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The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier

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Nano Research 2020年第10期13卷 2791-2802页

作者： Yaru Li Xiaojie Zhang Zhifeng Qi xueling guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du State Key Laboratory for Structural Chemistry of Unstable and Stable Species Center for Molecular ScienceInstiute of ChemistryChinese Academy of SciencesBeijing 100190China Graduate School University of Chinese Academy of SciencesBejing 100049China Cerebrovascular Diseases Research Institute Xuanwu Hospital of Captital Medical UniversityBeijing 100053China Department of Neurosurger The Second Hospial of Hebei Medical UniversityShijazhuang 050051China

Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke.

关键词： ischemic stroke blood-brain barrier salvianic acid A COG1410 reactive oxygen species(ROS)-responsive nanocarrier mitophagy

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Evaluation of Atypical Lymphocyte Warnings of Sysmex XE-4000 in Outpatient Children

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Agricultural Science & Technology 2014年第8期15卷 1256-1257页

作者： xueling guo Tingbo ZHANG Maofan WANG Department of Examination Chuxiong Medical College Department of Clinical Laboratory Chuxiong Prefecture People's Hospital

This study aimed to evaluate the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children. [Method] Randomly 280 specimens of outpatient children were selected to analyze atypical lymphocytes with Sysmex XE-4000 and artificial smear microscopy simultaneously. [Result] With artificial smear microscopy as the gold standard, the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children exhibited a sensitivity of 97.4%, specificity of 69.3%, positive predictive value （PPV） of 55%, and negative predictive value （NPV） of 98.5%. [Conclusion] Sysmex XE-4000 shows a high sensitivity in atypical lymphocyte warnings, which can reduce the number of blood smears, improve the specificity of microscopy, and decline the labor intensity of inspection personnel. However, there are stil certain false positives to be confirmed by artificial microscopy.

关键词： Hematology analyzer Atypical lymphocyte Microscopy

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Melatonin attenuates hippocampal neuron apoptosis and oxidative stress injury during chronic intermittent hypoxia exposure via up-regulation of BCL-2 and down-regulation of BAX

Melatonin attenuates hippocampal neuron apoptosis and oxidat...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： xueling guo Xiaoqin Tan Huiguo Liu the Department of Respiratory and Critical Care Medicine Tongji Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyKey Laboratory of Respiratory Disease of the Ministry of Health Wuhan Brain Hospital General Hospital of The Yangtze River Shipping

Objectives To investigated the effect of melatonin on the expression of BCL-2 and BAX,hippocampal neuron apoptosis and oxidative stress in rats exposed to chronic intermittent hypoxia(CIH),the major pathophysiologic feature of obstructive sleep apnea syndrome(OSAS). Methods Rats were randomly divided into three groups: a control group,a CIH group and a melatonin-treated (10mg/kg) CIH *** were exposed to either IH

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Combined incisional ropivacaine infiltration and pulmonary recruitment manoeuvre for postoperative pain relief after diagnostic hysteroscopy and laparoscopy

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Chinese Medical Journal 2014年第5期127卷 825-829页

作者： Liu Huili Ma Caihong Zhang Xiaoqing Yu Chen Yang Yan Song xueling Tang Yi guo Xiangyang Department of Anesthesiology Peking University Third Hospital Beijing 100191 China

