检索结果-南通市图书馆

Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1371-1386页

作者： Zeyu CHAI J.T.HAN xuyuan song Jian ZANG Yewei ZHANG Zhen ZHANG College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Jacobs School of Engineering University of California San DiegoSan Diego CA 92122U.S.A. Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of EducationNortheastern UniversityShenyang 110819China

A novel X-shaped variable stiffness vibration isolator(X-VSVI)is *** Runge-Kutta method,harmonic balance method,and wavelet transform spectra are introduced to evaluate the performance of the X-VSVI under various *** layer number,the installation angle of the X-shaped structure,the stiffness,and the active control parameters are systematically *** addition,a prototype of the X-VSVI is manufactured,and vibration tests are carried *** results show that the proposed X-VSVI has a superior adaptability to that of a traditional X-shaped mechanism,and shows excellent vibration isolation performance in response to different amplitudes and forms of ***,the vibration isolation efficiency of the device can be improved by appropriate adjustment of parameters.

关键词： bionic vibration isolation X-shaped structure variable stiffness structure nonlinear dynamics prototype experiment

Nonlinear Vibration Isolation of Spacecraft System by a Bionic Variable-Stiffness Device Enhanced by Electromagnetic Component

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2023年第6期36卷 921-932页

作者： Zeyu Chai xuyuan song Jian Zang Yewei Zhang College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China

This study addresses the modified bionic vibration isolation technology by introducing the electromagnetic system to simulate biological damping *** has been proven effective in improving the vibration *** assuming the spacecraft-adapter system as a two-degree-of-freedom system,an excellent simplified model can be *** novel bionic vibration isolation device(ABVS-EMVI),which combines an active bionic variable-stiffness device(ABVSVI)with the electromagnetic system,is proposed for the purpose of isolating vibration and harvesting energy at the same *** dynamic equations of the spacecraft-adapter system with ABVS-EMVI are obtained using the Taylor expansion within the framework of the Lagrange equation,and the harmonic balance method is introduced to acquire the amplitude and voltage response of the *** results indicate that the electromagnetic system can enhance the vibration isolation performance and provide energy harvesting *** confirming the ability of ABVS-EMVI to deal with different forms and amplitudes of excitation,the performance of vibration isolation and energy harvesting is investigated in terms of various parameters,and several new conclusions have been drawn.

关键词： Bionic structure Electromagnetic system Vibration isolation Energy harvesting

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 795-807页

作者： Yongchun Pan Xiaowei Luan Fei Zeng xuyuan Wang Shurong Qin Qianglan Lu Guanzhong He Yanfeng Gao Xiaolian Sun Xin Han Bangshun He Yujun song Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 211198China School of Medicine&Holistic Integrative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene ***,the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor ***,we propose a self-amplifying logic-gated gene editing strategy for gene/H_(2)O_(2)-mediated/starvation multimodal cancer *** this approach,a hypoxia-degradable covalent-organic framework(COF) is synthesized to coat a-ZIF-8 in which glucose oxidase(GOx) and CRISPR system are *** intensify intracellular redox dyshomeostasis,DNAzymes which can cleave catalase mRNA are loaded as *** the nano system gets into the tumor,the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx,which amplifies intracellular H^(+)and hypoxia,accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target *** tandem reactions deplete glucose and oxygen,leading to logic-gated-triggered gene editing as well as synergistic gene/H_(2)O_(2)-mediated/starvation ***,this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

关键词： CRISPRdelivery Enzymeencapsulation Logic gate Hybridmaterial Hypoxia Gene editing Precise nanomedicine Multimodal therapy

M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第3期67卷 579-595页

作者： Yuzhen Hu Li Jiang Guangwen Wang Yangming song Zhibo Shan xuyuan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Liling Liu Hualan Chen Chengjun Li State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China

