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民用直升机PMMEL工作要点解析

基于CBR和FTA的直升机故障诊断专家系统设计

中国科技纵横 2024年第3期 74-77页

作者：纪华东胡雪明李超秦璐中国直升机设计研究所江西景德镇 333001 北京航空航天大学北京 100191

民用直升机PMMEL是为了确保直升机在部分设备失效的情况下,仍能保持安全飞行和着陆的能力.它基于直升机的设计、运行经验和安全要求,列出了在特定情况下可以接受的最低设备配置.主最低设备清单建议书(PMMEL)是主最低设备清单(MMEL)审查... 详细信息

民用直升机PMMEL是为了确保直升机在部分设备失效的情况下,仍能保持安全飞行和着陆的能力.它基于直升机的设计、运行经验和安全要求,列出了在特定情况下可以接受的最低设备配置.主最低设备清单建议书(PMMEL)是主最低设备清单(MMEL)审查工作的基础,直接影响民用直升机运营时安全性和经济性的平衡.本文结合民用直升机型号经验梳理了PMMEL工作要点,可为民用直升机PMMEL工作的开展提供有意义的参考.

关键词： PMMEL MMEL 民用直升机

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Spatiotemporal characteristics of water exchange between the Andaman Sea and the Bay of Bengal

中国科技纵横 2024年第4期 80-83,161页

作者：纪华东胡雪明曹阳李超秦璐中国直升机设计研究所江西景德镇 333001 北京航空航天大学北京 100191

直升机各个系统之间交联关系非常复杂,而当前国内直升机外场故障诊断主要依靠维修人员经验,难以快速准确地进行故障定位,严重影响直升机的维护和使用.基于相关问题,对以往型号中积累的经验进行深入研究,形成故障诊断所需的知识库,建立... 详细信息

直升机各个系统之间交联关系非常复杂,而当前国内直升机外场故障诊断主要依靠维修人员经验,难以快速准确地进行故障定位,严重影响直升机的维护和使用.基于相关问题,对以往型号中积累的经验进行深入研究,形成故障诊断所需的知识库,建立基于案例推理(CBR)和故障树(FTA)的直升机故障诊断专家系统,并在实际工作中得到应用.该系统充分利用以往积累的经验和知识,以期提升故障诊断的效率,减轻维修人员的工作负担.

关键词：直升机 CBR FTA 故障诊断专家系统

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Acta Oceanologica Sinica 2024年第5期43卷 1-15页

作者： Yihao Wang Feng Zhou xueming Zhu Ruijie Ye Yingyu Peng Zhentao hu Haoran Tian Na Li Ocean College Zhejiang UniversityZhoushan 316021China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Observation and Research Station of Yangtze River Delta Marine Ecosystems Ministry of Natural ResourcesZhoushan 316022China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China School of Marine Sciences Sun Yat-sen UniversityZhuhai 519080China

A high-resolution customized numerical model is used to analyze the water transport in the three major water passages between the Andaman Sea(AS)and the Bay of Bengal,i.e.,the Preparis Channel(PC),the Ten Degree Channel(TDC),and the Great Channel(GC),based on the daily averaged simulation results ranging from 2010 to *** analysis and Empirical Orthogonal Function(EOF)methods are employed to investigate the spatiotemporal variability of the water exchange and controlling *** results of model simulation indicate that the net average transports of the PC and GC,as well as their linear trend,are opposite to that of the *** indicates that the PC and the GC are the main inflow channels of the AS,while the TDC is the main outflow channel of the *** transport variability is most pronounced at surface levels and between 100 m and 200 m depth,likely affected by monsoons and circulation.A 182.4-d semiannual variability is consistently seen in all three channels,which is also evident in their second principal *** on sea level anomalies and EOF analysis results,this is primarily due to equatorial winds during the monsoon transition period,causing eastward movement of Kelvin waves along the AS coast,thereby affecting the spatiotemporal characteristics of the flow in the *** first EOF of the PC flow field section shows a split at 100 m deep,likely due to *** first EOF of the TDC flow field section is steady but has potent seasonal oscillations in its time ***,the first EOF of the GC flow field section indicates a stable surface inflow,probably influenced by the equatorial Indian Ocean’s eastward current.

