检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

精细化工行业中浓相气力输送技术的应用研究

化工设计通讯 2024年第8期50卷 94-96页

作者：丁学巍宁夏工业设计院有限责任公司宁夏银川750001

在精细化工产业的发展过程中,浓相气力输送技术以其独特的应用特性,成为提升物料处理效率和安全性的关键技术。然而,传统输送系统在处理精细化工原料时面临效率低下、能耗高等问题。针对这一挑战,研究集中在新型浓相发送罐组件的开发、... 详细信息

在精细化工产业的发展过程中,浓相气力输送技术以其独特的应用特性,成为提升物料处理效率和安全性的关键技术。然而,传统输送系统在处理精细化工原料时面临效率低下、能耗高等问题。针对这一挑战,研究集中在新型浓相发送罐组件的开发、球形混合器的应用及其在精细化工行业的特定应用案例分析上。通过改进输送方案,包括发送罐的进料、进气和输送过程的优化,以及球形混合器的结构与功能特点,实现输送效率的显著提高和能耗的降低。具体应用案例分析展示技改方案在提高原料计量输送工艺效率、优化气力输送设计等方面的有效性。此外,通过对输送物料特性的深入分析和发送罐组件优化,确保输送过程的稳定性和可靠性,进而提升精细化工行业物料处理的整体性能。

关键词：精细化工行业浓相气流输送技术

Satisfactory surgical outcome of T2 gastric cancer after modified D2 lymphadenectomy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2017年第2期29卷 100-108页

作者： Shupeng Zhang Liangliang WU Xiaona Wang xuewei ding Han Liang Department of General Surgery the Fifth Central Hospital of Tianjin Tianjin 300450 China Department of Gastric Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center of Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Tianjin 300060 China

Objective： Though D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer （GC）, the modified D2 （D 1＋7, 8a and 9） lymphadenectomy may be more suitable than D2 dissection for T2 stage GC. The purpose of this study is to elucidate whether the surgical outcome of modified D2 lymphadenectomy was comparable to that of standard D2 dissection in T2 stage GC patients. Methods： A retrospective cohort study with 77 cases and 77 controls matched for baseline characteristics was conducted. Patients were categorized into two groups according to the extent of lymphadenectomy： the modified D2 group （roD2） and the standard D2 group （D2）. Surgical outcome and recurrence date were compared between the two groups. Results： The 5-year overall survival （OS） rate was 71.4% for patients accepted mD2 lymphadenectomy and 70.1% for those accepted standard D2, respectively, and the difference was not statistically significant. Multivariate survival analysis revealed that curability, tumor size, TNM stage and postoperative complications were independently prognostic factors for T2 stage GC patients. Patients in the mD2 group tended to have less intraoperative blood loss （P=0.001） and shorter operation time （P〈0.001） than those in the D2 group. While there were no significant differences in recurrence rate and types, especially lymph node recurrence, between the two groups. Conclusions： The surgical outcome of mD2 lymphadenectomy was equal to that of standard D2, and the use of mD2 instead of standard D2 can be a better option for T2 stage GC.

关键词： Gastric carcinoma T2 modified D2 lymphadenectomy prognosis complication

初诊手术治疗胃肠间质瘤临床病理特征及预后因素的真实世界研究

在线全文

学校读者我要写书评

暂无评论

中华消化外科杂志 2024年第8期23卷 1080-1086页

作者：王晓娜曹景新王宝贵詹宏杰刘勇丁学伟刘宁张汝鹏梁寒天津医科大学肿瘤医院胃部肿瘤科、国家恶性肿瘤临床医学研究中心、天津市肿瘤防治重点实验室、天津市恶性肿瘤临床医学研究中心、天津市消化系统肿瘤重点实验室天津300060 天津市东丽医院普通外科天津300301

目的探讨初诊手术治疗胃肠间质瘤(GIST)的临床病理特征及预后因素。方法采用回顾性队列研究方法。收集2011年1月至2020年12月天津医科大学肿瘤医院收治的847例初诊手术治疗GIST患者的临床病理资料;男405例, 女442例;年龄为(60±10)岁。... 详细信息

