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基于文献计量与定性分析法的我国数字博物馆研究进展

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东南文化 2015年第3期 105-113,127-128页

作者：孙逊上海交通大学钱学森图书馆上海200030 上海大学图书情报档案系上海200444

我国对数字博物馆研究进展的综述性研究乏见。"定性与定量"相结合是比较合适的研究方法,选取"1999—2014年间我国有关数字博物馆的研究文献(CNKI)"作为研究对象,利用文献计量法进行统计分析,通过定性分析法对我国数字博物馆研究进展进... 详细信息

我国对数字博物馆研究进展的综述性研究乏见。"定性与定量"相结合是比较合适的研究方法,选取"1999—2014年间我国有关数字博物馆的研究文献(CNKI)"作为研究对象,利用文献计量法进行统计分析,通过定性分析法对我国数字博物馆研究进展进行梳理与阐释。这不仅有助于对我国数字博物馆研究现状和整体脉络的把握,而且有助于提高业界对数字博物馆研究及建设的理性认识,推动数字博物馆研究体系的完善,乃至"数字博物馆学"的形成。

关键词：数字博物馆文献计量定性分析法定性与定量可视化分析

朝鲜“三国”史传文学中的儒学蕴涵及其本土特色——以《三国史记》、《三国遗事》为中心

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复旦学报（社会科学版） 2015年第2期57卷 87-94页

作者：孙逊上海师范大学人文与传播学院上海200234

古代中国和东亚同属汉字文化圈和儒家文化圈,虽然在朝鲜"三国"(新罗、高句丽、百济)时代,佛教占据了思想界的统治地位,但在此大背景下,儒学依然是个重要的存在。本文以朝鲜历史上的史传文学《三国史记》和《三国遗事》为考察中心,对其... 详细信息

古代中国和东亚同属汉字文化圈和儒家文化圈,虽然在朝鲜"三国"(新罗、高句丽、百济)时代,佛教占据了思想界的统治地位,但在此大背景下,儒学依然是个重要的存在。本文以朝鲜历史上的史传文学《三国史记》和《三国遗事》为考察中心,对其中所蕴涵的丰富的儒家思想观念进行细致地梳理和分析,并就新罗"花郎道"所体现的儒学本土特色作一初步论述,从而佐证了东亚各国既有相同的伦理选择,又有各自鲜明的民族特质。

关键词：朝鲜“三国” 史传文学儒学蕴涵本土特色

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韩国汉文小说的“剑侠”书写及其渊源特色

文学遗产 2019年第3期 169-178页

作者：孙逊上海师范大学"地方高水平大学创新团队"

在韩国汉文小说中,有关"剑侠"的书写占去了相当的篇幅,不仅有诸如《五台剑侠传》《剑女》《剑客某小传》《剑僧传》等单篇剑侠小说面世,而且在野谈笔记类和《壬辰录》等有关"倭乱"的小说中,剑侠书写也占据了一定的比重。这些小说除了描... 详细信息

在韩国汉文小说中,有关"剑侠"的书写占去了相当的篇幅,不仅有诸如《五台剑侠传》《剑女》《剑客某小传》《剑僧传》等单篇剑侠小说面世,而且在野谈笔记类和《壬辰录》等有关"倭乱"的小说中,剑侠书写也占据了一定的比重。这些小说除了描写和渲染剑侠出神入化的高超剑术,更着意表现他们快意恩仇、下助庶民、上效邦国等侠义品格,显示了古代韩国民众对于剑侠的追慕和敬仰,既反映了东亚汉文化圈剑侠崇拜的共同文化渊源,又凸现了韩国剑侠书写的本土特色。

关键词：韩国汉文小说剑侠书写文化渊源本土特色

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跨通道学习及其认知神经机制

生物化学与生物物理进展 2019年第6期46卷 565-577页

作者：孙洵伟孙莹付秋芳 )中国科学院心理研究所脑与认知科学国家重点实验室北京100101 )中国科学院大学心理学系北京100049

跨通道学习是指涉及从多个通道获取信息,对这些多通道的信息进行整合并加以利用的学习.多通道信息整合是跨通道学习的重要基础.尽管跨通道学习条件更接近人类学习的真实环境,但是目前多数研究依然采用单通道刺激,跨通道学习相关研究的... 详细信息

跨通道学习是指涉及从多个通道获取信息,对这些多通道的信息进行整合并加以利用的学习.多通道信息整合是跨通道学习的重要基础.尽管跨通道学习条件更接近人类学习的真实环境,但是目前多数研究依然采用单通道刺激,跨通道学习相关研究的结果还显得有些凌乱、不够系统.为了较好地概括跨通道学习的特点和机制,本文首先介绍了多通道信息整合的产生与影响因素,以及初级皮层具有通道非特异性的实验和理论研究,之后,系统梳理了跨通道学习的意识性、表征类型和迁移效应的相关研究,整理了采用神经元记录、ERP和f MRI等技术探讨跨通道学习神经机制的研究进展.最后,我们对目前跨通道学习的研究成果进行了总结,并对这些研究成果的潜在应用以及这一领域未来的研究方向进行了展望.

