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Genome-wide identification and characterization of the PbrATG family in Pyrus bretschneideri and functional analysis of PbrATG1a in response to Botryosphaeria dothidea

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Horticultural Plant Journal 2024年第2期10卷 327-340页

作者： Yun Wang xun sun Zhenwu Zhang Zhihua Xie Kaijie Qi Shaoling Zhang Center of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

The pear is an economic fruit that is widely planted around the world and is loved by people for its rich nutritional value. Autophagy is a self-protection mechanism in eukaryotes, and its occurrence often accompanied by the degradation of damaged substances in cells and the recycling of nutrients. Autophagy is one of the mechanisms through which plants respond to environmental stress and plays an important role in plant development and stress resistance. Functional studies of autophagy-related genes (ATGs) have been performed on a variety of plant species, but little information is available on the ATG family in pear (Pyrus bretschneideri Rehd). Therefore, we analyzed the evolutionary dynamics and performed a genome-wide characterization of the PbrATG gene family. A total of 28 PbrATG members were *** analysis showed that PbrATGs were more closely related to ATGs of European pear and apple. Evolutionary analysis revealed that whole-genome duplication (WGD) and dispersed duplication events were the main driving forces of PbrATG family *** analysis of different pear tissues showed that all the genes were expressed in different pear tissues, and different PbrATGs are expressed at different times and in different locations. Moreover, all PbrATGs also responded to different abiotic stresses, especially salt and drought stress, which elicited the highest expression levels. Pear seedlings were subsequently infected with Botryosphaeria dothidea (***). The results showed that different PbrATGs had different expression patterns at different infection stages. According to the gene expression data, PbrATG1a was selected as a key autophagy gene for further analysis. Silencing of PbrATG1a reduced the resistance of pear to B. dothidea, which resulted in increased lesions, reactive oxygen species (ROS) contents, antioxidant enzyme activity, and gene expression levels in the silenced pear seedlings after B. dothidea inoculation. In this s

关键词： Autophagy Pear PbrATGs Abiotic stress Botryosphaeria dothidea PbrATG1a

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Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy

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Nano Research 2024年第7期17卷 6400-6410页

作者： Hanming Zhang Honglin Gao Yicong Zhang Yikun Han Qing Lin Tao Gong xun sun Zhirong Zhang Ling Zhang Shiqi Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines,resulting in undesirable drug delivery efficacy and therapeutic ***,we constructed TRAIL-[NDHCPT]^(GAC),a synergistic hydroxycamptothecin(HCPT)and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)protein co-loaded disk-shaped nanocarrier withγ-glutamyl transpeptidase *** the novel nanodisks extravasated into the tumor interstitium,theγ-glutamyl transpeptidase overexpressed on the tumor cell membranes cleaved theγ-glutamyl portions of the nanodisk surface to produce positively charged amino *** a result,the cationic nanodisks possessed stronger tumor infiltration ability through transcytosis than anionic *** and TRAIL exerted synergistic antitumor effects with better overall therapeutic *** TRAIL-[ND-HCPT]^(GAC)system performed significantly better than free HCPT and remarkably prolonged the survival of breast tumor-bearing mice with no significant toxicity.

关键词： tumor penetration combination therapy charge reversal γ-glutamyl transpeptidase nanodisk

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Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8^(+)T cell proportion in tumor-bearing mice through the USP9X signaling pathway

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Chinese Journal of Natural Medicines 2024年第4期22卷 329-340页

作者： FENG Yutao LI Yuan MA Fen WU Enjiang CHENG Zewei ZHOU Shiling WANG Zhengtao YANG Li sun xun ZHANG Jiwei Shanghai Key Laboratory of Compound Chinese Medicines The MOE Key Laboratory for Standardization of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Gastrointestinal surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

The management of colorectal cancer(CRC)poses a significant challenge,necessitating the development of innovative and effective *** research has shown that notoginsenoside Ft1(Ng-Ft1),a small molecule,markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8^(+)T cells in tumor-bearing mice,thus restraining tumor *** into the mechanism revealed that Ng-Ft1 selectively targets the deubiquitination enzyme USP9X,undermining its role in shieldingβ-*** leads to a reduction in the expression of downstream effectors in the Wnt signaling *** findings indicate that Ng-Ft1 could be a promising small-molecule treatment for CRC,working by blocking tumor progression via the Wnt signaling pathway and augmenting CD8^(+)T cell prevalence within the tumor environment.

