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Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine

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Chinese Journal of Integrative Medicine 2025年第1期31卷 39-48页

作者： WU Wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG Hui LU fu-er YUAN Fen Institution of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(GLP-1)/GLP-1 receptor(GLP-1R) in both islet and intestine. Methods: The db/db mice were divided into the model(distilled water), low-dose HRD(LHRD, 3 g/kg), high-dose HRD(HHRD, 6 g/kg), and liraglutide(400 μg/kg) groups using a random number table, 8 mice in each group. The db/m mice were used as the control group(n=8, distilled water). The entire treatment of mice lasted for 6 weeks. Blood insulin, glucose, and GLP-1levels were quantified using enzyme-linked immunosorbent assay kits. The proliferation and apoptosis factors of islet cells were determined by immunohistochemistry(IHC) and immunofluorescence(IF) staining. Then,GLP-1, GLP-1R, prohormone convertase 1/3(PC1/3), PC2, v-maf musculoaponeurotic fibrosarcoma oncogene homologue A(MafA), and pancreatic and duodenal homeobox 1(PDX1) were detected by Western blot, IHC,IF, and real-time quantitative polymerase chain reaction, respectively. Results: HRD reduced the weight and blood glucose of the db/db mice, and improved insulin sensitivity at the same time(Pfunction and identity of islet β cell, and the underlying mechanism is related to promoting the paracrine and endocrine activation of GLP-1 in pancreas and intestine.

关键词： type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine

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Influence of Rhamnolipids Biosurfactant on the Anodic Electrochemical Performance in Marine Sediment Microbial fuel Cell and the Acceleration Degradation of Crude Petroleum

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Journal of Ocean University of China 2025年第1期24卷 139-146页

作者： HOU Luyao ZAI Xuerong MENG Yao LIANG Shengkang CAO Yali CHEN Yan ZHANG Huaijing HUANG Xiang fu Yubin College of Materials Science and Engineering Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China College of Marine Geosciences Ocean University of ChinaQingdao 266100China

Crude petroleum pollution causes some serious ecological disasters in the *** sediment microbial fuel cells(MSMFCs)have been utilized as a novel method for in-situ degradation and a long-term power ***,the effect of different concentrations of rhamnolipids biosurfactant on the electrochemical performance of MSMFCs anode and the higher efficiency of oil degradation are creatively *** results indicate that the anode in sediment containing rhamnolipids effectively enriches the indigenous electrogenic Pseudophaeobacter and Pseudomonas,which significantly enhances the electrochemical performance of the *** rhamnolipids at the concentration of 200 mg kg^(-1)in sediment,the anode specific capacitance(401.45 Fm^(-2)),exchange current density(4.87×10^(-2)mAm^(-2)),and cell maximum power density(140.24 mWm^(-2))increase by 2.50,38.65,and 2.11 times,respectively,in comparison with its natural *** the oil degradation rate(40.06%)was higher than the blank(17.55%).It demonstrates that the synergistic effect between electrochemical catalytic degradation and emulsifying solubilization of rhamnolipids surfactant directly accelerates the degradation of petroleum in marine sediment,which will provide a novel method and theoretical guidance for in-situ degradation and efficient removal of crude petroleum on ocean floor.

关键词： marine sediment microbial fuel cells petroleum pollution rhamnolipids biosurfactant electrochemical performance

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Towards high-performance, efficient and sustainable material processing technologies for aerospace applications

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Chinese Journal of Aeronautics 2025年第1期 3+6-7页

作者： Jun MA Mingwang fu Stefania BRUSCHI Heng LI State Key Laboratory of Solidification Processing Northwestern Polytechnical University Department of Mechanical and Industrial Engineering Norwegian University of Science and Technology Department of Mechanical Engineering The Hong Kong Polytechnic University Department of Industrial Engineering University of Padova State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The aerospace and aviation industry has long been at the forefront of materials and processing technologies,driven by its ongoing demand for lightweight,highly reliable,and durable *** manufacturing is a critical discipline that directly affects the performance,functionality,and safety of aircraft and aerospace *** meet the above-mentioned stringent requirements,advanced materials and cutting-edge processing technologies have evolved alongside aerospace *** the basic designs of the early20th century to today’s complex aerospace assemblies,the industry has transformed and embraced high-performance materials processing and advanced manufacturing ***,aerospace manufacturing is experiencing an accelerated development,driven by heightened performance and safety demands,alongside a growing focus on fuel efficiency and *** materials processing and manufacturing technologies are at the core of achieving these goals,presenting both opportunities and challenges for the aerospace manufacturing *** considerations include:

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In situ construction of Cu(Ⅰ)-Cu(Ⅱ) pairs for efficient electrocatalytic nitrate reduction reaction to ammonia

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Journal of Energy Chemistry 2025年第1期100卷 106-113页

作者： Muyun Zheng Yuchi Wan Leping Yang Shen Ao Wangyang fu Zhengjun Zhang Zheng-Hong Huang Tao Ling Feiyu Kang Ruitao Lv State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108FujianChina Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Tianjin Key Laboratory of Composite and Functional MaterialsSchool of Materials Science and EngineeringTianjin UniversityTianjin 300072China

Electrocatalytic nitrate reduction reaction (NO_(3)-RR) to ammonia under ambient conditions is expected to be a green process for ammonia synthesis and alleviate water pollution *** report a CuO nanoparticles incorporated on nitrogen-doped porous carbon (CuO@NC) catalyst for NO_(3)-*** of Cu(Ⅱ) is reduced to Cu(Ⅰ) during the NO_(3)-RR process to construct Cu(Ⅰ)-Cu(Ⅱ) pairs,confirmed by in situ X-ray photoelectron spectroscopy (XPS) and Raman *** functional theory (DFT) calculations indicated that the formation of Cu(Ⅰ) could provide a reaction path with smaller energy barrier for NO_(3)-RR,while Cu(Ⅱ) effectively suppressed the competition of hydrogen evolution reaction (HER).As a result,CuO@NC catalyst achieved a Faradaic efficiency of 84.2% at -0.49 V versus reversible hydrogen electrode (RHE),and a NH_(3)yield rate of 17.2 mg h^(-1)mg^(-1)*** -0.79 V ***,higher than the HaberBosch process (<3.4 g h^(-1)g^(-1)cat.).This work may open a new avenue for effective NO_(3)-RR by modulating oxidation states.

关键词： Ammonia synthesis Cu oxidation state Electrochemistry Nitrate reduction In situ XPS

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Two-dimensional lateral magnetic tunnel junction with ultrahigh tunneling magnetoresistance

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Nano Research 2025年第2期18卷 958-964页

作者： Qiu-Qiu Li Zhi-fu Duan Wen-Wen Liu Rong Yang Bo Li Ke-Qiu Chen Changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors(College of Integrated Circuits)Hunan UniversityChangsha 410082China Department of Applied Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China Research Institute of Hunan University in Chongqing Chongqing 401120China Shenzhen Research Institute of Hunan University Shenzhen 518063China

Giant tunneling magnetoresistance(TMR)has always been a pursuit in the research of magnetic tunnel junctions(MTJ).Two-dimensional(2D)magnetic materials have been used to construct lateral MTJ with high *** we investigated the crystal structure and magnetic property of CrSI monolayer,and found that it is a ferromagnetic semiconductor with a Curie temperature of about 180 *** CrSI monolayer with Li adsorption(Li-CrSI)show ferromagnetic half-metallic with a high Curie temperature of 300 *** we designed a lateral Li CrSI/CrSI/Li-CrSI monolayer *** TMR of the MTJs along b transport direction is 3 orders of magnitude times larger than that of the a transport direction,which should result from the different spin filtering ability along the two *** TMR of b transport direction in the MTJ is 7.67×10^(14),which is significantly higher than that of any reported lateral MTJs based on 2D *** results provide a promising avenue for designing lateral MTJs with giant TMR and high Curie temperature.