关键词：跨通道学习多通道整合神经机制认知机制

CD226 as a Genetic Adjuvant to Enhance Immune Efficacy Induced by Ag85A DNA Vaccination

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CD226 as a Genetic Adjuvant to Enhance Immune Efficacy Induc...

Electro-optical Properties and Temporal Stability of the Guest-Host DCNP/PEK-c Polymer Thin Film

第十六届中国科协年会——分13感染、免疫和疫苗论坛

作者： Yan LI xun sun Changlong LU Department of Immunology China Medical University Department of Immunology and Microbiology Liaoning College of Health Vocational Technology

Antigen-85A(Ag85A)is one of the major proteins secreted by Mycobacterium *** studies on animal models have shown that vaccination with the recombinant Ag85A-DNA or Ag85A protein induces powerful immune ***,these vaccines cannot induce sufficient protective immune response in the systemic ***226,a member of the immunoglobulin superfamily,is mainly expressed on NK cells,T cells,monocytes and platelets,and can be served as a co-stimulator that contributes to multiple innate and adaptive immune ***-CSF is an effective genetic adjuvant that increases Ag85A immunogenicity to enhance the activity of cytotoxic T lymphocytes(CTLs)in mice immunized with recombinant pRSC-Ag85A-GM-CSF plasmid ***,there has been no study showing that either CD226 protein or DNA has been used as an adjuvant for vaccine *** aim of this study was to develop a novel Ag85A DNA vaccine with CD226 as the genetic adjuvant to increase the immune efficacy of *** vaccination with pcDNA3.1-Ag85A-CD226 DNA induced potent immune responses in ***226 was an effective genetic adjuvant that improved the immune efficacy of Ag85A and enhanced the activity of CTLs and NK cells in *** results suggest that CD226 is an effective adjuvant to enhance the immune efficacy of *** findings provide a new strategy for the development of a DNA vaccine co-expressing Ag85A and CD226 against tuberculosis and tumors.

关键词： Ag85A,CD226,genetic adjuvant,DNA vaccine

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Chinese Physics Letters 2000年第1期17卷 22-24页

作者： SHI Wei FANG Chang-Shui PAN Qi-Wei sun xun GU Qing-Tian XU Dong WEI Hong-Zhen YU Jin-Zhong State Key Laboratory of Crystal Materials Shandong UniversityJi'nan 250100 Institute of Semiconductors Chinese Academy of SciencesBeijing 100083

The polyetherketone(PEK-c)guest-host system thin films in which the range of the weight percent of 3-(1,1-dicyanothenyl)-1-phenyl-4,5-dihydro-1H-pry azole(DCNP)is from 20% to 50% were *** predicted high value of electro-optical(EO) coefficient γ33=48.8 pm/V by using two-level model was obtained when the weight percent of DCNP in the polymer system is 40%,whereas EO coefficients are attenuated at higher chromophore loading than 40%.The temporal stability of the EO activity of the guest-host polymer was evaluated by probing the decay of the orientational order of the chromophores in the polymer system.

关键词： system polymer decay

Hydrothermal carbonization pretreatment makes a remarkable difference in activation of rice and lettuce in food waste

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Green Chemical Engineering 2024年第3期5卷 348-363页

作者： Lijun Zhang Yifan sun Chao Li Shu Zhang Mortaza Gholizadeh xun Hu School of Material Science and Engineering University of Jinan Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and Engineering Nanjing Forestry University Faculty of Chemical and Petroleum Engineering University of Tabriz

