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中小学生高度近视发生风险预测模型：基于巢式病例对照研究

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中国全科医学 2025年第9期28卷 1115-1121页

作者：陈胜蓝郑永韬胡旺成倪作为夏冰叶春梅杜持新陈晓丹浙江省杭州市萧山区疾病预防控制中心监测科浙江大学医学院附属第一医院护理部浙江萧山医院质管科浙江省杭州市临平区疾病预防控制中心免疫规划管理科

背景中小学生由于学习压力、电子产品普及以及不良用眼习惯，视力健康问题日益严重，成为近视的高发群体，高度近视作为近视的严重阶段，已成为全球范围内的公共卫生问题。尽管现有诸多研究对近视的危险因素进行了探讨，但鲜有研究针对... 详细信息

背景中小学生由于学习压力、电子产品普及以及不良用眼习惯，视力健康问题日益严重，成为近视的高发群体，高度近视作为近视的严重阶段，已成为全球范围内的公共卫生问题。尽管现有诸多研究对近视的危险因素进行了探讨，但鲜有研究针对性阐明风险因素与高度近视发生的复杂非线性关系，本研究结合巢式病例对照研究和限制性立方样条，开发一个中小学生高度近视风险预测模型，通过早期识别高风险个体，延缓或阻止高度近视的发展，实现近视的三级预防，对中小学生的学业和生活质量有积极意义。目的探究中小学生高度近视的流行现状及危险因素，构建风险预测模型，为中小学生高度近视防控提供科学依据。方法采用巢式病例对照研究，于2023年选取杭州市12所学校中度近视的学生作为研究对象建立队列，按照全国学生常见病和健康影响因素监测与干预工作方案，对纳入研究的中小学生开展近视状况监测，研究期间进展为高度近视的中小学生作为高度近视发生组，其余未进展为高度近视的中小学生作为对照组，对两组研究对象开展视力保健行为进行调查。采用Lasso回归筛选特征变量后进行多因素Logistic回归分析探究中小学生高度近视发生的影响因素，并采用列线图对风险预测模型可视化，同时采用Hosmer-Lemeshow检验、受试者工作特征（ROC）曲线、Calibration曲线、决策曲线分析（DCA）对模型性能进行评估，最后采用限制性立方样条进一步明确年龄与高度近视发生风险的关系。结果 12所中小学校共纳入2 468名学生，未进展为高度近视的学生1 293名，中度近视进展为高度近视的学生1 175名，高度近视发生率为47.61%(1 175/2 468)。两组学生年龄、年级、BMI、每日入睡时间、地区、户外活动时间、电子产品使用时间、课后作业时间、家用台灯比较，差异有统计学意义（P2 h/d(OR=1.440,95%CI=1.119～1.856)，课后作业时间1～2 h/d(OR=1.461,95%CI=1.126～1.899)、>2 h/d(OR=1.534,95%CI=1.218～1.935)为中小学生高度近视发生的危险因素（P<0.05）；而高中年级（OR=0.560,95%CI=0.419～0.743）为中小学生高度近视发生的保护因素（P<0.05）。基于年级、BMI、每日入睡时间、户外活动时间、电子产品使用时间、课后作业时间等6个变量构建的预测模型ROC曲线下面积为0.840(95%CI=0.825～0.855)，具有良好的拟合优度、一致性、应用性，限制性立方样条分析显示13～15岁为高度近视的高发年龄段。结论中小学生高度近视发生率较高，风险预测模型为高度近视的预防和控制提供了科学依据，应在初中年级加强近视防控措施，改善学生的视力保健行为，降低高度近视的发生。

关键词：近视学生高度近视巢式病例对照研究限制性立方样条预测模型

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Soil Taxonomy.and Distribution Characteristics of the Permafrost Region in the Qinghai-Tibet Plateau, China

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Journal of Mountain Science 2015年第6期12卷 1448-1459页

作者： FANG Hong-bing ZHAO Lin WU Xiao-dong ZHAO y.-guo ZHAO y.ng-hua hu Guo-jie Cry.sphere Research Station on the Qinghai-Tibetan Plateau State Key Laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Graduate University.of Chinese Academy.of Sciences School of Environmental and Municipal Engineering Lanzhou Jiaotong University State Key.Laboratory.of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences

Understanding the soil taxonomy.and distribution characteristics of the permafrost region in the Qinghai-Tibet Plateau(QTP) is very.important. On the basis of extensive field survey. and experimental analy.is, this study.carries out soil taxonomic classification of the permafrost region in the QTP. According to Chinese Soil Taxonomy. the soil of the permafrost region in the QTP can be divided into 6 Orders(Histosols, Aridosols, Gley.sols, Isohumosols, Cambosols, Primosols), 11 Suborders, 19 Groups and 24 Subgroups. Cambosols are the dominant soil ty.e in the permafrost region, followed by.Aridosols. From the east to the west of the permafrost region in the QTP, the soil ty.e gradually.changes from Cambosols to Aridosols, showing a meridional zonality. The eastern region is dominated by.Cambosols, with no obvious latitudinal zonality. From the south to the northwest of the western region, the dominance of Aridosols and Cambosols gradually.transited to Aridosols, presenting a latitudinal zonality. The soil in the western region shows a poor vertical zonality. while the distribution of suborders of Cambosols in the eastern region shows a more obvious vertical zonality. The result indicates that precipitation and vegetation are the main factors that influence the zonal distribution of soil. The permafrost in the east has some effect on the vertical soil zonality. but the effect is weakened in the west.

关键词： Qinghai-Tibet Plateau Permafrost region Soil taxonomy.Soil distribution

A Review of Functional Near-Infrared Spectroscopy.Studies of Motor and Cognitive Function in Preterm Infants

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Neuroscience Bulletin 2020年第3期36卷 321-329页

作者： Quan Wang Guang-Pu Zhu Li y. Xin-Xin Cui hui Wang Ru-y. Wei bing-Liang hu Key.Laboratory.of Spectral Imaging Technology Xi’an Institute of Optics and Precision Mechanics of the Chinese Academy of SciencesXi’an 710119China University.of Chinese Academy.of Sciences Beijing 100049China Key.Laboratory.of Biomedical Spectroscopy.of Xi’an Xi’an Institute of Optics and Precision Mechanics of the Chinese Academy of SciencesXi’an 710119China Child Study.Center Yale School of MedicineYale UniversityNew HavenCT 06520USA School of Psy.hological and Cognitive Sciences and Beijing Key.Laboratory.of Behavior and Mental Health Peking UniversityBeijing 100871China

Preterm infants are vulnerable to brain injuries,and have a greater chance of experiencing neurodevelopmental disorders throughout development. Early.screening for motor and cognitive functions is critical to assessing the developmental trajectory.in preterm infants, especially.those who may.have motor or cognitive deficits. The brain imaging technology.functional near-infrared spectroscopy.fNIRS) is a portable and low-cost method of assessing cerebral hemody.amics, making it suitable for large-scale use even in remote and underdeveloped areas. In this article, we review peer-reviewed, scientific f NIRS studies of motor performance, speech perception, and facial recognition in preterm infants. f NIRS provides a link between hemody.amic activity.and the development of brain functions in preterm infants. Research using fNIRS has shown different patterns of hemoglobin change during some behavioral tasks in early.infancy. fNIRS helps to promote our understanding of the developmental mechanisms of brain function in preterm infants when performing motor or cognitive tasks in a less-restricted environment.

关键词： Functional near infrared spectroscopy Preterm infant Motor performance Speech perception Facial recognition Cerebral hemody.amics

Detection of PRMT1 inhibitors with stopped flow fluorescence

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Signal Transduction and Targeted Therapy 2018年第1期3卷 274-283页