Influenza A virus(IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to be involved in the fusion of viral envelope and late endosomal membranes. In this study, we identified cation-dependent mannose-6-phosphate receptor(M6PR) as a crucial host factor for the replication of IAV. We found that siRNA knockdown of M6PR expression significantly reduced the growth titers of different subtypes of IAV, and that the inhibitory effect of M6PR siRNA treatment on IAV growth was overcome by the complement of exogenously expressed M6PR. When A549 cells were treated with siRNA targeting M6PR,the nuclear accumulation of viral nucleoprotein(NP) was dramatically inhibited at early timepoints post-infection, indicating that M6PR engages in the early stage of the IAV replication cycle. By investigating the role of M6PR in the individual entry and post-entry steps of IAV replication, we found that the downregulation of M6PR expression had no effect on attachment, internalization, early endosome trafficking,or late endosome acidification. However, we found that M6PR expression was critical for the fusion of viral envelope and late endosomal membranes. Of note, M6PR interacted with the hemagglutinin(HA) protein of IAV, and further studies showed that the lumenal domain of M6PR and the ectodomain of HA2 mediated the interaction and directly promoted the fusion of the viral and late endosomal membranes,thereby facilitating IAV replication. Together, our findings highlight the importance of the M6PR–HA interaction in the fusion of viral and late endosomal membranes during IAV replication.

关键词： influenza A virus M6PR HA membrane fusion late endosome

新疆上游水库浮游植物群落结构与环境因子关系

在线全文

学校读者我要写书评

暂无评论

塔里木大学学报 2024年第1期36卷 84-92页

作者：訾方泽葛建民王新月刘斐宋勇张蝶燕林旭元陈生熬塔里木大学生命科学与技术学院塔里木珍稀鱼类研究中心新疆阿拉尔843300 新疆生产建设兵团第一师农业技术推广站新疆阿拉尔843300 新疆生产建设兵团水产技术推广总站新疆乌鲁木齐830000

本研究旨在掌握新疆上游水库浮游植物分布特征,了解库区生态情况,于2021年8月13日(丰水期)和2022年5月3日(枯水期)进行浮游植物采集,并通过冗余分析法(RDA),分析其群落结构与环境因子之间关系。结果显示:上游水库5个典型水域断面共鉴定... 详细信息

本研究旨在掌握新疆上游水库浮游植物分布特征,了解库区生态情况,于2021年8月13日(丰水期)和2022年5月3日(枯水期)进行浮游植物采集,并通过冗余分析法(RDA),分析其群落结构与环境因子之间关系。结果显示:上游水库5个典型水域断面共鉴定出浮游植物6门29属40种,在门水平,两个水期中硅藻门均为主要优势种群,占总类的40.00%;其次为绿藻门和蓝藻门,占总类的27.50%、20.00%;裸藻门、金藻门和隐藻门种类较少;种水平上,优势种为梅尼小环藻、桥弯藻和谷皮菱形藻。两个水期浮游植物群落结构差异较大(P<0.05),枯水期浮游植物种类数量及生物量皆高于丰水期。通过浮游植物生物量及密度分析评价,上游水库水体呈贫营养状态。浮游生物Shannon-Wiener多样性指数为2.83,Margalef物种丰富度指数为2.97,Pielou均匀度指数为0.56。RDA结果表明电导率(EC)、水温(WT)及溶解氧(DO)是影响上游水库浮游植物群落变化的主要环境因子。本研究为新疆上游水库的可持续发展和丰富其生态多样性奠定了一定基础。

