检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

自媒体时代提升中职学校德育实效性探析

科教导刊 2017年第1Z期 84-86页

作者：何雪燕广州市从化区职业技术学校广东广州510920

随着移动互联网的高速发展,我们已经进入自媒体时代,自媒体时代的到来对中职德育来说既是机遇又是挑战。如何适应自媒体时代德育的方式,提升德育的实效性是中职学校的重要议题。

关键词：自媒体德育实效性

A mutation in TBXT causes congenital vertebral malformations in humans and mice

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： Shuxia Chen Yunping Lei Yajun Yang Chennan Liu Lele Kuang Li Jin Richard HFinnell xueyan Yang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China Shanghai Key Laboratory of Metabolic Remodeling and health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision Environmental health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s Hospital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(CVMs)involving T are not well ***,we report a family with 15 CVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members,indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its DNA-binding affinity,but reduces its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes CVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human CVM.

关键词： Congenital vertebral malformation TBXT T gene Loss-of-function mutation

国际经济循环格局调整与构建新发展格局的战略意义

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人文杂志 2024年第6期 1-9页

作者：何自力王雪颜南开大学经济学院

国际经济循环格局是国际范围内生产力与生产关系矛盾运动的体现,呈现出不断演变和调整的态势。西方主导的国际经济循环格局经历了海上商贸驱动的1.0版、工业化驱动的2.0版、去工业化驱动的3.0版后,正在向再工业化驱动的4.0版深度调整,... 详细信息

国际经济循环格局是国际范围内生产力与生产关系矛盾运动的体现,呈现出不断演变和调整的态势。西方主导的国际经济循环格局经历了海上商贸驱动的1.0版、工业化驱动的2.0版、去工业化驱动的3.0版后,正在向再工业化驱动的4.0版深度调整,构建新发展格局是我国主动应对国际经济循环格局深度调整挑战的重大战略举措,对于巩固和提升我国制造业优势,建设现代化产业体系,实现经济高质量发展,增强我国参与国际合作和竞争新优势,具有十分重要的战略意义。

关键词：国际经济循环格局制造业优势新发展格局

大刍草作为地质封存CO_2泄漏指示植物的评估

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

农业工程学报 2017年第18期33卷 224-229页

作者：马欣张雪艳田地何霄嘉韩耀杰纪翔中国农业科学院农业环境与可持续发展研究所北京100081 中国科学院地理科学与资源研究所北京100101 中国科学院农业政策研究中心北京100101 北京大学城市与环境学院北京100871 中国21世纪议程管理中心北京100038

随着神华集团鄂尔多斯全球第一个全流程CO_2盐水层封存项目进入长期监测与预警业务流程,选择适宜的CO_2泄漏指示植物方法和试验十分紧迫,但相关的认识还存在不足。采用新发展的植物对CO_2泄漏耐受指数方法,通过盆栽模拟CO_2泄漏的试验,... 详细信息

随着神华集团鄂尔多斯全球第一个全流程CO_2盐水层封存项目进入长期监测与预警业务流程,选择适宜的CO_2泄漏指示植物方法和试验十分紧迫,但相关的认识还存在不足。采用新发展的植物对CO_2泄漏耐受指数方法,通过盆栽模拟CO_2泄漏的试验,以广泛种植的人工牧草大刍草为例,系统评估大刍草对封存CO_2泄漏的耐受能力。结果发现:随着封存CO_2泄漏量的增加,大刍草株高呈下降趋势,生物量下降在70%以上。大刍草的耐受指数为0.26,属于较不耐受,没有达到CO_2泄漏指示性植物的标准,需要进一步扩大筛选范围。该文初步验证了耐受指数方法在筛选地质封存CO_2泄漏指标植物的适用性。同时,为增强地质封存CO_2泄漏指示植物筛选的稳健性,建议未来加强对植物栽培管理措施、全生长周期等的综合评估。

