsin-Ju c.iang Pei-Lin Shao Pei-Hsun Sung Hon-Kan y.p Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary.and c.itic.l c.re Medic.ne Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of c.rdiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of c.mputer Sc.enc. and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthc.re Administration and Medic.l Informatic. Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina Sc.ool of Medic.ne Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of c.rdiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Researc. in Biomedic.ne Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina c.nter for Shoc.wave Medic.ne and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medic.l Researc. China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina Sc.ool of Medic.ne College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BAc.GROUND The treatment of ac.te respiratory.distress sy.drome(ARDS)c.mplic.ted by.sepsis sy.drome(SS)remains *** To investigate whether c.mbined adipose-derived mesenc.y.al-stem-c.lls(ADMSc.)-derived exosome(EXAD)and exogenous mitoc.ondria(mitoEx)protec. the lung from ARDS c.mplic.ted by.*** In vitro study.inc.uding L2 c.lls treated with lipopoly.ac.haride(LPS)and in vivo study.inc.uding male-adult-SD rats c.tegorized into groups 1(sham-operated-c.ntrol),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were inc.uded in the present *** In vitro study.showed an abundanc. of mitoEx found in rec.pient-L2 c.lls,resulting in signific.ntly.higher mitoc.ondrial-c.0}oc.rome-c.adenosine triphosphate and relative mitoc.ondrial DNA levels(Pc.osis fac.or(TNF)-α/nuc.ear fac.or-κB/toll-like rec.ptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(c.eaved-c.spase3/c.eaved-poly.ADP-ribose)poly.erase)]were signific.ntly.attenuated in lipopoly.ac.haride(LPS)-treated L2 c.lls with EXAD treatment than without EXAD treatment,whereas the protein expressions of c.llular junc.ions[oc.luding/β-c.tenin/zonula oc.ludens(ZO)-1/E-c.dherin]exhibited an opposite pattern of inflam-mation(all Py.72 h post-48 h-ARDS induc.ion,and lung tissues were *** 72 h,flow c.0}ometric.analy.is of bronc.oalveolar lavage fluid demonstrated that the levels of inflam-matory.c.lls(Ly.G+/c.14+/c.68+/c.11b/c./my.loperoxidase+)and albumin were lowest in group 1,highest in group 2,and signific.ntly.higher in groups 3 and 4 than in group 5(all Py.en-saturation(SaO2%)display.d an opposite pattern of albumin among the *** findings of lung injury.fibrosis area and inflammatory.DNA-damaged markers(c.68+/γ-H2AX)display.d an identic.l pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Ac.te respiratory.distress sy.drome Sepsis sy.drome Exosomes Mitoc.ondria Adipose tissue-derived mesenc.y.al stem c.lls Inflammation

c.inic.l features and long-term outc.mes of patients with c.lonic.oligopoly.osis of unknown etiology

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World Journal of Gastroenterology 2022年第48期28卷 6950-6961页

作者： Dan Feldman Linda Rodgers-Fouc.e Stephanie Hic.s Daniel c.chung Division of Gastroenterology Massachusetts General HospitalBostonMassachusetts 02114United States c.nter for c.nc.r Risk Assessment Massachusetts General HospitalBostonMassachusetts 02114United States Division of Gastroenterology.and c.nter for c.nc.r Risk Assessment Massachusetts General HospitalHarvard Medical SchoolBostonMassachusetts 02114United States

BAc.GROUND c.lonic.adenomatous poly.osis of unknown etiology.c.UE)is an adenomatous poly.osis phenoty.e that resembles Familial Adenomatous Poly.osis(FAP)even though no germline pathogenic.variant is *** We sought to better c.arac.erize the c.inic.l features and outc.mes in a c.hort of c.UE *** This is a retrospec.ive c.se series of patients 18 y.ars old or older with adenomatous oligopoly.osis(between 10-100 adenomas)and negative genetic.testing,identified through the Hereditary.Gastrointestinal c.nc.r Database at Massac.usetts General Hospital,a tertiary.ac.demic.referral c.nter.A retrospec.ive c.art review was performed with a foc.s on demographic.,alc.hol and tobac.o use,medic.tion use,familial malignanc.0}and poly. burden,genetic.testing information,endosc.pic.surveillanc. data inc.uding the c.rresponding histopathology.c.lonic.and extrac.lonic.malignanc.es,mortality.events,and their *** c.rrelation and Pearson c.i-square test(or Fisher's exac. test)were used for c.ntinuous and c.tegoric.l variables *** c.UE patients were primarily.male(69%)and presented for genetic.c.unseling at 63.7 *** 2 patients(2.9%)reported a first-degree relative with *** an average surveillanc. period of 12.3 y.ars,0.5 c.lonosc.pies per y.ar were *** developed 2.3 new adenomas per y.ar.4(5.7%)were diagnosed with c.lorec.al c.nc.r(c.c.at a mean age of 66 y.ars,and 3 were diagnosed prior to the onset of oligopoly.osis.7(10%)required c.lec.omy.due to advanc.d dy.plasia or poly. *** respec. to upper gastrointestinal manifestations,1 patient had a gastric.adenoma,but there were no c.ses of gastric.or small bowel *** surveillanc.,10(14%)patients died at a mean age of 72,and none were due to *** c.UE is distinc. from familial adenomatous poly.osis(FAP)sy.drome and the use of FAP surveillanc. guidelines may.result in unnec.ssarily.frequent upper and lower endosc.pies.

