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Micro-coevolution of host genetics with gut microbiome in three Chinese ethnic groups

Journal of genetics and genomics 2021年第11期48卷 972-983页

作者： Mingyue Cheng xueling ge Chaofang Zhong Ruiqing Fu Kang Ning Shuhua Xu Key Laboratory of Molecular Biophysics of the Ministry of Education Hubei Key Laboratory of Bioinformatics and Molecular-imagingCenter of AI BiologyDepartment of Bioinformatics and Systems BiologyCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Computational Biology Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of genetic Engineering Center for Evolutionary BiologyCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Excellence in Animal Evolution and genetics Chinese Academy of SciencesKunming 650223China Henan Institute of Medical and Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450052China Human Phenome Institute Fudan UniversityShanghai 201203China

Understanding the micro-coevolution of the human gut microbiome with host genetics is challenging but essential in both evolutionary and medical *** gain insight into the interactions between host genetic variation and the gut microbiome,we analyzed both the human genome and gut microbiome collected from a cohort of 190 students in the same boarding college and representing 3 ethnic groups,Uyghur,Kazakh,and Han *** found that differences in gut microbiome were greater between genetically distinct ethnic groups than those genetically closely related ones in taxonomic composition,functional composition,enterotype stratification,and microbiome genetic *** also observed considerable correlations between host genetic variants and the abundance of a subset of gut microbial ***,interactions between gut microbiome species and host genetic variants might have coordinated effects on specific human *** ovatus,previously reported to modulate intestinal immunity,is significantly correlated with the host genetic variant rs12899811(meta-P=5.55×10^(-5)),which regulates the VPS33B expression in the colon,acting as a tumor suppressor of colorectal *** results advance our understanding of the micro-coevolution of the human gut microbiome and their interactive effects with host genetic variation on phenotypic diversity.

关键词： Micro-coevolution Gut microbiome Host genetics Uyghur Kazakh Han Chines

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Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders

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National Science Review 2019年第6期6卷 1201-1222页

作者： Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan xueling ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of Sciences School of Life Science and Technology Shanghai Tech University State Key Laboratory of genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratory of genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University The Eye Hospital School of Ophthalmology &Optometry Wenzhou Medical University China National Center for International Research in Regenerative Medicine and Neurogenetics Institute for Molecular Bioscience Queensland Brain Institute The University of Queensland Key Laboratory for Molecular genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region School of Medicine Xizang Minzu University Center for Excellence in Animal Evolution and genetics Chinese Academy of Sciences Collaborative Innovation Center of genetics and Development Human Phenome Institute Fudan University

Human genetic adaptation to high altitudes(>2500 m) has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified, largely owing to the lack of deep-genome sequencing data available to previous studies. Here, we build a list of putative adaptive variants, including 63 missense, 7 loss-of-function, 1,298 evolutionarily conserved variants and 509 expression quantitative traits loci. Notably, the top signal of selection is located in TMEM247, a transmembrane protein-coding *** Tibetan version of TMEM247 harbors one high-frequency(76.3%) missense variant, rs116983452(c.248 C > T; ***83 Val), with the T allele derived from archaic ancestry and carried by >94% of Tibetans but absent or in low frequencies(<3%) in non-Tibetan populations. The rs116983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p = 5.78 × 10), red blood cell count(p = 5.72 × 10) and hematocrit(p = 2.57 × 10). In particular, TMEM247-rs116983452 shows greater effect size and better predicts the phenotypic outcome than any EPAS1 variants in association with adaptive traits in Tibetans. Modeling the interaction between TMEM247-rs116983452 and EPAS1 variants indicates weak but statistically significant epistatic *** results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism.