Cooked rice and the vegetables like lettuce are common kitchen waste, which are carbonaceous materials and have the potential as feedstock for the production of activated carbon. Cooking is similar to hydrothermal treatment（HTC）, which might impact the subsequent activation of kitchen waste. In this study, the HTC of lettuce, rice, or their mixture and the activation of the resulting hydrochars were conducted. The results indicated that cross-polymerization between the N-containing organics from lettuce and the sugar derivatives from rice took place in their co-HTC, which significantly increased the hydrochar yield. Activation of the hydrochar from the coHTC generated the AC with a yield of 2 times that from direct activation of mixed lettuce/rice. However, the coHTC facilitated aromatization, reducing reactivity with K2C2O4in activation and producing the AC with main micropores and low specific surface area. Activation of the hydrochar from HTC of rice followed the above trend,while that from lettuce was the opposite. The organics in lettuce were thermally unstable and could not undergo sufficient aromatization. The activation of hydrochar from HTC of lettuce thus generated the AC with the lowest yield, but the highest specific surface area（1684.9 m2/g）, abundant mesopores, and superior capability for adsorption of tetracycline. However, the environmental impacts and energy consumption for the production of AC from the hydrochar of lettuce were higher than that from hydrochar of co-HTC.

关键词： Food waste Hydrothermal pretreatment Hydrochar Chemical activation Products properties

Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3862-3876页

作者： Na Jia Yunzhen Gao Min Li Yi Liang Yuwen Li Yunzhu Lin Shiqi Huang Qing Lin xun sun Qin He Yuqin Yao Ben Zhang Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringState key Laboratory of Polymer Materials EngineeringWest China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041P.R.China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610041China

Rheumatoid arthritis(RA)is a common chronic inflammatory disorder that usually affects *** was found that roburic acid(RBA),an ingredient from anti-RA herb Gentiana macrophylla Pall.,displayed strong anti-inflammatory ***,its medical application is limited by its hydrophobicity,lack of targeting capability and unclear functional ***,we constructed a pH responsive dual-target drug delivery system hitchhiking RBA(RBA-NPs)that targeted both CD44 and folate receptors,and investigated its pharmacological *** rat RA model,the nanocarriers effectively delivered RBA to inflammatory sites and significantly enhanced the therapeutic outcomes compared with free RBA,as well as strongly reducing inflammatory cytokine levels and promoting tissue *** analysis revealed that M1 macrophages in the joints were reprogrammed to M2 phenotype by *** the balance of pro-and anti-inflammatory macrophages play important roles in maintaining immune homeostasis and preventing excessive inflammation in RA,this reprogramming is likely responsible for the anti-RA ***,we revealed that RBA-NPs drove M1-to-M2 phenotypic switch by down-regulating the glycolysis level via blocking ERK/HIF-1α/GLUT1 ***,our work not only developed a targeting delivery system that remarkably improved the anti-RA efficiency of RBA,but also identified a potential molecular target to reversely reprogram macrophages though energy metabolism regulation.

关键词： inflammatory metabolism programming

Sodium selenite ameliorates dextran sulfate sodiuminduced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses

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World Journal of Gastroenterology 2017年第21期23卷 3850-3863页

作者： Li-Xuan Sang Bing Chang Jun-Feng Zhu Fang-Li Yang Yan Li Xue-Feng Jiang Da-Nan Wang Chang-Long Lu xun sun Department of Immunology China Medical University Department of Geriatrics First Affiliated HospitalChina Medical University Department of Gastroenterology First Affiliated HospitalChina Medical University

AIM To assess the effect of sodium selenite on the severity of dextran sulfate sodium(DSS)-induced colitis in C57BL/6 *** Mice were randomly divided into four groups(n = 10/group): normal group, selenium(Se) group, chronic colitis group, and Se + chronic colitis group. The mice were sacrificed on day 26. Survival rates, clinical symptoms, colon length, and histological changes were determined. The percentages and absolute numbers of immune system cells in the lamina propria lymphocytes(LPL) of the colon, the expression of m RNA in colon tissue, and the concentrations of Th1, Th17, and Treg cytokines in LPL from the large intestine, were *** Se significantly ameliorated the symptoms of colitis and histological injury(P < 0.05 each), increasing the proportions of neutrophils and CD4+ CD25+ T cells(P < 0.05 each) and decreasing the proportions of γδT cells, CD4+, CD4+CD44+, and CD4+ CD69+ T cells in LPL(P < 0.05 each). Moreover, Se reduced the expression of IL-6, IFN-γ, IL-17 A, IL-21, T-bet, and RORγt(P < 0.05 each), but enhanced the expression of IL-10 and Foxp3(P < 0.05 each). CONCLUSION These results suggest that Se protects against DSSinduced chronic colitis perhaps by increasing the number of CD4(+)CD25(+) Tregs that suppress the secretion of proinflammatory cytokines and populations of Th1, Th17, and γδT cells.

关键词： Sodium selenite Dextran sulfate sodium Chronic colitis