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口腔中幽门螺杆菌PCR检测方法的建立

基因组学与应用生物学 2019年第1期38卷 220-225页

作者：朱艳平何勇邢瑞林岳锋李鹏徐涛明会婷诸雪晶王珂孙梦研张艳芳孙国鹏徐文慧高冉孟萌王选年新乡学院生命科学技术学院新乡学院生物技术研究中心新乡453003 河南科技学院新乡453003

全世界大约有50%的人口感染幽门螺杆菌(Helicobacter pylori, Hp),Hp感染容易造成慢性胃炎、消化性溃疡、低度恶性胃MALT淋巴瘤及胃癌,对人类造成严重的危害。为寻求一种简便、准确、非创伤性的方法用于口腔中Hp的检测,本研究建立了口... 详细信息

全世界大约有50%的人口感染幽门螺杆菌(Helicobacter pylori, Hp),Hp感染容易造成慢性胃炎、消化性溃疡、低度恶性胃MALT淋巴瘤及胃癌,对人类造成严重的危害。为寻求一种简便、准确、非创伤性的方法用于口腔中Hp的检测,本研究建立了口腔中幽门螺杆菌的PCR检测方法,并对建立的PCR方法的敏感性、特异性进行分析,并应用于检测唾液样品和牙菌斑共50份。结果显示,50份样品中,阳性率为82%。结果表明,本研究建立的口腔中Hp的PCR检测方法特异性强、敏感性高,可以用于临床上Hp诊断的重要参考。

关键词：口腔幽门螺杆菌 PCR

Influence of Pr-Al-Co alloy diffusion source on magnetic properties and microstructure of sintered Nd-Fe-B magnets processed by grain boundary diffusion

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Journal of Rare Earths 2022年第12期40卷 1885-1893,I0003页

作者： Lei Jin Jinhao zhu Guangfei Ding Zhehuan Jin Bo Zheng xuejing Cao Shuai Guo Renjie Chen Aru Yan Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technologyand EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China

In this study,the influence of the content of Al and Co in the diffusion source on the magnetic performance and microstructure of the diffused magnet was studied by grain boundary diffusion treatment with Pr_(70)Al_(30-x)Co_(x)(x=0 at%,10 at%,15 at%,20 at%,30 at%)*** the Co content in the diffusion source increases from 0 at%to 10 at%,the coercivity enhancement in the Pr_(70)Al_(20)Co_(10)diffused magnet is the highest,increased from 1.62 to 2.24 T,higher than 2.01 T of the Pr_(70)Al_(30)diffused *** further increase of Co content in the diffused source,the coercivity of the diffused magnet decreases gradually,the coercivity of Pr_(70)Al_(15)Co_(15),Pr_(70)Al_(20)Co_(10)and Pr_(70)Co_(30)diffused magnet is 2.15,1.99 and1.81 T,*** analysis shows that plenty of continuous grain boundary phases(CGBPs)can be formed in the Pr_(70)Al_(20)Co_(10)diffused magnet under the synergistic effect of Al and Co,which leads to the enhancement of magnetic isolation between more adjacent ***,the amount of CGBP in the diffused magnets gradually decreases with the further increase of Co content in the diffusion source.

关键词： Nd-Fe-B Coercivity Pr-AI-Co alloys Grain boundary diffusion Rare earths

Solid-gas Phase Preparation Method for Porous Molybdenum Trioxide

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Journal of Wuhan University of Technology(Materials Science) 2020年第3期35卷 495-500页

作者： REN Jie MU Shichun YANG Daohe LI xuejing DONG Shengqi zhu Junwei LIN Xianghai DONG Xuebin State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Wuhan Construction Engineering Safety Supervision Station Wuhan 430015China School of Civil Engineering Wuhan Univer-sityWuhan 430072China

A novel solid-gas reaction preparation technology was used to adjust the composition and microstructure of the composite crystal materials by changing the preparation parameters. Compared with the commonly used sol-gel method, acid base neutralization sedimentation method, hydrothermal method, and gas phase deposition method, the technology was relatively simplified and the elemental composition was controllable, without the use of openings and additives. A kind of multi-element composite porous metal oxide was obtained by pre-intercalation and decarburization. In order to increase the porosity of MoO3 material and promote the adsorption and diffusion of reactant molecules, the microstructure of MoO3 was studied. The preparation process of porous molybdenum trioxide by solid gas combination process was discussed, which provides an innovative idea for the design and preparation of new materials with a large specific surface area and other desirable properties.

