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Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

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Protein & Cell 2024年第6期15卷 419-440页

作者： Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng Yifei Yang Tingting Feng Fanrong Zhang Xiying Shao xueyan he Lixing Zhang Guohong Hu Quentin Liu Yi-Zhou Jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesDepartment of OncologyKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Intelligent Pathology Institute and Department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230071China Department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Breast Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Shanghai Institute of Nutrition and health University of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Department of Breast Surgery Xiangya HospitalChangsha 410008China Department of Breast Surgery Tumor Hospital of Harbin Medic

Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant ***,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in ***,we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis(ETBF)was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant ***,albeit at low biomass,secreted the toxic protein BFT-1 to promote breast cancer cell stemness and *** studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 ***1 was highly expressed on ALDH+breast cancer stem cells(BCSCs)and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation,thereby activating the NOTCH1-heY1 signaling pathway to increase ***1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.

关键词： NOD1 breast chemotherapy

CONVERGENCE RATE FOR ITERATES OF q-BERNSTEIN POLYNOMIALS

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Analysis in Theory and Applications 2007年第3期23卷 243-254页

作者： xueyan Xiang Qian he Wenshan Yang Department of Mathematics Physics Information and Engineering Zhejiang Normal University Jinhua 321004 E R. China

Recently, q-Bernstein polynomials have been intensively investigated by a number of authors. Their results show that for q ≠ 1, q-Bernstein polynomials possess of many interesting properties. In this paper, the convergence rate for iterates of both q-Bernstein polynomials and their Boolean sum are estimated. Moreover, the saturation of {Bn（., qn）} when n → ∞ and convergence rate of Bn（f,q;x） when f ∈ C^n-1 [0, 1], q → ∞ are also presented.

关键词： q-Bernstein operator convergence rate saturation of positive lienar operator,iterates

腹腔镜下高位宫骶韧带悬吊术与经阴道骶棘韧带固定术对重度盆腔器官脱垂患者盆底功能、尿动力学影响的比较

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疑难病杂志 2024年第4期23卷 462-466页

作者：何雪妍李红英王婷慧程慧武汉科技大学医学部医学院 430065 湖北省妇幼保健院妇科武汉430070

目的观察腹腔镜下高位宫骶韧带悬吊术、经阴道骶棘韧带固定术对重度盆腔器官脱垂患者临床相关指标的影响。方法收集2021年5月—2022年5月湖北省妇幼保健院妇科诊治重度盆腔器官脱垂患者73例的病例资料进行回顾性分析,根据治疗方法不同... 详细信息

目的观察腹腔镜下高位宫骶韧带悬吊术、经阴道骶棘韧带固定术对重度盆腔器官脱垂患者临床相关指标的影响。方法收集2021年5月—2022年5月湖北省妇幼保健院妇科诊治重度盆腔器官脱垂患者73例的病例资料进行回顾性分析,根据治疗方法不同分为观察组37例及对照组36例。观察组开展腹腔镜下高位宫骶韧带悬吊术,对照组开展经阴道骶棘韧带固定术。比较2组围术期指标及预后情况,不同阶段器官脱垂情况、生活质量、尿动力学变化。结果观察组手术时间长于对照组,术中出血量少于对照组,拔除尿管时间、术后住院时间短于对照组(t/P=21.641/<0.001、6.195/<0.001、15.199/<0.001、17.575/<0.001)。观察组术后6个月PFIQ-7评分、PFDI-20评分低于对照组,各项POP-Q指示点(Aa、Ba、C、Bp)、I-QOL评分、最大膀胱容量、最大尿流率、平均尿流率高于对照组(t/P=5.189/<0.001、22.447/<0.001、11.051/<0.001、16.916/<0.001、31.005/<0.001、3.477/<0.001、11.211/<0.001、3.503/<0.001、5.728/<0.001、10.010/<0.001);观察组患者术后6个月新发压力性尿失禁率、再次手术率以及并发症发生率低于对照组[χ^(2)(t)/P=5.471/0.019、4.103/0.042、4.364/0.036]。结论腹腔镜下高位宫骶韧带悬吊术、经阴道骶棘韧带固定术均能作为重度盆腔脱垂患者有效的治疗方案,前者术式较后者手术用时略长,但在改善患者术后盆底功能以及尿动力学方面效果更优。

