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A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats

Neural Regeneration Research 2013年第18期8卷 1655-1662页

作者： Jiwei wang Wen Chen yuliang wang School of Medicine Shandong University Department of Physiology Weifang Medical University

The ginkgo biloba extract EGb761 improves memory loss and cognitive impairments in patients with senile dementia. It also promotes proliferation of neural stem cells in the subventricular zone in Parkinson＇s disease model mice and in the hippocampal zone of young epileptic rats. However, it remains unclear whether EGb761 enhances proliferation of endogenous neural stem cells in the brain of rats with vascular dementia. In this study, a vascular dementia model was established by repeatedly clipping and reperfusing the bilateral common carotid arteries of rats in combination with an intraperitoneal injection of a sodium nitroprusside solution. Seven days after establishing the model, rats were intragastrically given EGb761 at 50 mg/kg per day. Learning and memory abilities were assessed using the morris water maze and proliferation of endogenous neural stem cells in the subventricular zone and dentate gyrus were labeled by 5-bromo-2-deoxyuridine immunofluorescence in all rats at 15 days, and 1, 2, and 4 months after model establishment. The escape latencies in morris water maze tests of rats with vascular dementia after EGb761 treatment were significantly shorter than the model group. Immunofluorescence staining showed that the number and proliferation of 5-bromo-2-deoxyuridine-positive cells in the subventricular zone and dentate gyrus of the EGb761-treated group were significantly higher than in the model group. These experimental findings suggest that EGb761 enhances proliferation of neural stem cells in the subventricular zone and dentate gyrus, and significantly improves learning and memory in rats with vascular dementia.

关键词： neural regeneration traditional Chinese medicine ginkgo biloba extract EGb761 vasculardementia neural stem cells subventricular zone dentate gyrus learning and memory grants-supported paper neuroregeneration

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MATERIALS CHARACTERIZATION USING THE MICROBEAM AT SUNy/ALBANy

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Nuclear Science and Techniques 1990年第Z1期1卷 70-75页

作者： H.Bakhru W.G.morris A.Haberl State University of New york at Albany Albany N.Y. 12222 U.S.A

The State University of New york at Albany ion scanning microprobe has been used for materials characterization. Focused proton and helium ion beams have been used. Rutherford backscattering spectroscopy (RBS) and particle - induced X - ray emission (PIXE) analysis have been performed on microelectronic circuits with a spatial resolution of approximately 2 μm. Studies on thin films of superconductors will be presented. Several examples of chemical and microstructural analysis will be given.

关键词： Ion scanning microprobe Rutherford backscattermg spectroscopy PIXE Thin films of superconductors

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Oxygen Reduction Reaction Catalyzed by Carbon-Supported Platinum Few-Atom Clusters:Significant Enhancement by Doping of Atomic Cobalt

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Research 2020年第1期2020卷 1756-1767页

作者： Bingzhang Lu Qiming Liu Forrest Nichols Rene Mercado David morris Ning Li Peng Zhang Peng Gao yuan Ping Shaowei Chen Department of Chemistry and Biochemistry University of California1156 High StreetSanta CruzCalifornia 950564USA Department of Chemistry Dalhousie University6274 Coburg RoadHalifaxNova ScotiaCanada B3H 4R2 International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Electron Microscopy Laboratory School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Centre of Quantum Matter Beijing 100871China

Oxygen reduction reaction(ORR)plays an important role in dictating the performance of various electrochemical energy *** platinum nanoparticles have served as the catalysts of choice towards ORR,minimizing the cost of the catalysts by diminishing the platinum nanoparticle size has become a critical route to advancing the technological ***,first-principle calculations show that carbon-supported Pt9 clusters represent the threshold domain size,and the ORR activity can be significantly improved by doping of adjacent cobalt *** is confirmed experimentally,where platinum and cobalt are dispersed in nitrogen-doped carbon nanowires in varied forms,single atoms,few-atom clusters,and nanoparticles,depending on the initial *** sample consisting primarily of Pt_(2~7)clusters doped with atomic Co species exhibits the best mass activity among the series,with a current density of 4:16Amg^(-1)_(Pt)at+0.85V *** that is almost 50 times higher than that of commercial Pt/C.

