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CMIP6模式对欧亚大陆冬季雪水当量的模拟能力评估及未来预估

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气候与环境研究 2024年第1期29卷 75-89页

作者：陈红史学丽中国科学院大气物理研究所北京100029 中国气象局地球系统数值预报中心北京100081 中国气象局地球系统数值预报重点开放实验室北京100081

基于第六次耦合模式比较计划(CMIP6)的模式模拟数据和欧洲宇航局GlobSnow卫星遥感雪水当量(Snow Water Equivalent,SWE)资料,评估了CMIP6耦合模式对1981~2014年欧亚大陆冬季SWE的模拟能力,并应用多模式集合平均结果预估了21世纪欧亚大陆... 详细信息

基于第六次耦合模式比较计划(CMIP6)的模式模拟数据和欧洲宇航局GlobSnow卫星遥感雪水当量(Snow Water Equivalent,SWE)资料,评估了CMIP6耦合模式对1981~2014年欧亚大陆冬季SWE的模拟能力,并应用多模式集合平均结果预估了21世纪欧亚大陆SWE的变化情况。结果表明,CMIP6耦合模式对冬季欧亚大陆中高纬度SWE空间分布具有较好的再现能力,能模拟出欧亚大陆中高纬度SWE的主要分布特征;耦合模式对SWE变化趋势及经验正交函数主要模态特征的模拟能力存在较大差异,但多模式集合能提高模式对SWE变化趋势和主要时空变化特征的模拟能力;此外,多模式集合结果对欧亚大陆冬季SWE与降水、气温的关系也有较好的再现能力。预估结果表明,21世纪欧亚大陆东北大部分地区的SWE均要高于基准期(1995~2014年),而90°E以西的欧洲大陆SWE基本上呈现减少的特征;21世纪早期,4种不同排放情景下积雪变化的差异不大,但21世纪后期积雪变化的幅度差异较大,而且排放越高积雪变化的幅度越大,模式不确定性也越大;进一步的分析表明,欧亚大陆冬季未来积雪变化特征的空间分布与全球变化背景下局地气温、降水的变化密切相关,高温高湿的条件有利于欧亚大陆东北部积雪的增多。

关键词：欧亚大陆雪水当量 CMIP6 模式冬季模拟预估

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合欢对精神疾病的药理作用及机制研究进展

药物评价研究 2024年第8期47卷 1929-1936页

作者：黄辰杰樊明理杜晓娜施学丽广西中医药大学研究生学院广西南宁530200 防城港市中医医院科教科广西防城港538000 广西中医药大学壮医药学院广西南宁530001

合欢Albizia julibrissin是一种药食两用的中药材,在临床中应用广泛。合欢的主要药用部位有合欢皮和合欢花,内含多种有效成分,具有抗炎、抗氧化、抗抑郁、镇静催眠等多种药理作用。研究显示合欢皮和合欢花及有效成分能通过调节神经递质... 详细信息

合欢Albizia julibrissin是一种药食两用的中药材,在临床中应用广泛。合欢的主要药用部位有合欢皮和合欢花,内含多种有效成分,具有抗炎、抗氧化、抗抑郁、镇静催眠等多种药理作用。研究显示合欢皮和合欢花及有效成分能通过调节神经递质表达、减轻氧化应激及炎症反应、调控相关信号通路等机制起到改善及治疗抑郁症、焦虑症等精神疾病的目的。主要对合欢皮、合欢花及有效成分抗抑郁和抗焦虑等治疗精神疾病的药理作用及机制的研究现状进行综述,旨在为合欢作为抗精神疾病药物的开发与应用提供参考。

关键词：合欢合欢皮合欢花精神疾病抑郁症焦虑症

Climate effects of the GlobeLand30 land cover dataset on the Beijing Climate Center climate model simulations

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Science China Earth Sciences 2016年第9期59卷 1754-1764页

作者： shi xueli NIE SuPing JU WeiMin YU Le National Climate Center Beijing 100081 China International Institute for Earth System Science (ESSI) Nanjing University Nanjing 210093 China Ministry of Education Key Laboratory for Earth System Modeling Center for Earth System Science Tsinghua University Beijing 100084 China Joint Center for Global Change Studies Beijing 100875 China