目的探讨初诊手术治疗胃肠间质瘤(GIST)的临床病理特征及预后因素。方法采用回顾性队列研究方法。收集2011年1月至2020年12月天津医科大学肿瘤医院收治的847例初诊手术治疗GIST患者的临床病理资料;男405例, 女442例;年龄为(60±10)岁。正态分布的计量资料以x±s表示, 组间比较采用t检验。偏态分布的计量资料以M(范围)表示。计数资料以绝对数或百分比表示, 组间比较采用χ^(2)检验。等级资料比较采用非参数秩和检验。采用Kaplan-Meier法计算生存率。单因素分析采用Log-rank检验, 多因素分析采用COX回归模型。结果 (1)GIST临床病理特征。847例患者中, 肿瘤原发部位为胃585例、空肠和回肠142例、十二指肠76例、结直肠10例、食管3例、胃肠道外31例;合并肝转移13例, 合并腹腔转移22例;肿瘤最大径为(7±5)cm, 核分裂象为4(0~60)个/50高倍视野或5 mm2;美国国立卫生研究院(NIH)危险度分级为极低危31例、低危238例、中危213例、高危365例。847例患者中, CD117阳性839例, Dog-1阳性788例, CD34阳性710例;272例Ki-67指数<5%, 214例为5%~9%, 198例为≥10%, 163例未知;R0切除814例, 非R0切除33例。(2)GIST患者基因检测与术后辅助治疗。①基因检测情况:847例患者中, 424例行基因检测, 其中2011年、2012年、2013年、2014年、2015年、2016年、2017年、2018年、2019年、2020年基因检测率分别为1.89%(1/53)、9.76%(8/82)、8.45%(6/71)、15.66%(13/83)、50.00%(40/80)、55.26%(42/76)、73.86%(65/88)、68.27%(71/104)、80.65%(75/93)、88.03%(103/117)。424例行基因检测患者中, KIT突变338例, PDGFRA突变31例, 野生型55例。②辅助治疗情况:847例患者中, 253例行术后辅助治疗, 其中低、中、高危患者术后辅助治疗的比例分别为8.82%(21/238)、41.78%(89/213)、39.18%(143/365)。578例中高危患者中, 2011年、2012年、2013年、2014年、2015年、2016年、2017年、2018年、2019年、2020年术后辅助治疗比例分别为15.15%(5/33)、14.71%(10/68)、22.45%(11/49)、29.09%(16/55)、41.38 %(24/58)、46.15%(24/52)、32.81%(21/64)、60.00%(45/75)、60.42%(29/48)、61.84%(47/76)。253例术后辅助治疗患者中, 247例接受伊马替尼治疗、6例接受舒尼替尼治疗。(3)非胃来源和胃来源GIST临床病理特征的比较。847例患者中, 非胃来源和胃来源GIST分别为262例和585例, 两者性别、肿瘤数目、肿瘤最大径、Ki-67指数、NIH危险度分级、R0切除比较, 差异均有统计学意义(χ^(2)=8.62、8.40、12.97、6.57, Z=-6.15, χ^(2)=17.19, P<0.05)。(4)GIST患者无复发生存率的影响因素分析。多因素分析结果显示:初诊年度、原发部位、肿瘤最大径、核分裂象、NIH危险度分级、R0切除、基因检测、术后辅助治疗是影响初诊手术治疗GIST患者无复发生存率的独立因素(风险比=0.58, 0.61, 2.00, 1.71, 5.81, 2.56, 0.65, 0.38, 95%可信区间为0.39~0.85, 0.45~0.83, 1.46~2.74, 1.24~2.35, 3.16~10.69, 1.63~4.02, 0.46~0.94, 0.25~0.56, P<0.05)。结论初诊手术治疗GIST部位以胃多见, CD117和Dog-1阳性率高。GIST行基因检测和靶向治疗的人数逐年增加。非胃来源和胃来源GIST的临床病理特征及预后不同。初诊年度、原发部位、肿瘤最大径、核分裂象、NIH危险度分级、R0切除、基因检测、术后辅助治疗是影响初诊手术治疗GIST无复发生存率的独立因素。