关键词： Tibetan adaptive genetic variant high-altitude adaptation next-generation sequencing(NGS) archaic ancestry expression quantitative traits loci(eQTL) tissue-specific expression hemoglobin concentration hypoxia

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疫情防控常态化背景下硕士研究生招生考试面临的舆情风险及应对措施探析

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中国考试 2022年第9期 63-68页

作者：李琳娜时悦琪葛学玲西安邮电大学西安710121 北京科技大学北京100083

全国硕士研究生招生考试作为一项大规模高利害的国家教育考试,与考生切身利益息息相关,受到社会高度关注。在疫情防控常态化背景下,研究生考试考务管理工作面临的舆情风险主要有:考务人员在面对突发情况时应对考生诉求存在盲点风险,新... 详细信息

全国硕士研究生招生考试作为一项大规模高利害的国家教育考试,与考生切身利益息息相关,受到社会高度关注。在疫情防控常态化背景下,研究生考试考务管理工作面临的舆情风险主要有:考务人员在面对突发情况时应对考生诉求存在盲点风险,新增线上考务工作存在潜在流程风险,异地借考工作突发存在潜在管理风险,全媒体时代存在舆情信息的急剧爆发风险。在分析上述舆情风险点的基础上,提出应对的措施主要有:加强组织领导,强化风险责任意识;注重考务培训,强化舆情信息意识;组建专家智库,提升应急处突能力;搭建协同平台,提升舆情处置时效;拓宽咨询平台,提升服务考生意识。

关键词：研究生考试教育考试考试管理考试舆情教育舆情网络舆情

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Serum metabolism alteration behind different etiology, diagnosis, and prognosis of disorders of consciousness

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中华神经外科杂志(英文) 2024年第03期10卷 199-210页

作者： ge Qianqian Lu Hezhen geng Xiaoli Chen xueling Liu Xiaoyan Sun Haidan Guo Zhengguang Sun Jiameng Qi Feng Niu Xia Wang Aiwei He Jianghong Sun Wei Xu Long Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China-Japan Union Hospital of Jilin University Changchun China Core Instrument Facility Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China China National Clinical Research Center for Neurological Diseases (NCRC-ND) Beijing China

Background Patients with disorders of consciousness (DoC) exhibit varied revival outcomes based on different etiologies and diagnoses, the mechanisms of which remain largely unknown. The fluctuating clinical presentations in DoC pose challenges in accurately assessing consciousness levels and prognoses, often leading to misdiagnoses. There is an urgent need for a deeper understanding of the physiological changes in DoC and the development of objective diagnostic and prognostic biomarkers to improve treatment *** To explore biomarkers and understand the biological processes, we conducted a comprehensive untargeted metabolomic analysis on serum samples from 48 patients with DoC. Patients were categorized based on etiology (TBI vs. non-TBI), CRS-R scores, and prognosis. Advanced analytical techniques, including PCA and OPLS-DA models, were employed to identify differential *** Our analysis revealed a distinct separation in metabolomic profiles among the different groups. The primary differential metabolites distinguishing patients with varying etiologies were predominantly phospholipids, with a notable decrease in glycerophospholipids observed in the TBI group. Patients with higher CRS-R scores exhibited a pattern of impaired carbohydrate metabolism coupled with enhanced lipid metabolism. Notably, serum concentrations of both LysoPE and PE were reduced in patients with improved outcomes, suggesting their potential as prognostic *** Our study underscores the critical role of phospholipid metabolism in the brain’s metabolic alterations in patients with DoC. It identifies key biomarkers for diagnosis and prognosis, offering insights that could lead to novel therapeutic targets. These findings highlight the value of metabolomic profiling in understanding and potentially treating DoC.

关键词： Disorders of consciousness Serum biomarkers Untargeted metabolomic analysis

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基于护士危机意识的预警性管理干预应用于脑卒中偏瘫患者中的效果观察

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中外医学研究 2023年第24期21卷 80-84页

作者：葛学玲张万权鲍丽芳王元江苏省荣军医院江苏无锡214000

目的:探讨基于护士危机意识的预警性管理干预在脑卒中偏瘫患者中的应用效果。方法:选取2020年1月-2022年6月在江苏省荣军医院接受治疗的116例脑卒中偏瘫患者为研究对象,将其随机分为两组,各58例。对照组实施常规干预,观察组实施基于护... 详细信息

