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A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

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Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang yan Wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health Sciences National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University Shenyang Key Laboratory of Vascular Biology Science and Research Center Department of Pharmacology Shenyang Medical College Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University

Ischemic stroke(IS) is a prevalent neurological disorder often resulting in significant disability or mortality. Resveratrol, extracted from Polygonum cuspidatum Sieb. et Zucc.(commonly known as Japanese knotweed), has been recognized for its potent neuroprotective ***, the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl) quinoline(RV02), against ischemic stroke remains inadequately explored. This study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in vivo. The research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic conditions. The findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS) through mitophagy activation. Furthermore, Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in vitro. These results suggest that RV02 shows promise as a neuroprotective agent, with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3,5-dimethoxystyryl) quinoline Ischemic stroke Mitophagy Parkin Resveratrol

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Exploring Mechanism of Electroacupuncture in Modulating Neuroinflammation Based on Intestinal Flora and Its Metabolites

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Chinese Journal of Integrative Medicine 2025年第2期31卷 183-192页

作者： YE Hai-min LI Zhuo-yan ZHANG Peng KANG Zhen ZHOU De-sheng School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha(410208)China Neurology Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Acupuncture and Moxibustion Massage Rehabilitation Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Neurology Department The First Hospital of Hunan University of Chinese MedicineChangsha(410011)China

Neuroinflammatory responses play an important role in the pathogenesis of various diseases,particularly those affecting the central nervous *** of neuroinflammation is a crucial therapeutic strategy for the management of central nervous system *** intestinal microbial-gut-brain axis serves as a key regulatory pathway that modulates neuroinflammatory *** flora metabolites such as short-chain fatty acids,indoles and their derivatives,lipopolysaccharides,trimethylamine oxide,and secondary bile acids exert direct or indirect effects on *** have shown that electroacupuncture(EA)modulates the composition of the intestinal microbiota and its metabolites,while also suppressing neuroinflammation by targeting the TLR4/NF-κB,NLRP3/caspase-1,and microglial cell M2-type transformation *** review discusses the mechanisms by which EA regulates neuroinflammation via intestinal microbiota and its metabolites,providing information and a foundation for further investigation of the precise therapeutic mechanisms of EA in neurological disorders.

关键词： electroacupuncture intestinal flora metabolites of intestinal flora neuroinflammation nervous system disease review

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One Novel Nortriterpenoid from the Mastic(Pistacia lentiscus)and Its Anti-Inflammatory Activity

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 199-207页

作者： yan Wu Xuerui An Haofan Lv Zhiqiang Zhao Wei Liu Chunpeng Wan Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region School of Chemistry and Chemical EngineeringYili Normal UniversityYining835000China Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources School of Chemistry and Chemical EngineeringYili Normal UniversityYining835000China Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits and Vegetables College of AgronomyJiangxi Agricultural UniversityNanchang330045China

A novel pair of oleanane nor-triterpenes,with compound 1 featuring a unique 18α-H structure,was isolated from mastic,and this compound represents a noteworthy new entity not previously reported in the *** absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR,high-resolution mass spectrometry(HR-MS),ultraviolet(UV),infrared(IR)and single-crystal X-ray diffraction(SXRD).The compound actively mitigated inflammations by efficiently quenching nitric oxide(NO)synthesis within an ex vivo system using lipopolysaccharide activated murine macrophage RAW264.7 ***,compound 1 exhibit a better IC50 concentration of 11.69±1.39µM,surpassing the efficacy of the positive control dexamethasone,which exhibited an IC50 of 23.21±1.17μ*** compound 2 also demonstrated inhibitory activity,its potency was comparatively weaker,with an IC50 of 26.18±2.66μM.