关键词：胃肠道间质瘤手术临床病理无复发生存率预后

狼疮性肾炎患儿肾皮质及血清中干扰素-α/β表达水平及临床意义

在线全文

学校读者我要写书评

暂无评论

中国医师杂志 2024年第7期26卷 1005-1009,1016页

作者：才桁丁雪薇陶思思徐志泉任翼向伟张秋月何小解海南医学院儿科学院海口570312 南方医科大学南方医院儿科广州510000 中南大学湘雅二医院儿童医学中心长沙410011 长沙市妇幼保健院健康管理中心长沙410011 海南省妇女儿童医学中心海口570312 海口市妇幼保健院儿科海口570203

目的分析狼疮性肾炎(LN)患儿肾皮质及血清中干扰素(IFN)-α/β表达水平及临床意义。方法选取2017年12月至2020年9月中南大学湘雅二医院儿童肾脏专科确诊的32例LN患儿为研究对象(LN组),正常肾脏对照来自3例正常肾移植志愿者活检肾组织(... 详细信息

目的分析狼疮性肾炎(LN)患儿肾皮质及血清中干扰素(IFN)-α/β表达水平及临床意义。方法选取2017年12月至2020年9月中南大学湘雅二医院儿童肾脏专科确诊的32例LN患儿为研究对象(LN组),正常肾脏对照来自3例正常肾移植志愿者活检肾组织(正常肾脏对照组),同时收集14例健康体检儿童作为正常对照组。依据系统性红斑狼疮疾病活动度指数(SLEDAI)将LN患儿分为轻度活动组(n=8),中度活动组(n=9)和重度活动组(n=15)。依据国际肾脏病学会/肾脏病理学会(ISN/RPS)2003LN分型标准进行病理分型(轻度病理损害组3例,中度病理损害组8例,重度病理损害组11例);采用免疫组织化学方法检测IFN-α/β在肾小球、肾间质中的表达与分布;采用酶联免疫吸附法检测血清样本中IFN-α/β浓度,分析其与LN患儿病理分型、病情活动的相关性。结果LN组血清、肾皮质IFN-α/β水平分别高于正常对照组与正常肾脏对照组(均P<0.05)。重度活动组血清IFN-α/β水平均高于轻、中度活动组(均P<0.05)。重度病理损害组血清、肾皮质IFN-α/β水平均高于轻、中度病理损害组(均P<0.05)。结论肾皮质中IFN-α/β与LN的肾损伤密切相关;血清IFN-α/β可在一定程度上辅助评估LN的疾病活动程度。

关键词：狼疮肾炎干扰素α 干扰素β

预测浸润性乳腺癌无病生存期的临床影像融合模型研究

在线全文

学校读者我要写书评

暂无评论

浙江医学 2024年第2期46卷 156-161页

作者：曹婷婷丁雪委郑皓葛敏王世威浙江中医药大学附属第一医院(浙江省中医院)医学影像科杭州310006

目的构建术前临床影像组学融合模型,探讨其预测浸润性乳腺癌无病生存期的效能。方法收集2015年7月至2017年5月浙江中医药大学附属第一医院术前接受乳腺动态增强MRI检查的浸润性乳腺癌女性患者131例。按照7∶3的比例随机分为训练集91例... 详细信息

