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Stem cells： novel players in the treatment of erectile dysfunction

Asian Journal of Andrology 2012年第1期14卷 145-155,179页

作者： Haiyang Zhang Maarten Albersen xunbo jin Guiting Lin Minimally Invasive Urology Center Provincial Hospital Affiliated to Shandong University Jinan 250021 China Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA 94143 USA Laboratory of Experimental Urology Department of Urology University Hospitals Leuven Leuven 3000 Belgium

Stem cells are defined by their capacity for both self-renewal and directed differentiation; thus, they represent great promise for regenerative medicine. Historically, stem cells have been categorized as either embryonic stem cells （ESCs） or adult stem cells （ASCs）. It was previously believed that only ESCs hold the ability to differentiate into any cell type, whereas ASCs have the capacity to give rise only to cells of a given germ layer. More recently, however, numerous studies demonstrated the ability of ASCs to differentiate into cell types beyond their tissue origin. The aim of this review was to summarize contemporary evidence regarding stem cell availability, differentiation, and more specifically, the potential of these cells in the diagnosis and treatment of erectile dysfunction （ED） in both animal models and human research. We performed a search on PubMed for articles related to definition, iocalisation and circulation of stem cells as well as the application of stem cells in both diagnosis and treatment of ED. Strong evidence supports the concept that stem cell therapy is potentially the next therapeutic approach for ED. To date, a large spectrum of stem cells, including bone marrow mesenchymal stem cells, adipose tissue-derived stem cells and muscle-derived stem cells, have been investigated for neural, vascular, endothelial or smooth muscle regeneration in animal models for ED. In addition, several subtypes of ASCs are localized in the penis, and circulating endogenous stem cells can be employed to predict the outcome of ED and ED-related cardiovascular diseases.

关键词： adipose tissue-derived stem cells bone marrow stem cells erectile dysfunction mesenchymal stem cells stem cells

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TIPE2 mRNA overexpression correlates with TNM staging in Renal cell carcinoma tissues

TIPE2 mRNA overexpression correlates with TNM staging in Ren...

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中国中西医结合学会泌尿外科专业委员会第十四次全国学术会议暨2016年广东省中西医结合学会泌尿外科专业委员会学术年会

作者： ZONGLIANG ZHANG HAIYAN QI SICHUAN HOU xunbo jin Department of Urology Qingdao Municipal Hospital Minimally Invasive Urology Center Provincial Hospital Affiliated to Shandong UniversityShandong University

Tumor necrosis factor α induced protein-8 like-2(TIPE2) is a very recently identified immune homeostasis maintaining gene. We wondered whether TIPE2 is associated with Renal cell carcinoma(RCC). We examined the mR NA expression levels of TIPE2 and myxoma resistance protein(MX) 1(one of type I interferon inducible genes) in renal cancer tissue. 35 patients fulfilling the RCC criteria of WHO revised in 2004 and 26 renal contusion patients requiring surgical extraction as controls were enrolled. Tumor tissue and normal renal tissue were sampled from all the subjects through surgical operation. Total RNA was extracted and the expression of TIPE2 and MX1 gene was evaluated by real-time reverse transcription-polymerase chain reaction analysis(RT-PCR). The TIPE2 m RNA expression was significantly up-regulated in RCC patients compared with controls(P=0.001),while the MX1 m RNA expression was decreased in RCC patients compared with controls(P=0.0001).Furthermore,the TIPE2 m RNA expression levels positively correlate with TNM staging(r=0.803,P=0.001) and show a negative correlation with the MX1 mR NA expression levels(r=-0.763,P=0.001) in RCC patients. These results indicate that increased expression of TIPE2 gene is closely associated with RCC and suggest an important role for TIPE2 gene in the pathogenesis of RCC.

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Early and Late Urodynamic Assessment of the orthotopic “N” neobladder

Early and Late Urodynamic Assessment of the orthotopic “N”...

