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Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver

Acta Pharmaceutica Sinica b 2021年第12期11卷 3806-3819页

作者： Jian Jin banrida Wahlang Monika Thapa Kimberly Z.Head Josiah E.Hardesty sudhir Srivastava Michael L.Merchant Shesh N.Rai Russell A.Prough Matthew C.Cave Department of Pharmacology&Toxicology theUniversity of Louisville School ofMedicineLouisvilleKY 40202USA Department of Endocrinology the Second Affiliated Hospital&Yuying Children’s HospitalWenzhou Medical UniversityWenzhou 325027China Division of Gastroenterology Hepatology&NutritionDepartment of Medicinethe University of Louisville School of MedicineLouisvilleKY 40202USA Superfund Research Center the University of LouisvilleLouisvilleKY 40202USA eDepartment of Biochemistry and Molecular Geneticsthe University of Louisville School of MedicineLouisvilleKY 40202USA Department of bioinformatics and biostatistics the School of Public Health and Information Sciencesthe University of LouisvilleLouisvilleKY 40202USA Centre for Agricultural bioinformatics ICAR-Indian Agricultural Statistics Research InstituteNew Delhi 110012India The Center for Integrative Environmental Health Sciences University of LouisvilleLouisvilleKY 40202USA Division of Nephrology&Hypertension Department of Medicinethe University of Louisville School of MedicineLouisvilleKY 40202USA The Hepatobiology and Toxicology Center University of LouisvilleLouisvilleKY 40202USA Alcohol Research Center University of LouisvilleLouisvilleKY 40202USA biostatistics and bioinformatics Facility James Graham Brown Cancer CenterLouisvilleKY 40202USA

Dioxin-like molecules have been associated with endocrine disruption and liver *** better understand aryl hydrocarbon receptor(AHR)biology,metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this *** wild type(WT)and Ahr^(-/-) mice(Taconic)were fed a control diet and exposed to 3,3',4,4',5-pentachlorobiphenyl(PCb126)(61 nmol/kg by gavage)or vehicle for two ***126 increased expression of canonical AHR targets(Cyp1 a1 and Cyp1 a2)in WT but not Ahr^(-/-).Knockouts had increased adiposity with decreased glucose tolerance;smaller livers with increased steatosis and perilipin-2;and paradoxically decreased blood ***126 was associated with increased hepatic triglycerides in Ahr^(-/-).The liver proteome was impacted more so by Ahr^(-/-) genotype than ligandactivation,but top gene ontology(GO)processes were *** PCb126-associated liver proteome was *** principally regulated liver metabolism(e.g.,lipids,xenobiotics,organic acids)and bioenergetics,but it also impacted liver endocrine response(e.g.,the insulin receptor)and function,including the production of steroids,hepatokines,and pheromone binding *** effects could have been indirectly mediated by interacting transcription factors or *** biologic roles of the AHR and its ligands warrant more research in liver metabolic health and disease.

关键词： AHR Endocrine disruption Environmental liver disease Nonalcoholic fatty liver disease Perilipin-2 Pheromones PCb126

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Cluster sampling methodology to evaluate immunization coverage

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World Journal of Methodology 2024年第3期14卷 78-89页

作者： Aishwarya Sharma Rb Jain Jitesh Satija Aditi Sharma Avani Sharma sudhir Shekhawat Department of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Department of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Department of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Department of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Department of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent biostatistician Ghaziabad 201014UPIndia

bACKGROUND Immunization is a key component of primary health care and an indisputable human *** are critical to the prevention and control of infectious disease *** coronavirus disease 2019(COVID-19)pandemic and associated disruptions over the past two years have strained the health systems,with many children missing out on essential childhood *** To evaluate the immunization coverage among 12-23-month-old children in the rural areas of Community Health Centre(CHC)Dighal and to determine the factors influencing the existing immunization *** A coverage evaluation survey was conducted according to the 30-cluster sampling technique,which is the standard methodology for such surveys devised by World Health Organization.A total of 300 children aged 12-23 months were included,whose immunization details were noted from their immunization *** Full immunization rate was noted in 86.7%of the children,with partial and non-immunized children accounting for 9%and 4.3%*** full immunization dropout rate was 4.2%.The common reasons for partial or non-immunization were family problem including illness of mother,vaccine not being available and child being *** of birth(P=0.014)and availability of immunization card(Py was conducted in 2020/2021,health services were disrupted due to the COVID-19 *** Due to the coverage being higher than the national average,it was concluded that the immunization coverage was optimal and not affected by the COVID-19 pandemic.