作者： Kun Qian Hao hu hui Xu y.George Zheng Department of Pharmaceutical and Biomedical Sciences University of GeorgiaAthensGA 30602USA Present address:The Chemical Proteomics Center and State Key.Laboratory.of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Protein arginine methy.transferases(PRMTs)are crucial epigenetic regulators in eukary.tic organisms that serve as histone writers for chromatin *** also methy.ate a variety.of non-histone protein substrates to modulate their function and *** development of potent PRMT inhibitors has become an emerging and imperative research area in the drug discovery.field to provide novel therapeutic agents for treating diseases and as tools to investigate the biological functions of ***1 is the major ty.e I enzy.e that cataly.es the formation of asy.metric dimethy. arginine,and PRMT1 play. important regulatory.roles in signal transduction,transcriptional activation,RNA splicing,and DNA *** expression of PRMT1 is found in many.ty.es of cancers,pulmonary.diseases,cardiovascular disease,diabetes,and renal ***1 is a highly.promising target for therapeutic *** created a stopped flow fluorescence-based assay.for PRMT1 inhibitor detection and characterization that has the advantages of being homogeneous,nonradioactive,and mix-and-measure in nature,allowing for continuous measurement of the methy.ation reaction and its *** our knowledge,this is the first continuous assay.for PRMT1 reaction detection and inhibitor *** approach is not only.capable of quantitatively.determining the potency.IC50)of PRMT1 inhibitors but can also distinguish cofactor-competitive inhibitors,substrate-competitive inhibitors,and mixed-ty.e inhibitors.

关键词： PRMT1 stopped competitive

Study.on Amorphous Ni-Mo-Fe-Zn Coating Electrocataly.t forHy.rogen Evolution in Alkaline Solution

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Journal of Materials Science & Technology 1996年第3期12卷 190-194页

作者： Luo, DJ hu, WK Wang, y.Zhang, y. Wang, GS NANKAI UNIV INST NEW ENERGY MAT CHEMTIANJIN 300071PEOPLES R CHINA

Amorphous Ni-Mo-Fe-Zn quaternary.alloy.coatings are developed by.means of electrodeposit, and after most of zinc is leached out their electrocataly.ic activity.toward the hy.rogen evolution reaction (HER) in alkaline media is studied using electrochemical polarization and a.c. impedance techniques. The results show these coatings have very.high electrocataly.ic activity.and excellent stability. This might benefit from the increased active surface area, well-pronounced sy.ergism as well as their amorphous structures. The HER proceeds through the Volmer-Hey.ovsky.mechanism with a rate-determination-step (RDS) of Volmer at high overpotentials and the HER is controlled by.Hey.ovsky.in lower overpotential areas.

关键词： Zn Fe Mo Ni

Extracellular vesicle activities regulating macrophage- and tissue-mediated injury.and repair responses

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1493-1512页

作者： Qian hu Christopher J.Ly.n Jesse K.Fletcher Wenfu Tang Meihua Wan Tony.y.hu Department of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041China Center of Cellular and Molecular Diagnosis Tulane University School of MedicineNew OrleansLA 70112USA Department of Biochemistry.Molecular Biology Tulane University School of MedicineNew OrleansLA 70112USA

Macrophages are ty.ically.identified as classically.activated(M1) macrophages and alternatively.activated(M2) macrophages,which respectively.exhibit pro-and anti-inflammatory.phenoty.es,and the balance between these two subty.es play. a critical role in the regulation of tissue inflammation,injury.and repair *** studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by.stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury.and vice *** review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury.in a number of acute and chronic inflammatory.disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases.

关键词： Extracellular vesicles Macrophage Tissue injury Inflammatory.disease Interaction loop Stem cell Sepsis Targeted therapy

Freeze-dry.ng-assisted Sy.thesis of Mesoporous CoMoO4 Nanosheets as Anode Electrode Material for Enhanced Lithium Batteries

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Chemical Research in Chinese Universities 2019年第2期35卷 261-270页

作者： WANG Wei WANG Tao FAN Xuecheng ZHANG Cuilin hu Jinxing CHEN hui FANG Zhenxing y.N Jiefeng LIU bing College of Science & Technology Ningbo UniversityNingbo 315212P.R.China State Key.Labomtory.of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071P.R.China