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中国中西医结合学会泌尿外科专业委员会第十四次全国学术会议暨2016年广东省中西医结合学会泌尿外科专业委员会学术年会

作者： ZONGLIANG ZHANG RONGXIANG ZHOU HAIYAN QI xunbo jin Department of Urology Qingdao Municipal Hospital School of Medicine Shandong University Minimally Invasive Urology Center Provincial Hospital Affiliated to Shandong UniversityShandong University

The object of this study is to report the urodynamic data from 46 male patients who underwent orthotopic ‘‘N’’ neobladder replacement after radical cystectomy during a 12-month period and to provide urodynamic proof for the improvement of this technique. 46 consecutive male patients underwent radical cystectomy and orthotopic ‘‘N’’ neobladder substitution because of muscle-invasive bladder cancer. Uroflowmetry,cystometry,and urethral pressure profilometry were analyzed at 3-12 months after *** volumes of neobladders with a mean pressure of less than 15 cm HO was less than 400 ml and 100% capacity with 22.4 cm HO at 6 months. The mean pressure of contractions was less than 40 cm HO at 6 months. The mean filling pressure after operation at 3 months was higher compared with that at 6 months. No difference was observed in other time point. When comparing the 9-and 12-month urodynamic characteristics,no significant changes were observed in cystometric capacity. The mean post-void residual is 58 ml. A mean voiding peak of 16.2 ml/scan be obtained by Valsalva. The daytime continence rate was 90% at 12 months while the nighttime continence rate was 60%.

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Laparoscopic cyst decortication with capsule exfoliation in Polycystic Kidney Disease

Laparoscopic cyst decortication with capsule exfoliation in ...

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第十五届全国泌尿外科学术会议

作者： Qinghua Xia, xunbo jin, Peng Sun, Xiude Chen,Hui Xiong Provincial Hospital affiliated to Shandong University 250021

Objective: To investigate the methods and clinical value of laparoscopic cyst decortication with capsule exfoliation for the therapy of ADPKD. Method: From February 2004 to October 2005, 136 ADPKD patients with chronic pain(N=64), hypertension(N=94), and renal insufficiency(N=45) underwent 145 LCD with capsule exfolication procedures. The mean age of the patients was 43 years old (range 28～59 years).

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Hand-assisted laparoscopic radical nephrectomy and standard transperitoneal laparoscopic nephrectomy

Hand-assisted laparoscopic radical nephrectomy and standard ...

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第十五届全国泌尿外科学术会议

作者： Xia qinghua, jin xunbo,Jiang Shaobo,Zhao Yong Minimally Invasive Urologic Center Shandong Provincial Hospital 250021

Objective: To evaluate the result of hand-assisted laparoscopic radical nephrectomy and standard transperitoneal laparoscopic nephrectomy. Method: The results of 16 hand assisted and 24 standard laparoscopic nephrectomies were reviewed. Operation time, blood loss, length of stay and effect of operation were comparartively studied. Result: Total operative time was 70 minutes shorter

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Laparoscopic ureterolithotomy:the experience with a report of 36 cases

Laparoscopic ureterolithotomy:the experience with a report o...

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第十五届全国泌尿外科学术会议

作者： Qinghua Xia, xunbo jin,Xiude Chen, Hui Xiong, Peng Sun Provincial Hospital affiliated to Shandong University 250021

Objective To review our experience with laparoscopicureterolithotomy performed via a transperitoneal route. Patients and methods Since 2004, Transperitoneal laparoscopic ureterolithotomy was performed as a primary procedure in 36 patients who had either large or impacted stones in the upper ureter. The other indications were stones which could not be fragmented by shock wave lithotripsy or ureteroscopy. The mean (range) age of the patients was 38.5 years (21–65) and the mean (range) stone size was 16.3 mm (0.8– 32). The ureter was closed with intracorporeal laparoscopic suture with placing a stent. Associated ureteric strictures were incised at the time of ureterotomy. Results The stone was removed in all case laparoscopically. The mean (range) operative time was 96.8 min (55 – 220). No intraoperative complications were recorded. The mean (range) postoperative drain removal was 4.6 days (2–10). Postoperative complications included prolonged urinary leakage in one patient. All patients were stone free without any evidence of ureteral stricture after 24 months of follow up. Conclusions Laparoscopic ureterolithotomy can be a safe and effective procedure;it should be considered as a primary procedure for large mid- and upper ureteric stones. The technical recommendations were transperitoneal access and suturing the ureterotomy incision. The high stone-free rate after a single procedure is the distinct advantage of laparoscopic ureterolithotomy.