目的构建术前临床影像组学融合模型,探讨其预测浸润性乳腺癌无病生存期的效能。方法收集2015年7月至2017年5月浙江中医药大学附属第一医院术前接受乳腺动态增强MRI检查的浸润性乳腺癌女性患者131例。按照7∶3的比例随机分为训练集91例与内部验证集40例。从肿瘤和瘤体向外扩5mm区域分别提取原始肿块和瘤内加瘤周的影像组学特征。运用F检验及logistic回归分析对影像组学特征进行缩减后,分别建立影像组学模型。采用多因素Cox比例风险模型分析临床病理风险因素与无病生存期的关系,并确定有效的预测因素建立临床模型。将最优影像组学模型的影像组学评分(Radscore)和独立临床病理风险因素结合建立融合模型。采用ROC曲线评估影像组学模型和融合模型的预测效能。结果在验证集中,临床模型、原始肿块影像组学模型、瘤内加瘤周影像组学模型及融合模型的AUC(95%CI)分别为0.791(0.690~0.893)、0.898(0.839~0.956)、0.930(0.878~0.983)、0.969(0.941~0.996),灵敏度分别为0.789、0.895、0.842、0.947,特异度分别为0.714、0.821、0.857、0.938,其中融合模型预测效能最佳。结论基于术前MRI影像组学特征的临床影像融合模型对浸润性乳腺癌患者的复发风险具有较高的预测效能,对乳腺癌无病生存期的预测和个性化治疗具有一定的价值。

关键词：浸润性乳腺癌磁共振成像复发无病生存期

Virtuoso iQuantus Insight及Quantus Insight流程在FINFET先进工艺项目中加速后仿迭代的应用

在线全文

学校读者我要写书评

暂无评论

电子技术应用 2024年第8期50卷 26-31页

作者：李祉怡孙航丁学伟张慧丽曾义深圳市中兴微电子技术有限公司广东深圳518055 移动网络和移动多媒体技术国家重点实验室广东深圳518055 上海楷登电子科技有限公司上海200120

随着工艺演进,尺寸进一步缩小带来了更多寄生通路和更大的寄生电阻,后仿结果和前仿相去甚远。如何快速缩小前后仿之间的差距成为重要课题。传统设计中只能通过Quantus Extracted View相对直观地对寄生进行分析,无法更详细地进行分析,这... 详细信息

随着工艺演进,尺寸进一步缩小带来了更多寄生通路和更大的寄生电阻,后仿结果和前仿相去甚远。如何快速缩小前后仿之间的差距成为重要课题。传统设计中只能通过Quantus Extracted View相对直观地对寄生进行分析,无法更详细地进行分析,这成为设计者们面临的艰巨挑战。同时,后仿发现问题,只能通过“修改电路-版图迭代-再次后仿”反复优化,迭代周期长,如何降低时间成本成为各公司关注的重点。Virtuoso iQuantus Insight(ViQI)/Quantus Insight(QI)可基于寄生网表文件进行寄生分析及结果可视化。工程师可借此对寄生进行准确的分析及假设,无需版图迭代,即可进行设计优化。讨论了如何通过ViQI/QI工具在FINFET先进工艺项目中实现快速的后仿迭代,大幅提高工作效率。

关键词： Virtuoso iQuantus Insight Quantus Insight 后仿网表分析寄生假设快速迭代

A 26-Gb/s CMOS optical receiver with a reference-less CDR in 65-nm CMOS

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2022年第7期43卷 68-77页

作者： Quan Pan Xiongshi Luo Zhenghao Li Zhengzhe Jia Fuzhan Chen xuewei ding C.Patrick Yue School of Microelectronics Engineering Research Center of Integrated Circuits for Next-Generation CommunicationsMinistry of EducationSouthern University of Science and TechnologyShenzhen 518055China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyHong Kong SARChina ZTE Microelectronics Shenzhen 518055China