关键词： Mastic nor-triterpene 18α-H oleanane anti-inflammatory

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Priority sources identification and risks assessment of heavy metal(loid)s in agricultural soils of a typical antimony mining watershed

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Journal of Environmental Sciences 2025年第1期147卷 153-164页

作者： Lianhua Liu You Li Xiang Gu Roberto Xavier Supe Tulcan Lingling yan Chunye Lin Junting Pan Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Environment Beijing Normal UniversityBeijing 100875China Yiyang Academy of Agricultural Sciences Yiyang 413099China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China

Heavy metal(loid)(HM)pollution in agricultural soils has become an environmental concern in antimony(Sb)mining ***,priority pollution sources identification and deep understanding of environmental risks of HMs face great challenges due to multiple and complex pollution sources ***,an integrated approach was conducted to distinguish pollution sources and assess human health risk(HHR)and ecological risk(ER)in a typical Sb mining watershed in Southern *** approach combines absolute principal component score-multiple linear regression(APCS-MLR)and positivematrix factorization(PMF)models with ER and HHR *** pollution sources were distinguished for both models,and APCS-MLR model was more accurate and *** HM concentration source was natural source(39.1%),followed by industrial and agricultural activities(23.0%),unknown sources(21.5%)and Sb mining and smelting activities(16.4%).Although natural source contributed the most to HM concentrations,it did not pose a significant *** and agricultural activities predominantly contributed to ER,and attention should be paid to Cd and *** mining and smelting activities were primary anthropogenic sources of HHR,particularly Sb and As *** ER and HHR assessments,Sb mining and smelting,and industrial and agricultural activities are critical sources,causing serious ecological and health *** study showed the advantages of multiple receptor model application in obtaining reliable source identification and providing better source-oriented risk *** pollution management,such as regulating mining and smelting and implementing soil remediation in polluted agricultural soils,is strongly recommended for protecting ecosystems and humans.

关键词： Antimony Heavy metal(loid) Risk assessment Pollution sources Mining and smelting

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Dual-role regulator of a novel miR-3040 in photoperiod-mediated wing dimorphism and wing development in green peach aphid

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Insect Science 2025年第1期32卷 80-94页

作者： Yun-Hui Zhang Xin Qian Xin Zong Shi-Heng An Shuo yan Jie Shen College of Plant Protection Henan Agricultural UniversityZhengzhouChina Department of Plant Biosecurity College of Plant ProtectionChina Agricultural UniversityBeijingChina

Wing dimorphism is regarded as an important phenotypic plasticity involved in the migration and reproduction of ***,the signal transduction and regulatory mechanism of wing dimorphism in aphids are still ***,the optimal environmental conditions were first explored for inducing winged offspring of green peach aphid,and the short photoperiod was the most important environmental cue to regulate wing *** to 16 L:8 D photoperiod,the proportion of winged offspring increased to 90%under 8 L:16 D ***,5 differentially expressed microRNAs(miRNAs)in aphids treated with long and short photoperiods were identified using small RNA sequencing,and a novel miR-3040 was identified as a vital miRNA involved in photoperiod-mediated wing *** specifically,the inhibition of miR-3040 expression could reduce the proportion of winged offspring induced by short photoperiod,whereas its activation increased the proportion of winged offspring under long ***,the expression level of miR-3040 in winged aphids was about 2.5 times that of wingless aphids,and the activation or inhibition of miR-3040 expression could cause wing deformity,revealing the dual-role regulator of miR-3040 in wing dimorphism and wing *** summary,the current study identified the key environmental cue for wing dimorphism in green peach aphid,and the first to demonstrate the dual-role regulator of miR-3040 in photoperiod-mediated wing dimorphism and wing development.