Background Preoperative incisional local anaesthesia with ropivacaine is a common method of providing postlaparoscopy pain *** pulmonary recruitment manoeuvre also provides pain relief,but the combined effect of these two methods on pain following laparoscopic procedures has not been *** investigated the efficacy of combining local anaesthetic infiltration of ropivacaine with pulmonary recruitment manoeuvre on postoperative pain following diagnostic hysteroscopy and *** This prospective,randomized,controlled study involved 60 patients divided into two groups （n=30,each）.Group 1 received 20 ml of 0.5％ ropivacaine injected peri-incisionally preoperatively,with intra-abdominal carbon dioxide removed by passive *** 2 received 20 ml of 0.5％ ropivacaine injected peri-incisionally with five manual inflations of the lungs with a positive-pressure ventilation of 40 cmH2O at the end of *** last inflation was held for 5 *** intensity of postoperative incisional and shoulder pain was evaluated using a numerical rating scale at 0,2,4,8,12,24 and 48 hours postoperatively by an independent blinded *** was given postoperatively for *** Compared with group 1,incisional ropivacaine infiltration combined with pulmonary recruitment manoeuvre significantly reduced dynamic pain at 0 hour,4 hours,and 24 hours postoperatively （4.1 ± 2.2 vs.2.1 ± 1.9,P=0.002;2.7 ± 2.7 vs.1.2 ± 1.3,P=0.035; and 3.5 ± 2.1 vs.2.1 ± 1.8,P=0.03,respectively）.Static incisional pain was significantly relieved at 0 hour,2 hours,and 24 hours postoperatively （3.1 ± 1.7 vs.1.6 ± 1.3,P=0.001; 1.4 ± 1.3 vs.0.5 ± 0.8,P=0.012;and 2.3 ± 1.9 vs.1.0 ± 1.5,P=0.038,respectively）.Group 2 had more patients without shoulder pain （P＜0.05） and fewer requiring tramadol （P＜0.05）.Conclusion Ropivacaine with pulmonary recruitment manoeuvre provided simple and effective pain relief after diagnostic hysteroscopy and laparoscopy.

关键词： analgesia postoperative care ropivacaine local anaesthesia pulmonary recruitment manoeuvre

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HX2013 AT1R expression in rat aorta exposed to chronic intermittent hypoxia:effects of p38MAPK and ERK1/2 signaling

HX2013 AT1R expression in rat aorta exposed to chronic inter...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Jin Shang Yuanyuan Yang xueling guo Huiguo Liu Department of Respiratory and Critical Care MedicineTongji HospitalHuazhong University of Science and Technology

Obstructive sleep apnea is a frequent medical condition consisting of repetitive sleep-related episodes of upper air ways obstruction and can lead to ***Ⅱtype 1 receptor(AT1R) has played important roles in hypertension since it binds with AngⅡcontroling salt-water and blood pressure homeostasis. Object To study rat aorta AT1R expression in intermittent hypoxia and the signaling pathways involved. Methods Rat model preparation was used a

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ERK Signaling Mediates Enhanced Angiotensin Ⅱ-induced Rat Aortic Constriction following Chronic Intermittent Hypoxia(CIH)

ERK Signaling Mediates Enhanced Angiotensin Ⅱ-induced Rat A...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： xueling guo Yan Deng Jin Shang Kui Liu Yongjian Xu Huiguo Liu the Department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyKey Laboratory of Respiratory Disease of the Ministry of Health

Background Obstructive sleep apnea(OSA) has been recognized as an independent risk factor for systemic *** study investigates the functional consequences of chronic intermittent hypoxia(CIH) on aorticconstriction induced by Angiotensin II(Ang II) and the possible signaling involving ERK and contractile proteins such asmyosin light chain kinase (MLCK),myosin phosphatase targeting subunit(MYPT1) and myosin light chain(MLC).

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新建应用型本科高校提高档案管理工作水平途径的探索与实践——以齐齐哈尔工程学院为例

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职业技术 2015年第6期 5-6页

作者：郭学玲齐齐哈尔工程学院黑龙江齐齐哈尔161005

档案工作是应用型本科高校的重要基础工作之一,以齐齐哈尔工程学院为例,从着力提升档案管理工作的软硬件水平、将档案管理工作摆在重要位置和注重发挥档案管理工作作用三个方面,探索新建应用型本科高校提高档案管理水平途径。