关键词： Immunization coverage Children COVID 19 pandemic Vaccines Family health Routine immunization

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Endosulfan Causes Neoplastic Changes in the Liver Cells of Mice

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Open Journal of Pathology 2014年第3期4卷 86-93页

作者： Arun Kumar Mohammad Ali Jitendra Kumar Singh Akhileshwari Nath sudhir Kumar Srivastava Ranjit Kumar Department of Zoology Patna University Patna India Research Centre Mahavir Institute and Research Centre Patna India

The rapid growth in global population continues to challenge the world’s ability to provide enough food. As one of the most crucial issues for human development, food production must increase to offset hunger and poverty as well as social unrest. To augment the yield of crops a variety of pesticides like Endosulfan, Rogor, Aldrin, Chlorpyrifos, etc. are being used liberally by the farmers. In the present investigation, Endosulfan was administered orally (daily) by gavage method to female Swiss albino mice group for 4 weeks @ 3.0 mg/kg b.w. After that, they were left for 6 months and then sacrificed and liver tissues were fixed for light microscopy and Transmission Electron Microscopic study. The histopathological study of Endosulfan administered group liver showed hepatocytes with congestion in central vein with less dense cytoplasm, haemorrhaged bile duct, degenerated cytoplasm and central vein with vacuolations in sinusoidal spaces. Neoplastic changes in hepatocytes are the major finding of study. The ultrastuctural study revealed dilation in the nuclear pore complex and massive movement of cytoplasmic material from cytoplasm to the nucleus which is major finding which denotes neoplastic changes. Presence of abundant free lying polyribosomes in the cytoplasm, which denotes neoplastic changes in the cellis also one of theimportant finding observed. The present study thus deciphers that Endosulfan toxicity leads to onset of neoplasia thence carcinogenesis in liver cells in Swiss albino mice which is the novel finding in the field of toxicology.

关键词： Endosulfan Neoplasia Liver Cell Light Microscopy Transmission Electron Microscopy

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血清钙调神经磷酸酶活性与左室肥大之间呈正相关

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 57-58页

作者： Choudhary R. sastry b.K.S. Subramanyam C. 杜媛 Department of biochemistry Osmania University Hyderabad-500007India

background: Among various intracellular signaling cascades associated with cardiac hypertrophy, the involvement of calcineurin(CaN; Ca2+-calmodulin dependen t protein phosphatase) is gaining credence because of its enhanced activity in ventricular myocardium and the ability of CaN inhibitors to prevent pressure-overload hypertrophy. Since our recent finding s attribute clinical significance to serum CaN, the present investigation was co nducted to evaluate its significance in cardiac hypertrophy. Methods: The study group comprised of patients diagnosed for hypertensive hypertrophy, hypertrophic cardiomyopathy, chronic coronary artery disease with compensatory left ventricu lar hypertrophy, dilated cardiomyopathy and acute myocardial infarction. Serum c ontents of CaN and calmodulin were determined and activities of CaN as well as o f acid and alkaline phosphatases were assayed and correlated with 2D echocardiog raphy findings. The results were compared with those obtained from age-matched healthy volunteers. Results: Serum CaN activity, but not of acid or alkaline pho sphatases, was significantly enhanced by 2-fold in hypertensive hypertrophy, 3 -fold in hypertrophic cardiomyopathy and 3.75-fold in chronic coronary artery disease associated with left ventricular hypertrophy, unaccompanied by changes i n serum contents of calmodulin and CaN. No such increases were observed in acute myocardial infarction and dilated cardiomyopathy. Conclusions: Positive correla tions observed between serum CaN activity and enhanced left ventricular mass in cardiac hypertrophy suggest that assaying serum CaN activity may be useful in th e diagnosis and management of left ventricular hypertrophy.