关键词： platinum Oxygen cobalt

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A database of experimentally measured lithium solid electrolyte conductivities evaluated with machine learning

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npj Computational Materials 2023年第1期9卷 2265-2278页

作者： Cameron J.Hargreaves Michael W.Gaultois Luke M.Daniels Emma J.Watts Vitaliy A.Kurlin Michael Moran yun Dang Rhun morris Alexandra Morscher Kate Thompson Matthew A.Wright Beluvalli-Eshwarappa Prasad Frédéric Blanc Chris M.Collins Catriona A.Crawford Benjamin B.Duff Jae Evans Jacinthe Gamon Guopeng Han Bernhard T.Leube Hongjun Niu Arnaud J.Perez Aris Robinson Oliver Rogan Paul M.Sharp Elvis Shoko Manel Sonni William J.Thomas Andrij Vasylenko Lu wang Matthew J.Rosseinsky Matthew S.Dyer Department of Chemistry University of LiverpoolLiverpool L697ZDUK Leverhulme Research Centre for Functional Materials Design Materials Innovation FactoryUniversity of LiverpoolLiverpool L73NYUK Department of Computer Science University of LiverpoolLiverpool L693BXUK Stephenson Institute for Renewable Energy University of LiverpoolLiverpool L697ZFUK

The application of machine learning models to predict material properties is determined by the availability of high-quality *** present an expert-curated dataset of lithium ion conductors and associated lithium ion conductivities measured by *** *** dataset has 820 entries collected from 214 sources;entries contain a chemical composition,an expert-assigned structural label,and ionic conductivity at a specific temperature(from 5 to 873°C).There are 403 unique chemical compositions with an associated ionic conductivity near room temperature(15–35°C).The materials contained in this dataset are placed in the context of compounds reported in the Inorganic Crystal Structure Database with unsupervised machine learning and the Element Movers *** dataset is used to train a CrabNet-based classifier to estimate whether a chemical composition has high or low ionic *** classifier is a practical tool to aid experimentalists in prioritizing candidates for further investigation as lithium ion conductors.

关键词： spectroscopy lithium classifier

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艾司氯胺酮介导AMPK/PAK2信号通路调节内质网应激改善大鼠术后认知功能障碍

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解剖科学进展 2024年第2期30卷 157-160页

作者：王睿李闯张明宇曹芳榕孙晓峰沈阳医学院附属中心医院麻醉科辽宁沈阳110024 解放军总医院第一医学中心麻醉科北京100853

目的探讨艾司氯胺酮介导AMPK/PAK2信号通路调节内质网应激改善大鼠术后认知功能障碍(POCD)。方法30只雄性20月龄SD大鼠,随机分为对照组(Control),模型组(POCD)和艾斯氯胺酮处理组(Esketamine),使用胫骨骨折内固定法制备模型。morris水... 详细信息

目的探讨艾司氯胺酮介导AMPK/PAK2信号通路调节内质网应激改善大鼠术后认知功能障碍(POCD)。方法30只雄性20月龄SD大鼠,随机分为对照组(Control),模型组(POCD)和艾斯氯胺酮处理组(Esketamine),使用胫骨骨折内固定法制备模型。morris水迷宫实验评价各组大鼠认知功能,HE染色观察大鼠海马病理变化情况,ELISA检测大鼠血清中炎症因子GSH、SOD和MDA含量,免疫荧光检测大鼠脑组织海马区ROS含量,Western blot法检测大鼠脑海马组织PERK、ATF6、CHOP、AMPK、p-AMPK和PAK2蛋白表达。结果经艾斯氯胺酮处理后的大鼠,在morris水迷宫实验中缩短逃避潜伏期、穿越原平台区域次数与在原平台所在象限的时间均显著增加;大鼠脑组织海马区神经细胞结构有所改善,损伤减轻;大鼠氧化应激反应降低;脑组织海马区ROS生成减少;内质网应激降低。结论艾司氯胺酮可能介导AMPK/PAK2信号通路调节内质网应激改善大鼠术后认知功能障碍。

关键词：术后认知功能艾斯氯胺酮 AMPK PAK2 内质网应激

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血栓通对阿尔茨海默症模型小鼠认知功能及神经异常兴奋性的作用及其机制研究

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昆明医科大学学报 2024年第2期45卷 23-31页

作者：刘慧严国纪吴嘉王丹习杨彦彬李珊珊昆明医科大学神经科学研究院云南昆明650500 昆明医科大学基础医学院实验教学中心云南昆明650500

目的探究血栓通[主要有效成分为三七皂苷(panax notoginseng,PNS)]对阿尔茨海默症(Alzheimer’s disease,AD)模型小鼠认知功能及神经兴奋性的影响,并探讨其潜在分子机制。方法用APP/PS1小鼠作为AD研究动物模型,在小鼠淀粉样蛋白尚未检... 详细信息