关键词：应用型本科高校档案管理

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应用型本科院校的学院办公室职能的思考

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职业技术 2015年第7期15卷 22-23页

作者：郭学玲齐齐哈尔工程学院黑龙江省齐齐哈尔市161005

本文结合应用型本科院校实际,思考学院办公室职能如何改革创新更利于学院整体运行与发展,从四种政治意识、服务意识、大局意识和创新意识出发,探索学院办公室调研辅助决策,督查督办促进贯彻落实等职能,从高从严加强自身建设,促进应用型... 详细信息

本文结合应用型本科院校实际,思考学院办公室职能如何改革创新更利于学院整体运行与发展,从四种政治意识、服务意识、大局意识和创新意识出发,探索学院办公室调研辅助决策,督查督办促进贯彻落实等职能,从高从严加强自身建设,促进应用型本科院校发展。

关键词：应用型本科办公室职能档案管理

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自我护理管理在卫生院高血压患者的应用效果

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中国医药指南 2024年第22期22卷 135-137页

作者：郭雪玲泉州台商投资区东园镇中心卫生院内科泉州362122

目的分析不同护理模式在卫生院高血压患者护理中的干预效果。方法选择卫生院收治的62例高血压患者为研究对象,经随机数字表法分组后,对照组患者(31例)实施常规护理,观察组患者(31例)则采取自我护理管理干预,比较两组患者的血压值、治疗... 详细信息

目的分析不同护理模式在卫生院高血压患者护理中的干预效果。方法选择卫生院收治的62例高血压患者为研究对象,经随机数字表法分组后,对照组患者(31例)实施常规护理,观察组患者(31例)则采取自我护理管理干预,比较两组患者的血压值、治疗依从性以及自我管理效能等数据。结果观察组患者护理后的舒张压为(86.81±3.98)mmHg、收缩压为(131.95±6.42)mmHg低于对照组(P<0.05);观察组患者护理1周、2周、3周的自我管理效能评分分别为(26.30±1.26)分、(34.52±2.42)分、(39.95±2.59)分,高于对照组(P<0.05)。观察组患者护理后的治疗依从性以及健康生活行为评分均高于对照组(均P<0.05)。结论自我护理管理干预更有助于控制患者血压,并加快患者疾病自我管理能力的养成,促使患者时刻维持健康的生活行为习惯,符合慢性病患者临床干预要求。

关键词：高血压护理干预自我护理管理干预

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基于外泌体的纳米材料治疗肿瘤研究进展

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中国生物工程杂志 2024年第6期44卷 25-32页

作者：饶佩韩泽旭史海涛齐奕珂郭学玲王英泽河北科技大学食品与生物学院石家庄050018

外泌体(exosome)是指从细胞膜上脱落或由细胞分泌的双层膜结构的纳米级囊泡状小体,直径为40~150 nm,它可以包裹DNA、mRNA、microRNA、circRNA、蛋白质等。包括肿瘤细胞在内的几乎所有活细胞都能分泌外泌体,在细胞通信、信号转导、包裹... 详细信息

外泌体(exosome)是指从细胞膜上脱落或由细胞分泌的双层膜结构的纳米级囊泡状小体,直径为40~150 nm,它可以包裹DNA、mRNA、microRNA、circRNA、蛋白质等。包括肿瘤细胞在内的几乎所有活细胞都能分泌外泌体,在细胞通信、信号转导、包裹递送、肿瘤治疗和诊断中均起关键作用。外泌体具有独特的生物学特性,优良的肿瘤归巢性和对递送药物靶向性使外泌体成为癌症诊断中极具吸引力标志物和有效的肿瘤治疗工具,因此,对外泌体作为纳米材料更全面的研究,必将加速其在治疗肿瘤的研究进展。总结了外泌体的靶向递送功能,以及外泌体在肿瘤诊断、免疫疗法、肿瘤微环境、药物耐药性等癌症治疗相关问题,期望对基于外泌体在肿瘤治疗中的开发和评估提供思考。

关键词：外泌体纳米材料肿瘤

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