关键词： two-dimensional materials magnetic tunnel junctions CrSI monolayer tunneling magnetoresistance Li atom adsorption

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Multi-wavelength plasmonic optoelectronic memristor for reconfigurable logic operations and mixed-color pattern recognition

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Science China(Information Sciences) 2025年第2期68卷 5-14页

作者： Jiaqi HAN Zhuangzhuang LI Tao ZENG Xuanyu SHAN Riya SU Ya LIN Zhongqiang WANG Xiaoning ZHAO Shencheng fu Haiyang XU Yichun LIU Key Laboratory for UV Light-Emitting Materials and Technology (Northeast Normal University) Ministry of Education Department of Materials Science and Engineering National University of Singapore

Optoelectronic memristors have emerged as promising hardware platforms for highly efficient image perception owing to their low crosstalk, fast response, and low power consumption. However, the development of optoelectronic memristors with multi-wavelength recognition capabilities remains constrained by the limitations of their inherent bandgap. In this work, a multi-wavelength-modulated optoelectronic memristor that operates based on the localized surface plasmon resonance effect is developed using silver（Ag）-titanium dioxide（TiO2）/polymethyl methacrylate（PMMA） nanocomposites. The SET voltage can be gradually reduced by modulating the optical wavelength of visible irradiation. On this basis, reconfigurable IMP and False logic operations have been implemented in the memristive logic circuit. The neuromorphic visual preprocessing and recognition function for mixed-color patterns is demonstrated based on wavelength-dependent resistive switching behaviors. The proposed optoelectronic memristor enables high-density storage and in-memory computing.

关键词： optoelectronic memristor localized surface plasmon resonance multi-wavelength resistive switching color pattern recognition

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基于统计学习的概率潮流计算方法综述

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供用电 2021年第11期38卷 33-39页

作者：苟笳豪张梦婷张宇菁吴娴萍付学谦中国农业大学信息与电气工程学院北京100083

电力系统的发展对电网的稳定运行提出越来越高的要求。通过电网概率潮流计算,可以有效统计各潮流量的数字特征,从而运用于电力系统的规划和调度等。首先介绍了概率潮流的基本概念;其次介绍了基于统计学习的概率潮流计算方法,包括模拟法... 详细信息

电力系统的发展对电网的稳定运行提出越来越高的要求。通过电网概率潮流计算,可以有效统计各潮流量的数字特征,从而运用于电力系统的规划和调度等。首先介绍了概率潮流的基本概念;其次介绍了基于统计学习的概率潮流计算方法,包括模拟法、近似法、解析法和随机响应面法,阐述每种方法的原理和流程图,并进行总结和比较;然后通过IEEE-33节点系统仿真比对各个方法;最后进行总结和展望,预测概率潮流计算是未来潮流计算的发展方向。

关键词：概率潮流计算统计学习蒙特卡洛法点估计法随机响应面法

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The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice

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Journal of Environmental Sciences 2025年第5期151卷 54-67页

作者： Xiang Zuo Minghe Sun Huijuan Bai Shuhui Zhang Jialu Luan Qian Yu Zhenhua fu Qili Zhao Mingzhu Sun Xin Zhao Xizeng Feng College of Life Science State Key Laboratory of Medicinal Chemical BiologyThe Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071China Institute of Robotics&Automatic Information System College of Artificial IntelligenceNankai UniversityTianjin 300071China

17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly ***,17-TB acts as a hormone with properties similar to testosterone,and the consequences of juvenile exposure on adult social behavior remain *** A(BPA)acts as an estrogen-like hormone,compared to ***-week-old male Balb/c mice were exposed orally to 17-TB(100μg/(kg·day))and BPA(4 mg/(kg·day))for 28 *** of social interactions and a three-chamber test showed that 17-TB increased virility in male mice,intensified both male and female sexual behavior,and attracted and accepted female *** also increased social dominance through tube tests inmalemice and markedly activated the c-Fos^(+)immune response in themedial prefrontal cortex(mPFC)and basal amygdala(BLA).ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone(GnRH),growth hormone(GH),estradiol(E2),and luteinizing hormone(LH)levels,as well as testicular lesions and androgen receptor(ARβ)and estrogen receptor(ERα)*** transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic *** findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice,possibly through modulation of the hypothalamic-pituitary-gonadal *** study provides insights relevant to human reproductive health and neuro-social behavioral research,and the potential risk of environmental disturbances should not be overlooked.

关键词： 17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) Sex hormones Social dominance Sexual behavior

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal[3+2]annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China

Herein,the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO)complex catalyze asymmetric formal[3+2]cycloaddition between quinones and ynamides is explored,producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent ***,density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal[3+2]cycladdition Cu/SPDO complex DFT calculations

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin fu Xiaoting Yang Ya Yu Kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen fuqiang Fan Yuhang Li Yu fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

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