目的:探讨基于护士危机意识的预警性管理干预在脑卒中偏瘫患者中的应用效果。方法:选取2020年1月-2022年6月在江苏省荣军医院接受治疗的116例脑卒中偏瘫患者为研究对象,将其随机分为两组,各58例。对照组实施常规干预,观察组实施基于护士危机意识的预警性管理干预。比较两组下肢深静脉血栓形成(DVT)与下肢肿胀发生情况,肢体运动功能、负性情绪及生活质量。结果:干预1周后,观察组DVT发生率与下肢肿胀发生率均明显低于对照组,差异有统计学意义(P<0.05)。观察组干预1周后上肢评分、下肢评分及总分均明显高于对照组,差异有统计学意义(P<0.05)。观察组干预1周后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分均明显低于对照组,差异有统计学意义(P<0.05)。观察组干预1周后脑卒中专用生活质量量表(SS-QOL)评分明显高于对照组,差异有统计学意义(P<0.05)。结论:基于护士危机意识的预警性管理干预的应用,可降低脑卒中偏瘫患者发生DVT与下肢肿胀等不良事件,提高其肢体运动功能,同时还能够显著缓解患者的负性情绪,促进其生活质量的改善。

关键词：护士危机意识预警性管理干预脑卒中偏瘫

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脑卒中偏瘫病人日常生活活动能力训练中引入活动分析法的临床实践

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循证护理 2023年第12期9卷 2192-2195页

作者：葛学玲张万权鮑丽芳王元江苏省荣军医院江苏214000

目的:探讨脑卒中偏瘫病人日常生活活动能力训练中引入活动分析法的效果。方法:将2021年6月—2022年6月收治的符合纳入标准的脑卒中偏瘫病人80例,按入院先后顺序分为两组,各40例。对照组实施常规日常生活活动能力训练,试验组在此基础上... 详细信息

目的:探讨脑卒中偏瘫病人日常生活活动能力训练中引入活动分析法的效果。方法:将2021年6月—2022年6月收治的符合纳入标准的脑卒中偏瘫病人80例,按入院先后顺序分为两组,各40例。对照组实施常规日常生活活动能力训练,试验组在此基础上引入活动分析法。两组训练时间为每次30 min,每周1次,持续训练4周。评价两组训练前后运动功能、日常生活活动能力、神经功能及步行能力变化,进行比较分析。结果:试验组训练4周后上肢、下肢功能评分明显提高,且高于对照组(P<0.05);试验组训练4周后日常生活活动能力明显增强,且强于对照组(P<0.05);试验组训练4周后神经功能明显恢复,且优于对照组(P<0.05);试验组训练4周后步行能力明显提高,且优于对照组(P<0.05)。结论:脑卒中偏瘫病人日常生活活动能力训练中引入活动分析法可改善运动功能及日常生活活动能力,促进神经功能恢复,提高步行能力。

关键词：脑卒中偏瘫日常生活活动能力训练活动分析法运动功能神经功能步行能力护理

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Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na^+ neuronal current

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Neural Regeneration Research 2010年第19期5卷 1464-1469页

作者： Jingyan ge Yinan Wang Haiyan Liu Fangfang Chen xueling Cui Zhonghui Liu Department of Physiology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China Department of Immunology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China Department of Anatomy Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China Department of genetics Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China

Activin A, which was first described in 1986, has been shown to maintain hippocampal neuronal survival. Activin A increases intracellular free Ca2＋ via L-type Ca2＋ channels. Our previous study showed that activin A promotes neurite growth of dorsal root ganglia in embryonic chickens and inhibits nitric oxide secretion. The present study demonstrated for the first time that activin A could maintain cerebral cortex neuronal survival in vitro for a long period, and that activin A was shown to increase voltage-gated Na＋ current （/Na） in Neuro-2a cells, which was recorded by patch clamp technique. The present study revealed a novel mechanism for activin A, as well as the influence of activin A on neurons by regulating expressions of vasoactive intestine peptide and inducible nitric oxide synthase.