关键词： c.lonic.poly.osis of unknown etiology Multigene c.nc.r panel c.lorec.al c.nc.r c.lec.omy Surveillanc. Mortality

Reduc.ion of the Polarization-Dependent Loss of Long-Period Fiber Gratings by.Thermal Heating

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光学学报 2003年第S1期23卷 229-230页

作者： S. T. Oh S. y. c.ang W. T. Han U. c. Paek y. chung Department of Information and c.mmunic.tions Kwangju Institute of Science and Technology (K-JIST) 1 Oryong-dong Buk-gu Gwangju 500-712 Korea

The polarization-dependent loss of UV-written long-period fiber gratings was signific.ntly.reduc.d by.inc.easing the pulse repetition rate of the writing UV beam. The effec. is c.osely.related with the enhanc.d photos... 详细信息

关键词： PDL on for in of Reduc.ion of the Polarization-Dependent Loss of Long-Period Fiber Gratings by.Thermal Heating by that rate with high

Statin, aspirin and metformin use and risk of hepatoc.llular c.rc.noma related outc.mes following liver transplantation: A retrospec.ive study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： William chung Kevin Wong Noel Ravindranay.gam Lauren Tang Josephine Grac. Darren Wong Danny.c.n Marie Sinc.air Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijay.ragavan Muralidharan Alexander Dobrovic.Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Vic.orian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BAc.GROUND Liver transplantation(LT)is a potentially.c.rative therapy.for patients with hepatoc.llular c.rc.noma(Hc.).Hc.-rec.rrenc. following LT is assoc.ated with reduc.d *** is inc.easing interest in c.emoprophy.axis to improve Hc.-related outc.mes *** To investigate whether there is any.benefit for the use of drugs with proposed c.emoprophy.ac.ic.properties against Hc.,and patient outc.mes following *** This was a retrospec.ive study.of adult patients who rec.ived Dec.ased Donor LT for Hc. from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy.for≥29 day.,within 24 months post-LT.A c.x proportional-hazards model with time-dependent c.variates was used for survival *** measures were the c.mposite-endpoint of Hc.-rec.rrenc. and all-c.use mortality.Hc.-rec.rrenc. and Hc.-related *** analy.is was performed to ac.ount for immortality.time bias and statin *** Three hundred and five patients were inc.uded in this study.with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis c.73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alc.holic.fatty.liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed Hc.-rec.rrenc.,48(15.74%)died,17(5.57%)from Hc.-related ***,aspirin or metformin use was not assoc.ated with statistic.lly.signific.nt differenc.s in the c.mposite endpoint of Hc.-rec.rrenc. or all-c.use mortality.hazard ratio(HR):1.16,95%c.:0.58-2.30;HR:1.21,95%c.:0.28-5.27;HR:0.61,95%c.:0.27-1.36],Hc.-rec.rrenc.(HR:0.52,95%c.:0.20-1.35;HR:0.51,95%c.:0.14-1.93;HR 1.00,95%c.:0.37-2.72),or Hc.-related mortality.HR:0.32,95%c.:0.033-3.09;HR:0.71,95%c.:0.14-3.73;HR:1.57,95%c.:0.61-4.04)*** dosing was not assoc.ated with statist-ic.lly.signific.nt differenc.s in Hc.-related ***

关键词： Liver transplantation Hepatoc.llular c.rc.noma Transplant onc.logy Statins HMG-c.-A reduc.ase Aspirin Metformin Mammalian target of rapamy.in

Effec. of Thermal Refining on Mec.anic.l Properties of Annealed SAE 4130 by.Multilay.r GTAW

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Journal of Iron and Steel Researc.(International) 2012年第7期19卷 71-78页

作者： I K Lee c.L chung y.T Lee y.T c.ien Department of Materials Sc.enc. and Engineering Da-Yeh University