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80W KTP激光汽化术治疗大体积前列腺增生的临床应用

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中国男科学杂志 2008年第3期22卷 36-38,41页

作者：钟景琦金讯波赵勇熊晖山东中医药大学附属医院泌尿外科济南250011 山东省立医院泌尿微创中心

目的探讨80W KTP激光在治疗大体积前列腺增生中的临床应用。方法采用回顾性研究,对156例前列腺增生>60ml的患者行80W KTP激光汽化术(PVP)治疗。术前观察前列腺体积、血清钠以及血红蛋白含量。术中记录出血量及手术时间。观察术后第1天... 详细信息

目的探讨80W KTP激光在治疗大体积前列腺增生中的临床应用。方法采用回顾性研究,对156例前列腺增生>60ml的患者行80W KTP激光汽化术(PVP)治疗。术前观察前列腺体积、血清钠以及血红蛋白含量。术中记录出血量及手术时间。观察术后第1天血清钠、血红蛋白含量。术后留置尿管时间及术后住院时间。结果采用硬膜外麻醉,手术均获得成功,无一例中转开放手术。术前平均前列腺的体积为(88.9±27.1)ml,术中出血量(60.8±24.1)ml、手术时间(110.9±29.7)min。无一例需要输血。术后留置尿管时间(2.1±0.7)d。术前与术后血红蛋白含量、血清钠无明显变化。术后住院时间(3.2±1.1)d。结论PVP治疗大体积前列腺增生具有创伤小、并发症少、安全等优点,是治疗大体积前列腺增生的理想方法。

关键词：激光手术前列腺切除术

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腹腔镜肾部分切除术中肾血管处理方法的研究进展

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首都医科大学学报 2013年第3期34卷 376-379页

作者：金讯波张慧山东大学附属省立医院泌尿微创中心济南250021

随着肾部分切除术的应用增加,影响腹腔镜保留肾单位手术术后患肾功能恢复的因素受到重视,术中热缺血时间是肾部分切除术后对患肾功能影响最大也是最可控制的影响因素。腹腔镜肾部分切除术中肾蒂血管的不同处理方式对术中热缺血时间及患... 详细信息

随着肾部分切除术的应用增加,影响腹腔镜保留肾单位手术术后患肾功能恢复的因素受到重视,术中热缺血时间是肾部分切除术后对患肾功能影响最大也是最可控制的影响因素。腹腔镜肾部分切除术中肾蒂血管的不同处理方式对术中热缺血时间及患肾功能有不同影响。目前国际上主要有3种对肾蒂血管的处理方式,即完全阻断肾蒂血管、阻断肾段动脉及不阻断肾血管的方法,它们分别有其应用的优势及局限性,术者应根据患者的具体情况、术者个人技术水平和经验以及具体的医疗条件制定详尽的手术方案。

关键词：腹腔镜肾部分切除术热缺血时间肾血管

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阿霉素、卡介苗温敏凝胶膀胱癌灌注疗效研究

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中华实验外科杂志 2014年第12期31卷 2700-2702页

作者：夏庆华蒋伟孙鹏张栋兰晓鹏金讯波山东大学附属省立医院泌尿微创科济南250021

目的探讨表阿霉素（EPI）、卡介苗（BCG）联合温敏凝胶用于膀胱癌灌注治疗的效果及可行性.方法将大鼠依据是否给予BCG及EPI进行分组,建立大鼠膀胱癌模型,测定治疗前后大鼠体质量、膀胱重量水平以及尿液中肿瘤坏死因子相关诱导凋亡配体... 详细信息

目的探讨表阿霉素（EPI）、卡介苗（BCG）联合温敏凝胶用于膀胱癌灌注治疗的效果及可行性.方法将大鼠依据是否给予BCG及EPI进行分组,建立大鼠膀胱癌模型,测定治疗前后大鼠体质量、膀胱重量水平以及尿液中肿瘤坏死因子相关诱导凋亡配体（TRAIL）的变化,并检测细胞增殖抗原标志物（Ki-67）的表达水平.结果 BCG-EPI组膀胱重量[（101.2±8.2）g]明显低于对照组[（124.7±13.3）g,P＜0.01];10周末,TRAIL浓度EPI-BCG组为（404.24±71.33） ng/L,较对照组[（242.11±77.24） ng/L]明显升高（P＜0.05）;EPI-BCG组Ki-67增殖指数为（6.3±2.8）％,较对照组[（13.1±6.9）％]明显降低（P＜0.01）.结论 BCG、EPI联合温敏凝胶增强了膀胱组织的免疫应答,治疗效果更加显著和持久,减少了频繁膀胱灌注,为临床上治疗膀胱癌提供了新的思路.

关键词：膀胱癌表阿霉素卡介苗磁性纳米材料温敏凝胶

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Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel Dong jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes

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