关键词：上游水库浮游植物多样性环境因子

DeST 3.0:A new-generation building performance simulation platform

在线全文

学校读者我要写书评

暂无评论

Building Simulation 2022年第11期15卷 1849-1868页

作者： Da Yan Xin Zhou Jingjing An xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng Building Energy Research Center School of ArchitectureTsinghua UniversityBeijing 100084China School of Architecture Southeast UniversityNanjingJiangsu 210096China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China College of Civil Engineering Hunan UniversityChangshaHunan 410082China School of Mechanical Engineering Tongji UniversityShanghai200092China Beijing Key Lab of Heating Gas SupplyVentilating and Air Conditioning EngineeringBeijing University of Civil Engineering and ArchitectureBeijing 100044China China State Construction Technology Center Beijing 101320China School of Architecture Harbin Institute of TechnologyHarbinHeilongjiang 150090China School of Architecture Xi'an University of Architecture and TechnologyXi'anShaanxi 710055China School of Architecture South China University of TechnologyGuangzhouGuangdong 510641China Institute of Building Environment and Energy China Academy of Building ResearchBeijing 100013China Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Key Lab of Built Environment and Energy of Tianjin School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Civil Engineering Guangzhou UniversityGuangzhou 510006China Faculty of Computing Harbin Institute of TechnologyHarbinHeilongjiang 150001China Beijing Glory PKPM Technology Co. Ltd.Beijing 100013China Beijing Tangent Software Co. LtdBeijing 100081China Shanghai Huadianyuan Information Technology Co. LtdShanghai200092China Luoyang Hongye Information Technology Co. Ltd.LuoyangHenan 471822China

Buildings contribute to almost 30%of total energy consumption *** building energy modeling programs is of great significance for lifecycle building performance assessment and *** in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and *** meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and *** structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing *** 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation *** 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study *** 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and *** new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization.

关键词： DeST building performance simulation building energy modeling

改良Millin前列腺切除术的临床应用(附132例报告)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国临床医学 2005年第1期12卷 141-142页

作者：宋杰薄隽杰黄旭元江苏省海门市人民医院泌尿科海门226100 上海第二医科大学附属仁济医院泌尿科上海200001

目的:提高前列腺增生症患者开放手术的治疗效果。方法:2000年1月-2002年12月对132例前列腺增生症患者采用改良millin前列腺切除手术,其手术要点为前列腺摘除后将膀胱颈部粘膜拉下覆盖缝合于前列腺窝内壁。结果:手术时间50-135 min,平均8... 详细信息

目的:提高前列腺增生症患者开放手术的治疗效果。方法:2000年1月-2002年12月对132例前列腺增生症患者采用改良millin前列腺切除手术,其手术要点为前列腺摘除后将膀胱颈部粘膜拉下覆盖缝合于前列腺窝内壁。结果:手术时间50-135 min,平均81.5 min,术中出血50-750 mL平均失血量为150 mL,平均切除前列腺组织重量70.5 g。平均6.5 d,全部病例拔除导尿管、排尿通畅。108例获术后随防3-25月,IPSS自术前平均26.8分下降至4.5分,QOL自平均4.5分降至1.2分,平均最大尿流率自术前6.8 mL/s升至18.6 mL/s,未发现严重的并发症、疗效满意。结论该改良术式尽量保留了尿道粘膜的完整、止血效果好、恢复快、并发症少,是治疗前列腺增生症较理想的手术方法。

关键词：临床应用并发症前列腺增生症粘膜患者前列腺切除术改良平均下降目的

经尿道前列腺等离子双极汽化电切术(附25例报告)

在线全文

学校读者我要写书评

暂无评论

中国临床医学 2005年第2期12卷 292-293页

作者：宋杰薄隽杰黄旭元江苏省海门市人民医院泌尿外科海门226100 上海第二医科大学附属仁济医院泌尿科上海200001

目的:探讨经尿道前列腺等离子双极汽化电切术的疗效和安全性。方法:采用英国Gyrus公司提供的等离子体双极切割系统(Gyrus Plasma Kinetic System,PKS), 行经尿道前列腺切除术25 例。结果:25 例手术顺利,手术操作时间平均45min,平均切除... 详细信息