关键词：左室肥大钙调神经磷酸酶血清

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婴儿阑尾盲肠多重套叠并急性阑尾炎一例并文献复习

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中华小儿外科杂志 2017年第3期38卷 211-215页

作者：张远圆张杉杉吴学东李娜 sudhir Rajbhandari 李家萌大理大学第一附属医院暨临床医学研究中心小儿外科 671000 大理大学基础医学院寄生虫学教研室

目的探讨婴儿期阑尾盲肠多重套叠并急性阑尾炎的临床病理和诊治方法。方法回顾性分析1例阑尾盲肠多重套叠并急性阑尾炎8月龄婴儿的临床资料，并通过PubMed、ProQuest、中国知网（CNKI）、万方和维普数据库中检索2016年5月前的报道并复... 详细信息

目的探讨婴儿期阑尾盲肠多重套叠并急性阑尾炎的临床病理和诊治方法。方法回顾性分析1例阑尾盲肠多重套叠并急性阑尾炎8月龄婴儿的临床资料，并通过PubMed、ProQuest、中国知网（CNKI）、万方和维普数据库中检索2016年5月前的报道并复习相关文献资料，对各类儿童阑尾套叠进行系统性综述。结果本例阑尾盲肠多重套叠并急性阑尾炎经手术诊断，整复套叠后切除阑尾并经病理证实，术后顺利康复。共检索到215例阑尾套叠中儿童52例，阑尾盲肠套叠136例，仅3例阑尾自身套叠中有2例为儿童；检索到肠套叠并阑尾炎66例，儿童59例，其中小于1岁的患儿27例，回结型肠套叠43例，此外，检索到回肠盲肠型套叠7例和盲肠盲肠型套叠并阑尾炎1例均为成人患者，所有病例均行手术治疗而痊愈。儿童阑尾盲肠多重套叠并急性阑尾炎者未见报道。结论婴儿阑尾盲肠多重套叠并急性阑尾炎罕见，如套叠未导致回盲瓣排空完全梗阻则无典型症状体征，诊断困难，易误、漏诊。因此，对经保守治疗不能解除肠梗阻且不能解释其原因时，只要b型超声提示“同心圆征”或“套筒征”就应果断行手术探查以明确诊断并及时治疗。

关键词：肠套叠阑尾炎肠梗阻

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源自车辆的微粒磁性与Ficus infectoria(一个关键种)对它的改善

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AMbIO－人类环境杂志 2005年第B12期34卷 639-640页

作者： sudhir Kumar Pandey b.D.Tripathi Santosh Kumar Prajapati Virendra Kumar Mishra Alka Rani Upadhyaya Prabhat Kumar Rai Atul Prakash Sharma 王胜 Pollution Ecology Research Laboratory Centre of Advanced Study in botany banaras Hindu University

引言源自车辆燃烧的磁性矿物质主要是磁铁矿和金属铁颗粒,大小为0.1～0.7 μm[1].这种大小的颗粒对人类特别有害,因为它能被吸入肺里.而且,在悬浮尘粒中,磁铁与其它重金属(如锌、镉、铬)[2]和对人体健康有害的诱变有机化合物[3]结合在一起.

关键词：车辆排放磁性关键种微粒车辆制动系统燃烧过程有机化合物不规则形状铁颗粒人体健康

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原发性和获得性免疫缺陷疾患

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吉林医学 1987年第5期 65-65页

作者： sudhir Guptal 梁会泽敬华

人类淋巴细胞病毒（HTLV）是具有逆转录酶的一大组病毒。其感染人体的范围很大,既可引起携带 HTLV—Ⅳ型病毒的无感觉性疾病,也可引起与 HTLV-Ⅲ型病毒相关的获得性免疫缺陷综合征（AIDS）。人类免疫缺陷病毒（HIV）对免疫反应的作用是... 详细信息

人类淋巴细胞病毒（HTLV）是具有逆转录酶的一大组病毒。其感染人体的范围很大,既可引起携带 HTLV—Ⅳ型病毒的无感觉性疾病,也可引起与 HTLV-Ⅲ型病毒相关的获得性免疫缺陷综合征（AIDS）。人类免疫缺陷病毒（HIV）对免疫反应的作用是选择性地感染或/并杀伤带有 CD4抗原的细胞（CD4细胞的主要表型是辅助/抑制 T 细胞,但巨噬细胞、b 细胞和大脑的小胶质细胞也可是 CD4+）。利用 RNA 探针已经揭示在 HIV 感染的早期,大约有1%到1/10～6的 CD4+T 细胞受到 HIV 的感染。因此,在 AIDS 病人可能有许多机制引起免疫缺陷的直接细胞病理效应。这些机制