目的探究血栓通[主要有效成分为三七皂苷(panax notoginseng,PNS)]对阿尔茨海默症(Alzheimer’s disease,AD)模型小鼠认知功能及神经兴奋性的影响,并探讨其潜在分子机制。方法用APP/PS1小鼠作为AD研究动物模型,在小鼠淀粉样蛋白尚未检测到阶段(2月龄)开始每日以60 mg/kg对血栓通组(APP/PS1+PNS)行灌胃给药,每日1次,连续给药6个月(给药至8月龄);对照组小鼠予同等体积的0.9%氯化钠(APP/PS1+vehicle)灌胃处理,同月龄野生型小鼠予0.9%氯化钠灌胃处理作为正常对照组(WT+vehicle),每组各15只。6个月后,新物体识别实验、morris水迷宫实验检测小鼠的认知功能;EEG脑电检测、Western blot、细胞表面生物素化试验以检测各组小鼠皮质与海马中BACE1的活性、Nav1.1α的分布、表达以及Navβ2的表达与酶解情况(Navβ2的酶解片段Navβ2 full length及Navβ2-CTF表达检测)。结果新物体识别实验显示,与对照组APP/PS1小鼠相比,血栓通用药后APP/PS1小鼠的辨别指数(discrimination index,DI)上升(Pmorris水迷宫检测结果发现,血栓通灌胃6个月后小鼠在探索实验中逃避潜伏期缩短(P<0.05),撤除平台后在目标象限停留时间增加(P<0.05)、穿梭平台次数增加(P<0.05);EEG脑电检测结果发现,血栓通给药后减少了APP/PS1小鼠棘波放电出现的频率(P<0.05)。血栓通给药后显著降低了BACE1蛋白水平的表达(P<0.05),而全长片段Navβ2的蛋白水平显著上升(P<0.05),并纠正了Nav1.1α在神经元内外的异常分布(P<0.05)。结论血栓通可以改善AD模型小鼠的学习记忆能力、纠正大脑异常兴奋性,其作用机制可能与抑制BACE1的活性从而减少Navβ2由APP/PS1诱导的过度酶解,纠正皮质、海马神经元Nav1.1α的异常表达与分布,调节神经元的兴奋性有关。

关键词：血栓通阿尔茨海默症认知功能 BACE1 Navβ2酶解 Nav1.1α分布

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In-situ analysis of slip transfer and heterogeneous deformation in tension of Mg-5.4Gd-1.8y-1.5Zn alloy

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Journal of Magnesium and Alloys 2020年第4期8卷 1186-1197页

作者： Shaosong Jiang yong Jia Xiaojun wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

Slip transfer is influential in determining damage nucleation of polycrystalline *** interactions between dislocations and grain boundaries(GBs)was investigated using in-situ tension test in a multi-directionally forged Mg-5.4Gd-1.8y-1.5Zn(wt%)*** was found that strain accommodation of individual grains by means of slip occurred more easily than slip transfer when several slip systems were *** basal-basal slip transfer occurred when the GB misorientation was smaller than 34.2°,whereas basal-pyramidal type took place when the crystallographic misorientation was larger than 48.8°.The product of Luster-morris m factor and the sum of the Schmid factors of the two correlated slip systems indicated that the threshold for basal-basal slip transfer may exist,however,basal-pyramidal slip transfer shows no such threshold and is more *** results presented here demonstrated that besides the geometrical alignment,the deformation details(such as the number of operable slip systems)and stress state in each individual grain must be considered.

关键词： Slip transfer Mg-RE alloy Heterogeneous deformation In-situ tensile test

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丁苯酞对小鼠颅脑损伤后认知功能的保护作用

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川北医学院学报 2024年第3期39卷 289-292页

作者：牛文书张振红王玉斌李经纶刘扬联勤保障部队第九八八医院神经内科河南郑州450000 联勤保障部队第九八八医院神经外科河南郑州450000

目的:观察丁苯酞对小鼠颅脑损伤(TBI)后认知功能的保护作用。方法:将120只雄性昆明小鼠随机分为假手术组、手术对照组、丁苯酞处理组1和丁苯酞处理组2。采用压缩损伤法建立TBI模型,丁苯酞处理组1给予100 mg·kg^(-1)·d^(-1)丁苯酞腹腔... 详细信息

目的:观察丁苯酞对小鼠颅脑损伤(TBI)后认知功能的保护作用。方法:将120只雄性昆明小鼠随机分为假手术组、手术对照组、丁苯酞处理组1和丁苯酞处理组2。采用压缩损伤法建立TBI模型,丁苯酞处理组1给予100 mg·kg^(-1)·d^(-1)丁苯酞腹腔内注射,丁苯酞处理组2和假手术组给予200 mg·kg^(-1)·d^(-1)丁苯酞,手术对照组给予同等剂量的生理盐水。采用morris水迷宫和y型迷宫行为学测试评估小鼠空间认知功能,免疫印迹法检测海马和前额叶内侧皮质BDNF表达水平,TUNEL检测海马区神经元凋亡。结果:与手术对照组比较,TBI后7 d及14 d,丁苯酞处理组2小鼠自发轮替行为增多(P<0.05);TBI后14 d,丁苯酞处理组1和组2逃避潜伏期缩短(P<0.05);TBI后28 d,丁苯酞处理组2小鼠逃避潜伏期缩短(P<0.05);TBI后14 d,丁苯酞处理组1海马组织与丁苯酞处理组2海马组织及前额叶内侧皮质BDNF表达水平均上调(P<0.05)。各组海马区神经元凋亡率比较:假手术组<丁苯酞处理组2<丁苯酞处理组1<手术对照组(P<0.05)。结论:丁苯酞可改善小鼠TBI后空间记忆功能,上调海马及前额叶内侧皮质BDNF表达与抑制海马神经元的凋亡可能是其潜在机制。