目的:探讨经尿道前列腺等离子双极汽化电切术的疗效和安全性。方法:采用英国Gyrus公司提供的等离子体双极切割系统(Gyrus Plasma Kinetic System,PKS), 行经尿道前列腺切除术25 例。结果:25 例手术顺利,手术操作时间平均45min,平均切除前列腺38g, 无输血病例,术中无闭孔神经反射及电切综合征(TURS)出现。术后平均留置导尿管时间3.5 d,拔除尿管后排尿通畅,尿路刺激症状轻。术后随访3个月,无尿失禁、尿道狭窄等并发症。全部病例排尿通畅,前列腺症状评分从术前26.5降至5.8,平均最大尿流率从术前9.2ml/s增至21.5 ml/s。结论:经尿道前列腺等离子双极汽化电切术是一种安全有效的微创术式,尤其适合于高危、重度前列腺增生病人。

关键词：汽化电切术双极经尿道前列腺切除术前列腺症状评分重度前列腺增生手术操作时间闭孔神经反射尿路刺激症状电切综合征留置导尿管最大尿流率等离子体拔除尿管术后随访尿道狭窄微创术式平均安全性尿失禁

用于钢板厚度测量的常用电磁超声线圈特性研究

在线全文

学校读者我要写书评

暂无评论

中国测试 2020年第4期46卷 143-147页

作者：徐煦源涂君张旭宋小春湖北工业大学机械工程学院湖北武汉430068

为解决电磁超声检测信噪比低,为电磁超声线圈设计提供参考依据,该文针对常用的测厚电磁超声线圈开展一系列实验研究。首先对比螺旋线圈、矩形线圈、吕形线圈和蝶形线圈4种线圈结构的测厚反射回波信噪比,实验对象采用阶梯型钢板,结果发... 详细信息

为解决电磁超声检测信噪比低,为电磁超声线圈设计提供参考依据,该文针对常用的测厚电磁超声线圈开展一系列实验研究。首先对比螺旋线圈、矩形线圈、吕形线圈和蝶形线圈4种线圈结构的测厚反射回波信噪比,实验对象采用阶梯型钢板,结果发现螺旋线圈对于厚板测厚效果最佳,信噪比平均值达到14 dB以上。然后研究上述线圈的幅频特性,实验结果表明激励频率为1.8 MHz时,所有线圈的信噪比达到10 dB以上。最后通过线圈作用范围实验,得出不同类型线圈的主要作用区域也不同的结论。

关键词：电磁超声测厚线圈特性实验研究

集成DBR反馈区的1.3μm高速直接调制InGaAlAs/InP DFB激光器

在线全文

学校读者我要写书评

暂无评论

中国激光 2023年第10期50卷 27-33页

作者：朱旭愿剌晓波郭竟李振宇赵玲娟王圩梁松中国科学院半导体研究所半导体材料科学重点实验室北京100083 中国科学院大学材料与光电研究中心北京100049 低维半导体材料与器件北京市重点实验室北京100083

研制了以InGaAlAs多量子阱为有源材料的InP基1.3μm波段高速直接调制分布反馈(DFB)激光器,单片集成了与DFB激光器区具有相同量子阱材料的分布式布拉格反射器(DBR)反馈区。室温下DFB有源区长度为200μm时器件的3 dB小信号直接调制带宽大... 详细信息

研制了以InGaAlAs多量子阱为有源材料的InP基1.3μm波段高速直接调制分布反馈(DFB)激光器,单片集成了与DFB激光器区具有相同量子阱材料的分布式布拉格反射器(DBR)反馈区。室温下DFB有源区长度为200μm时器件的3 dB小信号直接调制带宽大于29 GHz。在速率为25 Gbit/s的非归零(NRZ)码数据调制下,光信号经10 km长的单模光纤传输后获得10-10误码率的功率代价在室温及80℃下均小于1 dB。激光器的有源区长度较大,有利于提高发光效率并且有助于减小电流热效应的不利影响。所研制的高速直接调制激光器是大容量短距光纤通信系统的理想光源,具有广阔的应用前景。

关键词：激光器半导体激光器高速直接调制 InGaAlAs/InP量子阱 1.3μm波段