关键词：植物试验评估 CO2封存泄漏大刍草

Sonodynamic therapy for the treatment of atherosclerosis

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第5期14卷 666-677页

作者： Yan Zhang Ying Yang Yudi Feng xueyan Gao Liping Pei Xiaopan Li Bingxin Gao Lin Liu Chengzeng Wang Shuochen Gao The Department of Ultrasound The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China The Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China

Atherosclerosis(AS)is a chronic inflammatory disease of large and medium-sized arteries that leads to ischemic heart disease,stroke,and peripheral vascular *** the current treatments,mortality and disability still remain *** therapy(SDT),a non-invasive and localized methodology,has been developed as a promising new treatment for inhibiting atherosclerotic progression and stabilizing *** progress has been made through cell and animal assays,as well as clinical *** example,the effect of SDT on apoptosis and autophagy of cells in AS,especially macrophages,and the concept of non-lethal SDT has also been *** this review,we summarize the ultrasonic parameters and known sonosensitizers utilized in SDT for AS;we elaborate on SDT's therapeutic effects and mechanisms in terms of macrophages,T lymphocytes,neovascularization,smooth muscle cells,lipid,extracellular matrix and efferocytosis within plaques;additionally,we discuss the safety of SDT.A comprehensive summary of the confirmed effects of SDT on AS is conducted to establish a framework for future researchers.

关键词： Atherosclerosis Sonodynamic therapy Sonosensitizer Ultrasound Reactive oxygen species

Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression:a randomized controlled study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 2036-2040页

作者： Xiaoyue Li Tao Liu Xuan Mo Runhua Wang xueyan Kong Robin Shao Roger S.Mclntyre Kwok-Fai So Kangguang Lin Department of Affective Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouGuangdong ProvinceChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Psychiatry The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Mood Disorders Psychopharmacology Unit Poul Hansen Family Centre for DepressionUniversity Health NetworkTorontoONCanada Department of Psychiatry University of TorontoTorontoONCanada Brain and Cognition Discovery Foundation TorontoCanada Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory ***,anti-inflammatory treatment has shown partial effectiveness in alleviating depression *** barbarum polysaccharide(LBP),derived from Goji berries,exhibits notable antioxidative and anti-inflammatory *** our recent double-blinded randomized placebo-controlled trial,we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold *** is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory *** the double-blinded randomized controlled trial,we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo *** the LBP group,adolescents were given 300 mg/d LBP.A 6-week follow up was completed by 24 adolescents,comprising 14 adolescents from the LBP group(15.36±2.06 years,3 men and 11 women)and 10 adolescents from the placebo group(14.9±1.6 years,2 men and 8 women).Our results showed that after 6 weeks of treatment,the interleukin-17A level in the LBP group was lower than that in the placebo *** analysis showed that LBP reduced the correlations and connectivity between inflammatory factors,which were associated with the improvement in depressive *** findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level,thereby exerting an antidepressant effect.

关键词： adolescents cytokines efficacy Goji berry inflammatory responses interleukin-17A Lycium barbarum polysaccharide randomized controlled study subthreshold depression

Designing weakly and strongly solvating polymer electrolytes:Systematically boosting high-voltage lithium metal batteries

在线全文

学校读者我要写书评

暂无评论

SusMat 2024年第4期4卷 50-64页

作者： Tianyi Wang Yimeng Zhang xueyan Huang Peifeng Su Min Xiao Shuanjin Wang Sheng Huang Dongmei Han Yuezhong Meng The Key Laboratory of Low-carbon Chemistry&Energy Conservation of Guangdong Province State Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhouChina Department of Chemical Engineering Tsinghua UniversityBeijingChina School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhaiChina Institute of Chemistry Henan Provincial Academy of SciencesZhengzhouChina

