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Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C

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National Science Review 2023年第11期10卷 45-60页

作者： Xiaoyu Meng Qiang Lin xuerui Zeng Jin Jiang Min Li Xin Luo Kaimin Chen Haixu Wu Yan Hu Cirong Liu Bing Su State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences National Resource Center for Non-Human Primates Kunming Primate Research Centerand National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility)Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Human-specific duplicated genes contributed to phenotypic innovations during the origin of our own species, such as an enlarged brain and highly developed cognitive abilities. While prior studies on transgenic mice carrying the human-specific SRGAP2C gene have shown enhanced brain connectivity, the relevance to humans remains unclear due to the significant evolutionary gap between humans and rodents. In this study,to investigate the phenotypic outcome and underlying genetic mechanism of SRGAP2C, we generated transgenic cynomolgus macaques(Macaca fascicularis) carrying the human-specific SRGAP2C *** MRI imaging revealed delayed brain development with region-specific volume changes,accompanied by altered myelination levels in the temporal and occipital regions. On a cellular level, the transgenic monkeys exhibited increased deep-layer neurons during fetal neurogenesis and delayed synaptic maturation in adolescence. Moreover, transcriptome analysis detected neotenic expression in molecular pathways related to neuron ensheathment, synaptic connections, extracellular matrix and energy metabolism. Cognitively, the transgenic monkeys demonstrated improved motor planning and execution skills. Together, our findings provide new insights into the mechanisms by which the newly evolved gene shapes the unique development and circuitry of the human brain.

关键词： transgenic monkey brain evolution brain development neurogenesis neoteny

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Description and surgical management of epiretinal membrane due to combined hamartoma of the retina and retinal pigment epithelium

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Advances in Ophthalmology Practice and Research 2023年第1期3卷 9-14页

作者： xuerui Zhang Yuan Yang Yanjun Wen Haodong Xiao Jie Peng Peiquan Zhao Department of Ophthalmology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Jiao Tong University School of Medicine ShanghaiChina

Purpose:To outline the characteristics of Combined Hamartoma of the Retina and Retinal Pigmentation Epithelium(CHRRPE)and provide a comprehensive overview of surgical management of epiretinal membrane(ERM)caused by *** text:CHRRPE is a rare ocular *** clinically mimics other diseases such as retinoblastoma and choroidal *** present study reviewed the multimodal imaging of CHRRPE,highlighted the multimodal imaging modalities which are useful for revealing the unique features of CHRRPE and hence allowing physicians to confirm the *** most of CHRRPEs are benign harmatoma,progressive visual loss may occur because of the traction of the tumor and other *** is treated through surgical removal of the ERM caused by CHRRPE to free retina from the ***,there is no consensus on the surgical management of ***,the current review was designed to explore the surgical management of ERM caused by CHRRPE and hence provide updated data on this ***:Multimodal imaging technologies,especially optical coherence tomography(OCT),significantly contributes to the diagnosis of CHRRPE and visual *** management of CHRRPE through removal of ERM is beneficial in patients with worsening VA which is secondary to ERM which is associated with ***,the strategy is limited to patients with long-standing poor ***,earlier surgical therapy and subsequent postoperative amblyopia therapy can be explored for children of amblyogenic age.

关键词： Combined hamartoma of the retina and retinal pigment(CHRRPE) Epiretinal membrane(ERM) Surgery

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The difference of the ionomer–catalyst interfaces for poly(aryl piperidinium)hydroxide exchange membrane fuel cells and proton exchange membrane fuel cells

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Nano Research 2024年第7期17卷 6102-6110页

作者： xuerui Liu Xingdong Wang Chanyu Zhang Yun Cai Bowen Chen Dongyue Xin Xiaoxiao Jin Wei Zhu Klaus Wippermann Hui Li Ruiyu Li Zhongbin Zhuang Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Institute of Petroleum Processing SINOPECBeijing 100083China DeepHytec Co. Ltd.Shenzhen 518118China Institute of Energy and Climate Research(IEK-14) Forschungszentrum Jülich GmbHJülich 52425Germany Beijing Key Laboratory of Energy Environmental Catalysis Beijing University of Chemical TechnologyBeijing 100029China