关键词： molybdenum trioxide porous structure solid-gas phase method synthetic

智能网联汽车L2部分驾驶自动化监管体系研究

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汽车文摘 2024年第7期 32-36页

作者：冯莉朱云尧吴胜男杨学婧文洋中国汽车工程研究院股份有限公司重庆404100 中汽院汽车技术有限公司北京100000

L2部分驾驶自动化(国内称“组合驾驶辅助”)技术加速演进、市场渗透快速提升,是智能网联汽车当前落地应用重要方向,也是我国政府当前关注的焦点,但我国当前缺少强制性的政策法规约束,亟需强化监管。通过深入研究美、欧、日等国家和地区... 详细信息

L2部分驾驶自动化(国内称“组合驾驶辅助”)技术加速演进、市场渗透快速提升,是智能网联汽车当前落地应用重要方向,也是我国政府当前关注的焦点,但我国当前缺少强制性的政策法规约束,亟需强化监管。通过深入研究美、欧、日等国家和地区针对智能网联汽车L2部分驾驶自动化相关政策法规及标准,充分吸收借鉴有益经验,同时系统分析我国组合驾驶辅助市场现状、技术水平和应用需求,为我国科学、有效提出组合驾驶辅助监管政策提供智力支撑。

关键词：智能网联汽车 L2部分驾驶自动化生产企业政策建议

Broad-spectrum and powerful neutralization of bacterial toxins by erythroliposomes with the help of macrophage uptake and degradation

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4235-4248页

作者： Chunying Liu Shuangrong Ruan Ying He xuejing Li Yuefei zhu Honglan Wang Hanwei Huang Zhiqing Pang School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China The Institute for Biomedical Engineering&Nano Science Tongji University School of MedicineShanghai 200092China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430022China

Anti virulence strategy has been considered as one of the most promising approaches to combat drug-rcesistant bacterial ***-forming toxins(PFTs)are the largest class of bacterial toxins,inficting their virulence ffect through creating pores on the cell ***,curent solutions for eliminating PFTs are mostly designed based on their molecular structure,requiring customized design for different *** the present study,we employed erythroliposome(denoted as RM-PL),a biomimetic platform constructed by artificial lipid membranes and natural erythrocyle membranes,to necutralize different hemolytic PFTs regardless of their molecular *** tested with model PFTs,including a-hemolysin,listeriolysin O,and streptolysin O,RM-PL could completely inhibit toxin-induced hemolysis in a concentration-dependent *** vivo studies further confirmed that *** eficiently neuralize various toxins and save animals'lives without causing damage to 0rgans or *** addition,we explored the underlying mechanisms of this efficient detoxification ability and found that it was mainly macrophages in the spleen and the liver that took up RM-PL-absorbed toxins through a variety of endocytosis pathways and digested them in *** summary,the biomimetic RM-PL presented a promising system for broad-spectrum and powerful toxin neutralization with a mech-anism of lysosome-mediaed loxin degradation.

关键词： Eythroliposome Broad-spectrum detoxifcation Hybrid nanovesicle Pore-forming toxins Macrophage uptake Red blood cell membrane Atificial lipid membrane

Multi-functional stimuli-responsive biomimetic flower assembled from CLCE and MOF-based pedals

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Chinese Chemical Letters 2023年第1期34卷 517-522页

作者： Dongpeng Sun Lin Zheng xuejing Xu Kaiyang Du Zhiqiang An Xuan Zhou Li Chen Jiliang zhu Dong Chen Department of Applied Physics Hebei University of TechnologyTianjin 300401China College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Simulating the structures and behaviors of living organisms are of great significance to develop novel multi-functional intelligent devices. However, the development of biomimetic devices with complex deformable structures and synergistic properties is still on the way. Herein, we propose a simple and effective approach to create the multi-functional stimuli-responsive biomimetic devices with independently pre-programmable colorful visual patterns, complex geometries and morphable modes. The metal organic framework(MOF)-based composite film acts as a rigidity actuation substrate to support and mechanically guide the spatial configuration of the soft chiral nematic liquid crystal elastomer(CLCE) sheet. We can directly program the structural color of the CLCE sheet by adjusting the thickness distribution without tedious chemical modification. By using this coordination strategy, we fabricate an artificial flower, which exhibits a synergistic effect of both shape transformation and color change like paeonia ‘Coral Sunset’at different flowering stages, and can even perform different flowering behaviors by bending, twisting and curling petals. The assembled bionic flower is innovatively demonstrated to respond to local stimuli of humidity, heat or ultraviolet irradiation. Therefore, the spatial assembly of CLCE combined with functional MOF materials has a wide range of potential application in multi-functional integrated artificial systems.