关键词： Notoginsenoside Ft1 Colorectal cancer CD8^(+)T cell Ubiquitin-specific peptidase 9 X-linked β-Catenin Wnt

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A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2263-2280页

作者： Leilei Wang Shanshan He Rong Liu Yuan Xue Yuan Quan Rongying Shi Xueying Yang Qing Lin xun sun Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Chemotherapeutics can induce immunogenic cell death(ICD)in tumor cells,offering new possibilities for cancer ***,the efficiency of the immune response generated is insufficient due to the inhibitory nature of the tumor microenvironment(TME).Here,we developed a pH/reactive oxygen species(ROS)dual-response system to enhance chemoimmunotherapy for *** system productively accumulated in tumors by specific binding of phenylboronic acid(PBA)to sialic acids(SA).The nanoparticles(NPs)rapidly swelled and released quercetin(QUE)and doxorubicin(DOX)upon the stimulation of tumor microenvironment(TME).The in vitro and in vivo results consistently demonstrated that the NPs improved anti-tumor efficacy and prolonged survival of mice,significantly enhancing the effects of the *** study revealed DOX was an ICD inducer,stimulating immune responses and promoting maturation of dendritic cells(DCs).Additionally,QUE served as a TME regulator by inhibiting the cyclooxygenase-2(COX2)-prostaglandin E2(PGE2)axis,which influenced various immune cells,including increasing cytotoxic T cells(CLTs)infiltration,promoting M1 macrophage polarization,and reducing regulatory T cells(Tregs)*** combination synergistically facilitated chemoimmunotherapy efficacy by remodeling the immunosuppressive *** work presents a promising strategy to increase anti-tumor efficiency of chemotherapeutic agents.

关键词： Quercetin Nanoparticle Responsiveness Chemoimmunotherapy Tumor immune microenvironment

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Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： Jiahui Xu Minghao Wang Minyi Jin Siyan Shang Chuner Ni Yili Hu xun sun Jun Xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

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高校人物纪念馆藏品数字化管理实践与思考

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中国博物馆 2024年第1期 85-92页

作者：孙逊上海交通大学钱学森图书馆上海200030

高校人物纪念馆藏品有其特殊性,藏品数字化管理是高校人物纪念馆信息化建设的基础。简要分析高校人物纪念馆藏品特点,重点以上海交通大学钱学森图书馆藏品管理系统为例,从馆藏分析、流程设计、功能模块及信息指标体系设计等方面进行阐释... 详细信息

高校人物纪念馆藏品有其特殊性,藏品数字化管理是高校人物纪念馆信息化建设的基础。简要分析高校人物纪念馆藏品特点,重点以上海交通大学钱学森图书馆藏品管理系统为例,从馆藏分析、流程设计、功能模块及信息指标体系设计等方面进行阐释,并从顶层设计、馆藏信息资源开发及系统平台化等进行总结与反思,以期为人物纪念馆藏品数字化建设与管理提供借鉴。

关键词：博物馆高校博物馆人物纪念馆藏品数字化管理系统

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作为符码的建筑:建筑叙事对电影的介入机制

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电影评介 2024年第1期 40-45页

作者：孙逊上海大学上海电影学院创作中心

本质上来说叙事学的产生得益于结构主义、符号学理论的发展,以索绪尔现代语言学和皮尔士的符号学为起源。电影叙事作为当代文艺叙事学的重要分支,有着深厚的结构主义和符号学背景,电影中的元素作为不同的符码,指向不同的含义。法国电影... 详细信息

本质上来说叙事学的产生得益于结构主义、符号学理论的发展,以索绪尔现代语言学和皮尔士的符号学为起源。电影叙事作为当代文艺叙事学的重要分支,有着深厚的结构主义和符号学背景,电影中的元素作为不同的符码,指向不同的含义。法国电影理论家让·米特里认为影像之所以可以超越它所映现的现实,是因为电影的再现形式成为再现事物的某种具体符号(符码)。((1))本文基于电影符号学的理论基础,分析作为符码的建筑叙事的可能性,以及在电影中建筑叙事的介入机制、表现形态和功能。