The microstructures of the ionomer–catalyst interfaces in the catalyst layers are important for the fuel cell performance because they determine the distribution of the active triple-phase ***,we investigate the ionomer–catalyst interactions in hydroxide exchange membrane fuel cells(HEMFCs)using poly(aryl piperidinium)and compare them with proton exchange membrane fuel cells(PEMFCs).It is found that different catalyst layer microstructures are between the two types of fuel *** ionomer/carbon(I/C)ratio does not have a remarkable impact on the HEMFC performance,while it has a strong impact on the PEMFC performance,indicating the weaker interaction between the HEMFC ionomer and *** dynamics simulations demonstrate that the HEMFC ionomer tends to distribute on the carbon support,unlike the PEMFC ionomer,which heavily covers the Pt *** results suggest that the poisoning effect of the ionomer on the catalyst is much weaker in HEMFCs,and the improved ionomer/catalyst interaction is beneficial for the HEMFC performances.

关键词： hydroxide exchange membrane fuel cells catalysts ionomer oxygen reduction reaction interfaces

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Key technologies of the emergency platform in China

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Journal of Safety Science and Resilience 2022年第4期3卷 404-415页

作者： Hongyong Yuan Lida Huang Tao Chen Yang Chen Hui Zhang xuerui Chen Qing Deng Zhichao He Jiajun Wang Yiting Wang Institute of Public Safety Research Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Tsinghua-Gsafety Joint Institute of Public Safety and Emergency Technology Research Gsafety CompanyBeijing 100094China Research Institute of Macro-Safety Science University of Science and Technology BeijingBeijing 100083China

An emergency platform is an informatization support platform for disaster information perception,disaster situa-tional awareness,and emergency decision *** is a key tool for ensuring the efficiency and effectiveness of emergency *** large countries have conducted in-depth research on the key technologies of emergency *** the past 20 years,with the reform of emergency management mechanisms,China has developed two generations of emergency platform *** paper reviews the two generations of emergency platforms and summarizes their key technologies including multi-source-based monitoring and early warning,multi-hazard risk assessment,“scenario-response”-based decision support,synthetical forecasting based on in-cident chain,and emergency common operational picture(COP)for command and *** research directions for the next generation emergency platforms are also proposed.

关键词： Emergency platform of China Technology development direction Multi-hazard Incident chain Scenario-response Emergency COP

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Whole genome sequencing exploitation analysis of dibutyl phthalate by strain Stenotrophomonas acidaminiphila BDBP 071

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Food Bioscience 2023年第1期51卷 168-178页

作者： Yingyue Zhang Jie Tang Min Wu xuerui Zhou Su Wang Hong Ye Wenliang Xiang Qing Zhang Ting Cai School of Food and Bioengineering Xihua UniversityChengdu610039SichuanPeople’s Republic of China

Dibutyl phthalate(DBP)is widely used as a plasticizer in plastic food packaging and has attracted extensive attention due to its residual hazards and ability to *** degradation is a very effective way to remove DBP from a polluted *** this study,Stenotrophomonas acidaminiphila BDBP 071,a strain that efficiently degraded DBP was isolated from tomato rhizosphere *** obtain a comprehensive understanding of the degradation mechanism of DBP by *** strain BDBP 071,whole genome sequencing of this strain was *** results showed that the genome size of BDBP 071 was 3.87 Mb,the G+C content was 69.43%,and the number of predicted coding sequences was *** on whole genome sequencing,the metabolic pathway related to DBP biotransformation was obtained,and key genes were subsequently verified by a real-time quantitative polymerase chain reaction to infer the degradation pathway of *** was preliminarily predicted that the relative expression of monoester hydrolase of EstB3 is increased in this *** study provides a scientific basis for applying *** BDBP 071 in environmental pollution bioremediation,as well as a rich resource for DBP biodegradation genes.