This paper presents a 26-Gb/s CMOS optical receiver that is fabricated in 65-nm technology. It consists of a tripleinductive transimpedance amplifier(TIA), direct current(DC) offset cancellation circuits, 3-stage gm-TIA variable-gain amplifiers(VGA), and a reference-less clock and data recovery(CDR) circuit with built-in equalization technique. The TIA/VGA frontend measurement results demonstrate 72-dB? transimpedance gain, 20.4-GHz-3-dB bandwidth, and 12-dB DC gain tuning range. The measurements of the VGA’s resistive networks also demonstrate its efficient capability of overcoming the voltage and temperature variations. The CDR adopts a full-rate topology with 12-dB imbedded equalization tuning range. Optical measurements of this chipset achieve a 10-12 BER at 26 Gb/s for a 2;-1 PRBS input with a-7.3-dBm input sensitivity. The measurement results with a 10-dB @ 13 GHz attenuator also demonstrate the effectiveness of the gain tuning capability and the built-in equalization. The entire system consumes 140 mW from a 1/1.2-V supply.

关键词： clock and data recovery equalizer optical receiver transimpedance amplifier variable-gain amplifier

Prognostic significance of lymphovascular infiltration in overall survival of gastric cancer patients after surgery with curative intent

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2019年第5期31卷 785-796页

作者： Liangliang Wu Yuexiang Liang Chen Zhang Xiaona Wang xuewei ding Chongbiao Huang Han Liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Gastrointestinal Oncology the First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Nutritional Department Tianjin Beichen HospitalTianjin 300000China Senior Ward Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Objective: Lymphovascular infiltration(LVI) is frequently detected in gastric cancer(GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without ***: In total, 1,007 patients with curatively resected GC at Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were retrospectively enrolled. The patients were categorized into two groups based on the LVI status: a positive group(PG;presence of LVI) and a negative group(NG;absence of LVI). The clinicopathological factors corrected with LVI and prognostic variables were analyzed. Additionally, a pathological lymphovascular-node(lvN) classification system was proposed to evaluate the superiority of its prognostic prediction of GC patients compared with that of the eighth edition of the N staging ***: Two hundred twenty-four patients(22.2%) had LVI. The depth of invasion and lymph node metastasis were independently associated with the presence of LVI. GC patients with LVI demonstrated a significantly lower overall survival(OS) rate than those without LVI(42.8% vs. 68.9%, respectively;P<0.001). In multivariate analysis,LVI was identified as an independent prognostic factor for GC patients(hazard ratio: 1.370;95% confidence interval: 1.094-1.717;P=0.006). Using strata analysis, significant prognostic differences between the groups were only observed in patients at stage I-IIIa or N0-2. The lvN classification was found to be more appropriate to predict the OS of GC patients after curative surgery than the pN staging system. The-2 log-likelihood of lvN classification(4,746.922) was smaller than the value of pN(4,765.196), and the difference was statistically significant(χ^2=18.434, P<0.001).Conclusions: The presence of LVI influences the OS of GC patients at stage Ⅰ-Ⅲ a or N0-2. LVI should be incorporated into the pN staging system to enhance the accuracy of the prognostic prediction of GC patients.

关键词： Gastric carcinoma lymphovascular infiltration LVI prognosis risk factors

Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2018年第2期30卷 254-262页

作者： Yuexiang Liang Donglei He Liangliang Wu xuewei ding Xiaona Wang Baogui Wang Rupeng Zhang Han Liang Department of Gastrointestinal Oncology the First Affiliated Hospital of Hainan Medical College Department of Gastric Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center of Cancer Tianjin's Clinical Research Cancer for Cancer Key Laboratory of Cancer Prevention and Therapy

Objective： Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level（PDL） on overall survival（OS） of gastric cancer（GC） patients undergoing curative surgery by applying propensity score ***： A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute ＆Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL： the elevated group（EG） and the normal group（NG）. To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were ***： In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm（67.5% vs. 55.8%, P=0.006）, elder mean age（64.0±10.8 years vs. 60.5±11.6 years, P〈0.001） and advanced tumor（T）, node（N）, and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL（27.0% vs. 42.6%, P〈0.001）, however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio： 1.13, 95% confidence interval（95% CI）： 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG（P=0.809, log-rank）.Conclusions： The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself.

关键词： Gastric carcinoma D-dimer prognosis