Land cover is one of the most basic input elements of land surface and climate models. Currently, the direct and indirect effects of land cover data on climate and climate change are receiving increasing attentions. In this study, a high resolution(30 m) global land cover dataset(Globe Land30) produced by Chinese scientists was, for the first time, used in the Beijing Climate Center Climate System Model(BCC_CSM) to assess the influences of land cover dataset on land surface and climate simulations. A two-step strategy was designed to use the Globe Land30 data in the model. First, the Globe Land30 data were merged with other satellite remote sensing and climate datasets to regenerate plant functional type(PFT) data fitted for the BCC_CSM. Second, the up-scaling based on an area-weighted approach was used to aggregate the fine-resolution Globe Land30 land cover type and area percentage with the coarser model grid resolutions globally. The Globe Land30-based and the BCC_CSM-based land cover data had generally consistent spatial distribution features, but there were some differences between them. The simulation results of the different land cover type dataset change experiments showed that effects of the new PFT data were larger than those of the new glaciers and water bodies(lakes and wetlands). The maximum value was attained when dataset of all land cover types were changed. The positive bias of precipitation in the mid-high latitude of the northern hemisphere and the negative bias in the Amazon, as well as the negative bias of air temperature in part of the southern hemisphere, were reduced when the Globe Land30-based data were used in the BCC_CSM atmosphere model. The results suggest that the Globe Land30 data are suitable for use in the BCC_CSM component models and can improve the performance of the land and atmosphere simulations.

关键词： Land cover Climate model Application strategy Numerical simulation Air temperature Precipitation

“三全育人”视角下中医专业学位研究生心理健康问题的分析及对策研究

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科教文汇 2024年第8期 180-183页

作者：施学丽黄辰杰汪磊广西中医药大学壮医药学院广西南宁530001 广西中医药大学基础医学院广西南宁530200 广西中医药大学赛恩斯新医药学院广西南宁530200

文章论述当前中医专业学位研究生存在的心理健康问题及其产生原因,并从“三全育人”视角提出解决或缓解中医专业学位研究生心理健康问题的策略,有助于中医专业学位研究生身心健康和顺利完成学业,并对中医专业学位研究生群体开展心理健... 详细信息

文章论述当前中医专业学位研究生存在的心理健康问题及其产生原因,并从“三全育人”视角提出解决或缓解中医专业学位研究生心理健康问题的策略,有助于中医专业学位研究生身心健康和顺利完成学业,并对中医专业学位研究生群体开展心理健康教育带来一些启发。

关键词：三全育人中医专业学位研究生心理健康问题

‘Initial’ Soil Moisture Effects on the Climate in China——A Regional Climate Model Study

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Journal of Ocean University of China 2009年第2期8卷 111-120页

作者： shi xueli Laboratory for Climate Studies National Climate Center China Meteorological Administration Beijing 100081 P. R. China

In this study,the effects of ‘initial’ soil moisture(SM) in arid and semi-arid Northwestern China on subsequent climate were investigated with a regional climate model. Besides the control simulations(denoted as CTL),a series of sensitivity experiments were conducted,including the DRY and WET experiments,in which the simulated ‘initial’ SM over the region 30 –50°N,75 –105°E was only 5% and 50%,and up to 150% and 200% of the simulated value in the CTL,respectively. The results show that SM change can modify the subsequent climate in not only the SM-change region proper but also the far downstream regions in Eastern and even Northeastern China. The SM-change effects are generally more prominent in the WET than in the DRY experiments. After the SM is initially increased,the SM in the SM-change region is always higher than that in the CTL,the latent(sensible) heat flux there increases(decreases),and the surface air temperature decreases. Spatially,the most prominent changes in the WET experiments are surface air temperature decrease,geopotential height decrease and corresponding abnormal changes of cyclonic wind vectors at the mid-upper troposphere levels. Generally opposite effects exist in the DRY experiments but with much weaker intensity. In addition,the differences between the results obtained from the two sets of sensitivity experiments and those of the CTL are not always consistent with the variation of the initial SM. Being different from the variation of temperature,the rainfall modifications caused by initial SM change are not so distinct and in fact they show some common features in the WET and DRY experiments. This might imply that SM is only one of the factors that impact the subsequent climate,and its effect is involved in complex processes within the atmosphere,which needs further investigation.