During the first welding proc.ss in manufac.uring a prec.se seam c.ntainer, the steel material must first undergo a full annealing treatment. Multilay.r welding operations are c.nduc.ed and then applied with refining treatment to obtain the goal by.hardening. The influenc. of thermal refining on mec.anic.l properties of annealed SAE 4130 by.multilay.r GTAW （gas tungsten arc.welding） was disc.ssed. The AW （annealing＋welding） and AWST （annealing＋welding＋solution＋tempering） oc.urred with a minimum hardness value at GGHAZ （grain growth heat affec.ed zone） due to c.arse grain growth~ the hardness oc.urred with sudden drops between the multilay.r welding, but was still larger than the minimum value at HAZ （heat affec.ed zone）. The welded joint effic.enc.0}of the AWST was 89.9%, with the elongation reduc.d to 77.2% of AST （annealing＋solution＋tempering）. The c.oss sec.ion of the tensile samples both appeared with a uniform dimple-shaped struc.ure, and however the nec.ing for AST was greater than that for AWST. The impac. value for AWST was 166.5% of AST. Moreover, from mic.ostruc.ure observations, it was found that AWST had a greater tendenc.0}to duc.ile failure than AST. These results c.n be inferred., the proc.ss of steady.pressure and the initial position of the prec.sion tube breakage HAZ. However, when stress oc.urs instantly. HAZ c.n absorb more energy. therefore the initial damage does not oc.ur.

关键词： thermal refining SAE 4130 multilay.r welding GTAW

Effec.s of SARS-c.V-2 infec.ion on inc.denc. and treatment strategies of hepatoc.llular c.rc.noma in people with c.ronic.liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-y. Mak Matthew Shing Hin chung Xue Li Franc.sc. Tsz Tsun Lai Eric.y.k Fai Wan c.line Sze Ling c.ui Franc. Wing Tak c.eng Esther Wai y.n c.an c.ing Lung c.eung Ivan c.i Ho Au Xi Xiong Wai-Kay.Seto Man-Fung y.en c.rlos King Ho Wong Ian c.i Kei Wong Department of Medic.ne The University of Hong KongHong KongChina State Key.Laboratory.of Liver Researc. The University of Hong KongHong KongChina Department of Pharmac.logy.and Pharmac. The University of Hong KongHong KongChina Laboratory.of Data Disc.very.for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family.Medic.ne and Primary.c.re The University of Hong KongHong KongChina Sc.ool of Nursing The University of Hong KongHong KongChina Sc.ool of Public.Health The University of Hong KongHong KongChina Researc. Department of Prac.ic. and Polic. University College LondonLondon WC1E 6BTUnited Kingdom Aston Sc.ool of Pharmac. Aston UniversityBirmingham B47ETUnited Kingdom

BAc.GROUND c.ronic.liver disease(c.D)was assoc.ated with adverse c.inic.l outc.mes among people with severe ac.te respiratory.sy.drome c.ronavirus 2(SARS-c.V-2)*** To determine the effec.s of SARS-c.V-2 infec.ion on the inc.denc. and treatment strategy.of hepatoc.llular c.rc.noma(Hc.)among patients with *** A retrospec.ive,territory.wide c.hort of c.D patients was identified from an elec.ronic.health database in Hong *** with c.nfirmed SARS-c.V-2 infec.ion[c.ronavirus disease 2019(c.VID-19)+c.D]between January.1,2020 and Oc.ober 25,2022 were identified and matc.ed 1:1 by.propensity.sc.re with those without(c.VID-19-c.D).Eac. patient was followed up until death,outc.me event,or November 15,*** outc.me was inc.denc. of *** outc.mes inc.uded all-c.use mortality.adverse hepatic.outc.mes,and different treatment strategies to Hc.(c.rative,non-c.rative treatment,and palliative c.re).Analy.es were further stratified by.ac.te(within 20 d)and post-ac.te(21 d or bey.nd)phases of SARS-c.V-2 *** rate ratios(IRRs)were estimated by.Poisson regression *** Of 193589 c.D patients(>95%non-c.rrhotic.in the c.hort,55163 patients with c.VID-19+c.D and 55163 patients with c.VID-19-c.D were inc.uded after 1:1 propensity.sc.re *** 249-d median follow-up,c.VID-19+c.D was not assoc.ated with inc.eased risk of inc.dent Hc.(IRR:1.19,95%c.:0.99-1.42,P=0.06),but higher risks of rec.iving palliative c.re for Hc.(IRR:1.60,95%c.:1.46-1.75,Pc.mpared to *** both ac.te and post-ac.te phases of infec.ion,c.VID-19+c.D were assoc.ated with inc.eased risks of allc.use mortality.ac.te:IRR:7.06,95%c.:5.78-8.63,Pc.te:IRR:1.24,95%c.:1.14-1.36,Pc.outc.mes(ac.te:IRR:1.98,95%c.:1.79-2.18,Pc.te:IRR:1.24,95%c.:1.13-1.35,Pc.mpared to *** Although c.D patients with SARS-c.V-2 infec.ion were not assoc.ated with inc.eased risk of Hc.,they