关键词： Dibutyl phthalate Stenotrophomonas acidaminiphila Whole genome sequencing RT-qPCR

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Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2186-2195页

作者： xuerui Zhang Lulu Song Lin Li Banghui Zhu Lina Huo Zhaoqing Hu Xinran Wang Jie Wang Mengyue Gao Jing Zhang Zichun Hua The State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjingChina Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc ChangzhouChina School of Biopharmacy China Pharmaceutical UniversityNanjingChina

Inflammatory bowel disease(IBD)is a chronic and relapsing disorder for many people associated with poor *** there are some clinical drugs for IBD treatment,the development of effective therapeutics on IBD patients has always been ***,we show that externalized phosphatidylserine(PS)is observed on the surface of colonic *** A5(ANXA5)with high affinity for PS has a good targeting to the colon and effectively alleviates experimental *** contrast,ANXA5 mutant(A5m)lacking the PS-binding ability,has no accumulation in the colon and no therapeutic effects on *** investigations indicate that ANXA5 reduces the inflammatory cell infiltration by inhibiting endothelial cell activation dependent on PS-binding *** the increasing of PS exposure on activated HUVECs(human umbilical vein endothelial cells),ANXA5 binding induces the internalization of TLR4 via PS-dependent *** provide new insights on the molecular mechanism of ANXA5 for its anti-inflammatory *** data suggest that PS-externalization is a potential target of ANXA5 aiming at targeted drug delivery(TDD)for IBD treatment.

关键词： colonic colon drugs

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Defective Ni_(3)S_(2)nanowires as highly active electrocatalysts for ethanol oxidative upgrading

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Nano Research 2022年第4期15卷 2987-2993页

作者： Yufeng Zhang Wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue Di Liu Rui Sui Qingqing Lv xuerui Liu Yongsheng Wang Wei Chen Zhongbin Zhuang State Key Lab of Organic-Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Beijing Key Laboratory of Energy Environmental Catalysis Beijing University of Chemical TechnologyBeijing 100029China

Electrochemical upgrading of biomass ethanol to value-added chemicals is promising for sustainable ***,we synthesize defective Ni_(3)S_(2) nanowires(NWs),which show high activity towards electrochemical oxidation of ethanol to *** Ni_(3)S_(2) NWs are formed by the oriented attachment mechanism,and rich defects are introduced during the growth.A low onset potential of 1.31 V and high mass activity of 8,716 mA·mgNi^(-1) at 1.5 V are achieved using the synthesized Ni_(3)S_(2) NWs toward the ethanol electro-oxidation,which are better than the Ni(OH)2 NWs and the Ni_(3)S_(2) nanoparticles(NPs).And the selectivity for the acetate generation is ca.99%.The high activity of Ni_(3)S_(2) NWs is attributed to the easier oxidation of Ni(II)to the catalytically active Ni(III)species with the promotion from S component and rich *** results demonstrate that the defective NWs can be synthesized by the oriented attachment method and the defective Ni_(3)S_(2) NWs structure as the efficient nonnoble metal electrocatalysts for oxidative upgrading of ethanol.

关键词： nickel sulfide electrocatalyst ethanol oxidation defects oriented attachment

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Associations of Education with Blood Pressure in Hypertensive Patients: A Chinese Community Survey

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Chinese Medicine 2013年第3期4卷 97-100页

作者： Xiaojun Chen xuerui Tan Department of Cardiovascular Diseases The First Affiliated Hospital of Shantou University Medical College Shantou China

Objective: To examine the association between education and blood pressure in hypertensive Chinese. Methods: A cross-sectional study was conducted at the health care center of a university affiliated hospital in 2008 to enroll 502 mild to moderate essential hypertensive patients. All participants completed a questionnaire addressing their sociodemographic information before they were given a routine physical check-up. Results: The baseline blood pressure was 151.87/95.76 mmHg for 277 females and 149.80/97.74 mmHg for 225 males. Only few women reported smoke (4%, n = 11) or drink alcohol (6.9%, n = 19). Over half of men smoke and drink (63.2% and 52.9% respectively). Alcohol consumption was found different among educational attainment groups in males. Correlation analyses demonstrated that education was inversely related to systolic blood pressure in female hypertensives. Conclusion: Education is associated with blood pressure in females.