关键词： soil moisture regional climate numerical model experiments

酸枣仁-合欢花对抑郁模型大鼠海马内质网应激IRE1α/ASK1/JNK通路的影响

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中药新药与临床药理 2024年第2期35卷 200-207页

作者：施学丽黄辰杰范丽丽马晓聪郭超峰广西中医药大学壮医药学院广西南宁530001 广西中医药大学研究生院广西南宁530200 广西中医药大学药学院广西南宁530200 广西中医药大学学科办广西南宁530200 广西中医药大学基础医学院广西南宁530200

目的基于内质网应激(ERS)肌醇依赖性激酶1α(IRE1α)/凋亡信号调节激酶1(ASK1)/c-Jun氨基末端激酶(JNK)通路探讨酸枣仁-合欢花对孤养结合慢性不可预见性温和应激(chronic unpredictable mild stress,CUMS)抑郁模型大鼠的干预作用。方法... 详细信息

目的基于内质网应激(ERS)肌醇依赖性激酶1α(IRE1α)/凋亡信号调节激酶1(ASK1)/c-Jun氨基末端激酶(JNK)通路探讨酸枣仁-合欢花对孤养结合慢性不可预见性温和应激(chronic unpredictable mild stress,CUMS)抑郁模型大鼠的干预作用。方法将144只大鼠随机分为正常组、模型组及酸枣仁-合欢花高、中、低剂量组和文拉法辛组。除正常组外,其他各组进行21 d的孤养结合CUMS制备大鼠抑郁模型。用旷场实验和Morris水迷宫实验观察大鼠行为学变化;用透射电镜观察海马神经细胞超微结构变化;用TUNEL染色法观察海马神经细胞凋亡情况;用Western Blot法检测海马组织IRE1α、磷酸化(P)-IRE1α、ASK1、P-ASK1、JNK、P-JNK、B细胞淋巴瘤2(Bcl-2)、Bcl-2相关X蛋白(Bcl-2 associated X protein,Bax)、胱天蛋白酶3(Caspase-3)蛋白表达水平;用Real-Time PCR法检测海马IRE1α、ASK1、JNK、Bax、Bcl-2、Caspase-3 mRNA表达水平。结果与正常组比较,模型组旷场实验中水平运动和垂直运动得分下降(P<0.01);水迷宫实验中逃避潜伏期增加、跨越原平台次数减少(P<0.01);海马神经细胞凋亡数增加(P<0.01);海马P-IRE1α/IRE1α、P-ASK1/ASK1、P-JNK/JNK、Bax、Caspase-3蛋白及IRE1α、ASK1、JNK、Bax、Caspase-3 mRNA表达水平升高、Bcl-2蛋白及mRNA表达水平降低(P<0.01)。与模型组比较,酸枣仁-合欢花各组及文拉法辛组旷场实验中水平运动和垂直运动得分升高(P<0.01);水迷宫实验中逃避潜伏期缩短、跨越原平台次数增加(P<0.01);海马神经细胞凋亡数减少(P<0.01);海马P-IRE1α/IRE1α、P-ASK1/ASK1、P-JNK/JNK、Bax、Caspase-3蛋白及IRE1α、ASK1、JNK、Bax、Caspase-3 mRNA表达水平降低,Bcl-2蛋白及mRNA表达水平升高(P<0.05,P<0.01),且酸枣仁-合欢花中剂量组较高、低剂量组效果更好。结论酸枣仁-合欢花可能通过调节内质网应激IRE1α/ASK1/JNK通路发挥抗抑郁作用。

关键词：酸枣仁-合欢花抑郁症海马内质网应激 IRE1α/ASK1/JNK通路胱天蛋白酶-3 大鼠

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中医药调控内质网应激治疗抑郁症的研究进展

四川中医 2024年第1期42卷 218-222页

作者：黄辰杰樊明理施学丽广西中医药大学研究生学院广西南宁530200 广西中医药大学壮医药学院广西南宁530001

抑郁症是一类精神障碍的常见疾病,具有高患病率和复发率。内质网应激(ERS)通过激活未折叠蛋白反应(UPR)来介导包括抑郁症在内的多种精神疾病的发病机制。传统抗抑郁药物存在副反应大、药物依赖性强等不足,因此寻找疗效更佳的药物替代治... 详细信息