关键词：脑损伤模型小鼠丁苯酞神经保护

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Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats

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Neural Regeneration Research 2010年第5期5卷 353-357页

作者： Xiaojuan wang Hong Liu Liang Li Department of Pathology College of Basic Medical Sciences Capital Medical University Beijing 100069 China

BACKGROUND： Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer＇s disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. Early clinical symptoms in Alzheimer＇s disease patients include learning and memory deficits. OBJECTIVE： To measure learning and memory, as well as β- and β-secretase activities in the hippocampus of a cerebral ischemia/hypoxia rat model with chronic cerebral hypoperfusion. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Department of Pathology, Capital Medical University from March to December, 2008. MATERIALS： β- and y-secretase activity kits were purchased from R ＆ D Systems, USA. METHODS： Male Sprague Dawiey rats, aged 23 weeks, were randomly assigned to model （n = 56） and sham-surgery （n = 46） groups. Cerebral hypoperfusion rat models were established by bilateral common carotid occlusion. MAIN OUTCOME MEASURES： morris water maze was used to test changes in escape latency and path length, and β- and y-secretase activities were measured on days 10, 30, 90, and 180 following surgery. RESULTS： Progressive cognitive impairment resulted from 30 days of chronic cerebral hypoperfusion, which lasted for 180 days after cerebral hypoperfusion. β-secretase activity was increased at 10 days after hypoperfusion, which continued until 180 days, with a 14.25% increase compared to the sham-surgery group; y-secretase activity was increased by 10.5%. CONCLUSION： Chronic cerebral hypoperfusion results in impaired spatial memory and upregulated β- and y-secretase activities, which could play an important role in β-amyloid production.

关键词： chronic cerebral hypoperfusion β-amyloid β-secretase γ-secretase Alzheimer's disease brain injury neural regeneration

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Drofenine as a Kv2.1 inhibitor alleviated AD-like pathology in mice through A β/Kv2.1/microglial NLRP3/neuronal tau axis

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中国药理学与毒理学杂志 2023年第7期37卷 546-547页

作者： LU Jian ZHOU Qian ZHU Danyang ZHAO Xuejian HUANG yujie CAO Peng wang Jiaying SHEN Xu Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine

OBJECTIVE Alzheimer disease(AD) is a neurodegenerative disease with clinical hallmarks of progressive cognitive impairment. Synergistic effects of Aβ-tau cascade reaction are tightly implicated in AD pathology, and microglial NLRP3 inflammasome activation drives neuronal tauopathy through microglia and neurons crosstalk. However, the underlying mechanism of how Aβ mediates NLRP3 inflammasome remains unclear. Shab related potassium channelmember1(Kv2.1)asavoltagegatedpotassium channel widely distributed in the central nervous system and plays an important role in regulating the outward potassium flow in neurons and glial cells. In current work, we aimed to explore the underlying mechanism of Kv2.1 in regulating Aβ/NLRP3 inflammasome/tau axis by using a determined Kv2.1 inhibitor drofenine(Dfe).METHODS Cell-based assays including Western blotting and immunofluorescence staining against primary microglia or neurons were carried out to expound the role of Kv2.1 channel in NLRP3 inflammasome activation and subsequent neuronal tau *** animal studies, new object recognition, y-maze and morris water maze were performed to evaluate the amelioration of Kv2.1 inhibition through either Kv2.1 inhibitor Dfe treatment or adeno-associated virus AAV-ePHP-siKv2.1injectionon5×FADADmodel mice. Assays of histology and immunostaining of tissue sections and Western blotting of brain tissues were performed to verify the conclusion of cellular assays. RESULTS We reported that oligomeric Aβ(o-Aβ) bound to microglial Kv2.1 and promoted Kv2.1-dependent potassium leakage to activate NLRP3 inflammasome through JNK/NF-κB pathway subsequently resulting in neuronal tauopathy. Treatment of either Kv2.1 inhibitor Dfe or AAV-ePHP-si-Kv2.1 for brain-specific Kv2.1 knockdown deprived o-A β of its capability in inducing microglial NLRP3 inflammasome activation and neuronal tau hyperphosphorylation, while improved the cognitive impairment of 5×FAD AD model mice. CONCLUSION Our results

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