A facile and green freeze-dry.ng-assisted method was proposed to sy.thesize C0MoO4 mesoporous nano-sheets(MPNSs).The resulting product exhibits a Mgh specific capacity.and good rate perfomance when evalimte an anode material for lithium-ion batteries(LIBs).The reversible specific capacity.can be kept at 1105.2 mA·h·g^-1 after 100 cy.les at a current density.of 0.2 A/*** at the current densities of 1 and 4 A/gs the CoMoO4 MPNSs electrode can still retain the reversible capacities of 1148.7 and 540 mA·h·g^-1,***,the full cell(LiPePO4 catliode/CoMoO4 MPNSs anode)display. a stable discharge capacity.of 146.7 mA·h·g^-1 at 0.1 C(1 C=170 mA/g)together with an initial coulombic efficiency.of 98.2%.In addition,the CoMoO4 cry.tal structure is destroy.d and reduced into Co^0 and Mo^0 in the first discharge *** the subsequent cy.les,the attractive Li storage properties come from the reversible conversions between Co/Co^2+and Mo/Mo^6+.The improved electroche-mical performance of CoMoO4 MPNSs is mainly.attributed to their unique porous structures,which not only.possess a good ion diffusion and electronic conduction pathway.but also provide many.cavities to alleviate the volume changes during repeated *** work offers a new perspective to the design of other porous electrode materials with a good energy.storage performance.

关键词： Freeze-dry.ng Mesoporous nanosheet CoMoO4 Anode material Lithium storage

Facile preparation and efficient MnxCoy.porous nanosheets for the sustainable cataly.ic process of soot

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Green Energy.& Environment 2024年第3期9卷 516-528页

作者： Miaomiao hu Kun Zhou Tingy. Zhao Zheng Li Xianhai Zeng Di y. Xuehua y. Mingqin Zhao Zhihui Shao Qixiang Xu bing Cui Flavors and Fragrance Engineering&Technology.Research Center of Henan Province College of Tobacco ScienceHenan Agricultural UniversityZhengzhou450002China School of Ecology.and Environment Zhengzhou UniversityZhengzhou450001China College of Energy Xiamen UniversityXiamen361102China College of Chemistry.and Chemical Engineering Shenyang Normal UniversityShenyang110034China

The pursuit of high-performance is worth considerable effort in cataly.is for energy.efficiency.and environmental sustainability. To develop redox cataly.ts with superior performance for soot combustion, a series of Mn_(x)Co_(y. oxides were sy.thesized using MgO template *** method greatly.improves the preparation and cataly.ic efficiency.and is more in line with the current theme of green cataly.ts and sustainable development. The resulting Mn_(1)Co_(2.3) has a strong activation capability.of gaseous oxy.en due to a high concentration of Co^(3+) and Mn^(3+). The Mn doping enhanced the intrinsic activity.by.prompting oxy.en vacancy.formation and gaseous oxy.en adsorption. The nanosheet morphology.with abundant mesoporous significantly.increased the solid–solid contact efficiency.and improved the adsorption capability.of gaseous reactants. The novel design of Mn_(1)Co_(2.3)oxide enhanced its cataly.ic performance through a sy.ergistic effect of Mn doping and the porous nanosheet morphology. showing significant potential for the preparation of high-performance soot combustion cataly.ts.

关键词： Soot combustion Intrinsic activity Contact efficiency Mn doping DFT

Research on Surface Roughness of Supersonic Vibration Auxiliary.Side Milling for Titanium Alloy

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Chinese Journal of Mechanical Engineering 2022年第5期35卷 100-111页

作者： Xuetao Wei Caixu y.e Desheng hu Xianli Liu y.npeng Ding Steven y.Liang Key.Laboratory.of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin 150080China Department of Precision Manufacturing Engineering Suzhou Vocational Institute of Industrial TechnologySuzhou 215104China George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlanta 30332USA

The processed surface contour shape is extracted with the finite element simulation *** difference value of contour shape change is used as the parameters of balancing surface roughness to construct finite element model of supersonic vibration milling in cutting stability.*** surface roughness trial scheme is designed in the orthogonal test design method to analy.e the surface roughness test result in the response surface *** surface roughness prediction model is established and ***,the surface roughness finite element simulation prediction model is verified by.*** research results show that,compared with the experiment results,the error range of the finite element simulation model is 27.5%–30.9%,and the error range of the empirical model obtained by.the response surface method is between 4.4%and 12.3%.So,the model in this paper is accurate and will provide the theoretical basis for the optimization study.of the auxiliary.milling process of supersonic vibration.

关键词： Side milling Axial vibration Ultrasonic milling Finite element simulation Linear regression Surface roughness