关键词：电影符号学电影理论家电影叙事结构主义当代文艺符号学理论叙事学皮尔士

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Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

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Acta Pharmaceutica Sinica B 2024年第1期14卷 350-364页

作者： Yongshun Zhang Lan Yang Yangsen Ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma Tao Gong Ling Zhang Zhirong Zhang xun sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)***,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB ***,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor *** demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell ***,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in *** order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor *** anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.

关键词： Triple therapy Adeno-associated virus PTEN PPSG@anti-PD-1 CpG Immunogenic cell death Antitumor immune response Immune memory

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跨通道迁移及其认知神经机制

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生物化学与生物物理进展 2024年第1期51卷 94-110页

作者：孙莹孙洵伟王一帆付秋芳中国科学院心理研究所脑与认知科学国家重点实验室北京100101 中国科学院大学心理学系北京100049 北京大学心理与认知科学学院北京100871

跨通道迁移是指将在一种感觉通道获得的知识应用于另一感觉通道的能力。跨通道迁移的相关研究探索了大脑表征不同感觉通道信息的方式,为减少重复学习、提高认知加工效率提供了新的见解。为较好地概括跨通道迁移的特点和机制,本文首先介... 详细信息

跨通道迁移是指将在一种感觉通道获得的知识应用于另一感觉通道的能力。跨通道迁移的相关研究探索了大脑表征不同感觉通道信息的方式,为减少重复学习、提高认知加工效率提供了新的见解。为较好地概括跨通道迁移的特点和机制,本文首先介绍了在物体识别、类别学习和时间知觉等不同领域对跨通道迁移效应的实验研究,之后介绍了支持跨通道迁移的表征类型和相关理论,梳理了跨通道迁移产生的理论及采用事件相关电位(ERP)和功能磁共振成像(fMRI)等技术探讨跨通道迁移神经机制的研究进展,并指出了影响跨通道迁移的因素。最后,对目前跨通道迁移研究成果及其潜在应用进行了总结,并对这一领域未来的研究问题进行了展望。

关键词：跨通道迁移多通道表征跨通道识别通道优势元通道理论

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椭圆鞍形单层正交索网结构解析计算方法与形态优化

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工程力学 2024年第1期41卷 103-113页

作者：王博厚孙逊方立新东南大学土木工程学院江苏南京210096 东南大学建筑设计研究院有限公司江苏南京210096 东南大学建筑学院江苏南京210096

常见的单层正交索网结构由马鞍面和椭圆柱面相切而成,该类型结构在国内外的大型场馆、公共建筑中得到广泛应用。该文提出一种连续化解析计算方法,以求解椭圆鞍形单层正交索网结构的变形、内力和最优形态,求解过程中仅需解一元方程。计... 详细信息

常见的单层正交索网结构由马鞍面和椭圆柱面相切而成,该类型结构在国内外的大型场馆、公共建筑中得到广泛应用。该文提出一种连续化解析计算方法,以求解椭圆鞍形单层正交索网结构的变形、内力和最优形态,求解过程中仅需解一元方程。计算方法利用平衡方程、变形协调方程,以竖向位移为未知量,推导了正交单层索网连续化计算公式,采用伽辽金法求得近似解。在此基础上,以外环梁平面内弯矩最小为优化目标,以中央承重索垂度为优化变量,以索力、竖向位移和矢跨比为约束条件,利用外环梁弯矩计算公式,通过求解方程得到结构的最优形态并给出优化流程。最后对一个简单算例分别采用有限元法与解析法计算,验证了解析法所得位移、索力、外环弯矩和形态优化结果的准确性。在结构初步设计阶段,利用该解析计算方法,可快速得到荷载态下结构的位移、受力情况和最优形态,避免了有限元法编程、反复试算的繁杂过程。

关键词：单层索网结构解析解连续化理论形态优化有限元

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