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艾滋病肾损伤进展中的能量代谢重编程

传染病信息 2024年第6期37卷 555-560页

作者：苏比奴尔·阿不都克力木秦旭阳陆蕾朱慧敏舒占钧新疆医科大学第四临床医学院乌鲁木齐830000 新疆医科大学第四附属中医医院乌鲁木齐830000

随着艾滋病的后高效抗逆转录病毒治疗时代的到来,让艾滋病成为需长期管理的慢性感染性传染病,但因持续的人类免疫缺陷病毒复制及免疫炎症刺激可导致艾滋病患者合并其他慢性疾病,如艾滋病合并慢性肾脏病。近年来越来越多的研究表明,代谢... 详细信息

随着艾滋病的后高效抗逆转录病毒治疗时代的到来,让艾滋病成为需长期管理的慢性感染性传染病,但因持续的人类免疫缺陷病毒复制及免疫炎症刺激可导致艾滋病患者合并其他慢性疾病,如艾滋病合并慢性肾脏病。近年来越来越多的研究表明,代谢重编程与艾滋病、慢性肾脏病密切相关,其涉及线粒体氧化磷酸化及糖酵解,对于维持人体代谢平衡至关重要,并可能参与艾滋病肾损伤的发生和进展。然而,关于代谢重编程与艾滋病肾损伤之间的研究有限,因此,本文综述代谢重编程在艾滋病肾损伤的研究进展,以期为艾滋病肾损伤患者的生存健康提供新的治疗策略。

关键词：艾滋病合并慢性肾脏病代谢重编程糖酵解肾损伤肾纤维化

Detecting neutrinos from supernova bursts in PandaX-4T

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Chinese Physics C 2024年第7期48卷 14-21页

作者：庞彬宇阿布都沙拉木·阿布都克力木薄子豪陈葳谌勋程晨成兆侃崔祥仪樊英杰方德清符长波付孟婷耿立升 Karl Giboni 顾琳慧郭绪元韩晨成韩柯何昶达何金荣黄迪黄彦霖黄俊挺黄周侯汝全侯钰季向东巨永林李晨翔李家富李名川李帅杰李涛林箐刘江来陆聪聪芦晓盈罗棱尹罗云阳马文博马余刚冒亚军孟月宁旭阳祁宁春钱志成任祥祥 Nasir Shaheed 尚晓凤邵熙元申国防司琳孙文良谈安迪陶奕王安庆王萌王秋红王少博王思广王为王秀丽王舟魏月环武蒙蒙邬维浩夏经铠肖梦姣肖翔谢鹏伟燕斌斌颜玺雨杨继军杨勇姚玉坤喻纯旭袁影苑哲鑫宁张丹张敏桢张鹏张世博张澍张涛张洋张瀛心张园园赵力郑其斌周济芳周宁周小朋周永周钰博 New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai200240China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237ShandongChina School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 102206China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Nankai UniversityTian

Neutrinos from core-collapse supernovae are essential for understanding neutrino physics and stellar ***-phase xenon dark matter detectors can be used to track explosions of galactic supernovae by detecting neutrinos through coherent elastic neutrino-nucleus *** this study,a variation of progenitor masses and explosion models are assumed to predict neutrino fluxes and spectra,which result in the number of expected neutrino events ranging from 6.6 to 13.7 at a distance of 10 kpc over a 10-s duration with negligible backgrounds at *** specialized triggering alarms for monitoring supernova burst neutrinos are *** efficiency of detecting supernova explosions at various distances in the Milky Way is *** alarms will be implemented in the real-time supernova monitoring system at PandaX-4T in the near future,which will provide supernova early warnings for the astronomical community.