Practical high-voltage lithium metal batteries hold promise for high energy density applications,but face stability challenges in electrolytes for both 4 V-class cathodes and lithium *** address this,we delve into the positive impacts of two crucial moieties in electrolyte chemistry:fluorine atom(-F)and cyano group(-CN)on the electrochemical performance of polyether electrolytes and lithium metal ***-bearing polyether electrolytes possess strong solvation,accelerating Li^(+)desolvation with minimal SEI *** polyether electrolytes possess weak solvation,and stabilize the lithium anode via preferential decomposition of F-segment,exhibiting nearly 6000-h stable cycling of lithium symmetric ***,the electron-withdrawing prop-erties of-F and-CN groups significantly bolster the high-voltage tolerance of copolymer electrolyte,extending its operational range up to 5 *** advance-ment enables the development of 4 V-class lithium metal batteries compatible with various cathodes,including 4.45 V LiCoO_(2),4.5 V LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),and 4.2 V LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2).These findings provide insights into design prin-ciples centered around polymer components for high-performance polymer electrolytes.

关键词： cyano-bearing copolymer electrolyte fluorinated copolymer electrolyte high-voltage lithium metal battery in situ polymerization solvation

Safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 according to phenotype and whole genome-sequencing analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 2048-2059页

作者： xueyan Mo Mengcheng Zhou Yanmei Li Lili Yu Huashang Bai Peihong Shen Xing Zhou Haojun Zhu Huijie Sun Ru Bu Chengjian Jiang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Science and TechnologyGuangxi UniversityNanning 530004China National Engineering Research Center for Non-Food Biorefinery State Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Research Center for Biological Science and TechnologyGuangxi Academy of SciencesNanning 530007China Guangxi Key Laboratory for Green Processing of Sugar Resources College of Biological and Chemical EngineeringGuangxi University of Science and TechnologyLiuzhou 545006China

The application of microorganisms as probiotics is limited due to lack of safety ***,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove *** safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing *** showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely *** morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were *** hyphae and phospholipase were *** one retroelement(Tad1-65_BG)was *** biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined ***6 had no resistance to common antifungal *** enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were *** toxicity test with mice demonstrated that GXDK6 is ***6 has a good reproduction ability in the simulation gastrointestinal ***6 also has a strong antioxidant ability,β-glucosidase,and inulinase *** sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.

关键词： Meyerozyma guilliermondii Safety assessment Probiotics Marine mangrove microorganisms Whole-genome sequencing analysis

Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1413-1426页

作者： xueyan Chen Weilin Wu Ji-Hak Jeong Matjaz Rokavec Rui Wei Shaolong Feng Werner Schroth Hiltrud Brauch Shangwei Zhong Jun-Li Luo Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Molecular Medicine The Scripps Research InstituteJupiter 33458USA Dr.Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart 70376Germany iFIT Cluster of Excellence University of TübingenTübingen 72074Germany The Cancer Research Institute and the Second Affiliated Hospital Henyang Medical SchoolUniversity of South ChinaHengyang 421001China National health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410008China

Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive(ER+)breast ***,the efficacy of agents such as tamoxifen(Tam)is often compromised by the development of *** we report that cytokines-activated nuclear IKKαconfers Tam resistance to ER+breast cancer by inducing the expression of FAT10,and that the expression of FAT10 and nuclear IKKαin primary ER+human breast cancer was correlated with lymphotoxinβ(LTB)expression and significantly associated with relapse and metastasis in patients treated with adjuvant ***αactivation or enforced FAT10 expression promotes Tam-resistance while loss of IKKαor FAT10 augments Tam *** induction of FAT10 by IKKαis mediated by the transcription factor Pax5,and coordinated via an IKKα-p53-miR-23a circuit in which activation of IKKαattenuates p53-directed repression of ***,our findings establish IKKα-to-FAT10 pathway as a new therapeutic target for the treatment of Tam-resistant ER+breast cancer.

关键词： nuclear IKKα breast cancer Tam-resistance FAT10 Pax5 lymphotoxin nuclear IKKα-FAT0 pathway