关键词：重度盆腔器官脱垂腹腔镜下高位宫骶韧带悬吊术经阴道骶棘韧带固定术盆底功能生活质量

布地奈德雾化吸入联合抗生素序贯治疗支原体肺炎患儿的效果

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中国药物滥用防治杂志 2024年第9期30卷 1651-1653页

作者：李寒梅何雪燕彭香李燕漳州市东山县医院儿科福建漳州363400

目的:探究布地奈德雾化吸入联合抗生素序贯干预对支原体肺炎患儿临床症状及炎性因子的影响。方法:纳入2021年2月—2023年2月我院收治的支原体肺炎患儿96例为研究对象,按随机数字表法设为两组。对照组(n=48)接受抗生素序贯治疗,研究组(n=... 详细信息

目的:探究布地奈德雾化吸入联合抗生素序贯干预对支原体肺炎患儿临床症状及炎性因子的影响。方法:纳入2021年2月—2023年2月我院收治的支原体肺炎患儿96例为研究对象,按随机数字表法设为两组。对照组(n=48)接受抗生素序贯治疗,研究组(n=48)在此基础上给予布地奈德雾化吸入治疗。比较两组临床症状消失时间、炎性因子及免疫指标。结果:研究组高热、咳嗽、喘息消失时间短于对照组(P<0.05);两组治疗后白介素6(IL-6)、白介素2(IL-2)、肿瘤坏死因子α(TNF-α)水平低于治疗前,且研究组低于对照组(P<0.05);两组治疗后免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平低于治疗前,且研究组低于对照组(P<0.05)。结论:布地奈德雾化吸入联合抗生素序贯干预可明显改善支原体肺炎患儿临床症状,调节机体炎性因子水平。

关键词：支原体肺炎儿童布地奈德雾化吸入炎性因子

真实感材质外观的表示和高效渲染技术研究现状及展望

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计算机辅助设计与图形学学报 2024年第8期36卷 1131-1154页

作者：陶成之孙奇过洁袁军平周辰熙何雪滟范之闽史鹏程郭延文计算机软件新技术全国重点实验室(南京大学) 南京210033

在虚拟场景的组成中,除了三维几何模型之外最重要的要素就是物体表面的材质外观,对材质进行基于物理的建模和真实感绘制是保证虚拟场景真实感的重要手段.然而,由于现实世界材质外观本身的多样性和复杂性,迄今为止对真实感材质的研究一... 详细信息

在虚拟场景的组成中,除了三维几何模型之外最重要的要素就是物体表面的材质外观,对材质进行基于物理的建模和真实感绘制是保证虚拟场景真实感的重要手段.然而,由于现实世界材质外观本身的多样性和复杂性,迄今为止对真实感材质的研究一直是计算机图形学领域的热点和难点.文中总结了材质外观的近期相关工作,从材质的表示建模和材质的真实感绘制2大方向展开讨论;进一步,将材质模型分为表达范围广的通用材质模型和针对毛发及布料等材质的特殊材质模型2大类;并将材质绘制方法分为用于离线渲染的点采样优化和用于实时渲染的材质预过滤2种;最后指出材质研究可能的3个发展方向:神经网络材质、波动光学材质和材质的统一标准,为未来该领域的研究提供思路.

关键词：真实感绘制材质表面微结构毛发渲染皮肤渲染布料渲染重要性采样纹理预过滤

Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1686-1698页

作者： Yongxi Liang Delin Min Hulin Fan Kunlin Liu Juchuanli Tu xueyan he Bingjie Liu Lu Zhou Suling Liu Xun Sun School of Pharmacy Fudan UniversityShanghai 201203China The Institutes of Integrative Medicine of Fudan University Shanghai 200040China Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200032China