关键词：细胞数抗原 CD HIV 单克隆抗体 HTLV 有丝分裂间接分裂免疫缺陷 MHC bLS

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bárány协会:“颈性头晕”的观点

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神经损伤与功能重建 2023年第12期18卷 691-696页

作者：王钰茹(译) 邢玥(译) 冯宇菲(译) 凌霞(译) 隋汝波(审校) 杨旭(审校) barry M.Seemungal yuri Agrawal Alexander bisdorff Adolfo bronstein Kathleen E.Cullen Peter J.Goadsby Thomas Lempert sudhir Kothari Phang boon Lim Måns Magnusson Hani J.Marcus Michael Strupp David Susan L.Whitney 航天中心医院(北京大学航天临床医学院)神经内科锦州医科大学附属第一医院神经内科北京大学第一医院神经内科帝国理工学院脑科学系前庭神经病学中心约翰·霍普金斯大学医学院耳鼻喉头颈外科学系 Emile Mayrisch医疗中心神经内科约翰·霍普金斯大学医学院生物医学工程、神经科学和耳鼻喉科-头颈外科系英国伦敦国王学院和美国加州大学洛杉矶分校 Schlosspark-Klinik医院神经内科浦那医院与研究中心帝国理工学院哈默史密斯医院心内科隆德大学&Skane大学医院耳鼻咽喉科和临床科学部英国伦敦国立神经病学与神经外科医院神经外科路德维希马克西米利安大学神经病学系与德国眩晕和平衡障碍中心匹兹堡大学健康与康复科学学院物理治疗系

本文介绍了bárány协会分类监督委员会(COCS)对颈性头晕(有时也称为颈性眩晕)的观点。这些内容首先由多个领域的专家进行了初步审查,之后由bárány协会COCS进行进一步审定。基于当前已发表的文献,bárány协会COCS认为,自身运动的错觉... 详细信息

本文介绍了bárány协会分类监督委员会(COCS)对颈性头晕(有时也称为颈性眩晕)的观点。这些内容首先由多个领域的专家进行了初步审查,之后由bárány协会COCS进行进一步审定。基于当前已发表的文献,bárány协会COCS认为,自身运动的错觉(眩晕-旋转感或其他)与颈部病理和(或)颈部疼痛症状(通过影响颈椎、软组织结构或颈神经根)之间机制的关联尚缺乏证据支持。当头颈部联合运动诱发出现旋转的错觉时,其原因可能是尚未确诊的常见前庭疾病(如偏头痛或bPPV),也可能是较少见的中枢性前庭疾病(包括急性起病的危急状况,例如椎动脉夹层伴后循环卒中以及极其罕见的椎动脉压迫综合征)。同时,COCS指出,迄今为止,偏头痛(包括前庭性偏头痛)为颈部疼痛和前庭症状同时出现的最常见原因。而且,在几乎所有前庭疾病中,头部运动常会导致患者症状的加重,推测在这些前庭疾病患者中常见颈部肌肉紧张度的增加(因果关系尚不清楚)可能与头部运动减少有关。此外,还存在一些尚未探索的理论机制问题,如颈部疼痛可能促发血管迷走反射、心脏抑制反射继而通过晕厥前机制导致短暂的定向障碍和(或)失衡。COCS提出还有一些少见的案例,如那些颈部肌肉痉挛伴模糊的空间定向障碍和(或)失衡感的患者是否确实存在颈部本体感觉受损机制,值得进一步深入研究。展望未来,通过严格纳入和排除标准,以减少敏感性而增加特异性的方法进行研究对象的选择,进一步采用双盲、安慰剂对照的研究方案将更为理想。为进一步促进“颈性头晕/眩晕”的研究,在进行设计机制和治疗的对照研究时,亦应考虑到那些重要的混杂因素相关问题。基于此,目前的bárány COCS并未提出用于研究之外的临床初步诊断标准。相信随着新的研究证据的不断积累,这一观点将可能会发生改变。

关键词：颈性颈源性颈部头晕眩晕前庭

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