关键词： 3D assembly Biomimetic structure Synergistic responses Cholesteric liquid crystal elastomer Bragg reflection

石蜡与氨基酸废母液粉配施对烟草重金属Cd吸附的阻控效应

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环境化学 2024年第4期43卷 1365-1373页

作者：李云捷李佳陈振国李建平喻雪婧云月利孙光伟朱蓉李亚东湖北大学生命科学学院武汉430062 湖北省烟草科学研究院武汉430033

烟草是强富集镉(Cd)的重要经济作物.为降低烟草对Cd的吸收,以矿区污染土壤(Cd含量为0.678 mg·kg^(−1))为种植基质,烟草专用肥(硝态氮)为对照,氨基酸母液粉为新型氮肥(氨基氮),并分别配施作为土壤微生物碳源的食品级石蜡,以期促进土壤... 详细信息

烟草是强富集镉(Cd)的重要经济作物.为降低烟草对Cd的吸收,以矿区污染土壤(Cd含量为0.678 mg·kg^(−1))为种植基质,烟草专用肥(硝态氮)为对照,氨基酸母液粉为新型氮肥(氨基氮),并分别配施作为土壤微生物碳源的食品级石蜡,以期促进土壤微生物种群与数量的持续增加(石蜡降解速度缓慢),通过微生物的生化调控达到降低土壤有效态Cd含量,从而减少烟叶对镉的吸收.结果表明:(1)石蜡和氨基酸废母液粉配施(T4处理)显著(P<0.05)提高土壤微生物丰富度,ACE指数达到4464.47,Chao1指数达到3888.30,氨基酸废母液粉(T3处理)土壤微生物多样性最好,Shannon指数达到6.4066;(2)施加氨基酸废母液粉(T3、T4处理)可显著(P<0.05)提高土壤pH值,3个时期(烟叶旺长期、打顶期、成熟期)最大提高量分别为0.23、0.49和0.35;(3)石蜡和氨基酸废母液粉显著(P<0.05)降低土壤有效态Cd含量,3个时期较烟草专用肥组(T1处理)分别降低了14.8%—20.7%、18.6%—34.5%、20.5%—36.7%;(4)石蜡和氨基酸废母液粉显著(P<0.05)降低烟叶Cd含量,3个时期较烟草专用肥(T1处理)分别降低了0.6%—10.2%、8.2%—26.2%、13.8%—38.9%.因此,石蜡和氨基酸废母液粉配施能够有效提高土壤微生物丰富度和多样性,降低土壤有效态Cd含量,减少烟草对Cd的吸收.

关键词：石蜡氨基酸废母液粉土壤微生物烟草镉

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早晚兼用型优质杂交水稻新组合五乡优398的选育

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杂交水稻 2023年第5期38卷 80-82页

作者：曾博虹赵佳梁万建林吴晓峰蔡耀辉范燕波朱雪晶李永辉谢红卫曹志斌江西省超级水稻研究发展中心江西南昌330200 江西省天仁种业有限公司江西吉安331300

五乡优398是江西省天仁种业有限公司、广东省农科院水稻所和江西省超级水稻研究发展中心利用恢复系广恢398和优质香型三系不育系五乡A联合选配的早晚兼用型三系杂交水稻新组合,具有熟期早、米质较优、稳产性好等优点,2020、2021年先后... 详细信息

五乡优398是江西省天仁种业有限公司、广东省农科院水稻所和江西省超级水稻研究发展中心利用恢复系广恢398和优质香型三系不育系五乡A联合选配的早晚兼用型三系杂交水稻新组合,具有熟期早、米质较优、稳产性好等优点,2020、2021年先后作为晚稻、早稻通过江西省农作物品种审定委员会审定,适宜在江西省稻作区早、晚季种植。

关键词：杂交水稻早晚兼用型五乡优398 选育

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冷球蛋白血症性肾炎的临床病理特点

临床与病理杂志 2017年第7期37卷 1376-1381页

作者：龚再良朱雪婧袁曙光杨淡昳张磊王畅李勰家刘映红刘虹中南大学湘雅二医院肾内科中南大学肾脏病研究所长沙410011

目的:分析冷球蛋白血症性肾炎的临床病理特点,以提高其诊治率。方法:回顾性分析2014年8月至2015年7月中南大学湘雅二医院确诊的冷球蛋白血症性肾炎的3例患者的临床资料。结果:3例冷球蛋白血症性肾炎患者中2例为中年女性,1例为青年男性,... 详细信息

目的:分析冷球蛋白血症性肾炎的临床病理特点,以提高其诊治率。方法:回顾性分析2014年8月至2015年7月中南大学湘雅二医院确诊的冷球蛋白血症性肾炎的3例患者的临床资料。结果:3例冷球蛋白血症性肾炎患者中2例为中年女性,1例为青年男性,所有患者均伴有系统性损伤的表现,3例患者的冷球蛋白的血清冷凝集试验为阳性。2例合并HBV感染,1例合并HCV感染。结论:冷球蛋白血症性肾炎有其独特的肾脏病理特征,肾活检可提高冷球蛋白血症性肾炎的诊断率,提高临床医生对此病的认识,及早进行标准化的治疗。

关键词：冷球蛋白血症性肾炎临床病理特点诊断