关键词： core-collapse supernovae neutrinos liquid xenon detectors supernova early warnings

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油气开采套管法兰盘断裂分析

失效分析与预防 2019年第5期14卷 328-332页

作者：吴轲源吴高路徐良清徐良乐吴高明马鞍山旭阳机械有限公司

油气开采套管用的42CrMo法兰盘在工作过程中发生崩裂。通过宏观观察、断口分析、成分与夹杂物检测、组织结构与晶粒度分析,以及法兰盘齿面三维光学形貌成像等手段,对崩裂原因进行分析。结果表明,齿根部位的脆性夹杂物超标和表面加工质... 详细信息

油气开采套管用的42CrMo法兰盘在工作过程中发生崩裂。通过宏观观察、断口分析、成分与夹杂物检测、组织结构与晶粒度分析,以及法兰盘齿面三维光学形貌成像等手段,对崩裂原因进行分析。结果表明,齿根部位的脆性夹杂物超标和表面加工质量差是发生整体崩裂的主要原因。通过加强冶金和精加工过程的控制,取得了良好的效果。

关键词： 42CrMo 法兰盘断裂失效夹杂物加工质量

Waveform simulation in PandaX-4T

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Chinese Physics C 2024年第7期48卷 1-13页

作者：李家富阿卜杜萨拉姆薄子豪陈葳谌勋程晨成赵侃崔祥仪樊英杰方德清耿立升 Karl Giboni 郭绪元韩晨成韩柯何昶达何金荣黄迪黄俊挺黄周侯汝全侯钰季向东巨永林李晨翔李名川李帅杰李涛林箐刘江来陆聪聪芦晓盈罗棱尹罗云阳马文博马余刚冒亚军孟月宁旭阳庞彬宇祁宁春钱志成任祥祥 Nasir Shaheed 尚晓凤邵熙元申国防司琳孙文良谈安迪陶奕王安庆王萌王秋红王少博王思广王为王秀丽王旭王舟魏月环武蒙蒙邬维浩吴渊肖梦姣肖翔燕斌斌阎玺宇杨勇喻纯旭袁影苑哲运有辉曾鑫宁张敏桢张鹏张世博张澍张涛张威张洋张瀛心张园园赵力周济芳周宁周小朋周永周钰博周知震 School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Beihang UniversityBeijing 102206China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Physics Peking UniversityBeijing 100871China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China Department of Physics University of MarylandCollege ParkMaryland 20742USA Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China SJTU Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics Yantai UniversityYantai 264005Ch

Signal reconstruction through software processing is a crucial component of the background and signal models in the PandaX-4T experiment,which is a multi-tonne dark matter direct search *** accuracy of signal reconstruction is influenced by various detector artifacts,including noise,dark count of photomultiplier,photoionization of impurities in the detector,and other relevant *** this study,we presented a detailed description of a semi-data-driven approach designed to simulate a signal *** work provides a reliable model for the efficiency and bias of the signal reconstruction in the data analysis of *** comparing critical variables that relate to the temporal shape and hit pattern of the signals,we found good agreement between the simulation and data.

关键词： dark matter time projection chamber simulation

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压裂车液力端阀箱内孔开裂分析

失效分析与预防 2022年第1期17卷 58-62页

作者：吴轲源徐良清吴高路徐良乐吴高明斯庭智李孔斋昆明理工大学冶金与能源工程学院昆明650031 马鞍山旭阳机械有限公司安徽马鞍山243121

采用宏观观察、断口分析、成分与夹杂物检测、组织结构与晶粒度分析、裂纹扩展路径观察等手段,对油气开采压裂车液力端阀箱内孔裂纹产生的原因进行分析。结果表明:阀箱的化学成分符合标准规定,材料的洁净度高;试样组织为回火索氏体,奥... 详细信息

采用宏观观察、断口分析、成分与夹杂物检测、组织结构与晶粒度分析、裂纹扩展路径观察等手段,对油气开采压裂车液力端阀箱内孔裂纹产生的原因进行分析。结果表明:阀箱的化学成分符合标准规定,材料的洁净度高;试样组织为回火索氏体,奥氏体晶粒度为8.0~8.5级;裂纹萌生、扩展与阀箱的化学成分、组织结构无关,裂纹附近的基体上分布着约1μm左右的小微孔;采用递减功率重熔和增加电渣锭头尾的切除率,阀箱油气田的工作寿命稳定在300 h以上,再未发生类似的失效事故。

关键词： 30CrNi3MoV钢压裂车阀箱裂纹扩展微孔