关键词： Andaman Sea water exchange Regional Ocean Modeling Systems(ROMS) Kelvin waves spatiotemporal characteristics

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Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO Lei DOU Renjie CHEN xueming CAO Yu DAI Zhen hu Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

Spinal IL-33/ST2 Signaling Contributes to Chronic Itch via Astroglial JAK2–STAT3 Cascade in Mice

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Spinal IL-33/ST2 Signaling Contributes to Chronic Itch via A...

中国神经科学学会第十二届全国学术会议

作者： Lixia Du xueming hu Wenqiang Cui Langyue hu Yang Zhou Yanqing Wang Wenli Mi Department of Integrative Medicine and Neurobiology The Academy of Integrative Medicine School of Basic Medical Sciences Institutes of Brain Science Brain Science Collaborative Innovation Center State Key Laboratory of Medical Neurobiology Fudan University

Increasing evidence including our previous studies indicates that interleukin-33（IL-33） and its receptor ST2 contribute to spinal glial activation and chronic pain sensitization. The recent study showed the critical role of peripheral IL-33 in poison ivy induced chronic itch. But the role of spinal IL-33/ST2 signaling in chronic itch is unclear. In this study, the ST2 gene knockout（ST2-/-） mice showed substantial reductions in scratching in chronic itch models of allergic contact dermatitis（ACD） induced by DNFB, as well as dry skin induced by acetone and diethylether followed by water（AEW）. In the ACD mice, the expression of spinal IL-33 and ST2 was significantly increased. The increased IL-33 was predominantly distributed in oligodendrocytes and astrocytes, while ST2 mainly expressed in astrocytes. Further studies showed that in the ACD mice, the activation of astrocytes and the increased phosphorylation of the transducer and activator of transcription 3（STAT3）, an emerging and critical molecule associated with itch, were markedly attenuated by intrathecal administration of neutralizing anti-ST2 antibody or ST2 gene knockout. Moreover, intrathecal injection of AG490, an inhibitor of the STAT3 activator Janus kinase（JAK）, significantly reduced the scratching behavior in DNFBinduced ACD mice. The above results indicate that spinal IL-33/ST2 signaling contributes to chronic itch via activating the astroglial JAK2–STAT3 cascade which providing a potential therapeutic option for treating itch.

关键词： IL-33/ST2 signaling Chronic itch Astrocytes JAK2-STAT3

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提高陆风SUV汽车正面碰撞安全性的研究

汽车工程 2008年第10期30卷 835-838,860页

作者：曾应龙胡学明李长银江铃控股有限公司开发中心南昌330200

针对"陆风SUV汽车被动安全性改进开发"项目的要求,采用CAE技术,找出了陆风SUV现有车身结构存在的问题,提出了改进方案,并对其效果进行了验证。

关键词：汽车碰撞安全车身 CAE

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对我国男篮部分高大队员投篮技术与存在问题的分析

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河南师范大学学报(自然科学版) 1987年第3期 90-93页

作者：胡学明河南师范大学体育系

本文运用观察法和临场专题技术统计,对我国男篮一线队伍中22名身高在2米以上的高大队员在比赛中各种投篮方式的运用能力与存在问题进行统计分析。揭示我国男篮高大队员在运用技术中的差距,以及训练工作中的薄弱环节。

关键词：高大队员投篮技术投篮方式

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第04期 307-317页

作者： TAO Lei DOU Renjie CHEN xueming CAO Yu DAI Zhen hu Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical Pharmacy China Pharmaceutical University

Ulcerative colitis（UC）, a prevalent form of inflammatory bowel disease（IBD）, may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species（ROS） and subsequent cellular oxidative stress *** studies have identified both peroxisome proliferator-activated receptor-γ（PPARγ） and endoplasmic reticulum（ER） stress as critical targets for the treatment of IBD. Oroxyloside(C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium（DSS）-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis,including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662(1 mg·kg-1, i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages（BMDM） and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

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馆员与大学生管理员协同创新关系之刍议

农业网络信息 2013年第6期 78-80页

作者：胡学明广东轻工职业技术学院广东广州510300

高职院校让大学生参与图书馆管理工作并实施正确的引导和有效的管理,可以充分发挥其主观能动性,有利于高职院校图书馆馆员与大学生管理员协同创新,有助于促进高校图书馆事业的发展。

关键词：高校图书馆大学生管理员协同创新管理模式

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