关键词： Education Blood Pressure Hypertension Survey

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Pt single atoms coupled with Ru nanoclusters enable robust hydrogen oxidation for high-performance anion exchange membrane fuel cells

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Nano Research 2024年第7期17卷 6147-6156页

作者： Jianmei Wang Bingxing Zhang Xiaozhong Zheng xuerui Liu Wei Guo Zhouxin Luo Yongfeng Liu Mingxia Gao Jian Chen Zhongbin Zhuang Hongge Pan Wenping Sun School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Lab of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an 710021China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

The sluggish reaction kinetics of alkaline hydrogen oxidation reaction(HOR)is one of the key challenges for anion exchange membrane fuel cells(AEMFCs).To achieve robust alkaline HOR with minimized cost,we developed a single atom-cluster multiscale structure with isolated Pt single atoms anchored on Ru nanoclusters supported on nitrogen-doped carbon nanosheets(Pt1-Ru/NC).The well-defined structure not only provides multiple sites with varied affinity with the intermediates but also enables simultaneous modulation of different sites via interfacial *** addition to weakening Ru–H bond strength,the isolated Pt sites are heavily involved in hydrogen adsorption and synergistically accelerate the Volmer step with the help of Ru ***,this catalyst configuration inhibits the excessive occupancy of oxygen-containing species on Ru sites and facilitates the HOR at elevated *** Pt1-Ru/NC catalyst exhibits superior alkaline HOR performance with extremely high activity and excellent *** AEMFC with a 0.1 mg·cmPGM^(−2)loading of Pt1-Ru/NC anode catalyst achieves a peak powder density of 1172 mW·cm^(−2),which is 2.17 and 1.55 times higher than that of Pt/C and PtRu/C,*** work provides a new catalyst concept to address the sluggish kinetics of electrocatalytic reactions containing multiple intermediates and elemental steps.

关键词： nanoclusters multiscale structure hydrogen oxidation reaction electrocatalysis anion exchange membrane fuel cells

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An all-metallic nanovesicle for hydrogen oxidation

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National Science Review 2024年第6期11卷 233-242页

作者： Juntao Zhang Lujie Jin Hao Sun Xiaozhi Liu Yujin Ji Youyong Li Wei Liu Dong Su xuerui Liu Zhongbin Zhuang Zhiwei Hu Qi Shao Xiaoqing Huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Key Laboratory for Special Functional Materials of Ministry of Education National &Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology School of Materials Science and EngineeringCollaborative Innovation Center of Nano Functional Materials and Applications Henan University Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials& Devices Soochow University State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences State Key Lab of Organic-Inorganic Composites Beijing University of Chemical Technology Max Planck Institute for Chemical Physics of Solids College of Chemistry and Chemical Engineering and Materials Science Soochow University

Vesicle, a microscopic unit that encloses a volume with an ultrathin wall, is ubiquitous in ***, it remains a huge challenge to create its inorganic metal-based artificial counterparts. Here,inspired by the formation of biological vesicles, we proposed a novel biomimetic strategy of curling the ultrathin nanosheets into nanovesicles, which was driven by the interfacial strain. Trapped by the interfacial strain between the initially formed substrate Rh layer and subsequently formed RhRu overlayer, the nanosheet begins to deform in order to release a certain amount of strain. Density functional theory（DFT）calculations reveal that the Ru atoms make the curling of nanosheets more favorable in thermodynamics applications. Owing to the unique vesicular structure, the RhRu nanovesicles/C displays excellent hydrogen oxidation reaction（HOR） activity and stability, which has been proven by both experiments and DFT calculations. Specifically, the HOR mass activity of RhRu nanovesicles/C are 7.52 A mg（Rh+Ru）-1at an overpotential of 50 m V at the rotating disk electrode（RDE） level; this is 24.19 times that of commercial Pt/C(0.31 m A mgPt-1). Moreover, the hydroxide exchange membrane fuel cell（HEMFC） with RhRu nanovesicles/C displays a peak power density of 1.62 W cm-2in the H2-O2condition, much better than that of commercial Pt/C(1.18 W cm-2). This work creates a new biomimetic strategy to synthesize inorganic nanomaterials, paving a pathway for designing catalytic reactors.

关键词： biomimetic synthesis nanovesicle interfacial strain hydrogen oxidation reaction

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