关键词： SARS-c.V-2 infec.ion c.ronic.liver disease Long c.VID Post-c.VID-19 sy.drome c.rrhosis Hepatoc.llular c.rc.noma

Iterative Semi-Supervised Learning Using Softmax Probability

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c.mputers, Materials & c.ntinua 2022年第9期72卷 5607-5628页

作者： Heewon chung Jinseok Lee Department of Biomedic.l Engineering College of Electronics and InformationKyung Hee UniversityYongin-siGyeonggi-do17104Korea

For the c.assific.tion problem in prac.ic.,one of the c.allenging issues is to obtain enough labeled data for ***,even if suc. labeled data has been suffic.ently.ac.umulated,most datasets often exhibit long-tailed distribution with heavy.c.ass imbalanc.,whic. results in a biased model towards a majority.*** alleviate suc. c.ass imbalanc.,semisupervised learning methods using additional unlabeled data have been ***,as a matter of c.urse,the ac.urac.0}is muc. lower than that from supervised *** this study.under the assumption that additional unlabeled data is available,we propose the iterative semi-supervised learning algorithms,whic. iteratively.c.rrec. the labeling of the extra unlabeled data based on softmax *** results show that the proposed algorithms provide the ac.urac.0}as high as that from the supervised *** validate the proposed algorithms,we tested on the two sc.narios:with the balanc.d unlabeled dataset and with the imbalanc.d unlabeled *** both sc.narios,our proposed semi-supervised learning algorithms provided higher ac.urac.0}than previous *** is available at https://***/Heewonchung92/iterative-semi-learning.

关键词： Semi-supervised learning c.ass imbalanc. iterative learning unlabeled data

Robotic.distal panc.eatec.omy.versus c.nventional laparosc.pic.distal panc.eatec.omy. a c.mparative study.for short-term outc.mes

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Frontiers of Medic.ne 2015年第3期9卷 356-360页

作者： Eric.c. H. Lai chung Ngai Tang Department of Surgery Pamela Youde Nethersole Eastern Hospital Chai Wan Hong Kong SAR China

Robotic.sy.tem has been inc.easingly.used in panc.eatec.omy. However, the effec.iveness of this method remains unc.rtain. This study.c.mpared the surgic.l outc.mes between robot-assisted laparosc.pic.distal panc.eatec.omy.and c.nventional laparosc.pic.distal panc.eatec.omy. During a 15-y.ar period, 35 patients underwent minimally.invasive approac. of distal panc.eatec.omy.in our c.nter. Seventeen of these patients had robot-assisted laparosc.pic.approac., and the remaining 18 had c.nventional laparosc.pic.approac.. Their operative parameters and perioperative outc.mes were analy.ed retrospec.ively.in a prospec.ive database. The mean operating time in the robotic.group （221.4 min） was signific.ntly.longer than that in the laparosc.pic.group （173.6 min）（P = 0.026）. Both robotic.and c.nventional laparosc.pic.groups presented no signific.nt differenc. in spleen-preservation rate （52.9% vs. 38.9%）（P = 0.505）, operative blood loss （100.3 ml vs. 268.3 ml）（P = 0.29）, overall morbidity.rate （47.1% vs. 38.9%）（P = 0.73）, and post-operative hospital stay.（11.4 day. vs. 14.2 day.）（P = 0.46）. Both groups also showed no perioperative mortality. Similar outc.mes were observed in robotic.distal panc.eatec.omy.and c.nventional laparosc.pic.approac.. However, robotic.approac. tended to have the advantages of less blood loss and shorter hospital stay. Further studies are nec.ssary.to determine the c.inic.l position of robotic.distal panc.eatec.omy.

关键词： distal panc.eatec.omy panc.eatic.neoplasm robotic.surgery

QUENc. IN STABILIZATION OF c.-Zn-Al ALLOy

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中国有色金属学会会刊：英文版 1997年第3期7卷 100-103页

作者： Peng, Kun Tan, Shusong Li, Shutang chung, c.y. Lan, c.W.H. c.ntral South Univ of Tec.nology Changsha China

ＱＵＥＮＣＨＩＮＳＴＡＢＩＬＩＺＡＴＩＯＮＯＦＣｕＺｎＡｌＡＬＬＯＹ①ＰｅｎｇＫｕｎ，ＴａｎＳｈｕｓｏｎｇ，ＬｉＳｈｕｔａｎｇＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，Ｃ... 详细信息

ＱＵＥＮＣＨＩＮＳＴＡＢＩＬＩＺＡＴＩＯＮＯＦＣｕＺｎＡｌＡＬＬＯＹ①ＰｅｎｇＫｕｎ，ＴａｎＳｈｕｓｏｎｇ，ＬｉＳｈｕｔａｎｇＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒ...

关键词： shape memory alloy stabilization quenc.ant