抑郁症是一类精神障碍的常见疾病,具有高患病率和复发率。内质网应激(ERS)通过激活未折叠蛋白反应(UPR)来介导包括抑郁症在内的多种精神疾病的发病机制。传统抗抑郁药物存在副反应大、药物依赖性强等不足,因此寻找疗效更佳的药物替代治疗必不可少,已成为时下治疗抑郁症方面的研究热点。研究发现中药及其有效成分、复方等中医疗法能发挥多途径、多环节、多靶点的作用机制,有效减少ERS诱导的神经细胞凋亡,从而发挥抗抑郁作用,改善抑郁症状。因此,运用中医药治疗由ERS介导的抑郁症值得总结与推广。

关键词：中医药内质网应激抑郁症综述

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酸枣仁及其复方抗抑郁作用机制研究进展

现代中药研究与实践 2024年第3期38卷 91-95页

作者：黄辰杰樊明理施学丽广西中医药大学研究生学院广西南宁530200 广西中医药大学壮医药学院广西南宁530001

抑郁症是一类常见且复杂的精神疾病,严重影响人们的健康水平和生活质量。酸枣仁是治疗抑郁症的常用中药之一,大量临床研究和动物实验均证实其确有疗效,在抑郁症防治领域得到广泛关注。本文总结了酸枣仁主要活性成分及其复方的抗抑郁作... 详细信息

抑郁症是一类常见且复杂的精神疾病,严重影响人们的健康水平和生活质量。酸枣仁是治疗抑郁症的常用中药之一,大量临床研究和动物实验均证实其确有疗效,在抑郁症防治领域得到广泛关注。本文总结了酸枣仁主要活性成分及其复方的抗抑郁作用机制研究成果,从调节单胺类神经递质、炎性细胞因子及脑源性神经营养因子(BDNF)等方面归纳总结其抗抑郁作用机制,为酸枣仁主要活性成分及其复方抗抑郁机制进一步深入研究提供参考。

关键词：酸枣仁抑郁症作用机制活性成分中药复方

Climate Sensitivity and Feedbacks of BCC-CSM to Idealized CO2 Forcing from CMIP5 to CMIP6

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Journal of Meteorological Research 2020年第4期34卷 865-878页

作者： xueli shi Xiaolong CHEN Yunwei DAI Guoquan HU National Climate Center China Meteorological AdministrationBeijing 100081 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences(CAS)Beijing 100101 Huafeng Meteorological Media Group China Meteorological AdministrationBeijing 100081

Climate sensitivity represents the response of climate system to doubled CO2 concentration relative to the preindustrial level, which is one of the sources of uncertainty in climate projections. It is unclear how the climate sensitivity and feedbacks will change as a model system is upgraded from the Coupled Model Intercomparison Project Phase 5(CMIP5) to CMIP6. In this paper, we address this issue by comparing two versions of the Beijing Climate Center Climate System Model(BCC-CSM) participating in CMIP6 and CMIP5, i.e., BCC-CSM2-MR and BCC-CSM1.1 m,which have the same horizontal resolution but different physical parameterizations. The results show that the equilibrium climate sensitivity(ECS) of BCC-CSM slightly increases from CMIP5(2.94 K) to CMIP6(3.04 K). The small changes in the ECS result from compensation between decreased effective radiative forcing(ERF) and the increased net feedback. In contrast, the transient climate response(TCR) evidently decreases from 2.19 to 1.40 K, nearly the lower bound of the CMIP6 multimodel spread. The low TCR in BCC-CSM2-MR is mainly caused by the small ERF overly even though the ocean heat uptake(OHU) efficiency is substantially improved from that in BCC-CSM1.1 *** shortwave feedback(λSWCL) is found to be the major cause of the increased net feedback in BCC-CSM2-MR,mainly over the Southern Ocean. The strong positive λSWCL in BCC-CSM2-MR is coincidently related to the weakened sea ice-albedo feedback in the same region. This result is caused by reduced sea ice coverage simulated during the preindustrial cold season, which leads to reduced melting per 1-K global warming. As a result, in BCCCSM2-MR, reduced surface heat flux and strengthened static stability of the planetary boundary layer cause a decrease in low-level clouds and an increase in incident shortwave radiation. This study reveals the important compensation between λSWCL and sea ice-albedo feedback in the Southern Ocean.

关键词： Beijing Climate Center Climate System Model(BCC-CSM) climate sensitivity cloud feedback sea icealbedo feedback Coupled Model Intercomparison Project Phase 6(CMIP6)