关键词： miR-3040 Myzus persicae photoperiod wing development wing dimorphism

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Cu/TiO_(2)adsorbents modified by air plasma for adsorption-oxidation of H_(2)S

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Journal of Environmental Sciences 2025年第2期148卷 476-488页

作者： Yongqi yan Xinyu yang Ping Ning Chi Wang Xin Sun Fei Wang Peng Gao Kai Li Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500China Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China City College Kunming University of Science and TechnologyKunming 650500China

In this study,non-thermal plasma(NTP)was employed to modify the Cu/TiO_(2)adsorbent to efficiently purify H_(2)S in low-temperature and micro-oxygen *** effects of Cu loading amounts and atmospheres of NTP treatment on the adsorption-oxidation performance of the adsorbents were *** NTP modification successfully boosted the H_(2)S removal capacity to varying degrees,and the optimized adsorbent treated by air plasma(Cu/TiO_(2)-Air)attained the best H_(2)S breakthrough capacity of 113.29 mg H_(2)S/gadsorbent,which was almost 5 times higher than that of the adsorbent without NTP *** studies demonstrated that the superior performance of Cu/TiO_(2)-Air was attributed to increased mesoporous volume,more exposure of active sites(CuO)and functional groups(amino groups and hydroxyl groups),enhanced Ti-O-Cu interaction,and the favorable ratio of active oxygen ***,the X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results indicated the main reason for the deactivationwas the consumption of the active components(CuO)and the agglomeration of reaction products(CuS and SO_(4)^(2−))occupying the active sites on the surface and the inner pores of the adsorbents.

关键词： Non-thermal plasma(NTP) Surface modification Simultaneous adsorption-oxidation Cu/TiO_(2)(TiO_(2)loaded with copper) H_(2)S

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The advanced development of innovative photocatalytic coupling strategies for hydrogen production

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Chinese Chemical Letters 2025年第1期36卷 80-91页

作者： Yuehai Zhi Chen Gu Huachao Ji Kang Chen Wenqi Gao Jianmei Chen Dafeng yan College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing 210023China Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals&Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&College of Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China

Photocatalytic technology harnesses solar energy to facilitate chemical transformations,presenting significant potential in energy generation and environmental ***,the conventional O_(2)evolution process is hindered by high reaction barriers and inefficiencies,which limit its widespread ***,exploring novel photocatalytic coupling strategies to replace water oxidation has become a key route to enhance the efficiency of H_(2)*** this review,organic pollutants removal and the valorization of organics as substitutes for water oxidation coupling strategies for photocatalytic H_(2)production are comprehensively *** strategies not only circumvent the high reaction barriers associated with O_(2)evolution to enhance the H_(2)production but also aid in the removing of organic pollutants or synthesis of value-added *** also present future research directions and underscore the significance of advanced catalyst design,in-depth analysis of reaction mechanisms,and systematic optimization strategies in realizing an efficient and sustainable photocatalytic *** guidance is anticipated to provide theoretical and practical new insights for the future development of photocatalytic coupling reactions,fostering further explorations in the realm of renewable energy and environmental governance.

关键词： Photocatalysis Pollutants removal Valorization of organics Catalyst design

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Experimental Study for Effect of Multi-Site Spark Ignition on Dedicated Hybrid Engine Performance under High Dilution Condition

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Journal of Thermal Science 2025年第1期34卷 254-267页

作者： yan Bowen WATERS Benjamin HAINES Andrew MCGHEE Mike HU Tiegang DENG Wei PU Yongxian MA Tianyu Powertrain Engineering R&D Center Chongqing Changan Automobile Co.Ltd.Chongqing 400000China Changan UK R&D Centre Limited Birmingham B377YGUnited Kingdom

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-L dedicated hybrid engine(DHE).On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 MPa BMEP(brake mean effective pressure)show that with highly increased in-cylinder flow intensity,using only passive prechamber(PPC)has a lower lean limit than that with single central spark plug(CSP),thereby leading to slightly higher minimum fuel consumption and nitrogen oxides(NO_(x))*** side spark plugs(SSP)based on PPC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs(TSP).As the excess air ratio λ increases,the advantage of PPC and PPC with SSP in improving the combustion phasing compared with CSP gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSP based on PPC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of PPC and PPC with SSP in terms of combustion characteristics over CSP becomes much *** contrast,the TSP ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSP ignition achieves the lowest raw NO_(x)***,it can also reduce the raw carbon monoxide(CO)and hydrocarbons(HC)emissions compared to CSP due to a more thorough combustion of the end gas *** on the excellent performance of TSP,the highest engine brake thermal efficiency(BTE)was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaus

关键词： dedicated hybrid engine triple spark plug scheme passive prechamber high dilution condition thermal efficiency NO_(x)emissions

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Interfacial electron rearrangement of 3D Fe_(3)O_(4)/h-YFeO_(3)composites for efficient electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 609-618页

作者： Yi Sui Yingde Zhang Guang Liu Lei Ji Junyu Yue Chen Wu Mi yan School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China Key Laboratory of Rare Earths Chinese Academy of SciencesGanzhou 341119China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Interface modulation is an important pathway for highly efficient electromagnetic wave ***,tailored interfaces between Fe_(3)O_(4)particles and the hexagonal-YFeO_(3)(h-YFeO_(3))framework were constructed via facile *** resulting interfa-cial electron rearrangement at the heterojunction led to enhanced dielectric and magnetic loss *** results and density function theory(DFT)simulations demonstrate a transition in electrical properties from a half-metallic monophase to metallic Fe_(3)O_(4)/h-YFeO_(3)composites,emphasizing the advantages of the formed *** transformation of electron behavior is also accompan-ied by a redistribution of electrons at the Fe_(3)O_(4)/h-YFeO_(3)heterojunction,leading to the accumulation of localized electrons around the Y-O-Fe band bridge,consequently enhancing the polarization.A minimum reflection loss of-34.0 dB can be achieved at 12.0 GHz and 2.0 mm thickness with an effective bandwidth of 3.3 GHz due to the abundant interfaces,enhanced polarization,and rational ***,the synergistic effects endow the Fe_(3)O_(4)/h-YFeO_(3)composites with high performance and tunable functional properties for efficient electromagnetic absorption.

关键词： self-assembling heterojunction electron rearrangement interface modulation electromagnetic wave absorption

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A smart finger patch with coupled magnetoelastic and resistive bending sensors

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Journal of Semiconductors 2025年第1期46卷 194-203页

作者： Ziyi Dai Mingrui Wang Yu Wang Zechuan Yu yan Li Weidong Qin Kai Qian School of Integrated Circuits Shandong UniversityJinan 250100China Department of Mechanical Engineering University of AucklandAuckland 1010New Zealand Department of Urology Qilu Hospital of Shandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518000China Department of Critical Care Medicine Qilu hospital of Shandong universityJinan 250100China

In the era of Metaverse and virtual reality(VR)/augmented reality(AR),capturing finger motion and force interactions is crucial for immersive human-machine *** study introduces a flexible electronic skin for the index finger,addressing coupled perception of both state and process in dynamic tactile *** device integrates resistive and giant magnetoelastic sensors,enabling detection of surface pressure and finger joint *** e-skin identifies three phases of finger action:bending state,dynamic normal force and tangential force(sweeping).The system comprises resistive carbon nanotubes(CNT)/polydimethylsiloxane(PDMS)films for bending sensing and magnetoelastic sensors(NdFeB particles,EcoFlex,and flexible coils)for pressure *** inward bending resistive sensor,based on self-assembled microstructures,exhibits directional specificity with a response time under 120 ms and bending sensitivity from 0°to 120°.The magnetoelastic sensors demonstrate specific responses to frequency and deformation magnitude,as well as sensitivity to surface roughness during sliding and material *** system’s capability is demonstrated through tactile-based bread type and condition recognition,achieving 92%*** intelligent patch shows broad potential in enhancing interactions across various fields,from VR/AR interfaces and medical diagnostics to smart manufacturing and industrial automation.

关键词： human machine interface flexible sensor wearable sensor giant magnetoelastic effect inward bending sensor

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