关键词： activin A cerebral cortex neuron voltage-gated sodium current neuro-2a cell neural regeneration

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Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

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Cellular & Molecular Immunology 2009年第2期6卷 129-133页

作者： Jingyan ge Yinan Wang Ye Feng Haiyan Liu xueling Cui Guixiang Tai Zhonghui Liu Department of Immunology Norman Bethune College of Medicine Jilin University Changchun 130021 China Department of Surgery China-Japan Union Hospital Jilin University Changchun 130031 China

Macrophages play critical roles in innate immune and acquired immune v/a secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor （TGF-β） superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC Ⅱ expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages.

关键词： activin macrophage MHCⅡ CD80

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A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo

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Cellular & Molecular Immunology 2009年第5期6卷 387-392页

作者： Yinan Wang xueling Cui Guixiang Tai Jingyan ge Nan Li Fangfang Chen Fang Yu Zhonghui Liu Department of Immunology Norman Bethune College of Medicine JilinUniversity Changchun 130021 China These authors contributed equally to this work Department of Immunology Norman Bethune College of Medicine Jilin University Changchun 130021 China

Activin A, a multifunctional factor of the transforming growth factor-beta （TGF-β） superfamily, is mainly produced by microglia and macrophages, and its anti-inflammatory and pro-inflammatory activities are both related to macrophage functions. However the direct effect of activin A on the rest macrophages in vivo remains unclear. In the present study, the results showed that activin A not only increased NO and IL-1β release, but also promoted phagocytic abilities of mouse peritoneal macrophages in vitro and in vivo, whereas it did not influence MHC Ⅰ and MHC Ⅱ expression. Moreover, we found that activin A significantly upregulated the expressions of CD14 and CD68, markers of mature macrophages, on the surface of macrophages in vitro and in vivo. These data suggest that activin A can induce primary macrophage maturation in vitro and in vivo, but may not trigger the acquired immune response via regulating expression of MHC molecules involved in presentation of antigen.

关键词： activin A macrophage maturation CD68 CD14

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Molecular insights on Ca^(2+)/Na+separation via graphene-based nanopores:The role of electrostatic interactions to ionic dehydration

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Chinese Journal of Chemical Engineering 2022年第1期35卷 220-229页

作者： Yumeng Zhang Yingying Zhang xueling Pan Yao Qin Jiawei Deng Shanshan Wang Qingwei Gao Yudan Zhu Zhuhong Yang Xiaohua Lu College of Chemical Engineering State Key Laboratory of Materials-oriented Chemical EngineeringNanjing Tech UniversityNanjing 211816China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China School of Chemical Engineering State Key Laboratory of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Ca^(2+)/Na+separation is a common problem in industrial applications,biological and medical ***,Ca^(2+)and Na+have similar ionic radii and hydration radii,thus Ca^(2+)/Na+separation is *** by biological channels,group modification is one of the effective methods to improve the separation *** this work,molecular dynamics simulations were performed to investigate the effects of different functional groups(COO,NH3+)on the separation performance of Ca^(2+)and Na+through graphene nanopores under an electric *** pristine graphene nanopore was used for *** showed that three types of nanopores preferred Ca^(2+)to Na+,and Ca^(2+)/Na+selectivity followed the order of ge-COO(4.06)>ge(1.85)>ge-NH3+(1.63).Detailed analysis of ionic hydration microstructure shows that different nanopores result in different hydration factors for the second hydration layer of Ca^(2+)and the first layer of Na+.Such different hydration factors corresponding to the dehydration ability can effectively evaluate the separation *** addition,the breaking of hydrogen bonds between water molecules due to electrostatic effects can directly affect the dehydration ***,the electrostatic effect generated by group modification will affect the ionic hydration microstructure,thus reflecting the differences in dehydration *** in turn affects the permeable and separation performance of *** results of this work provide perceptive guidelines for the application of graphene-based membranes in ion separation.

关键词： Separation Microstructure Molecular simulation Modified graphene nanopores Metal-ions Nanoconfinement

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