Triple-negative breast cancer(TNBC)is a nasty disease with extremely high malignancy and poor *** A3(ANXA3)is a potential prognosis biomarker,displaying an excellent correlation of ANXA3 overexpression with patients'poor *** the expression of ANXA3effectively inhibits the proliferation and metastasis of TNBC,suggesting that ANXA3 can be a promising therapeutic target to treat ***,we report a first-in-class ANXA3-targeted small molecule(R)-SL18,which demonstrated excellent anti-proliferative and anti-invasive activities to TNBC cells.(R)-SL18 directly bound to ANXA3 and increased its ubiquitination,thereby inducing ANXA3 degradation with moderate family ***,(R)-SL18 showed a safe and effective therapeutic potency in a high ANXA3-expressing TNBC patient-derived xenograft ***,(R)-SL18 could reduce theβ-catenin level,and accordingly inhibit the Wnt/β-catenin signaling pathway in TNBC ***,our data suggested that targeting degradation of ANXA3 by(R)-SL18 possesses the potential to treat TNBC.

关键词： Annexin A3(ANXA3) Degrader Triple-negative breast cancer Ubiquitination Patient-derived xenograft

Distributed Fault-Tolerant Control of Uncertain Multi-Agent Systems with Connectivity Maintenance

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Journal of Systems Science & Complexity 2024年第1期37卷 40-62页

作者： XING xueyan HU Guoqiang Continental-NTU Corporate Lab Nanyang Technological UniversitySingapore 639798Singapore Continental-NTU Corporate Lab and the School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In this paper,a distributed cooperative control protocol is presented to deal with actuator failures of multi-agent systems in the presence of connectivity *** the developed strategy,each agent can track the reference trajectory of the leader in the presence of actuator failures,disturbances and *** connectivity of the multi-agent system can always be ensured during the control *** achieve the aforementioned control objectives,a potential function is introduced to the distributed adaptive fault-tolerant control algorithm to preserve the initial connected network among the *** uncertainty of the multi-agent system,which is allowed to be described by discontinuous functions,is approximated and compensated using the fuzzy logic *** asymptotic stability of the closed-loop system is demonstrated through the use of Cellina’s approximate selection theorem of nonsmooth *** to the developed adaptive laws,the upper bound of the disturbance is allowed to be uncertain,which facilitates the implementation of the control ***,simulation results are provided to verify the effectiveness of the proposed control scheme.

关键词： Actuator failure connectivity maintenance coordination control uncertainties

Comparison of the Teaching Concepts between Chinese and Americans

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科技信息 2007年第20期 240-240,289页

作者： he xueyan Wang Weiming Nanjing Agricultural University College of Life Science

This paper makes a comparative study on higher education in respect of four aspects in educational system between China and America,in the hope of finding reasons that can be useful to our cultivation in China.

关键词：高等教育教学观念中国美国比较研究原因分析

Supersaturation-driven self-assembly formation of ceftriaxone sodium spherulites:From amorphous form to spherulites

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Particuology 2024年第7期90卷 10-19页

作者： Shankun Liang Yuchao Niu xueyan Hu Wu Xiao Xuehua Ruan Gaohong he Xiaobin Jiang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Chemical Engineering at Panjin Dalian University of TechnologyPanjin124221China

Drug particles with spherical morphology possess amazing advantages in terms of particle flowability,mechanical properties,drug solubility,and *** growth mechanism of drug spherulite is of great importance for the preparation and regulation of ***,ceftriaxone sodium spherulites were fabricated by the antisolvent crystallization method using dropwise addition of ceftriaxone sodium solution to *** observation of the whole crystallization process combined with electron microscopy technique revealed the spherical growth process from amorphous form to *** the supersaturation of the crystallization system was adjusted,the ceftriaxone sodium crystals transformed from amorphous form to *** the process of antisolvent crystallization with acetone as antisolvent,when the theoretical supersaturation degree S was higher than 2.62,the crystallization system tended to appear amorphous form;when S was between 2.57 and 2.62,the amorphous form transformed into clustered spherulites;when S was less than 2.57,the surface of spherulites will be covered with flaky crystal,which transformed into urchin-like *** the understanding of the spherical growth mechanism,the ceftriaxone sodium spherulites prepared in this research with modified supersaturation control had a low residue of antisolvent acetone,and the flowability was significantly improved.

关键词： Spherulite Ceftriaxone sodium Antisolvent crystallization Supersaturation Online observation